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PubMed1994

Circulatory response of young adult trauma victims with alcohol intoxication.

Young adults are a subgroup particularly susceptible to traumatic injury; alcohol intoxication is a major risk factor for trauma in young adults. During the first hours following multiple trauma, however, little is known about the specific effects of alcohol intoxication on the circulatory response of critically injured young adults. The purpose of this prospective study was to compare the circulatory response of 5 severely injured young adults (15-40 years old) with acute alcohol intoxication to the circulatory response of 5 severely injured, nonintoxicated young adults. Data were collected every hour for the first 8 hours after admission to a surgical intensive care unit. Subjects with alcohol intoxication had significantly higher heart rates (t = 2.8176, p < .05) than their nonintoxicated counterparts. Heart rate and blood pressure, however, showed no statistically significant (p < .05) Group x Time interaction between the two groups. Subjects with alcohol intoxication also had injuries that caused more blood loss, more invasive monitoring, more operative procedures, more fluid replacement, and higher oxygen requirements.

Adolescent↗
PubMed1990

[Changes in the aminopeptidase activity in the brain neurons of rats subjected long-term to alcoholic intoxication].

A histochemical investigation was made of aminopeptidase activities using L-leucine-beta-naphthylamide and D, L-alanine-beta-naphthylamine as respective substrates in the rat's sensomotor cortex neurons during the period of ethanol withdrawal after a prolonged alcohol intoxication. Alcohol intoxication of the rat continued for 8 months. Different dynamics of aminopeptidase activities was shown depending on the substrate used during ethanol withdrawal. The results are discussed from the point of view of the existence of multiple forms of aminopeptidase in the brain and of their involvement in protein metabolism in pathological states.

Alanine↗
PubMed1979

An outbreak of acute methyl alcohol intoxication.

An outbreak of acute methyl alcohol intoxication occurred in Port Moresby, Papua New Guinea, in March 1977. Twenty-eight young men attended a drinking party and drank methyl alcohol. The amount consumed by each individual ranged from an equivalent of 60--600 ml of pure methanol. Three had prior ethanol ingestion. All 28 became ill 8--36 hours after drinking and were hospitalized. The most commonly observed clinical syndromes were: acute metabolic acidosis, severe visual impairment and acute pancreatitis. Four died within 72 hours after admission to the hospital. All had severe metabolic acidosis and visual impairment and three pancreatitis. Of 24 who recovered, 16 showed no residual complications, six had bi-lateral visual impairment and two had difficulty in speech as well as visual impairment. A three month follow-up examination showed no change in the findings. Coma, seizures and prolonged acidosis were poor prognostic signs. The estimated amount of consumed methanol and the rapidity of the appearance of signs of toxicity following methanol ingestion did not seem to influence the outcome of poisoning. The treatment of acute methyl alcohol intoxication in centres where dialysis is not available is discussed.

Adolescent↗
PubMed2003

Aggressiveness, family history of alcoholism, and the heart rate response to alcohol intoxication.

Some sons of male alcoholics (SOMAs) are characterized by an increased heart rate (HR) response to alcohol intoxication, which is thought to reflect increased sensitivity to alcohol-induced reward. Such a response has also been related to increased physical aggression. However, the confounding effect of aggression in SOMAs may be obscuring the interpretation of these findings. The HR response to alcohol was therefore assessed in 4 groups: high/low aggressive SOMAs and high/low aggressive non-SOMAs. Results indicate that aggressive SOMAs had the highest intoxicated HR response and that they reported the most alcohol consumption. This suggests that in some cases the high comorbidity between alcohol misuse and aggression is related to an increased sensitivity to alcohol-induced reward.

Adolescent↗
PubMed1996

Alterations in CNS gene expression in a rodent model of moderate traumatic brain injury complicated by acute alcohol intoxication.

