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At least 1,063 records · Page 59Linked to original sources
PubMed2002

Sensitivity of photoscreening to detect high-magnitude amblyogenic factors.

PURPOSE: To determine the sensitivity of a unique pupil-size based set of referral criteria of the MTI PhotoScreener(Medical Technology and Innovations, Inc, Cedar Falls, Iowa) to detect high magnitude refractive error. METHODS: The photoscreening photographs of 949 preschool children previously analyzed were reevaluated with the new referral criteria. The original photographs had been obtained from pediatricians' offices and public health and Women, Infants, and Children's (WIC) clinics. The results of this analysis were compared with the gold standard clinical examination and cycloplegic refraction. Sensitivities were calculated for amblyogenic factors based on the magnitude of the refractive error. RESULTS: For 26 patients with anisometropia, the sensitivity to detect anisometropia increased from 46% for +1.25 or greater spherical interocular difference to 100% for +2.50 spherical intraocular difference. For 36 patients with hypermetropia in at least 1 meridian ranging from +3.75 to +7.50 D, sensitivity increased from 53% to detect +3.75 D or greater to 70% for +5.00 D or greater. The sensitivity to detect hypermetropia of +5.75 D or greater was 100%. These criteria detected 82% of patients with astigmatism greater than or equal to +3.00 D, and 100% of patients with astigmatism greater than +3.50 D. CONCLUSION: It is crucial that screening programs avoid over-referrals caused by high false-positive screening rates. The sensitivity of our new criteria increases with higher magnitude refractive error; patients with moderate and severe amblyogenic factors are almost never missed. While the sensitivity to detect lower magnitude refractive error is poor, the amblyogenic impact of such errors remains to be determined.

Amblyopia↗
PubMed2000

Recruitment methods for community-based screening for diabetic retinopathy.

Regular screening of all people with diabetes is the most efficient and cost-effective way to detect early stages of diabetic retinopathy so that laser treatment can be performed at the optimal time. A major aim of the Program for the Early Detection of Diabetic Retinopathy was to increase compliance with guidelines for screening for diabetic retinopathy. This community-based screening program used non-mydriatic retinal photography and was initiated in four areas of Victoria, Australia from 1996-1998. Recruitment strategies included targeted mail-outs, provision of the program brochure in English and the main languages spoken in the areas and media promotion in ethnic newspapers and on ethnic radio stations. In Victoria, only 55% of the population with diabetes currently access eye care services at the recommended intervals. This program was able to increase compliance with guidelines to 70% among people with diabetes that had not had a recent eye examination. A total of 1,197 people with diabetes were screened for diabetic retinopathy. Of the 1,197 people who were screened, 620 (15% of the estimated number of people with diabetes) had not had their eyes examined in the past two years. This pilot study identified strategies to encourage people with diabetes to have their eyes examined at the recommended intervals.

Age Distribution↗
PubMed2002

The progression of refractive error in school-age children: Shunyi district, China.

PURPOSE: To assess the progression of refractive error and the incidence of myopia in school-age children in the Shunyi District of Beijing, China. DESIGN: A longitudinal cohort study. METHODS: A population-based sample of 4,662 children initially examined in 1998 at ages 5 to 13 years was reexamined between September and November, 2000. Refractive error was measured under cycloplegia with autorefraction. Age, sex, and baseline refractive error were evaluated as risk factors for progression. RESULTS: In 28.5 months, the average change in refractive error was -0.42 diopters (standard deviation, 0.68) in right eyes. Myopic shift of refractive error was associated with female sex, older age, and higher myopic or hyperopic refractive error at baseline. The average change in astigmatic error was essentially zero, with significant change in both directions more likely among those with higher baseline astigmatism. Findings were similar for left eyes. The cumulative incidence of myopia, defined as a spherical equivalent refractive error of -0.50 diopters or more in either eye, among initial emmetropes and hyperopes was 14.1% (95% confidence interval [CI], 11.8%-16.5%) for male and 23.5% (95% CI, 20.8%-26.1%) for female subjects. Myopia incidence increased sixfold to sevenfold between baseline age 5 and 12, before decreasing at age 13, for both male and female subjects. CONCLUSIONS: In the design of cost-effective programs for the periodic screening and treatment of uncorrected refractive error, children initially found to require refractive correction should be targeted for relatively frequent rescreening, as should girls and older children. Further study is required to better understand environmental and genetic risk factors for myopia development and progression.

