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PubMed2003

Effects of beer administration in mice on acute toxicities induced by X rays and carbon ions.

We have investigated the tissue specificity of radioprotection by beer, which was previously found for human lymphocytes. C3H/He female mice, aged 14 weeks, received an oral administration of beer, ethanol or saline at a dose of 1 ml/mouse 30 min before whole-body irradiation with 137Cs gamma rays or 50 keV/microm carbon ions. The dicentrics of chromosome aberrations in spleen cells were significantly (p < 0.05) reduced by beer and ethanol-administration for gamma-ray irradiation, but not for carbon-ion irradiation. The number of jejunal crypts plotted against the dose showed that both beer and ethanol significantly increased D0 (slope of a dose-survival curve) for gamma rays and carbon ions as well. Beer administration significantly (p < 0.05) increased LD(50/30) (radiation dose required to kill 50% of mice within 30 days) for gamma rays and carbon ions. Ethanol-administration also significantly (p < 0.05) increased the LD(50/30) value for gamma rays, but not for carbon ions. It is concluded that beer administration reduces the radiation injury caused by photons and carbon ions, depending on the tissue type. Radioprotection by beer administration is not solely due to OH radical-scavenging action by the ethanol contained in beer.

Animals↗
PubMed1999

Reduced urination rate while drinking beer with an unpleasant taste and off-flavor.

A lowered subjective evaluation of the taste and flavor of beer due to staleness or to the addition of an unpleasant taste and flavor was found to be closely correlated with the urination rate. Beer in the same lot was compared immediately after shipment from the brewery and after leaving at room temperature for 1 month or 5 months. Each beer sample was given to volunteers at the rate of 3 ml/kg/15 min for 2 hours, and the urine volume was measured every 30 minutes. The urination rate was highest from the volunteers who drank fresh beer and lowest from those who drank 5-month-old beer. The subjective evaluation of both the taste and drinkability of 5-month-old beer was significantly lower than that of fresh beer. Beer samples with various unpleasant taste and flavor substances added lowered the urination rate. The results suggest that the perception of an unpleasant taste and off-flavor would lower the urination rate.

Adult↗
PubMed2003

Effects of communities, neighborhoods and stores on retail pricing and promotion of beer.

OBJECTIVE: This study examines how communities, neighborhoods and stores influence retail pricing and promotion of beer. METHOD: In the year 2000, trained field staff conducted observations in 2,024 retail alcohol stores in 160 communities throughout the contiguous United States. Based on a nationally representative sample of schools, we selected communities defined by the school's catchment area, or the vicinity from which the majority of students are drawn. We randomly selected off-sale alcohol retail establishments from a complete list of stores likely to sell tobacco or alcohol in the selected communities. Beer price and promotions are based on observations of Miller and Budweiser beer brands in the stores. Neighborhoods are defined by the store's census block. We used cross-sectional, hierarchical regression models and mixed methods procedures to analyze data. RESULTS: Community, neighborhood and store characteristics were related to beer price; however, only community and store characteristics were predictive of beer promotions. CONCLUSIONS: Overall, the pricing and promotion of beer vary systematically by some characteristics of communities, neighborhoods and stores, but not significantly by the number of young people populating a neighborhood. In addition, pricing and promotion of Budweiser and Miller beers, in particular, do not appear to target racial minority populations. Because of the significant effect of store characteristics, public health agencies and advocates might focus prevention efforts on collaborations with liquor control agencies to reduce variations in pricing and promotion of beer, which ultimately encourage risky drinking behaviors. Further studies are needed to examine the effects of pricing and promotion on alcohol-related social problems.

Adolescent↗
PubMed2004

Beer consumption and premature mortality in Louisiana: an ecologic analysis.

