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At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Anti-acne effects of Oriental herb extracts: a novel screening method to select anti-acne agents.

The acne-therapeutic effects of Oriental herb extracts were investigated in terms of antichemotactic effect on polymorphonuclear leucocytes, antilipogenic actions, antibacterial activity against Propionibacterium acnes and resistance induction potency in the bacteria. The ethanol extract (0.01%) of Angelica dahurica markedly suppressed neutrophil chemotaxis, comparable to the effect of erythromycin (0.01%), whereas a strong antilipogenic effect was obtained with rhizoma coptidis (Coptis chinensis) extract (0.01%), leading to a higher efficacy than that of retinoic acid (0.01%). Interestingly, only Glycyrrhiza glabra showed a remarkable antibacterial activity against P. acnes, resulting in negligible induction of resistance, in comparison with a marked development of resistance in the bacteria treated with erythromycin. We suggest that an appropriate formulation containing A. dahurica, rhizoma coptidis and G. glabra could be helpful for the prevention and treatment of acne lesions.

Acne Vulgaris↗
PubMed1978

[Porphyrinsynthesis of Propionibacterium acnes in acne and seborrhea (author's transl)].

The porphyrin productions of P a.-strains, isolated on the one hand from inlfammatory acne lesions, on the other hand from sebaceous follicle filaments from 10 persons each were compared quantitatively and qualitatively, after the appropriate material had been pooled, With respect to the acne strains one could observe a somewhat increased porphyrin production as well as the discharging of a precentually greater portion of porphyrins to the surrounding material. When separated by TLC the acne material showed a more intense coproporphyrin band.

Acne Vulgaris↗
PubMed1998

Propionibacterium acnes colonization in acne and nonacne.

Propionibacterium acnes is a number of the resident bacterial flora and resides in sebaceous follicles. Age-related and body-dependent quantitative differences exist, indicating the role of sebum as an important ecological factor for P. acnes. Acne patients demonstrate marked increases in this organism which generates inflammation through a variety of mechanisms.

Acne Vulgaris↗
PubMed1981

Contribution to the interpretation of the occurrence of unsuccessful therapeutical results in acne vulgaris with topical erythromycin (Propionibact. acnes).

Investigations are reported which attempt to contribute towards an understanding of those cases in which topical treatment with erythromycin is unsuccessful. In 13 acne patients no resistance of P. acnes was observed after seven weeks of topical treatment with erythromycin. This demonstrates that the 20% frequency of resistance induction reported in the literature is too high. In the 13 treated patients there was no essential reduction in the number of inflammatory lesions although a decrease in the number of Propionibacteria in the pilosebaceous ducts occurred. This result is perhaps connected with a concurrent increase in Micrococcaceae, which could suggest that not only Propionibacteria, but also Micrococcaceae play a role in the pathogenesis of acne.

Acne Vulgaris↗
PubMed2000

Natural killer activity in mice infected with rabies virus and submitted to P. acnes (Propionibacterium acnes) as immunomodulator.

The natural killer (NK) activity and lethality were evaluated in swiss mice experimentally infected with street rabies virus and submitted to immunomodulation by P. acnes (formerly Corynebacterium parvum). The infected animals were sacrificed at different times and spleen non-adherent cells were obtained through ficoll-hypaque gradient and depletion of glass-adherent cells. Immunosuppression was observed in rabies virus infected mice correlated with lower NK activity in clinically ill animals. Higher NK activity and percentual of survival were observed in the group submitted to P. acnes. The increased survival correlated with higher NK activity induced by P. acnes suggests a protective role of this natural barrier against rabies virus infection in mice.

Animals↗
PubMed1989

Acne of the heel: acne vulgaris complicating a free vascularized latissimus dorsi musculocutaneous flap.

An interesting case of acne vulgaris complicating a free vascularized latissimus dorsi musculocutaneous flap used for heel reconstruction is presented. The development of acne in a free musculocutaneous island transfer has not been described before, and we speculate as to its cause. We conclude that quiescent donor site acne scarring may be a contraindication to the use of free skin flap transfer for soft tissue reconstruction.

Acne Vulgaris↗
PubMed1979

Bone lesions in systemic acne (acne fulminans).

An 18-year-old West Indian male presented with severe sternal pain and an exacerbation of facial acne. Radiographs of the sternum revealed several lytic lesions which appeared as hot areas on successive technetium bone scans. Painful areas over the right iliac crest and left greater trochanter likewise appeared as transient hot areas on successive scans. Histology of affected bone revealed reactive changes only. High dose prednisolone provided rapid alleviation of pain, which recurred on reducing the dose to less than 10 mg daily. Auto-immune complex disease has been considered the most likely aetiological mechanism of systemic acne (acne fulminans), but lytic lesions of bone have never previously been reported in auto-immune disorders.

Acne Vulgaris↗
PubMed1986

A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra-comedonal lipids of acne patients.

Skin surface lipids and lipids from open and closed comedones in acne patients were analysed by thin layer chromatography. The results showed that these lipids were enriched in polar lipids, as compared with the skin surface lipids obtained from controls without acne. In both open and closed comedones, these polar lipids appeared to be derived mainly from the oxidation of squalene, which is in agreement with our previous in vitro results. We suggest that squalene oxidation is the link between comedogenesis and bacterial colonization, and based on this, we propose a hypothesis of the pathogenesis of acne.