Adolescent↗
PubMed1991

The cost effectiveness of strategies to reduce barriers to cataract surgery. The Operations Research Group.

The cost and effectiveness of eight approaches to reducing barriers to cataract surgery were evaluated in a rural area of South India during 1987-1989. The approaches were based on four intervention alternatives--aphakic motivator (AM), basic eye health worker (BW), screening van (SV), and mass media (MM). Each intervention was offered at two levels of economic incentive: partial, which provides free surgery and hospital stay, and full, which also provides transport from the recipient's village to the hospital and free food during the hospital stay. Evaluations took place in a probability selection of 90 villages, including ten control villages not subjected to either of the interventions. Only costs unique to patients from the intervention villages were considered: Health education and screening costs were included, surgery costs were not. Percentage reductions in the cataract blind backlog and increases in surgical coverage were used as effectiveness measures. Analyses suggest that the SV and AM interventions, both with full economic incentive, offer the greatest advantage. The AM intervention is the more effective of the two, but also the more costly.

Adult↗
PubMedDate not supplied

Retinopathy of prematurity in Denmark. Epidemiological considerations and screening limits.

The epidemiology of retinopathy of prematurity (ROP) in Denmark is analysed based on two sources. Regional experience is presented from 12 years' prospective ophthalmic control of infants at risk, in a Danish county with population 342,000 and 44,805 liveborns over the period 1982-93. Out of 127 subjects with ROP 101 reached stage 1 or 2 only; 26 progressed to at least stage 3. Seven with blindness due to ROP amounted to 15.6/100,000 liveborns, a high frequency. The trend over the twelve years was towards less serious sequelae. Currently, the national screening limits for ROP have been adjusted under guidance from the compulsory registration of childhood visual impairment; with birth years 1974-94 there were 157 ROP-children in the register. Blindness due to ROP is now seen only in the very immature. It is suggested that gestational age 30 weeks will soon replace the present limits of less than 32 weeks/1750 g.

Adolescent↗
PubMed2004

[Ocular changes in Down syndrome].

BACKGROUND, MATERIAL AND METHODS: Down's syndrome is the most common cause of mental retardation with an incidence of about 1.5/1000 live births. Life expectancy and quality of life have improved substantially for this group over the last decades. The aim of this paper is to give an updated short survey of ocular changes present in Down's syndrome based on current international literature and the clinical experience of the authors. RESULTS AND INTERPRETATION: Ocular problems are common, mostly refractive errors, poor accommodation, strabismus, cataract, and keratoconus. Accommodation deficit is present in a majority of individuals with Down's syndrome, also in children and young people. Bifocal or progressive glasses should therefore be prescribed liberally. Because of the high frequency of ocular pathology, all individuals with Down's syndrome should be enrolled in a continuous visual screening programme from birth. We suggest the following screening guidelines: first examination at one month of age, then at one year of age, at 2-3 years of age, at 5-6 years of age (school start), and thereafter every five years. In case of positive findings (e.g. refractive errors, poor accommodation, strabismus) the frequency of examination should be increased and determined individually by the responsible ophthalmologist.

Accommodation, Ocular↗
PubMed1991

Eye care by primary care physicians. A survey of internists and family practitioners in the Sacramento, California, area.

To assess the status of eye care as provided by primary care physicians, 193 internists or family practitioners were asked to complete a survey that focused on screening methods and referral patterns. In screening adult patients for glaucoma, 14% of 74 respondents await visual complaints before evaluation and/or referral. Eighteen percent of respondents first refer type II diabetic patients only after personally noting typical funduscopic changes in the undilated fundus. Other ophthalmic care issues are addressed. Results of the survey suggest that greater effort in ophthalmic education of primary care physicians could result in improved ophthalmic care.