OBJECTIVE: This study was conducted to determine whether beer consumption is associated with premature mortality across municipalities in Louisiana. METHOD: We conducted a cross-sectional ecologic study using tax data on the sales of beer and mortality data from Louisiana. We aggregated deaths that occurred before the age of 65 to the level of the municipality and calculated age-adjusted rates of both overall premature mortality and specific causes of premature mortality that may be related to alcohol. After controlling for potential confounders including population distributions for race, income, employment and education, we examined whether beer sales were independently associated with premature mortality rates due to homicides, unintentional injuries, other acute alcohol-related causes, liver diseases, cardiovascular disease and other chronic alcohol-related causes. RESULTS: After controlling for race and socioeconomic status, municipalities with greater beer consumption had higher premature mortality, with the model explaining up to 24% of all premature deaths. Beer consumption was also independently associated with homicide, liver diseases and cardiovascular disease. Neither unintentional injuries nor other chronic alcohol-related causes of mortality were significantly associated with beer consumption. CONCLUSIONS: The population-level association between beer consumption and mortality may reflect population-level determinants of beer consumption as well as indirect health effects of alcohol consumption on persons who are not heavy drinkers.

Adolescent↗
PubMed1999

Alcohol content of beer and malt beverages: forensic consideration.

Beer consumption is commonly an issue in a medico-legal setting, requiring estimates either of a likely blood alcohol concentration (BAC) for a given pattern of consumption or vice versa. Four hundred and four beers and malt beverages available for sale in the State of Washington were tested by gas chromatography for their alcohol content. Considerable variability in the alcoholic strength was found, even within the same class. Overall the range of concentrations was 2.92%v/v to 15.66%v/v. The mean alcohol concentration for ales was 5.51%v/v (SD 1.23%v/v), and for lagers, 5.32% (SD 1.43%v/v). Some specialty brews had characteristically higher or lower mean concentrations: ice beers 6.07%v/v, malt liquor 7.23%v/v, light beer 4.13%v/v, seasonal ales 6.30%v/v. Six brands of lager and four light beers account for the majority of all beer sales in the United States, and the mean alcohol concentration for these products was measured as 4.73%v/v and 4.10%v/v respectively. Few of the beers (17%) were labeled with respect to alcohol content, and in some cases, there was a significant disparity between the concentration listed on the label, and the measured alcohol concentration. Toxicologists need to exercise caution when performing Widmark type calculations, using all available information to select the most appropriate estimate for alcoholic strength of a beer or malt beverage.

Alcoholic Beverages↗
PubMed1982

Effect of drinking bottled beer on plasma insulin and glucose responses in normal subjects.

Alcohol may provoke reactive hypoglycaemia when drunk with a sucrose mixer ('gin and tonic') but does not do so when taken in the form of a starch-based beverage like sorghum beer. We examined the hypoglycaemic potential of bottled beer (Lion Lager; South African Breweries), which differs from sorghum beer in that it contains less carbohydrate (polysaccharides and simple sugars) and has a higher alcohol content. After an overnight fast 5 Black men each drank 2 litres of Lion Lager over an hour. Over the ensuing 5 hours their plasma insulin, glucose and alcohol concentrations were compared with the responses previously documented before and after consuming the same volume of sorghum beer or a 100 g control carbohydrate solution. Bottled beer elicited a prompt but short-lived rise in plasma insulin (mean +/- SEM, 37 +/- 7 mU/l at 1 hour), which was significantly greater than that produced by sorghum beer but less sustained than after drinking the control carbohydrate solution. After drinking bottled beer plasma glucose levels fell to a mean nadir of 3,6 mmol/l at 2 hours (compared with 5,4 mmol/l for sorghum beer), thereafter slowly returning to the basal value, while a substantial rise in the blood alcohol concentration occurred. We conclude that the development of alcohol-induced reactive hypoglycaemia is largely determined by the nature of the carbohydrate ingested together with alcohol.

Adult↗
PubMed1978

[Analytic study of foaming agents in imported beers].