Acne Vulgaris↗
PubMed2006

Acne and acne scarring - the case for active and early intervention.

Acne as a disease is so common as to be considered a normal rite of passage, and costs the community a substantial amount in resources. Yet acne is a devastating disease striking most adolescents at their most vulnerable time when their life long self esteem and sense of identity is being developed. This article reviews the importance of acne to the individual and attempts to make the case for early and aggressive treatment.

Acne Vulgaris↗
PubMed1990

[Acne conglobata-like exacerbation of acne vulgaris following administration of anabolic steroids and vitamin B complex-containing preparations].

This article reports the aggravation of preexisting acne vulgaris in a 21-year-old male patient due to the abuse of anabolic drugs during body-building training. After cessation of anabolic drugs the acne healed, leaving hypertrophic scars. This case report shows that the acute aggravation of an acne vulgaris should cast suspicion on the use of hormone preparations.

Acne Vulgaris↗
PubMed1981

Acne with acute systemic reaction (acne fulminans?). Report of a case.

A 17-year-old girl, hospitalized because of severe cystic acne of six weeks' duration, developed symptoms of systemic disease, with fever, accelerated erythrocyte sedimentation rate, leukocytosis, thrombocytosis, arthralgia and anemia. Extensive investigation ruled out other possible causes for the systemic involvement, and there was a prompt response to steroid therapy. This case had features similar to those associated with "acute, febrile, ulcerative conglobate acne with poly-arthralgia," except that there was an absence of ulcerative lesions: nonetheless, the dominant picture was that of cystic involvement. We believe that the use of the term "acne fulminans" for this and similar cases would be appropriate.

Acne Vulgaris↗
PubMed1988

Granulocyte activating factor released from Propionibacterium acnes. A possible mediator of inflammation in acne vulgaris.

Incubation of Propionibacterium acnes but not of Propionibacterium granulosum or Propionibacterium avidum (for 30 min at 37 degrees C in physiological saline) released a soluble factor that produced enhanced chemiluminescence response of human granulocytes as well as increased chemotactic motility of these cells. Sephadex G-25 filtration of the granulocyte activating factor (GAF) revealed its low molecular weight and apparent peptide character. Thus, GAF may be a stimulus for inflammation in acne vulgaris since low molecular weight chemotactic factors can be expected to penetrate follicular walls.

Acne Vulgaris↗
PubMed1984

Acne treatment with topical erythromycin and zinc: effect of Propionibacterium acnes and free fatty acid composition.

A double-blind investigation has been conducted to examine the effect of topical 4% erythromycin/1.2% zinc acetate solution and its vehicle on quantitative bacterial counts (skin surface washings) of propionibacterium acnes and the free fatty acids of the skin surface. The logarithmic counts for P. acnes in the erythromycin/zinc group showed a significant reduction (98%) following 10 weeks of therapy. This compared with a 43% change shown for the vehicle-control group. A significant reduction (69%) in the percentage of free fatty acids in the surface lipids was seen at week 4 in the erythromycin/zinc group as compared to the control group. Triglyceride levels were significantly increased at all time points for the erythromycin/zinc group as compared to the control group. There was also a significant decrease (69%) in inflammatory lesions shown for the erythromycin/zinc treatment group at week 8 as compared to a 9% reduction in the control group.

Acetates↗
PubMed2003

Antibiotic resistance of Propionibacterium acnes in acne vulgaris.

Acne vulgaris is a common skin disease affecting all ages. Antibiotics remain the most common prescribed agent for the treatment of acne. Improper use of antibiotics in the dermatological setting needs to be evaluated to prevent the increasing prevalence of antibiotic resistance.

Acne Vulgaris↗
PubMed1980

[Propionibacterium acnes in acne vulgaris (comparative biochemical study of the comedone and the pustule].

The biochemical properties of the Propionibacterium acnes in 22 patients with inflammatory Acne vulgaris was studied. Group I/II was found in most cases. There was no difference between the biochemical properties of the comedone and the pustule. The authors suggest that factors other than those depending on the PA degradative metabolism can be responsible for the purulent inflammatory process of the pil-sebaceous follicle.

Acne Vulgaris↗
PubMedDate not supplied

The assessment of acne: an evaluation of grading and lesion counting in the measurement of acne.

The basic morphology of acne--comedones, papules, pustules, and nodules--and the extent of involvement do not permit simple evaluation due to the number of variables involved. Because these acne lesions may vary in number during the natural course of the disease, various measurements have been developed, based on clinical examination and photographic documentation. These range from global assessments to lesion counting, with the latter providing more objective data.

Acne Vulgaris↗
PubMed1976

[The problem of vitamin B6/B12 acne. A contribution on acne medicamentosa (author's transl)].

Deterioration of acne vulgaris or eruption of an acneiform exanthema could be established during treatment with vitamin B6 and/or vitamin B12 in 14 patients. Females were by far the more frequently affected. The appearance of skin symptoms, even outside the age groups typically affected by acne vulgaris is characteristic. The clinical appearance of acneiform exanthema occurring during treatment with vitamin B6 or B12 consists of loosely disseminated small papules or papulopustules on the face (especially on the forehead and chin), on the upper parts of the back and chest and spreading to the upper arm. The pathogensis of the change is not yet certain. The acneiform rash generally fades within a short time after vitamin B6 or vitamin B12 treatment has been stopped.

Acne Vulgaris↗