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Results for “Altitude adaptation”

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At least 109 records · Page 6Linked to original sources
PubMed1982

[Quantitative analysis of the mitochondrial ultrastructure of cardiomyocytes in rats adapting to altitude hypoxia].

A study was made of the quantitative characteristics of mitochondria of the myofibrillar, perinuclear and subsarcolemmal zones of cardiomyocytes during long-term adaptation of rats to an "altitude" of 9000 m in a pressure chamber. The data are presented on the role played by hypertrophic and hyperplastic processes occurring in the mitochondrial apparatus in supporting viability of cardiac cells at high altitude.

Adaptation, Physiological↗
PubMed1977

[Effect of adaptation to altitude hypoxia on vascular resistance].

The resistance of vessels in the hind limbs was determined under controlled perfusion in rats adapted to hypoxia at 2100 m altitude and in control animals at 200 m above the sea level. It was found that 15 days after the onset of adaptation the resistance of the resistive vessels decreases, after 30 days the degree of this decrease of resistance grows and it becomes statistically significant. The decrease of resistance in the resistive vessels of adapted animals persists after denervation of the extremity and depends on the reduction of the myogenic component of the vascular tonicity. This reduction of the myogenic component of the tonicity is accompanied by a reduction of the pressor reactions to asphyxia and addition of noradrenaline to the perfusate. The obtained data indicate that preliminary adaptation decelerates the development of experimentally induced hypertension.

Adaptation, Physiological↗
PubMed1980

[Prevention of stress injuries to the heart by using preliminary adaptation to altitude hypoxia].

Reduced contractile function of the isolated heart and increased flow of CPK from it into the perfusate were observed in animals who had suffered an emotional-pain stress in the form of anxiety neurosis; the hupoxic test caused more marked changed in these animals. Preliminary adaptation to high altitude hypoxia prevented the damaging effect of stress according to the criterion of enzyme escape; there was no deficiency of contractile function.

Adaptation, Physiological↗
PubMed1977

[Contractile function of the heart and its reactivity to noradrenaline in the process of the bodies adaptation to moderate altitudes].

In acute experiments on rats adapted for 4 weeks to the altitude of 2100 m it was found that at the early period of altitude adaptation the left ventricular systolic pressure and the maximal rates of pressure rise and fall considerably exceeded the values of control tests conducted in Moscow. Later on the parameters of the cardiac contractile function stabilized gradually. In 4 weeks the heart of adapted animals showed a greater increment of the contractility parameters in response to noradrenaline injection and a higher stability of the contractile function at very high heart rates.

Adaptation, Physiological↗
PubMedDate not supplied

[Influence of preliminary adaptation to altitude hypoxia on catecholamine concentration in the hypothalamus, adrenals and heart under great physical stress].

Rats were subjected to adaptation to heigth hypoxia in an altitude chamber at the "heigth" 6 km within 7 weeks for 6 hrs a day. Concentration of noradrenaline and adrenaline was normal in hypothalamus; in myocardium content of noradrenaline was also normal but content of adrenaline was slightly decreased; in adrenal glands content of both hormones was distinctly increased. High physical activity (7 hrs swimming) did not alter content of noradrenaline in hypothalamus and adrenal glands of unadaptated rats but decreased 3-fold the content in myocardium. In adaptated rats, by contrast, such loading caused distinct decrease in content of noradrenaline in hypothalamus and adrenal glands and did not affect the content of adrenaline and noradrenaline in myocardium. Thus, adaptation to the heigth hypoxia prevented completely the decrease of catecholamines content in myocardium under loading and simultaneously increased the extent of mobilization of noradrenaline stores in hypothalamus and adrenal glands.

Adaptation, Physiological↗