Intestinal antisepsis: rationale and results.
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Resulting from the infectiologically established novel definition of antiseptic which contains the local application of antiseptics for prophylactical, preventive or therapeutical indication on skin, mucous membrane, wounds, in body cavities or on surgical exposed resp. opened endosomatic areas the antiseptical indications in a branch of dermatology and venereal diseases are represented. With the analysis of the actual knowledge in vitro and in vivo requirements to local antiinfectiva are defined combined with the recommendations for the clinical use. At present mainly prophylactically used agents are submitted to an benefit risk analysis with refer to the choice of agents. There by agents for the application on skin as well as on genitals, in mouth cavity and on wounds were taken into consideration.
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Between February 1983 and September 1985, an outbreak of methicillin-resistant Staphylococcus aureus involving 151 patients and staff occurred in a district general hospital. At its peak, 43 cases occurred in 3 months. Sixty-two patients suffered morbidity and two died. Conventional isolation techniques and once-daily whole body washing of affected patients with triclosan successfully controlled the outbreak.
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