The puzzling success of allograft tympanoplasty. Possible immunological explanations.
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The reduction of capillary hemorrhage obtained with ketamine induced us to use this agent in anaesthesia for eardrum plastic surgery. During a period of 8 years 278 operations of this type were performed with this method. Its results were very satisfactory especially with regard to postoperative analgesia. No increase of capillary bleeding was observed after a temporary rise of arterial pressure following induction. Premedication consisted of atropine 0.5 mg intravenous and diazepam (later substituted by midazolam) according to age and weight. Induction was realized with fentanyl 0.1 mg intravenously followed by ketamine 3 mg.kg-1 intravenously. Anaesthesia was maintained by infusion of ketamine (500 mg in 500 ml of saline solution), nitrous oxide-oxygen (50% each) inhalation and pancuronium or vecuronium. Ketamine infusion was stopped approximately 45 min before operation was completed. Most patients regained consciousness in about 15 to 30 min after nitrous oxide was discontinued. Side effects such as bad dreams were noticed only in 29 patients (10.43%). Perturbed recovery from ketamine anaesthesia might be largely prevented by psychological preoperative preparation and adequate dosage of the benzodiazepine used for premedication.
This study presents the use of human type IV collagen film in myringoplasty in dogs. Evaluation criteria were clinical (repeated otoscopies) and histological (histological analysis of cicatrised membranes). This new biomaterial should seem to be a technological advance on temporal bone aponevrosis or perichondria auto-grafts. This study constitutes the necessary preliminary research to any application in man.
In a topographic investigation the authors assessed on 20 cadaverous temporal bones the relationship between the size of the enlarged recessus facialis and the dimensions of the mastoid process as well as topographic possibilities of a lower medial communication between the trepanation cavity and sinus tympani. Only in two instances the maximal and minimal dimensions of the recessus facialis corresponded to the maximal and minimal dimensions of the mastoid process resp. The possibility to establish a lower medial communication between the trepanation and tympanal cavity depended on the size of the tip of the mastoid process and on the position of the sigmoid sinus and bulbus jugularis resp. in relation to the facial nerve.
The history of implants in otology is reviewed. Currently available biocompatible ossicular implants are described, and a survey of their use by members of the American Otological Society and the American Neurotology Society is reported.
The choice of surgical techniques has gone through a great evolution during the last few years in our service. Closed techniques were formally used in 80 per 100 of our operations (1974-1979) and now this has dropped to 12.5 per 100 (1979-1983) motivated by the failures we obtained with the closed techniques. This is similar to the observations of other services. We have determined the causes of failure to be related to: difficulties in dominating the surgical field, treatment of the cavity, or reconstruction of the walls. We present the antro-exclusion attic elimination on demand (A.A.D) technique which is designed to resolve not only the elimination of the lesion, but also the cavity problem. We have also evaluated the possibility of reconstructing the mastoid and pneumatic cavities connected to the tympanic case.
Ninety-nine ears of otitis media with cholesteatoma were operated from October 1982. The indications for different techniques and staging principles were discussed in detail. One to four years' postoperative observation in 72 ears proved that residual cholesteatoma could be controlled to 1.4%. Patients undergone intact wall technique had maintained almost normal ear structure. With the open cavity technique, a large external auditory meatus was created with perfectly healed drum. Auditory results indicated that 66.5% of patients had hearing gain greater than or equal to 10 dB with 41.7% air-bone gap less than or equal to 20 dB.
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Gelatine sponge packs (Marbagelan) saturated in rolitetracycline (Reverin) were evaluated. The antimicrobiotic efficacy of the substance was determined in 26 packs before insertion and in 20 packs removed from the external ear meatus after varying periods. High concentrations of rolitetracycline were found independent of saturation grade in the packs before insertion. In the packs removed from the external meatus acceptable antimicrobial activity was found independent of the time the packs remained in the ear. An efficient prophylaxis against infection in ear surgery is guaranteed.
The effectiveness of different surgical procedures to eradicate cholesteatoma in the middle ear was studied. The author reviewed 1405 cases conducted during 10 years (1974 to 1984) and found that the most important causes of failure are pocket cholesteatoma and residual cholesteatoma. With the goal of diminishing these factors, a la demanda (AAD) technique has been used for the past 5 years, with optimistic results--only 2.4% failures during this period. Other causes of failures have also been studied. The evolution of the surgical technique has had two orientations: to improve the results and to eliminate the failures. In the author's clinic there has been a percentage of failures, which has motivated an orientation toward more resolutive and destructive instead of conservative, techniques.
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We report on a 5-year experience with 44 patients (1980-1985) with incus interposition using a modelled or sculptured incus, either autograft or homograft, to correct ossicular discontinuity when a functional malleus and stapes are present. After a period of 21 months, 75% of our patients achieved an air-bone gap closure between 1 and 10 dB. The postoperative hearing results of patients with trauma and middle ear atelectases were better than the hearing results of patients with cholesteatomas. These long-term results are dependent upon intact malleus attic ligaments and an intact tensor tympani tendon. It is very important that the modelled incus is repositioned under the malleus handle neck.