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Results for “Behavioral immune system”

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PubMed2004

The effect of cocaine sensitization on mouse immunoreactivity.

Recent studies indicate a role of the immune system in the behavioral effects of cocaine in rodents. In the present study, we attempted to find a correlation between the behavioral changes induced by repeated, intermittent administration of cocaine and some immunological consequences of sensitization to cocaine. Male Albino Swiss mice were treated repeatedly (for 5 days) with cocaine (10 or 15 mg/kg, intraperitoneally, ip). On day 9, they received a challenge dose of cocaine (10 or 15 mg/kg). Acute administration of cocaine increased the locomotor activity of mice. In animals treated repeatedly with the higher dose of cocaine, the locomotor hyperactivity induced by a challenge dose of the psychostimulant (15 mg/kg) was ca. twice as high as that after its first administration; in consequence, evidence for behavioral sensitization was obtained. Immune functions were evaluated by measuring the ability of splenocytes to proliferate and to produce cytokines such as interferon-gamma (IFN-gamma), interleukin (IL)-4 and IL-10. Acute cocaine administration significantly decreased proliferation of splenocytes to concanavalin A (Con A) and increased their ability to produce IFN-gamma. Repeated intermittent treatment with cocaine in a dose of 10 mg/kg significantly decreased the thymus weight and the proliferative response of T cells to a suboptimal dose of Con A. Sensitization with the higher dose of cocaine significantly enhanced IFN-gamma production. These data indicate that cocaine sensitization results in the development of a tolerant state to the cocaine-induced suppression of a thymus dependent T-lymphocyte response. It may be suggested that the cocaine sensitization partly depends on the altered balance of cytokine production, e.g. an increase in IFN-gamma production. Since repeated, intermittent use of cocaine by humans leads to psychoses or craving for this drug, our findings also seem to indicate considerable importance of monitoring and correcting immune changes in the therapy of cocaine addiction.

Animals↗
PubMed1991

Self-regulation of the immune system through biobehavioral strategies.

Increasing scientific study and attention is being directed to mind-body interactions, particularly to the interrelationships between the brain and the immune system. This effort has created a new interdisciplinary field, psychoneuroimmunology. An overview of this new field is provided, followed by a comprehensive survey of the growing evidence suggesting that measurable immune system parameters can be influenced by biobehavioral strategies involving self-regulation. Modalities included are relaxation and imagery techniques, biofeedback-assisted strategies, the use of humor, and affiliation to influence emotional states, hypnosis, and conditioning paradigms. The majority of studies have reported significant immune parameter changes. Additional well-designed research is needed to clarify and confirm these initial findings. Future research would benefit from investigating the clinical implications of these immune parameter changes. Knowledge of effects of the mind on the body is rapidly expanding and may be important for achieving improved immune system functioning and health.

Behavior Therapy↗
PubMed2006

Differential DNA methylation patterns of small B-cell lymphoma subclasses with different clinical behavior.

Non-Hodgkin's lymphoma (NHL) is a group of malignancies of the immune system with variable clinical behaviors and diverse molecular features. Despite the progress made in classification of NHLs based on classical methods, molecular classifications are a work in progress. Toward this goal, we used an array-based technique called differential methylation hybridization (DMH) to study small B-cell lymphoma (SBCL) subtypes. A total of 43 genomic DMH experiments were performed. From these results, several statistical methods were used to generate a set of differentially methylated genes for further validation. Methylation of LHX2, POU3F3, HOXC10, NRP2, PRKCE, RAMP, MLLT2, NKX6.1, LRP1B and ARF4 was validated in cell lines and patient samples and demonstrated subtype-related preferential methylation patterns. For LHX2 and LRP1B, bisulfite sequencing, real-time reverse transcriptase-polymerase chain reaction and induction of gene expression following treatment with the demethylating agent, 5'-aza-2'-deoxycytidine, were confirmed. This new epigenetic information is helping to define molecular portraits of distinct subtypes of SBCL that are not recognized by current classification systems and provides valuable potential insights into the biology of these tumors.

Adult↗
PubMed2005

Behavioral conditioning with interferon beta-1a in humans.

