Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “APHTHOID”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 109 records · Page 6Linked to original sources
PubMed1993

Perioperative endoscopy of the whole small bowel in Crohn's disease.

The aim of this study was to search for small bowel lesions by means of a perioperative endoscopy in 20 patients operated on for Crohn's disease. Seven women and 13 men (mean age 29 years) had a total retrograde exploration to the angle of Treitz during an ileocolectomy (16 of 20 patients) or a colonic or ileal resection (four of 20 patients). Endoscopic exploration was completed, through an enterotomy, from the surgical area to the angle of Treitz. Periendoscopic biopsy samples were taken on macroscopic lesions and every 20 cm systematically. In 13 of 20 cases, various lesions scattered over the whole small intestine were found. These were aphthoid ulcerations (10 patients), superficial ulcerations (seven patients), mucosal oedema (three patients), non-ulcerative stenosis (three patients), erythema (two patients), pseudopolyps (two patients), deep ulcerations (two patients), and ulcerative stenosis (one patient). In seven patients none of the lesions detected at perioperative endoscopy had been recognised by preoperative evaluation or surgical inspection of the serosal surface. A typical granuloma was found at biopsy of lesions identified by endoscopy in three cases and at biopsy of an apparently healthy area in one case. Thus 65% of patients operated on for Crohn's disease had lesions of the small intestine detected by endoscopy, which were unrecognised before surgery in more than half of the cases.

Adolescent↗
PubMed1983

Isolation of Chlamydia trachomatis from prostatic fluid in association with inflammatory joint or eye disease.

We describe two patients, one with peripheral arthritis, sacro-iliitis, positive HLA B27, and autoantibodies to smooth muscle and gastric parietal cell; the other with aphthoid ulcers, geographical tongue, conjunctivitis, anterior uveitis, peripheral arthralgia, and diarrhoea with distal proctocolitis. Neither patient would have been diagnosed as having urethritis on the basis of accepted microscopic criteria. In both patients, however, Chlamydia trachomatis was isolated from the prostatic fluid, but not the urethra.

Adult↗
PubMed1993

Intestinal Behçet disease: serial changes at radiography.

To clarify the characteristic radiographic findings and serial radiographic changes in nonsurgical cases of intestinal Behçet disease (BD), seven patients were followed up for an average of 4 1/2 years (range, 8 months to 11 years 4 months). They underwent repeated examination with barium meal studies and double-contrast barium enema meal studies and double-contrast barium enema radiography. Initial radiography revealed one to three deep ulcers in the terminal ileum or ileocecal region in five patients. The ulcers healed while patients were treated with medical therapy but recurred during the follow-up period. In four of these five patients, follow-up radiography demonstrated various changes within each case: At each examination, an enlarged ulcer or a newly developed ulcer was often found in conjunction with a healed ulcer. In the other two patients, multiple shallow ulcers or innumerable aphthoid ulcers were seen throughout the entire colon, and these ulcers showed a good response to medical treatment. These results indicate that serial radiographic changes in patients with intestinal BD may mimic those in patients with Crohn disease, with findings in the terminal ileum and colon that wax and wane with medical treatment.

Adult↗
PubMed1995

Idiopathic inflammatory bowel disease: endoscopic-radiologic correlation.

PURPOSE: To assess the comparative and adjunctive diagnostic value of double-contrast barium enema examination (DCBE) and colonoscopy in cases of idiopathic inflammatory bowel disease. MATERIALS AND METHODS: Radiographic and endoscopic findings were correlated, with use of a standardized evaluation sheet, in a prospective, blinded study in 99 patients with previously well-established Crohn disease of the colon (CD [ n = 51]) or ulcerative colitis (UC [n = 48]). RESULTS: Overall, substantial to almost perfect agreement was found in more than 80% of scores with respect to the items of the standardized evaluation sheet in the colon segments depicted with both imaging modalities. Almost perfect agreement (kappa > 60%) was found for two essential diagnostic and differential diagnostic features: aphthoid erosions and fine granularity. CONCLUSION: DCBE and colonoscopy are complementary imaging modalities for optimal detection of all mucosal and structural colon lesions, except inflammatory lesions without distortion of the mucosal relief and small numbers of inflamed superficial erosions and ulcers.

