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Results for “Aluminum Compounds”

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At least 109 records · Page 6Linked to original sources
PubMed1978

[Neurofilament hypertrophy induced in the rabbit spinal cord after intracisternal injection of aluminum chloride (author's transl)].

The cytological changes induced in the spinal cords of rabbits by intracisternal injections of aluminum chloride have been studied at the light- and electron-microscopic level for examining the progress of the 100 A filament hypertrophy. A moderate increase in the number of the 100 A filament was detected in perikarya of neurones in anterior, lateral, and dorsal horns 4--5 days after aluminum injection. Tangles of 100 A filament were seen in perikarya and proximal parts of dendrites in these neurones 1--2 weeks after the administration of aluminum. In this stage the tangles were detected as large clear spots at light-microscopic level. The 100 A filament bundles developed in between clumps of densely aggregated endoplasmic reticulum keeping close contact with this and squeezing other organella out. In high resolution studies the 100 A filament closely resembled the neurofilament in normal neurones in size and appearances and was seen to be connected with each other via side arms coming out from its wall. Relations between the endoplasmic reticulum and the 100 A filament hypertrophy was discussed referring to intoxicating effects of aluminum compounds on the nucleus of the neuron.

Aluminum↗
PubMed1990

Aluminum-induced microcytosis in a child with moderate renal insufficiency.

A child with moderate renal failure, on high doses of aluminum compounds for treatment for hyperphosphatasemia, presented with unexplained microcytosis. The patient also had psychomotor delay. On discontinuation of aluminum, microcytosis reversed in 2 months. Four months later, psychomotor development improved. Children with renal failure, on aluminum supplementation, should be carefully monitored for toxicity. Microcytosis may be a clue to aluminum toxicity in such patients.

Aluminum Hydroxide↗
PubMed1985

Gastrointestinal absorption of aluminum.

It has recently been documented that a small amount of aluminum is absorbed from a variety of different orally administered aluminum compounds. A variety of factors including gastric acidity, fluoride ingestion, parathyroid hormone, vitamin D and the quantity of aluminum ingested could theoretically modulate aluminum absorption from the gastrointestinal tract. However, partially because of the unavailability of an aluminum isotope, knowledge regarding factors which modify aluminum absorption is quite limited. In healthy individuals the absorbed aluminum is largely eliminated from the body by the kidneys. However, with renal failure the absorbed aluminum is retained and can markedly alter the body aluminum burden with resulting toxicity. In view of this finding, it is suggested that uremic patients receive the smallest amount possible of aluminum-containing, phosphate-binding gels consistent with the control of serum phosphorus levels and that alternate methods for the control of the serum phosphorus should be sought.

Absorption↗
PubMed1998

Reaction of the Primary Alane (2,4,6-t-Bu(3)H(2)C(6)AlH(2))(2) with Nitriles, Isonitriles, and Primary Amines.

The reactions of the sterically encumbered primary alane (MesAlH(2))(2) (Mes = C(6)H(2)-2,4,6-t-Bu(3)) with the nitriles t-BuCN, MesCN (Mes = C(6)H(2)-2,4,6-Me(3)) or MeCN lead eventually to dimeric amido alane products in which one of the ortho t-Bu groups of the Mes ligand is metalated and the nitrile is reduced to the amide ligand N(H)CH(2)R (R = t-Bu, Mes, or Me). The compounds (R = t-Bu, 2 (cis), 3 (trans); Mes, 4 (cis), 5 (trans); Me, 6 (cis)) have been isolated and characterized spectroscopically and also by X-ray crystallography in the cases of 4 and 5. The intermediate, dimeric iminato complex [MesAl(H){&mgr;(2)-NC(H)t-Bu}](2) (1), can also be isolated under carefully controlled, mild conditions. Reaction of (MesAlH(2))(2) with the isonitrile t-BuNC affords the cyclic species {MesAlN(t-Bu)CH(2)}(2) (7) featuring a six-membered (AlNC)(2) ring which, when heated, affords the cyclometalated species (8). Recognition that the products 2-6 and 8 were derivatives of primary amides led to an investigation of synthetic approaches to these product types via the direct reaction of (MesAlH(2))(2) with some primary amines. Treatment of (MesAlH(2))(2) with H(2)NCH(2)Mes affords the dimeric amido alane [Mes(H)Al{&mgr;(2)-N(H)CH(2)Mes}](2) as a mixture of trans (9) and cis (10) isomers. Further heating of 9 and 10 affords the ortho-metalated compounds 4 and 5. The reaction of (MesAlH(2))(2) with H(2)NSiPh(3) furnishes the bis amido aluminum compound MesAl{N(H)SiPh(3)}(2) (11) and [Mes(H)Al{N(H)SiPh(3)}](2). The latter yields the dimeric imide {MesAlNSiPh(3)}(2) (12) at elevated temperature.

Journal Article↗