Behavioral conditioning is one of the most impressive demonstrations of brain-immune system interaction. Numerous animal studies have demonstrated behavioral conditioned effects on immune functions, however, human studies are rare. We investigated whether it is possible to behaviorally condition the acute response to interferon (IFN)beta-1a. In a double-blind placebo-controlled study, 30 healthy subjects received a single injection of IFN(beta)-1a (6MIU of REBIF, Serono International) (unconditioned stimulus, UCS) together with a novel drink (conditioned stimulus, CS). Blood was drawn at baseline, 4, 8, and 24 h after drug administration. Within the first 8 h peripheral granulocytes significantly increased, while monocytes, lymphocytes, T-, B- and natural killer (NK) cell numbers were significantly reduced. In parallel, body temperature, heart rate, norepinephrine and interleukin (IL)-6 plasma levels were heightened within 8 h after injection. 8 days later, all previously IFN(beta)-treated subjects received a subcutaneous placebo (NaCl) injection, but only 15 subjects were re-exposed to the CS (experimental group), while a control group (N=15) drank water and an additional group of subjects (n=8) remained untreated (untreated group). Blood sampling was performed at baseline and at 4, 8, and 24 h. Re-exposition to the CS did not elicit conditioned responses in the experimental group. Moreover, no differences were observed between groups. These data provide negative findings regarding behavioral conditioning of cytokine effects in humans employing a one-trial learning paradigm.

Adult↗
PubMed1983

Internal images of antigens within the immune network.

The variable regions of antibody molecules react with each other via specific recognition of clonally distributed antigenic determinants, known under the general term of idiotypes. The totality of such interactions determines a special behavior of the immune system, as a whole, and its ability to regulate immune responses has been analyzed by the 'immune network theory' of Jerne [5]. In light of this theory, a particular property of idiotypes appears to be of special interest: as revealed by recent experiments, frequently idiotype-like determinants represent internal images of antigens. These internal images can be topochemical copies of nominal non-self antigenic determinants, of various functional non-lymphoid receptors, or of transplantation antigens. In this article, we present a view according to which internal images are essential structures which mediate cellular interactions leading to the selection and conservation of the immune repertoire of T and B lymphocytes. Our opinion is exposed in the context of experimental data obtained in several laboratories, including ours.

Animals↗
PubMedDate not supplied

Modification of lymphocyte subsets in patients with rhinoscleroma.

PURPOSE: Rhinoscleroma is a rare, chronic, granulomatous disorder of the upper airways. This disease presents some etiopathogenetic aspects that are not yet clear. Infection by Klebsiella rhinoscleromatis is fundamental for the onset of the disease, but it is impossible to reproduce rhinoscleroma experimentally only via infection with the bacteria both in man and in animals. Furthermore, this disease mainly affects blood-related people and occurs in certain geographic areas. In this context, we present a study that brings to light some of the quantitative abnormalities of the lymphocyte subsets. MATERIALS AND METHODS: The study group consisted of 5 patients with rhinoscleroma. The following parameters were studied for each patient: clinical manifestations, histologic examinations, number of leukocytes, lymphocytes, and lymphocyte subsets. RESULTS: In all patients, we noted the following: There was a relative reduction of the CD4+ cells, an absolute increase of the CD8+ cells, and an inversion of the CD4+/CD8+ ratio. There was an absolute increase of the CD56+ cells and cytotoxic cells that coexpress CD8+CD56+ antigens. There was a relative reduction of the CD3+ cells, and the CD19+ cells tended to show an ambiguous behavioral pattern. CONCLUSION: We believe that K. rhinoscleromatis does not play a major role in the etiopathogenesis of rhinoscleroma. However, we do believe that the anomalous behavior of the immune system can favor rhinoscleroma.

Adult↗
PubMed2003

Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives.

While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant. Gene transfer offers the prospect of highly specific therapies for childhood cancer. "Corrective" genes may be transferred to overcome the genetic abnormalities present in the precancerous cell. Alternatively, genes can be introduced to render the malignant cell sensitive to therapeutic drugs. The tumor can also be attacked by decreasing its blood supply with genes that inhibit vascular growth. Another possible approach is to modify normal tissues with genes that make them more resistant to conventional drugs and/or radiation, thereby increasing the therapeutic index. Finally, it may be possible to attack the tumor indirectly by using genes that modify the behavior of the immune system, either by making the tumor more immunogenic, or by rendering host effector cells more efficient. Several gene therapy applications have already been reported for pediatric cancer patients in preliminary Phase 1 studies. Although no major clinical success has yet been achieved, improvements in gene delivery technologies and a better understanding of mechanisms of tumor progression and immune escape have opened new perspectives for the cure of pediatric cancer by combining gene therapy with standard therapeutic available treatments.