The combined effects of acute alcoholic intoxication and moderate traumatic brain injury (TBI) on zif/268, glial fibrillary acidic protein (GFAP), and preproenkephalin (PPE) mRNA expression were examined. Adult male Wistar rats received ip injections of a 5% alcohol solution (2.4 g/kg in a final volume of 20 ml isotonic saline) 10 min prior to fixed-head, mechanical injury. Using Northern analysis, a transient three- to fourfold induction of zif/268 mRNA levels was observed 45 min after injury in both TBI and alcohol-treated rats. This induction occurred in regions close to the impact site, namely, the olfactory bulb (OB) and frontal cortex (FTCTX) but not in the more distal piriform/amygdala cortex (P/A). No PPE mRNA changes were observed at 45 min for any experimental group. By 6 h, zif/268 transcript levels returned to or fell below basal levels in the OB and FTCTX while GFAP mRNA levels began to increase in TBI rats. At 24 h, GFAP mRNA levels were greatly increased in all three brain regions of TBI rats. However, alcohol inhibited the temporal induction of GFAP mRNA in the FTCTX and P/A triggered by TBI at 6 and 24 h. These results suggest that although acute alcohol intoxication prior to TBI does not influence gene expression patterns immediately after injury, it may minimize the transcriptional activation of astrocytes particularly in more distant brain regions that were influenced by the impact in nonintoxicated rats.

Alcoholic Intoxication↗
PubMedDate not supplied

[Clinical picture and diagnosis of mild craniocerebral injuries during alcoholic intoxication].

The authors analysed 273 cases with brain contusion suffered in a state of acute alcohol intoxication. It was found that alcohol intoxication alters its clinical picture considerably. The dependence of the neurological symptoms on the degree and phase of alcohol intoxication is shown. Statistical processing of the information obtained allowed the most informative neurological symptoms of brain injury to be revealed. The significance of additional examination methods for the diagnosis is discussed. A dependence of the rheographic indices in brain injury on the phase of concomitant alcohol intoxication is demonstrated.

Adult↗
PubMed1998

Relationships between ambulance transports for alcohol intoxication and assault.

OBJECTIVE: To evaluate the association between ambulance transports for assault and those for alcohol intoxication. METHODS: A retrospective analysis of emergency medical services (EMS) calls was performed. The authors used logistic regression models to compare patients transported for alcohol intoxication with a control group of patients transported for respiratory distress (asthma or shortness of breath) with respect to whether they had been transported on a separate occasion for a chief complaint of assault. RESULTS: Patients transported for alcohol intoxication had 9 times the risk of transport for assault as compared with the control group (OR = 9.3; 95% CI = 6.4, 13.6). The odds of transport for assault among the alcohol patients increased 17.1% with each alcohol transport (OR = 1.17; 95% CI = 1.14, 1.20) but decreased for the control group (OR = 0.34; 95% CI = 0.26, 0.44). Repeat transports for assault were more common among the alcohol patients than among the control group (OR = 3.3; 95% CI = 1.1, 11.3). The mean number of assault transports was higher among the alcohol patients than among the patients never transported for alcohol intoxication (p < 0.0001). CONCLUSIONS: Patients transported on multiple occasions for acute alcohol intoxication are at relatively high risk for assault. This risk group should be targeted for focused assault prevention interventions that include components designed to reduce incidents of repeat alcohol intoxication.

Adult↗
PubMed2003

Alcohol intoxication increases morbidity in drivers involved in motor vehicle accidents.

We prospectively examined the correlation of alcohol intoxication with injury severity, morbidity, and mortality in drivers involved in motor vehicle accidents in a prospective cohort study. The study enrolled 923 injured patients, of whom 421 were legally intoxicated (blood alcohol concentration [BAC] > or = 50 mg/dL) and 502 were not intoxicated (BAC < 50 mg/dL). The intoxicated drivers had a significantly higher injury severity score (ISS), lower Glasgow Coma Score, lower systolic blood pressure; higher rate in old age, male sex, greater rate of habitual drinking, greater lack of use of safety gear, and greater accident-related morbidity. After logistic regression analysis, alcohol intoxication was not associated with severe injury (ISS > or = 9); however, alcohol intoxication analyzed either as a preinjury or postinjury risk factor, was one of the predictors for morbidity. Severe head injury was the only predictor of mortality. In conclusion, although alcohol intoxication is not associated with an increased incidence of severe injury or mortality in drivers involved in motor vehicle crashes, it is one of the significant predictors for morbidity after injury.