The French consumer expects a natural high-quality drink. It was therefore of interest to ascertain the quality of imported beers (they reached 2,440,000 hl in 1976, or 9.8 f. 100 of total sales) as well as how far their composition complies with present French legislation. Fifteen imported bottled beers were analyzed, from the following countries: West Germany, England, Belgium, Denmark, Luxemburg and the Netherlands. Attempts were first of all made to detect the presence in these beers of iron and cobalt, since both metals are recognized froth-improving agents. The search for cobalt produced negative results for all the beers. On the other hand we found that five of the 15 samples examined were questionable for their iron content (0.56--1.52 mg/l). We than looked for alginates in these imported beers, using a method comprising the following sequence of operations: concentration of the beer, dextrine hydrolysis, alginate precipitation at pH 5 by calcium chloride, treatment of the heated preparation with sodium hexametaphosphate, and colorimetric measurement at 670 nm with a reagent comprising orcinol, ferric sulfate and hydrochloric acid. In most of the 15 imported beers studied, the presence of alginates (up to 16.5 mg/l) was indisputable. The French consumer therefore has a right to expect the composition of foreign beers to comply with the French food laws, especially as regards the absence of frothing agents.

Alginates↗
PubMedDate not supplied

Introduction of high-alcohol beer in Ontario: preliminary observations on its use by underage drinkers.

Preliminary data are reported on the use of high-alcohol beer by underage drinkers in Ontario. Students in grades 11 and 12 with a valid driver's licence completed a questionnaire between January and May, 1994 (i.e., between three and seven months after the introduction of high-alcohol beer). About one-half of students who had drunk alcohol within the previous four weeks reported consuming high-alcohol beer within that period. In this group, males were much more likely to report high-alcohol beer consumption in the previous month. Both male and female high-alcohol beer consumers drank alcohol more frequently, got drunk more frequently, and drank five or more drinks on the same occasion more frequently than non-consumers. One reason for trying high-alcohol beer, "wanted a higher alcohol content", was endorsed by more than one-third of high-alcohol beer consumers. Our data suggest that the users of high-alcohol beer among this underage drinking sample tend to be heavier drinkers and more likely to experience alcohol-related problems.

Adolescent↗
PubMed2005

Beer halls as a focus for HIV prevention activities in rural Zimbabwe.

OBJECTIVE: The authors conducted an assessment of the role of beer halls in the HIV epidemic of rural Zimbabwe as part of the ongoing identification of risky places for the targeting of prevention activities. STUDY: A population-based survey of 9480 adults collected data on number of visits to beer halls in the last month, together with sociodemographics, sexual behavior, and HIV infection from 1998-2000. RESULTS: Fifty percent of men, but only 4% of women, had been to a beer hall in the last month. They reported higher levels of sexual behavior and stronger associations with commercial sex than those who had not been to a beer hall. A recent visit to a beer hall was also associated with HIV infection (men: odds ratio [OR] = 1.9, P <0.001; women: OR = 1.7, P = 0.001) and with ever having experienced urethral/vaginal discharge or genital sores. Only 225 respondents experienced an HIV prevention activity at a beer hall in the last 6 months. CONCLUSIONS: Beer hall attendance is associated with high-risk behavior for HIV infection and cofactor sexually transmitted infections. Beer halls represent an underused focus for HIV prevention.

Adolescent↗
PubMed2006

Inappropriate prescribing in the elderly: a comparison of the Beers criteria and the improved prescribing in the elderly tool (IPET) in acutely ill elderly hospitalized patients.