Journal Article↗
PubMed1988

Gender differences in response to HIV infection.

There is strong epidemiologic evidence from studies of i.v. drug users in New York City for the existence of one or more gender-related cofactors in response to HIV infection. The strength of the evidence comes from the variety of data sets that indicate a gender-related cofactor and from the consistency of the pattern found: in all of the data sets, females appear to have a more "favorable" response than do males. The extent of underrepresentation of females in the cases of AIDS in i.v. drug users--a possible 35% reduction in the development of clinical AIDS-suggests that such a cofactor should be considered of practical importance. Identifying the mechanism(s) for a gender difference may lead to ways of deliberately affecting the course of the infection. Further research on the gender difference may also contribute to our understanding of interactions among the various components of the immune system and the interaction of the immune system with other behavioral and physiologic systems.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Immunologic study of carcinoma of the digestive tract. Effects of the tumor stage. I. Cellular immunity in the preoperative period.

We studied the behavior of the cellular immune system in two types of carcinoma of frequent clinical occurrence: large bowel and gastric cancers. We contrasted both types of neoplasia with respect to the behavior of cellular immunity in the preoperative period, according to the evolutive stage of the tumor. Two hundred and nine subjects were studied: 86 with gastric adenocarcinoma, 63 with adenocarcinoma of colon-rectum and 60 healthy controls. Total lymphocytes were quantitated, as were B and T cell subpopulations, and T cell function by measuring the response to PHA. Summarizing the results, a clear depression in cellular immunity was observed in stage III of gastric cancer. In large bowel cancer the repression of cellular immunity is of lesser magnitude than in gastric cancer.

Adenocarcinoma↗
PubMed1992

Conditioned immunopharmacologic effects on cell-mediated immunity.

One of the several lines of evidence documenting a relationship between the brain and the immune system is the research on behaviorally induced alterations in immune reactivity. The present review concentrates on the use of immunopharmacologic agents, stress, and antigenic stimuli as unconditioned stimuli (UCSs) in the classically conditioned suppression and enhancement of cell-mediated immune reactions including host-vs-graft and graft-vs-host reactions and delayed type hypersensitivity.

Adjuvants, Immunologic↗
PubMed2004

Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues.

A central feature of the immune system is the migratory behavior of its cellular components. Thus, fully understanding the generation and maintenance of immune responses must include consideration of how hematopoietic cells home to, interact within, and exit from secondary lymphoid organs as well as peripheral tissues. Recent advances in in situ imaging techniques now permit direct observation of these events in their physiologic settings with high spatiotemporal resolution. This review summarizes progress in this area of investigation from a lymphocentric perspective. We highlight controversies, point out key unanswered questions, and briefly outline what we believe are some of the near-term directions that in situ microscopic analysis of the immune system will take.

Animals↗
PubMed1982

Stress, behavior, and immunity: animal models and mediating mechanisms.

Research with animal model systems demonstrates a causal relation between stress and disease susceptibility. The physiological sequelae of stressful stimulation vary with type of stressor, chronicity, and perceived control. Different patterns of endocrine secretion are thus associated with specific behavioral parameters. The immune system is regulated at several levels: genetic, cellular, hormonal, and neuronal. Stress and behavioral factors can modulate both cell-mediated and humoral immunity by impacting on the latter three levels of regulation. Both corticosteroids and catecholamines, released as part of the response to aversive stimulation, profoundly inhibit immune responsivity by binding directly to the lymphocyte surface or by releasing secondary mediators that increase the function of suppressor lymphocytes. In addition, there are direct neuroanatomical connections between the hypothalamus and lymphoid organs. Subtle changes in experimental design have yielded significant differences in results that have increased understanding of intermediary mechanisms. Such research complements psychoneuroimmunological and behavioral epidemiological studies in humans.

Animals↗
PubMed1997

Involvement of glucocorticoids in the reorganization of the amphibian immune system at metamorphosis.