Adolescent↗
PubMed1994

Papular-purpuric 'gloves and socks' syndrome: not only parvovirus B19.

We previously described an acute dermatosis characterized by pruritic erythematous and slightly papular lesions on the hands and feet in a 'gloves and socks' distribution associated with oral aphthoid lesions and fever (papular-purpuric 'gloves and socks' syndrome = PPGSS). We strongly suspected a viral origin, but serologic tests for a large panel of viruses remained negative. Subsequently, 2 cases of PPGSS with serologic evidence of a parvovirus B19 infection have been reported in the literature. Since then we observed 5 additional patients with a PPGSS. Parvovirus B19 infection could be confirmed in only 2 cases. Our findings suggest that the PPGSS can be another, yet undescribed manifestation of parvovirus infection. However, this cannot be shown in all the cases. As the papular acrodermatitis of childhood, this syndrome may be caused by various viral agents.

Adolescent↗
PubMed1992

An endoscopic study of antibiotic-associated hemorrhagic colitis.

Colonoscopy was performed on acute stage within 72 hours from onset in 48 patients with antibiotic-associated hemorrhagic colitis (AAHC). From our observations we have developed a new endoscopic classification of AAHC and investigated the incidence of each finding in further detail. We have classified in principle the endoscopic findings of the 48 subjects into two groups: major and minor ones respectively. Category of major findings were: 1) diffuse mucosal hemorrhage (100%); 2) spotty mucosal hemorrhage (100%), and 3) linear mucosal hemorrhage (22.9%), while minor findings were: 1) irregular ulcers in 10.4%; 2) aphthoid ulcers in 6.3%, and 3) linear erosions or ulcers in 4%. Minor findings were ulcers or erosions present over the hemorrhagic mucosa associated with the moderate degree of inflammation. A histopathologic study of colon biopsy specimens from 24 patients with AAHC showed hemorrhage and inflammatory cell infiltration in the lamina propria mucosae varying from mild to moderate in extent. It was concluded that AAHC was a colonic mucosal hemorrhagic disease caused by the destruction of mucosal vessels from unknown causes and in this disease mild to moderate inflammation was partially followed by ulceration over the edematous and hemorrhagic mucosa of the colon.

Adolescent↗
PubMed2006

Isolated ileal erosions in patients with mildly altered bowel habits. A follow-up study of 28 patients.

This study evaluated 28 patients to characterize the morphologic features associated with typical Crohn disease (CD). All patients had similar complaints, an endoscopically normal colon, and small isolated, aphthoid erosions in the terminal ileum. The mean length of follow-up was 5.8 years. Of 28 patients, 25 (89%) were female (mean age, 32.3 years). Four patients were ingesting nonsteroidal anti-inflammatory drugs. All 28 lesions were morphologically similar, with focal lamina propria edema, mild active inflammation, and crypt disarray. Most had a lymphoid aggregate within the region of edema. Erosion was identified histologically in 21 cases. Following colonoscopy, symptoms resolved in all 28 patients. Typical, full-blown CD developed in 8 patients (29%) after a mean interval of 3.6 years. CD lesions were morphologically identical to non-CD lesions. Most focal ileal erosions in patients with mildly altered bowel habits are idiopathic and clinically insignificant. They represent early CD in approximately 30% of patients. The interval between initial examination and typical CD can be long. Pathologists should remain diagnostically vigilant when examining ileal biopsy specimens obtained from patients with previous abnormal ileal biopsy findings, regardless of the interval. Persistent, mild morphologic abnormalities have a high likelihood of being CD.

Adolescent↗
PubMed1998

Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia.

A 54-year-old woman came to our office because of pretibial edema. She had no gastrointestinal symptoms. Laboratory tests revealed severe hypoproteinemia. Upper gastrointestinal endoscopy demonstrated enlarged gastric folds and multiple aphthoid nodules on the body and the fornix of the stomach. The biopsy specimen revealed a large number of CD8 positive intraepithelial T-lymphocytes infiltrating the gastric mucosa. Both serum total protein and the gastric lesions improved eight months after her first visit without any therapy for peptic ulcer or eradication of Helicobacter pylori. The data suggest that spontaneous remission may occur in lymphocytic gastritis without any gastrointestinal symptoms.