BACKGROUND: In appropriate prescribing is a significant and persistent problem in elderly people, both in hospital and the community and has been described in several countries in Europe and also the USA. The problem of inappropriate prescribing has not been quantified in the Republic of Ireland. The most commonly used criteria for the identification of inappropriate prescribing are the Beers' criteria [both independent of diagnosis (ID) and considering diagnosis (CD) - 2003 version]. The Beers' criteria ID includes 48 different categories of either single medications or multiple medications of a similar class identified as inappropriate prescriptions and the Beers' criteria CD contains 19 different categories containing possible drug-disease interactions. A second tool, the improved prescribing in the elderly tool (IPET) has also been validated and used in hospital and community studies and has 14 categories of either explicitly contraindicated medications or possible drug-disease interactions. OBJECTIVES: The primary aim of the study is to measure the incidence of inappropriate prescribing among older community-dwelling individuals presenting to an acute hospital in the Republic of Ireland. A secondary aim of this study was also therefore to compare the efficacy of the above two tools in identifying inappropriate prescribing. METHODS: A prospective, consecutive observational cohort study was carried out over a 4-month period. The setting was an urban-based university hospital acute geriatric medicine assessment unit. Subjects in this study (n = 350) were consecutively screened on admission to hospital (mean age = 80.3 +/- 6.1 years) and all patients had both Beers' criteria ID and CD and IPET applied to their list of prescription drugs on admission, cross-referenced with their list of current active medical diagnosis. RESULTS: The results of the study identified a high rate of inappropriate prescribing among this population of community-dwelling subjects. The total number of inappropriate prescriptions identified using the Beers' criteria (ID) was 148 affecting 121 patients. The Beers' criteria (CD) identified 69 inappropriate prescriptions in 60 patients and the IPET identified 112 inappropriate prescriptions in 78 patients. The Beers criteria (ID and CD combined) identified at least one inappropriate prescription in 34% of subjects and the IPET identified one in at least 22% of subjects. CONCLUSIONS: This study identifies high rates of use of inappropriate medications in community-dwelling elderly presenting with acute illness to hospital. These are comparable with inappropriate prescribing rates identified in previous studies. The revised Beers' criteria (2003) identified more inappropriate prescriptions than the IPET in this population of elders.

Aged↗
PubMed2005

Fungi, aflatoxins, fumonisin Bl and zearalenone contaminating sorghum-based traditional malt, wort and beer in Botswana.

Brewing and consumption of traditional beer have social-economic significance in most African countries including Botswana. Traditional sorghum malt, wort, and beer samples were collected from three villages around Gaborone, Botswana. Forty-six malt samples were analyzed for fungi on three different media and developing colonies were subcultured for identification. Rhizopus, Fusarium, Mucor, and Aspergillus were the most common genera isolated. Out of the 46 malt samples, 72% contained Rhizopus stolonifer, 63% Fusarium verticillioides (syn. Fusarium moniliforme), and 37% Aspergillus flavus. Although Aspergillus flavus was isolated from malt samples, aflatoxins (B(1), B(2), G(1), and G(2)) were not detected in any of the samples analyzed. When the malt, wort, and beer samples were analyzed for fumonisin B(l) and zearalenone, fumonisin B(1) was detected in 3 malt samples, with concentrations ranging from 47 to 1316 mug/kg, while zearalenone was detected in 56%, 48% and 48% of the malt, wort and beer samples, respectively. Zearalenone concentration in samples ranged from 102 to 2213 mug/kg in malt, 26 to 285 mug/l in wort and 20 to 201 mug/l, in beer. Zearalenone carry-over from wort to beer ranged from 23 to 403%. Therefore, although aflatoxins and fumonisin B(1) do not appear to be major contaminants, zearalenone is common and could pose a potential problem in traditional beer in Botswana.

Aflatoxins↗
PubMed1989

N-nitrosodimethylamine in German beer.