In recent years, integrative animal biologists and behavioral scientists have begun to understand the complex interactions between the immune system and the neuroendocrine system. Amphibian metamorphosis offers a unique opportunity to study dramatic hormone-driven changes in the immune system in a compressed time frame. In the South African clawed frog, Xenopus laevis, the larval pattern of immunity is distinct from that of the adult, and metamorphosis marks the transition from one pattern to the other. Climax of metamorphosis is characterized by significant elevations in thyroid hormones, glucocorticoid hormones, and the pituitary hormones, prolactin and growth hormone. Previously, we and others have shown that elevated levels of unbound glucocorticoid hormones found at climax of metamorphosis are associated with a natural decline in lymphocyte numbers, lymphocyte viability, and mitogen-induced proliferation. Here we present evidence that the mechanism for loss of lymphocytes at metamorphosis is glucocorticoid-induced apoptosis. Inhibition of lymphocyte function and loss of lymphocytes in the thymus and spleen are reversible by in vitro or in vivo treatment with the glucocorticoid receptor antagonist, RU486, whereas the mineralocorticoid receptor antagonist, RU26752, is poorly effective. These observations support the hypothesis that loss of larval lymphocytes and changes in lymphocyte function are due to elevated concentrations of glucocorticoids that remove unnecessary lymphocytes to allow for development of immunological tolerance to the new adult-specific antigens that appear as a result of metamorphosis.

Aldosterone↗
PubMed1995

What is the role of the immune system in determining individually distinct body odours?

Genetically inbred mice and rats which are identical except for the genes of the major histocompatibility complex (MHC) produce unique urinary odours which can be discriminated by other animals. Congenic strains differing in both the Class I and Class II regions of the MHC produce distinct urinary odours. These urine odours can be used for mate selection and parental recognition, and it has been suggested that they provide a unique genetic mechanism for kin recognition. However, the non-MHC genes and the X and Y chromosomes also modulate the urinary odours of rodents, and rearing rats in a bacteria-free environment inhibits the production of unique MHC-related odours. We have found that dietary differences produce a greater effect on individual odours than differences at one MHC locus. These results suggest that the MHC, commensal bacteria, and dietary products interact to produce urinary odours which can be used for individual recognition in rodents. The problem is: what is the role of the immune system in determining individually distinct body odours? A model that suggests possible answers to this question is proposed.

Animals↗
PubMed2005

Reflections on the discovery and significance of estrogen receptor beta.

We have known for many years that estrogen is more than the female hormone. It is essential in the male gonads, and in both sexes, estrogen has functions in the skeleton and central nervous system, on behavior, and in the cardiovascular and immune systems. An important aspect of the discovery of estrogen receptor (ER) beta is that the diverse functions of estrogen can now be divided into those mediated by ERalpha and those mediated by ERbeta. Pharmacological exploitation of this division of the labors of estrogen is facilitated by the ligand-binding specificity and selective tissue distribution of the two ERs. Because the ligand binding domains of ERalpha and ERbeta are significantly different from each other, selective ligands can be (and have been) developed to target the estrogenic pathway that is malfunctioning, without interfering with the other estrogen-regulated pathways. Because of the absence of ERbeta from the adult pituitary and endometrium, ERbeta agonists can be used to target ERbeta with no risk of adverse effects from chemical castration and uterine cancer. Some of the diseases in which there is hope that ERbeta agonists will be of benefit are prostate cancer, autoimmune diseases, colon cancer, malignancies of the immune system, and neurodegeneration.

Animals↗
PubMed2005

Norman Cousins Lecture. The uses and abuses of psychoneuroimmunology: a global overview.

Studies of interactions between the nervous and immune systems that effect immunological and behavioral changes are relevant to our understanding biological issues pertinent to evolution, ethology, ecology, and aging, in addition to our understanding the immune and nervous systems per se. Psychoneuroimmunology also relates to homeland security, science education, and the practice of conventional as well as complementary and alternative medicine. This paper will highlight just some of these global implications of psychoneuroimmunology.

Animals↗
PubMedDate not supplied

Psychoneuroimmunology, new approaches to neurobehavioral testing.

A review of the literature in the field of psychoneuroimmunology was reported by Robert Ader [1]. Basically, three research approaches have been used to demonstrate a relationship between central sites within the brain that have modulatory influences on the immune system. These include: (1) both the electrical stimulation and surgical lesioning of nuclei in the hypothalamus; (2) traditional behavioral conditioning; and (3) behavioral stress studies. The mechanisms of action for the psychoneuroimmunologic response appear to be focused in three areas: (1) the autonomic nervous system, where direct anatomical connections from the brain to the immune system have been recently demonstrated; (2) the endocrine system where the individual hormones have direct and indirect effects on the immune system; and (3) enkephalins-endorphins in the brain, pituitary, and adrenals that also have direct and indirect effects on the immune system. Examples of drug effects on the above complex systems will be centered on morphine and the enkephalins-endorphins with reference to drugs of abuse, food additives, and cosmetics.

Behavior↗