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Modified activity of the human auditory cortex during auditory hallucinations.

Previous reports have shown abnormalities in brain metabolism and evoked responses of schizophrenic patients with hallucinations. The authors recorded electric and magnetic auditory responses during transitory auditory hallucinations in two patients. Small but replicable response delays occurred during hallucinations. The results suggest that the effect of hallucinations on auditory cortex activity is similar to the effect of real sounds.

Acoustic Stimulation↗

Boys with reading disabilities and/or ADHD: distinctions in early childhood.

We examined distinctions in the early childhood characteristics of boys with reading disabilities (RD) and/or attention-deficit/ hyperactivity disorder (ADHD). A four-group mixed design consisting of boys identified at age 11 with reading disabilities only (RD only; n = 46), reading disabilities and ADHD (RD/ADHD; n = 16), ADHD only (n = 20), and a comparison group (n = 281) was utilized. Differences on receptive and expressive language and temperament for ages 3 and 5 were investigated. Analyses indicated that the boys from the RD-only group performed worse on measures of receptive and expressive language. The results also indicated that boys from the RD/ADHD groups consistently performed worse on measures of receptive language and exhibited more behaviors indicative of an undercontrolled temperament. In summary, we suggest that reading disabilities and ADHD represent moderately unique disorders that frequently co-occur and are characterized by distinct developmental pathways.

Attention Deficit Disorder with Hyperactivity↗

Validity of the Auditory Continuous Performance Test in differentiating central processing auditory disorders with and without ADHD.

The use of continuous performance tasks has been examined as a potential measure for clinical/laboratory identification of Attention-deficit/hyperactivity disorder. The present study compared the performance of 30 children, 26 boys and 4 girls ranging in age from 9-0 to 12-11, with central auditory processing disorders (CAPD) who did not meet criteria for coexisting ADHD with the performance of children with CAPD coexisting with ADHD (CAPD/ADHD) on the Auditory Continuous Performance Test (ACPT). In interpreting the results, the variability as well as the actual counts for correct responses and total errors were considered. Results indicated limited potential for the use of the ACPT in the differential diagnosis of ADHD. Implications of the results as well as considerations for future research are discussed.

Attention↗

Central auditory processing ability in children with ADHD with and without learning disabilities.

A few studies have shown more central auditory processing deficits in children with attention-deficit/hyperactivity disorder (ADHD) than in nondisabled children. Because these studies failed to screen participants with ADHD for learning disabilities (LD), it is not clear whether these deficits are correlates of ADHD or LD or both. In the present study, the central auditory processing ability of children with ADHD, ADHD with LD, and no disabilities was examined. Results indicated lower central auditory processing ability, and significant correlations between reading and ADHD symptoms and reading and central auditory processing ability in the ADHD with LD group compared with the other two groups. These findings suggest that central auditory processing deficits are more likely to be associated with LD than ADHD.

Attention Deficit Disorder with Hyperactivity↗

Human evoked potentials and the lateralization of a sound.

If an identical noise is presented to each ear with one ear receiving the noise slightly earlier than the other, the listener perceives the sound as originating from the side of the leading ear. If the interaural time-difference reverses, the subject perceives a shift in the lateralization of the sound to the other ear. This shift in lateralization evokes a late auditory potential with a negative wave at 135 ms and positive waves at 75 and 220 ms. This evoked potential specifically indexes central auditory processing since information about the timing of the auditory stimuli must be compared between the two ears. The response increases in amplitude with increasing interaural time-difference reaching maximum values between 0.3 and 1.5 ms. The response is evoked through acoustic frequencies below 2,000 Hz. In patients with multiple sclerosis the response is often abnormally delayed or small. The response may therefore be helpful in the clinical evaluation of patients with central auditory dysfunction.

Acoustic Stimulation↗

Mismatch negativity and auditory sensory memory in chronic alcoholics.