California↗
PubMed1998

The eye in von Hippel-Lindau disease. Long-term follow-up of screening and treatment: recommendations.

Von Hippel-Lindau disease (VHL) is an autosomal dominant tumour syndrome caused by germline mutations of the VHL tumour suppressor gene located on chromosome 3p25-26. In VHL tumours may occur in 14 different target organs, including the eye. Retinal angiomas are considered the first manifestation of VHL disease in 43% of cases, and the cumulative probability of developing a retinal angioma in one or both eyes rises during each decade of life, reaching 80% for patients over 80 years old. Since 1976 patients with VHL at the University Hospital of Utrecht and their at-risk relatives have been screened periodically by a multidisciplinary team. Long-term follow-up ophthalmological data were analysed with special attention to natural course and results of treatment. In addition, we looked for a genotype-phenotype correlation. Retinal angiomas were found in all families. In one large family with a missense mutation (V170D) of the VHL gene, in which the complete spectrum of visceral- and central nervous system (CNS) features of VHL is present, macular, parapapillary, optic disc and ora serrata angiomas were also found. In general, however, a clear-cut genotype-phenotype correlation could not be found. Only early detection and treatment of peripheral retinal angiomas can be expected to decrease the percentage of patients with decreased visual acuity. Therefore, early detection and treatment of these tumours is of paramount importance. Ophthalmological screening of patients and persons at risk should start as early as possible. In patients with apparently sporadic retinal angiomas it is advisable to perform germline DNA analysis, since the risk of developing VHL is high, especially if the angiomas are bilateral, or unilateral and multifocal, if the patient is young, or if there is a family history suggestive of VHL.

Adult↗
PubMed2001

Evaluating a visual field screening test for glaucoma: how the choice of the gold standard affects the validity of the test.

OBJECTIVE: To examine the effects of the gold standard on sensitivity, specificity, and area under the ROC curve when determining the validity of a screening test. METHODS: Fifty-eight people were recruited from a Veterans' Administration eye clinic. Screening included testing with the 26-point oculokinetic perimeter (OKP). We used different gold standards to categorize patients as positive or negative for glaucoma. The glaucoma hemifield test (GHT) and corrected pattern standard deviation (CPSD) from the Humphrey visual field analyzer (HVF) were used as objective gold standards. Ophthalmologist review of the HVF, using two different methods for classifying visual field defects, was also used as a gold standard. RESULTS: Using the review of the HVF that included mild, moderate, or severe defects, the area under the ROC curve was not significantly different from 50%. However, for all the other gold standards, the area under the ROC curve was significantly different from 50%. CONCLUSIONS: In determining the ability of the OKP to differentiate between glaucoma and normal subjects, the choice of a gold standard led to different conclusions about its usefulness as a screening test for glaucoma. Furthermore, sensitivity and specificity varied widely depending on which gold standard was used, and what cutoff point was used for the OKP. Although clinician review of the HVF may be used when specific criteria are given to define visual field defects, using objective measures from the HVF is easier and will allow for better comparisons between studies.

Aged↗
PubMed2003

[Prevalence of diabetic retinopathy in insulin-dependent diabetes mellitus, in the Dolj district].

260 patients with type I diabetes treated in Diabetes and Nutrition Diseases Clinic of Emergency District Hospital Dolj, were included in the selective screening program, for evaluation the incidence of diabetic retinopathy. The results of this screening were determine both including all new cases and reevaluating all the old cases, because the progression of ocular lesions under treatment. The retrospective study of 156 patients revealed the incidence of diabetic retinopathy in 35.2% at the time of implementation of the screening program, being 50.2% after 5 years of continuous surveillance. From 10,000 followed-up patients, the type I of insulin-dependent diabetes represents 13.3%. The incidence of new cases is minimal in the age group 0-10 years (1.9%) and the retinopathy was absent. The maximal prevalence was after 25 years old, being present in 69 cases from 164.