Biopsy↗
PubMed1994

Barium studies in patients with Candida esophagitis: pseudoulcerations simulating viral esophagitis.

OBJECTIVE: The purpose of this report is to describe an abnormality identified on barium studies in patients with Candida esophagitis that simulates discrete or aphthous ulceration. This finding may be misinterpreted as suggesting viral esophagitis. PATIENTS AND RESULTS: Between 1989 and 1993, four patients with endoscopically confirmed Candida esophagitis and no evidence of associated viral infection were treated at Hahnemann University. These patients were selected for study because double-contrast barium studies showed an "aphthoid" complex consisting of a superficial punctate barium collection surrounded by a thin radiolucent rim. Most of the complexes were 2-3 mm in diameter. No typical plaques were present, and the lesions were separated by normal mucosa. In two cases, only one or two lesions were observed on initial esophagograms because of limited distension. Additional esophagograms with additional distension showed more lesions. In two cases, the results of the barium studies were misinterpreted as evidence of viral esophagitis. CONCLUSION: Multiple esophageal lesions that resemble aphthous ulcers are a subtle radiographic manifestation of Candida esophagitis and may be responsible for either missed diagnoses or misinterpretation as viral esophagitis. Features suggestive of pseudoulceration include uniformity of size and relatively sharp margination of the filling defect, and punctate rather than stellate collections of barium.

Adult↗
PubMed2003

[Case of vascular Behçet's disease initially presented with Bürger's disease-like vasculitides].

The patient was a 24-year-old man. Bürger's disease was diagnosed initially based on the finding of bilateral radial artery obstruction, and the patient underwent vascular reconstructive surgery. After the operation, however, formation of false aneurysms was observed frequently in the left brachial artery at the elbow, which necessitated performance of vascular reconstructive surgery up to five times in total, including of the right common femoral artery, which had been punctured several times for investigational procedures. During the clinical course, fever, oral aphthoid ulcers, genital ulcers, and nodular erythema appeared, and incomplete Behçet's disease was diagnosed. Histopathological examination suggested that the vascular lesion was consistent with necrotizing angiitis. The systemic inflammatory findings and angiitis improved following steroid administration. Vascular Behçet's disease is known as a special type of Behçet's disease, but usually develops in the patients with a long history of the disease. Our patient was believed to be very instructive because, when Behçet's disease occurs with angiitis and the epidemiological characteristics agree with those of Bürger's disease like in our patient, differentiation may be difficult.

Adult↗
PubMed1987

Lymphoid follicular pattern in the colon: an indicator of barium coating.

A lymphoid follicular pattern was noted more frequently when high-density (100% w/v) replaced low-density (58% w/v) barium in children undergoing double-contrast barium enema examinations. Therefore, a retrospective study was undertaken to compare the presence of follicles seen in 24 consecutive patients under 10 years old given low-density barium with that of 50 patients given high-density barium. The high-density studies revealed follicles in 90% of the children compared with 46% of the children having low-density studies. All follicles were less than 2 mm in diameter. An aphthoid appearance was present in nine of these 50 children. The most common indications for the high-density examination were rectal bleeding and abdominal pain. The final diagnosis was normal bowel in more than two thirds; no child under six years old given high-density barium had inflammatory bowel disease. There was no correlation between final clinical diagnosis and the presence, extent, or severity of the lymphoid follicular pattern.

Barium Sulfate↗
PubMed1977

Air contrast studies of the colon in inflammatory bowel disease.

The purpose of this review is to evaluate the role of double-contrast examination of the colon, in the detection and differential diagnosis of colitis. The emphasis is on correlation with endoscopy, (twelve color endoscopic photographs are included with the corresponding radiographs illustrating the spectrum of abnormalities in ulcerative and granulomatous colitis), differential diagnosis between ulcerative and granulomatous colitis (the double-contrast technique allows for accurate examination of the rectum and careful mapping of the extent and nature of disease in an involved segment. This facilitates the differential diagnosis between ulcerative and granulomatous colitis), and detection of early changes (in ulcerative colitis, the early stage of mucosal edema results in a finely granular mucosa on double-contrast study. In granulomatous colitis, small, shallow, "aphthoid" ulcers are frequently seen as the earliest lesion). The accuracy of the double-contrast technique is assessed by review of series comparing the radiologic and endoscopic findings. This is compared to the accuracy of the conventional enema. Some of the important technical considerations necessary for good double-contrast studies are discussed, as well as some of the potential pitfalls in interpretation.