A total of 514 beer samples (called 'first samples'), produced in Baden-Württemberg, FRG, between October and December 1987, were analysed for their N-nitrosodimethylamine (NDMA) content. In 302 of the samples NDMA was not detected (less than 0.2 microgram/kg), 191 contained indeterminable traces of NDMA (0.2-less than 0.5 microgram/kg) and 21 samples showed NDMA contents of 0.5 microgram/kg to 1.7 micrograms/kg. The technical threshold value of 0.5 microgram/kg was exceeded by 14 samples. No significant differences in the NDMA content were observed between the different beer types, but beers with a higher malt extract content (strong beer) showed slightly increased average NDMA content. Top fermented pale ale produced from wheat malt showed, as expected, the lowest average NDMA content. For those samples containing greater than 0.5 microgram/kg NDMA an additional sample of the same beer type, but produced some months later (called the 'second sample'), was analysed. The highest content of NDMA found in the second samples was 3.2 micrograms/kg. The average NDMA content of the 514 first samples was 0.16 micrograms/kg and the average daily intake was calculated as 0.1 microgram for men and 0.03 microgram for women. Individual daily intake of NDMA, depending on the amount of beer consumed and the beer type, may reach up to 10 micrograms/person/day.

Beer↗
PubMedDate not supplied

In search of an alternative placebo: estimating alcohol content of nonalcoholic, light, and regular beer.

Alcohol research has demonstrated that expectancies about what one has consumed may supercede pharmacological effects of the drink. The present study sought to expand the scope of the placebo designs by examining an alternative manipulation, using widely available nonalcoholic beverages. The nonalcoholic beers used in this study have recently become marketed and made available to consumers by two major breweries. Subjects were provided with a total of four beer samples: two nonalcoholic samples ("O'Doul's" and "Sharp's"), one light sample ("Busch Light"), and one regular sample ("Busch"). Results indicated that subjects estimated the alcohol content in "O'Doul's" as significantly lower than that of the light and regular beers; the estimate of alcohol content in Sharp's was not significantly lower than either the light or regular beers. In addition, the mean alcohol estimates for both nonalcoholic beers approximated the actual alcohol content of a light beer (roughly 3%). These results indicate that nonalcoholic beers may provide a viable alternative to the placebo manipulations currently in vogue.

Adult↗
PubMedDate not supplied

Morphine increases intake of beer among rats.

Rats were maintained on a daily regimen of 22 h of water deprivation followed by a 2-h opportunity to take water and sweetened alcoholic beverage containing 12% ethanol. After 30 days, the alcoholic beverage was changed to beer containing either 3% or 6% ethanol. After 20 daily sessions with beer, they received, before the next session, an injection of saline. On the next day, they received a 1.0 mg/kg injection of morphine before the session. Morphine reliably increased rats' mean intake of both kinds of beer. Subsequently, the concentration of ethanol in each groups' beer was changed. The 3% group's beer was switched to 6%, and the 6% group's to 3%. Both groups altered their mean intake of beer in an apparent attempt to maintain intakes of nearly the same amount of ethanol, but presentation of 6% beer resulted in greater intakes of ethanol.

Alcohol Drinking↗
PubMed2005

Inhibition of PhIP-induced mammary carcinogenesis in female rats by ingestion of freeze-dried beer.

This study evaluated the modulating effect of non-alcoholic constituents of beer on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis. Female Sprague-Dawley (SD) rats at 6 weeks of age were divided into four groups (n=26-30) and fed either a high fat diet or high fat diets containing 1, 2 or 4% freeze-dried beer (FD beer). One week after the start of feeding, rats received PhIP at a dose of 85 mg/kg by gavage four times weekly for 2 weeks. There were no differences in the body weights or diet intakes of rats between the control and the experimental groups. Weekly observation of palpable tumors indicated that tumor incidence and tumor multiplicity in the 2 and 4% FD beer groups were lower than in the control group throughout the experiment. Neoplastic lesions were pathologically examined at the end of the 22-weeks experiment. Tumor development was inhibited by FD beer intake in a dose-dependent manner. Tumor incidence (38.5%) and tumor multiplicity (0.8+/-0.4) for the group fed with a diet containing 4% FD were significantly reduced as compared with the control group (73.3% and 1.8+/-0.7). Supplementation with FD beer for 3 weeks together with the PhIP treatments resulted in increased liver GST activity, decreased liver CYP1A2 activity and a decrease in the number of DNA adducts in the mammary tissue, though these values were not significant. In conclusion, our results suggest that intake of FD beer may reduce the risk of carcinogenesis caused by heterocyclic amines.