Accidents, Traffic↗
PubMed1989

[Injuries of the cervical segment of the spinal cord in alcoholic intoxication. Preliminary report].

The clinical documentation of 777 patients treated for traumatic injury of the cervical spinal cord has been analyzed. A comparison of consequences of accidents, neurologic and functional results of treatment in two groups of patients: admitted for treatment while being drunk and sober, has been presented. There were 246 intoxicated persons (32 per cent of the patients) in the analyzed group. An analysis of the data has indicated a smaller degree of spinal cord injury and better neurologic and functional results in patients that were not intoxicated by alcohol on admission. A statistic analysis (chi-square test)has shown that the quoted relationships have a high degree of probability. The authors have criticized incomplete documentation in previously used preliminary examination charts and have introduced a modified examination chart including data about the degree of a patient's sobriety.

Accidents↗
PubMed1986

Transplacental alcohol intoxication.

The world literature contains few reports of infants born while intoxicated by alcohol. I describe the clinical course of such a child who had a high blood alcohol concentration on delivery, and exhibited features of acute alcohol withdrawal in the days after birth. He later demonstrated features consistent with a partial alcohol foetopathy (foetal alcohol effects).

Alcoholic Intoxication↗
PubMed1994

Hormonal derangements in patients with severe alcohol intoxication.

Controversial results of fluid and electrolyte derangements in patients with moderate alcohol intoxication have been described. However, no information is available about severe alcohol intoxication. We investigated differences of hormonal disorders between alcohol-habituated and alcohol-naive subjects with severe ethanol intoxication. The hormonal derangements and recommendations on therapy of these patients are discussed. Thirty-three patients [10 alcohol-naive (group A) and 23 alcohol-habituated (group B) subjects] with severe alcohol intoxication (blood ethanol > 200 mg/dl) were selected for the study. Electrolytes and osmolarity of serum and urine, blood ethanol, vasopressin, renin, and aldosterone were determined on admission 2, 4, and 6 hr later. Fluid balance was calculated for each hour. All patients received isotonic saline solution according to urine production. Group A: On admission, serum osmolarity was increased (308 mOsmol/kg). Concomitantly, vasopressin level was elevated on admission (9.12 pg/ml). Increased serum osmolarity was correlated with elevated vasopressin levels (r = 0.8211; p < 0.005). Serum electrolytes, renin, and aldosterone values were within normal ranges. Group B: On admission, vasopressin level was significantly decreased (0.9 pg/ml), despite an elevated serum osmolarity (309 mOsmol/kg). Serum osmolarity remained high despite a sufficient fluid substitution. In addition, vasopressin level remained suppressed over the observation period. Aldosterone level was significantly increased on admission (319 ng/ml). Accordingly, serum sodium was increased from 142 to 148 mM/liter, and serum potassium was decreased from 3.9 to 3.4 mM/liter. Response to hyperosmolarity due to severe alcohol intoxication is different in alcohol-naive and alcohol-habituated subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

[Mineral metabolism and tissue-specific cytotoxic activity of the blood serum in the progeny in chronic alcoholic intoxication of the progenitors].

Late sequelae of chronic alcoholic intoxication were studied in the 3rd generation of animals. The peculiarities of trace element and macronutrient balance and the offspring blood serum tissue-specific cytotoxic activity against brain, testes, thymus, are discussed in their relation to the nature of chronic alcoholic intoxication of the 1st generation on paternal, maternal and both sides. Characteristic features are shown for the indices under study in the offspring, including the chronic alcoholic intoxication in males of the 1st generation. These peculiarities suggest the possibility of a differentiated therapeutical approach to correction of alcoholic embryo-/fetopathy.

