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Carcinoma of the cervix uteri in Ibadan: coital characteristics.

Carcinoma of the cervix uteri has been found to be the most common female malignancy in Ibadan, excluding the reticuloendothelial tumors. In a study to investigate associated etiological factors in this environment, it was demonstrated that certain coital characteristics of women with cervical cancer can be identified. These were a common denominator which could explain the frequency of the disease among some categories of patients who engage in early sexual practice, have intercourse frequently and with multiple partners, and have many pregnancies. Support was given to the view that a sexually transmitted factor might be important in the cause of carcinoma of the cervix.

Adolescent↗

Partial necrosis of cervix uteri as a complication to HELLP-syndrome.

BACKGROUND: The HELLP-syndrome is a rare complication to pregnancy and a potential fatal condition. CASE: We report such a case in a 32-year-old para 2, gravida 1 woman with no known risk factors. A lower transverse uterotomy was performed at 29 weeks and 6 days' gestation based on an indication of HELLP-syndrome. Uncharacteristically lower back pain developed on the second day postoperatively and a gynaecological examination was performed. A partial necrotic cervix uteri was found with many trombosed vessels and necrotic tissue. CONCLUSION: Partial necrosis of cervix uteri can be seen as a complication to the HELLP-syndrome.

Adult↗

[The level of immunoglobulins and antispermatic antibodies in the cervical mucus of infertile women with cervix uteri pathology].

This article is about determination of local immunity indices, immunoglobulins of A, M, G, sIgA classes and antispermal immunity of the cervical mucus in infertile women with pathology of cervix uteri. It is shown that usage of complex tests with local immunity as well as identification antispermal antibody should be a reliable basis to diagnose infertile women with benign and precancerous diseases of cervix uteri.

Antibodies↗

Anatomy and histology of the cervix uteri of the ewe: new insights.

The gross and microscopical anatomy of the cervix uteri of the ewe has been studied in an attempt to provide a three-dimensional description of the cervix as it relates to the histological appearance cervical tissue sections. Casts of the inside of the cervical lumen show its convoluted structure consisting of six circular folds, the second fold being eccentric to the other concentric folds and acting as a physiological barrier. Previous histological descriptions of the ovine cervix have failed to provide a clear understanding of the complex structure of its wall. The cervical wall of the ewe comprises five defined layers. The structure of the circular folds is comparatively simple as they consist only of the two deeper layers.

Animals↗

Cervix uteri cancer incidence in relation to ethnic situation in Opole province, Poland.

This paper presents results of a retrospective ecological analysis of cervix uteri cancer incidence in relation to the ethnic situation in the province of Opole, Poland. A few well-known methodological procedures were applied in the study. Detecting spatial disease clusters followed Tango's method. Estimates of relative risks of cancer morbidity were calculated via Clayton and Kaldor's empirical Bayes approach. To measure spatial correlation between neoplasmatic incidence and ethnic density, Moran's statistic was used. The Poisson modelling of the variables was performed using Markov Chain Monte Carlo technique--Gibbs sampling. The results presented in tables and graphs suggest a possible association between the ethnic pattern and risk of cervix uteri cancer in the analyzed province.

Bayes Theorem↗

[Histological diagnosis of precancerous and early stages in cancer of the cervix uteri].

The histologic diagnosis of premalignant and early malignant lesions of the cervix uteri necessitates the teamwork of histologists and clinicians. This cooperation amounts to: 1. the indication for biopsy; 2. the technic of biopsy; 3. the histologic technic; 4. the agreement of nomenclature of pathologic epithelium with identical prognostic evaluation of the different lesions. The indication for biopsy is confirmed by the result of cytology and colposcopy. In every single case seeming suspicious either by cytology or colposcopy a biopsy must be done. Great numbers of biopsies require a method which can be performed at an outpatient department, such as Schiller's scraping, punch biopsy and curettage of the cervical channel. The positive diagnosis originating from such a small biopsy specimen only justifies the necessity of treatment, not however the method of therapy. The extent of treatment is determined by the histologic diagnosis of cone biopsy which has to be done next. At what extent, depends on the visibility of the whole lesion and especially on the visibility of the maximum of possible existent invasion. Good technic of conization and step serial sections satisfy this condition. If handled as said reduced cancer therapy is admissible: in cases of carcinoma in situ or of severe dysplasia by conization or by total hysterectomy; in cases of early stromal invasion by hysterectomy or even by conization. Whether or not a reduced cancer therapy was permissible, also in cases of microcarcinoma, is to be decided by follow up controls of cases treated by these methods. Here too the condition is the exact determination of the whole lesion by step serial sections of the cone.

Biopsy↗

[Complications of preoperative high-dose-rate iridium-192 irradiation in cervix uteri carcinoma].

A report is given about the experience in preoperative, nonfractionated high-dose iridium-192 irradiation in cases of carcinoma of the cervix uteri. A few days prior to radical hysterectomy a dose of 20 Gy (in 2 cm distance) was applied locally by means of a loop-applicator (afterloading technique, Buchler). In cases without postoperative irradiation severe vaginal necroses, in cases with postoperative irradiation severe local and peripheral lesions were observed. In 8 of 10 cases irradiated pre- and postoperatively, another surgical intervention was necessary because of complications in the urinary or intestinal tract. This publication is presented as a warning for preoperative high-dose irradiation with 20 Gy applied locally in cases of carcinoma of the cervix uteri.

Brachytherapy↗

Study of sequences of DNA of the human papilloma virus genotypes 6 and 16 in patients with cancer of vulva and cervix uteri.

Puntaction hybridization method was used to determine the incidence of the human papilloma virus infection in cases with the squamous cell cancer of the vulva and cervix uteri. The presence of sequences of DNA of the HPV genotype and 16 was found in 74.2% of cases, which points to a suspicion for the involvement of the above viruses in etiology of cervix uteri cancer, as well as vulva cancer.

DNA Probes, HPV↗

[Laser DNA-flow cytofluorometry in the differential diagnosis and prognosis of the cervix uteri cancer].

Laser DNA-flow cytofluorometry (DNA-FC) was used to examine 102 primary patients with morphologically verified pathology of the epithelium of the cervix uteri. There was a significant reduction in the count of cells in the cellular cycle phase (CCP) G0/1 and its increase in the CCP S and G2 + M, as well as a rose in the cell proliferation index (PI) in actually invasive (n=45) and microinvasive cancer of the cervix uteri (CCU) (n=21) as compared with the baseline values (n=8), CIN I-II (n=7), and CIN III (21 patients with severe dysplasia and cancer in situ; their DNA-FC parameters were close and significantly indistinguishable). With unfavorable clinical and morphological factors of CCU prognosis (age over 50 years, postmenopause, stages II-III, high-grade tumor, more than 3 mm stromal invasion, more than 4 cm in size, lymphovascular invasion in the regional lymph nodes, the endophytic form of growth, and a primary focus in the endocervix), aneuploid tumors were more significantly frequently found. The poor CCU prognostic factors significantly decreasing total and relapse-free 4-year survival included tumors of aneuploid type, those containing greater than 40% of aneuploid cells, those containing less than 70% of tumor cells in CCP G0/1, those having 10% of tumor cells or more in CCP S or more than 30% cell PI. While predicting CCU, the DNA index (DNAI) and PI with 0.09 and 0.05 informative value coefficients, respectively are the most significant DNA-FC parameters (after Shenon). By using them, the risk of progressive disease may be predicted with 67.9% probability. When DNAI and PI are used in combination with the most significant clinical and morphological factors of CCU, the likelihood of the latter increases up to 89.3%.

Aneuploidy↗