BACKGROUND & METHODS: Preattentive auditory processing and sensory memory were investigated by means of mismatch negativity (MMN) in a sample of 22 middle-aged abstinent chronic alcoholics and 25 age-matched healthy controls. Stimuli were presented at two inter-stimulus intervals (ISIs, 0.75 sec and 2.0 sec) in separate blocks. RESULTS: No significant differences in amplitude or latency of MMN were found between alcoholic and control subjects in either of the two ISI conditions. However, when age was included as a factor in the analysis, MMN amplitude was attenuated in chronic alcoholics who were older than 40 years of age. CONCLUSIONS: These results indicate that the automatic stimulus-change detector mechanism associated with MMN generation is impaired in chronic alcoholics over the age of 40, suggesting that the neurotoxic effects of chronic consumption of alcohol are more prone to appear after a critical age.

Adult↗

Augmentation of special-needs services and information to students and teachers "ASSIST"--a telehealth innovation providing school-based medical interventions.

An innovative school-based telehealth technology was introduced in Hawaii with the purposes of: (1) evaluating students for medical/developmental conditions with educational implications, (2) providing a professionally-monitored Internet-based system of learning/development, and (3) delivering medically-based physical and occupational therapy at the students school. Electronically recorded satisfaction surveys from parents, teachers, and providers revealed significant improvement in all three areas.

Attention Deficit Disorder with Hyperactivity↗

Auditory and visual dysfunction following lead exposure.

The effects of lead exposure on cognitive function have been intensively studied during the past decade, but relatively little effort has been made to understand the impact on sensory function. Subtle impairments of visual and/or auditory processing, however, could have profound effects on learning. The objectives of this paper are to review what is known about the effects of lead exposure on visual and auditory function and to identify related research needs. In particular, the effects of lead exposure on sensory function in children, which have not been studied adequately, will be discussed. Evidence from human and animal studies reveal that lead exposure impairs auditory function. The cochlear nerve and more central structures appear to be preferentially sensitive in both developing and mature humans and experimental animals. Elevations in hearing thresholds and increased latencies of brainstem auditory evoked potential have been reported at low-moderate levels of lead exposure. Higher doses of lead increase the threshold of the auditory nerve action potential, produce segmental demyelination and axonal degeneration of the cochlear nerve, but appear to have no effect on cochlear microphonics or structure. Lead exposure affects both the retina and visual cortex of the developing and mature visual system. Low to moderate level developmental lead exposure produces selective rod deficits which can be detected with electrophysiological and behavioral techniques. At slightly higher levels of lead exposure the visual cortex is affected. A wide range of functional and neurochemical effects on retinal function occurring at blood lead levels below 20 micrograms/dl, the current level of concern, have been observed in rats. Structural, biophysical and photochemical similarities of rods in rats, monkeys and humans argue the relevance of this data for pediatric lead screening. To date, however, rod-mediated visual functions have not been examined in lead-exposed children. Undetected sensory deficits of these kinds may have profound impact on the motor and mental development of children as well as on the quality of life of affected adults. There is clearly a need for more extensive sensory testing in children and workers to screen for lead-induced health effects and in animal models to clarify the mechanisms of lead neurotoxicity.

Auditory Perceptual Disorders↗

Brainstem auditory evoked potentials in receptive developmental language disorder.

It has been hypothesized that receptive developmental language disorder (RDLD) may be explained by an auditory processing deficit. The neuroanatomical locus of this deficit is unknown. Brainstem auditory evoked potentials (BAEPs) reflect the functioning of the auditory nerve and auditory brainstem pathways to high-frequency acoustical stimulation in humans and reflect the first stages of auditory processing. These were studied in 12 subjects with RDLD (four females and eight males, ages 12 to 19) and twelve control subjects (three females and nine males, ages 14 to 24). Click intensity and rate of stimulation were varied. The BAEPs for the RDLD group were comparable to the control group as well as to hospital norms across intensity levels and stimulation rates. The evidence obtained suggests that a disorder in the neurophysiological systems underlying the BAEPs and reflecting initial stages of auditory processing is not essential for RDLD.

Adolescent↗

[Age dependent maturation of NC-ERP].

