Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ANALEPTICS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 109 records · Page 6Linked to original sources
PubMed1989

Synthesis and quantitative structure-activity relationships of analeptic agents related to dimefline.

Some new dimefline-type derivatives have been synthesized and their pharmacological activity, as well as their distribution coefficients have been determined. The distribution coefficients of a number of previously published analogue compounds have also been measured and the QSAR analysis of the whole set has been carried out. The results of such analysis allow to point out which factors are influencing the biological activity of this group of compounds.

Animals↗
PubMed1986

Human corticotropin-releasing factor (hCRF) is a potent respiratory analeptic. Physiological and clinical aspects.

During intravenous corticotropin-releasing factor stimulation tests we observed a deepening of the tidal volume in 35 patients. To investigate this presumed respiratory stimulation we measured respiratory parameters in 12 healthy male volunteers in a single-blind placebo-controlled trial. The intravenous 60-s infusion of 100 micrograms of human corticotropin-releasing factor induced a very potent respiratory stimulation in every subject: respiratory minute volume (mean +/- S.D.) increased by 81% from 6.319 +/- 0.577 to 11.464 +/- 1.264 liters per min (P less than 0.001), whereas there was only a slight rise in the mean respiratory rate from 12.4 +/- 3.0 to 14.7 +/- 2.7 breaths per min (P less than 0.001). Mean tidal volume increased from 531 +/- 105 to 809 +/- 175 ml (P less than 0.001). Mean end-tidal partial pressure of carbon dioxide decreased (P less than 0.001) from 40.3 +/- 1.2 to 33.4 +/- 1.2 mmHg, whereas mean end-tidal partial pressure of oxygen increased (P less than 0.001) from 93.2 +/- 5.4 to 113.5 +/- 5.4 mmHg. After 10 to 20 min both end-tidal carbon dioxide and oxygen partial pressures returned to the baseline values. The placebo had no measurable effects. We conclude that human corticotropin-releasing factor is a potent respiratory stimulant. With 100 micrograms the resting respiratory minute volume increases by 81%. These data point to the possible importance of the corticotropin-releasing factor as a useful adjunct in the management of patients with alveolar hypoventilation.

Adult↗