Alcoholism↗
PubMed2004

HIV risk behaviors and alcohol intoxication among injection drug users in Puerto Rico.

This paper reports results of an analysis of the association between alcohol intoxication and injection and sexual HIV risk behaviors among 557 Hispanic heroin and cocaine injectors, not in treatment, who were recruited in poor communities in Puerto Rico. Subjects were part of a longitudinal prevention-intervention study aimed at reducing drug use and HIV risk behaviors. Participants reported a high prevalence of co-occurring conditions, particularly symptoms of severe depression (52%) and severe anxiety (37%), measured by Beck's Depression Index and Beck's Anxiety Index, respectively. Alcohol intoxication during the last 30 days was reported by 18% of participants. Associations were found between alcohol intoxication and both injection and sexual risk behaviors. In the bivariate analysis, subjects reporting alcohol intoxication were more likely to inject three or more times per day, pool money to buy drugs, share needles, and share cotton. They were also significantly more likely to have a casual or paying sex partner and to have unprotected sex with these partners. After adjustment, sharing needles and cotton, having sex with a paying partner or casual partner, and exchanging sex for money or drugs were significantly related to alcohol intoxication. HIV prevention programs, to be effective, must address alcohol intoxication and its relation to injection and sexual risk behaviors as a central issue in HIV prevention among drug injectors.

Adolescent↗
PubMed1989

The structure of psychological defense mechanisms in women as a function of alcohol intoxication.

The present experiment tested whether moderate alcohol intoxication influences the relative strength of different psychoanalytic defense mechanisms and whether the overall level of defense activity is changed. Thirty-six women were randomly assigned to either an alcohol, a placebo, or a control group. The alcohol dose was 1.0 ml of 100% alcohol/kg body weight. Subjects were tested with the Defense Mechanism Test (DMT), which gives a valid measure of both elaborate or late and primitive or early defense mechanisms. Results indicated no significant effects of alcohol intoxication on any aspect of the defense system. This was taken as supportive of the psychoanalytic notion in respect of the stability of the defense system. Possible complications were discussed.

Adult↗
PubMed1999

Young, wet & wild? Associations between alcohol intoxication and violent behaviour in adolescence.

AIMS: To assess gender- and age-specific associations between alcohol intoxication and engagement in violent behaviours in young people. DESIGN, PARTICIPANTS AND MEASUREMENT: Cross-sectional study comprising a national sample of 12,000 Norwegian adolescents aged 12-20 years. Data on violent behaviour, alcohol intoxication and various confounders were obtained by self-administered questionnaires in school. FINDINGS: 2.8% had been in fight with a weapon and 32.6% had been beating or threatening to beat someone during the past year. Violent behaviours were more often reported among boys, in the younger age groups, with increasing frequency of alcohol intoxication, among users of other drugs, among those engaged in criminal activities and among those in wet environments (friends drinking regularly and parents often being intoxicated). The impact of intoxication frequency on number of times engaged in violent behaviours was of modest magnitude. It was greater in the youngest age group compared to those in the middle and late teens and greater for boys than for girls. However, when criminal activities were controlled for, the adjusted effect of intoxication on violent behaviour was significantly reduced, the effect was then of the same magnitude for both genders, whereas there was no longer any significant effect in the youngest age group. Controlling also for parents' and friends' drinking and parental monitoring did not alter these findings. CONCLUSIONS: A small direct effect of alcohol intoxication on violent behaviour appears to remain after controlling for various relevant confounders in middle and late teens. However, possible indirect effects of alcohol intoxication, mediated by own deviant life-style and wetness of environment, should also be taken into consideration.

Adolescent↗