BACKGROUND: Neutral condition event related potentials (NC-ERP) are not suitable for differentiating between children suffering from auditory processing disorders (APD) alone and APD-children with attention deficit disorder. Other factors beside severity of APD may cause "pathological" NC-ERP. Here we raise the question of whether maturational factors may be responsible for disordered NC-ERP. METHODS: NC-ERP data from 142 APD children (range 5.4-17.2 years; mean 9.8 years) were analysed. Data were grouped according to age of children (I: <7.11 years n=34; II: 8.0-9.11 years n=46; III: 10.0-11.11 years n=39; IV: >12.0 years n=23). RESULTS: Pathological NC-ERP were found in 82.3% (group I), 56.6% (group II), 46.2% (group III) and 8.8% (group IV). Additional analyses confirmed no correlation with ADHD. DISCUSSION: Although there is a whole body of evidence that late auditory evoked potential may mature with age, it is not known if NC-ERP are also age dependent. Our results that NC-ERP mature with age are consistent with data for other late auditory evoked potentials. Since normative date of NC-ERP for different age groups are still lacking, NC-ERP results in children should be interpreted very cautiously.

Adolescent↗

Central auditory pathologies.

This chapter considers specific deficits in auditory processing ('negative' disorders) due to neurological conditions and 'positive' disorders of central auditory processing caused by abnormal activity in central auditory mechanisms. Recent work focuses on the assessment of auditory processing in disorders that are not specifically auditory. In this case, auditory measurement may provide a 'window' into the condition.

Audiometry, Pure-Tone↗

[Late auditory potentials (NC-ERP) in children with symptoms of auditory processing and perception disorder. With and without attention deficit disorder].

BACKGROUND: Auditory processing disorders (APD) result from dysfunctions of processes dedicated to audition and affect processing of information in the auditory modality. Children with APD exhibit symptoms similar to those with attention deficit disorders (ADHD). With regard to therapeutic strategies it seems mandatory to employ diagnostic procedures able to differentiate between APD and ADHD. Recently it was found that auditory evoked neutral condition event-related potentials (NC-ERP) correlate with results from psychoacoustic measures suitable to unveil dysfunctions of auditory processing, thus confirming APD. Here we investigated whether NC-ERP may be used as a tool to differentiate between APD and ADHD. METHODS: In a retrospective analysis, NC-ERP data from 99 children with (+ADHD) and 43 without ADHD symptoms (-ADHD) were examined. All patients suffered from symptoms consistent with information processing deficits in the auditory modality. Analysis of variance was applied. RESULTS: +ADHD children and -ADHD children did not show a significantly different distribution pattern of pathological NC-ERP. DISCUSSION: Since the probability of pathological NC-ERP is equally distributed in children with or without ADHD, all of whom suffered from auditory processing deficits, it seems fair to conclude that NC-ERP are not suitable to differentiate between APD and ADHD. This may be due to methodological limitations. Alternatively, APD and ADHD may indeed be overlapping entities with a common yet unidentified origin.

Adolescent↗

Auditory event-related potentials in the assessment of auditory processing disorders: a pilot study.

The aim of this pilot study was to investigate whether children with a suspected auditory processing disorder (sAPD) in the presence of normal hearing, differ significantly from normal age-matched controls on particular parameters of auditory event-related potentials. We assessed nine children (mean age 9.5 years) in whom the clinical profile and the results in a screening test for auditory processing disorder (SCAN/SCAN-A) suggested the presence of an auditory processing disorder, and nine age-matched normal control subjects, using auditory event-related potentials (ERP) to phonemes/ba/(standard) and/da/(deviant). Analysis of the auditory ERP recordings revealed an enlarged P85 - 120 and attenuated N1 and P2 in all sAPD children compared to controls. We also found significantly increased N1 peak latency, and a larger peak to peak amplitude of the P85 - 120-N1 and P2-N2 and smaller peak to peak amplitude of the N1-P2 in the sAPD children. Subtraction of the standard auditory ERP from the deviant revealed a mismatch negativity with no significant differences in duration, peak or onset latency between the control subjects and sAPD. Our results indicate that neurophysiological measures may identify a group of children with specific problems suggestive of an auditory processing disorder in the absence of an obvious structural or functional lesion who warrant further study in order to assess whether these findings reflect delayed CNS myelination.

Acoustic Stimulation↗