Animals↗
PubMed2005

Preparation of novel solid-phase microextraction fibers by sol-gel technology for headspace solid-phase microextraction-gas chromatographic analysis of aroma compounds in beer.

3-(Trimethoxysilyl)propyl methacrylate (TMSPMA) was first used as precursor as well as selective stationary phase to prepare the sol-gel-derived TMSPMA-hydroxyl-terminated silicone oil (TMSPMA-OH-TSO) solid-phase mircroextraction (SPME) fibers for the analysis of aroma compounds in beer. TMSPMA-OH-TSO was a medium polarity coating, and was found to be very effective in carrying out simultaneous extraction of both polar alcohols and fatty acids and nonpolar esters in beer. The extraction temperature, extraction time, and ionic strength of the sample matrix were modified to allow for maximium sorption of the analytes onto the fiber. Desorption temperature and time were optimized to avoid the carryover effects. To check the matrix effects, several different matrices, including distilled water, 4% ethanol/water (v/v) solution, a concentrated synthetic beer, a "volatile-free" beer and a real beer were investigated. Matrix effects were compensated for by using 4-methyl-2-pentanol as internal standard and selecting the "volatile-free" beer as working standard. The method proposed in this study showed satisfactory linearity, precision and detection limits and accuracy. The established headspace SPME-gas chromatography (GC) method was then used for determination of volatile compounds in four beer varieties. The recoveries obtained ranged from 92.8 to 105.8%. The relative standard deviations (RSD, n = 5) for all analytes were below 10%. The major aroma contributing substances of each variety were identified via aroma indexes.

Beer↗
PubMed2000

Determination of zearalenone and its metabolites alpha- and beta-zearalenol in beer samples by high-performance liquid chromatography-tandem mass spectrometry.

A fast, robust and sensitive LC-MS-MS method for the determination of zearalenone (ZON) and its metabolites alpha-zearalenol (alpha-ZOL) and beta-zearalenol (beta-ZOL) in beer samples is described. Sample preparation was performed by direct RP-18 solid-phase extraction of undiluted beer samples followed by selective determination of analytes by LC-MS-MS applying an atmospheric pressure chemical ionization (APCI) interface. Using the negative ion mode limits of determination of 0.03-0.06 microg l(-1) beer and limits of quantification of 0.07-0.15 microg l(-1) beer were achieved, which was distinctly more sensitive than in the positive ion mode. Twenty-three beer samples from different countries, produced from different grains and under different brewing conditions, were investigated by this method, but only in one sample could beta-ZOL and ZON be detected. Independently of the type of beer, relative standard deviations between 2.1% and 3.3%, a linear working range of 0.15 microg l(-1) to 500 microg l(-1) beer and recovery rates around 100% could be achieved when zearalanone (ZAN) was used as internal standard.

Beer↗
PubMed2001

Use of GC-olfactometry to identify the hop aromatic compounds in beer.

This paper describes a sensorial aroma extract dilution analysis (AEDA) approach to the analysis of beer aromas derived from hops. To obtain an extract with an odor representative of the original product, the XAD extraction procedure was applied and the experimental conditions were optimized. The aromagrams of three beers were compared: one brewed without hops, one brewed with Saaz hop pellets, and one brewed with Challenger hop pellets. One spicy/hoppy compound, unmodified from hop to beer, proved responsible for the most intense odor in both hopped beer extracts. Another flavoring compound in hops, linalool, also survives through the process to the final beer. Other compounds such as gamma-nonalactone and humuladienone, although not found in our extracts of hop, significantly modify beer aromagrams after hopping. Sulfur compounds characteristic of Challenger hops proved to be at least partially responsible for the unpleasant flavor found in the corresponding beer.

Beer↗