Adolescent↗
PubMed2002

Diabetic retinopathyA clinical update.

Easy observation of the fundus oculi makes retinopathy the most frequently reported chronic complication of diabetes and, consequently, the one we know best in terms of epidemiology and natural history. Achieving near-normal levels of blood glucose and blood pressure provides empirical though powerful tools for clinicians to delay the onset and progression of diabetic retinopathy. Even when these measures have failed and retinopathy becomes sight-threatening, laser photocoagulation has proven remarkably effective. Nonetheless, retinopathy remains a leading cause of blindness and there is little evidence that diabetes-related visual loss is decreasing in industrialized countries. This may result from the mixed blessing of prolonged survival of patients who had become diabetic when metabolic control was pursued less fastidiously than today. Screening for sight-threatening retinopathy is the most cost-effective medical procedure known and should help optimise the use of diagnostic and therapeutic resources, but its widest deployment still meets with inertia and lack of interest within most health care systems. Improving clinical skills and technology, however, allow us to take a more optimistic look at the future, as pathogenesis-targeted forms of treatment are being developed and tested through appropriately powered clinical trials.

Animals↗
PubMedDate not supplied

Diabetic retinopathy screening: a clinical quality improvement project.

BlueCross BlueShield on the Rochester Area (BCBSRA) initiated a clinical quality improvement project that increased its diabetic retinopathy screening rate from 42.8% in 1995 to 58.1% in 1997. A multidisciplinary team examined the processes and discovered both member (patient) and provider (physician) barriers to annual screening. Members did not understand the clinical importance and were uncertain as to how frequently diabetic eye examinations were covered by insurance. Providers identified a role for BCBSRA to reinforce patient education on eye examinations and to assist with tracking of services. Involvement of these key stakeholders was critical to understanding and overcoming barriers.

Blue Cross Blue Shield Insurance Plans↗
PubMed2000

Ophthalmological findings in children with congenital toxoplasmosis. Report from a Swedish prospective screening study of congenital toxoplasmosis with two years of follow-up.

UNLABELLED: Congenital toxoplasmosis may lead to severe visual impairment or neurological sequelae in the child. PURPOSE: To study the severity of the primary and late ophthalmological dysfunction during a prospective incidence study of congenital toxoplasmosis in the Stockholm and Skåne counties. METHODS: Blood collected on phenylketonuria (PKU) cards from 40,978 consecutively born children were investigated for antitoxoplasma antibodies. Children with verified congenital toxoplasmosis were treated for 12 months with antiparasitic therapy and followed ophthalmologically, neurologically and serologically every third month. RESULTS: Three children had congenital toxoplasmosis. Two of these were asymptomatic at birth and would have escaped early detection without screening. One child had unilateral severe visual impairment and CNS involvement. The incidence of congenital toxoplasmosis was less than 1:10,000. CONCLUSION: Neonatal screening is of importance to diagnose asymptomatic infected children with congenital toxoplasmosis as treatment has been shown to reduce long-term sequelae. Ophthalmological investigations should start early and continue in co-operation with paediatricians.

Adult↗
PubMed1996

Mobile retinal photography. A means of screening for diabetic retinopathy in aboriginal communities.

BACKGROUND: Mobile fundus photography undertaken by Aboriginal health workers has been suggested as a practical and effective method of screening for diabetic retinopathy among Aboriginal and Torres Strait Islander communities. METHODS: A pilot study was undertaken to demonstrate that interpretable colour slides of the retina could be produced by Aboriginal health workers trained over a two-week period. RESULTS: Of 47 subjects, 36 (76.6%) had interpretable retinal photographs. CONCLUSIONS: These findings warrant further evaluation as to the benefits and cost effectiveness of mobile retinal photography.

Australia↗
PubMed1993

The binocular videorefractoscope for visual screening in infancy.