Barium Sulfate↗
PubMed1987

[Differential diagnosis and therapy of recurrent aphthae].

The differential diagnosis of aphthous stomatitis includes several viral diseases, such as gingivostomatitis herpetica, recurrent intraoral herpes simplex, herpangina, hand-, foot-and mouth disease, as well as drug eruptions, traumatic ulcers, and aphthoid lesions in neutropenia. The therapy of aphthous stomatitis is designed to control pain, shorten the course of present lesions, and prevent the development of new lesions.

Diagnosis, Differential↗
PubMed1987

Diversion colitis. Pathologic findings in a resected sigmoid colon and rectum.

We present here the detailed pathologic findings in the resected colon and rectum from a paraplegic patient with severely symptomatic diversion colitis and lack of anorectal function. Previous reports of the pathology of this condition have been confined to biopsy findings. A diffuse nodularity caused by lymphoid hyperplasia and an inflammatory process confined to the colorectal mucosa with erosions, crypt abscesses, mucin granulomas, and aphthoid ulcers were the main features. There was minimal distortion of crypt architecture. The pathologic features of this entity are compared to those of other inflammatory disorders of the colon and rectum.

Adult↗
PubMed1987

[Clinical aspects and therapy of frequent diseases of the oral mucosa].

Different diseases of the oral mucosa may closely resemble each other and may therefore pose considerable differential diagnostic problems. The most frequent oral mucous membrane disorders are briefly presented according to their main clinical feature. Recurrent aphthous ulcerations have to be differentiated from viral infections causing aphthoid defects. Blisters and erosions are characteristic for erythema multiforme and oral lesions of bullous autoimmune dermatoses. Leucoplakias may be due to exogenous irritant factors, but may also be a symptom of oral disease. Warts and granulomas may simulate malignant tumours. Pigmentations are due to a variety of endogenous and exogenous factors. Some very frequent, but harmless alterations of the tongue are also briefly described.

Diagnosis, Differential↗
PubMed1985

[Oral and cutaneous lesions in Crohn's disease. A case report].

Cutaneous and buccal manifestations of Crohn's disease are common. They are diagnostically helpful either by their specificity or from a biopsy which whilst access is easy offers less satisfactory results with buccal lesions. Stomatological clinical aspects are varied, most commonly of aphthoid or vesicular stomatitis type (as in the case reported here).

Adult↗
PubMed1983

A freeze fracture study of Crohn's disease of the terminal ileum: changes in epithelial tight junction organization.

Freeze fracture replicas of the plasma membrane and tight junctions of epithelial cells of the terminal ileum from 10 patients with Crohn's disease involving the small bowel and from the terminal ileum of two patients without inflammatory bowel disease were studied to determine if significant morphological variations could be documented. Samples of diseased tissue were taken from: 1) macroscopically normal ileal resection margins, 2) pinpoint aphthoid ulcers, 3) small 5 mm ulcers, 4) cobblestone mucosa. Samples of ileal mucosa from the proximal margin of ileocolic resections for carcinoma of the right colon were identically processed and served as controls. Control specimens showed normal villus structures lined by absorptive and goblet cells linked to adjacent cells by four to seven tight junction strands, arranged as an anastomosing network of fibrils oriented perpendicularly to the long axis of the cell. Crohn's disease specimens taken from the cobblestone area displayed the greatest degree of tight junction disorganization. Tight junctions commonly formed bizarre patterns, were fragmented, and often showed misalignment in a direction parallel to the cell axis. Specimens taken from areas 2 and 3 displayed a less severe form of tight junction rearrangement. Junctional strand fragmentations, as well as areas of plasma membrane lacking strands, were apparent. The resection margins had minor irregularities in junctional structure in some, but not all, cases. The predominant alteration in those cases which showed change was varying degrees of strand fragmentation. We postulate that the tight junction abnormalities of epithelial cells from the terminal ileum of patients with Crohn's disease may contribute to a disturbance in barrier functions.

Adult↗