Photorefraction is a promising technique for screening infants for amblyopiogenic defects, but currently used instruments often produce images that are difficult to interpret due to inaccurate control of the subject's fixation, to the narrow range (+/- 4 D) of the measurable error, to ill-defined crescent borders, and to chromatic aberration. A charge-coupled device (CCD) camera with near-infrared sensitivity connected to a computer with an image grabber for real-time equalization was devised to overcome the aforementioned problems. This binocular videorefractoscope (VRB) enables a dynamic and nondissociating refractive status and an ocular motility testing. Fixation and accommodative response are observed on-line and the strabismic angle is measured off-line. Arrays of infrared-emitting diodes with a variable eccentricity and position reveal sphere and/or cylinder errors (+/- 10 D; null interval, +0.00 to -2 in an 8-mm pupil diameter) as well as squint (> 5 prism diopters) and dioptric media opacities. The VRB was tested during noncycloplegic screening for amblyopiogenic defects in 212 3-year-old children. The findings were compared with the results of manifest and cycloplegic autorefractometry in a blind study. The VRB revealed a sensitivity of 81% and a specificity of 97%. In conclusion, the VRB can give a fast, noninvasive, and reliable evaluation of amblyopiogenic factors in infants.

Accommodation, Ocular↗
PubMed1990

Prevalence of anisometropia in volunteer laboratory and school screening populations.

For 10 years our laboratory has conducted, a longitudinal study of focusing and motor behavior of a volunteer population of 686 subjects aged 3 months to 9 years. Its purpose is to characterize normal refractive development in infants and children and to relate refractive anomalies to subsequent visual problems. Using age-related criteria for anisometropia adjusted to detect the most unusual 5% of the refractions on a test battery, we have found 19 nonstrabismic, anisometropic subjects (2.8% of total subject population). Of these, eight were either seen once or their anisometropia appeared at their last visit. Of the remaining 11 subjects, all had a reduction of their anisometropia to within normal limits on subsequent visits. Thus our current best estimate of persistent infant anisometropia is 0%, a startling result. By comparison, we found ten strabismic subjects (1.46%), two of whom had persistent anisometropia. Although we did not believe that anisometropic subjects could self-select and not participate in the study, it was possible that the volunteer laboratory population had characteristics atypical of the county at large. Thus we conducted a screening of 374 Head Start and first-grade pupils throughout the county, using the same methods. We found virtually no difference in the average refractive conditions between the laboratory and school populations and no significant difference in the prevalence of visual disorders. The very low prevalence of anisometropia in infants and young children in both populations has important implications for the etiology of anisometropic amblyopia.

Anisometropia↗
PubMed1992

Screening for pediatric eye disease.

The majority of preschool children in the United States are not screened for visual problems. To avoid permanent visual loss, standardized screening should be incorporated into well-child examinations so that treatment can be initiated promptly. Newborns should be checked for the red reflex, pupillary responses and any constant eye deviation. Infants six months old should be checked for these responses and for "fixation and following" and ocular alignment. Visual acuity should be tested in three- to four-year-old children using the "tumbling E" test, Allen pictures or the HOTV chart.

Blinking↗
PubMed1988

Evaluation of adaptive spatial enhancement in suprathreshold visual field screening.

Sixty-three normal subjects and 94 abnormal patients, most of whom had glaucoma, were tested in the central visual field using a threshold-related, eccentricity-compensated, spatially adaptive suprathreshold screening program and a full-threshold program on the Humphrey field analyzer. The initial stimulus locations on the screening test were identical to those of the threshold test; additional screening stimuli were presented surrounding each missed initial stimulus. Surprisingly, this spatial enhancement strategy did not improve sensitivity or specificity rates of the screening beyond that achieved by considering the initial stimulus locations alone. Points missed during screening often showed a depressed sensitivity rate (measured threshold greater than 6 dB below the age-corrected normal reference value) in the same area of the threshold field. This was true in fields from abnormal and normal subjects. This finding of persistent shallow defects in the same test session among otherwise normal persons has disturbing implications for the importance of "confirmed" defects in the diagnosis of disease.

Adolescent↗