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[Prevention of recurrent nerve paresis and parathyroid lesions in thyroidectomy].

At present the risk of a post-operative nerve lesion or of hypothyroidism occurring after surgery of the thyroid still exists. Those surgeons who expose the entire length of the nerve are few but they obtain the lowest rate of post-operative vocal cord palsy. In a series of a 100 patients undergoing thyroid surgery, the nerves were visually exposed along their entire length. A nerve stimulator was used to facilitate recognition and identification. During electrical stimulation, spasmodic contractions of the larynx could be observed behind the crico-thyroid muscle, close to the ligatures of the superior thyroid vessels. The lobe was freed as for a total lobectomy. During this procedure, due to their anatomical relations, the parathyroid glands are unendangered as only the vessels which reach the thyroid itself are ligated. The safety of this operative technique was demonstrated by the absence of either nerve lesions or hypoparathyroidism in this series of 100 patients. The ensuing security allows modification of the surgical technique or procedure according to the situation. For all solid cold nodules total lobectomy is unequivocably indicated. In Graves' disease and endemic goitre the classical subtotal thyroidectomy is replaced by total lobectomy on one side and subtotal lobectomy on the other.

Humans↗

[Advantages of systematic recurrent laryngeal nerve resection during thyroid surgery. Results of 422 thyroidectomies employing this procedure (author's transl)].

Thyroidectomy for different thyroid disorders was conducted in 422 patients during 1978, after normal pre-operative laryngoscopy findings. Dissection of the recurrent laryngeal nerve was employed systematically in all patients except those having isthmectomy or enucleation operations, with a total number of 556 nerves dissected. Pre-and post-operative laryngoscopic examinations in the alert patient was conducted in all cases. After one year, 8% of the patients with abnormal post-operative laryngoscopic findings had not returned for follow-up. The known rate of recurrent nerve paralysis after one year was 0.7% of the nerves exposed, the maximum rate being 2% if patients not followed-up are included. These results confirm the value of systematic recurrent nerve dissection during thyroid surgery.

Humans↗

Effect of ovariectomy, thyroidectomy and of thyroxine treatment on the plasma level of corticosterone of the female Japanese quail.

Corticosterone was determined by means of competitive protein binding in the plasma of ovariectomized, thyroidectomized, ovariectomized and thyroidectomized, thyroxin-treated, corticosterone-treated and control Japanese quails, exposed to short or long photoperiod. Female birds exposed to short photoperiod possessed a slightly (not significantly) higher plasma corticosterone level than male ones. In photostimulated animals, however, the plasma corticosterone level showed no sex difference. Unlike in male quails, photostimulation did not enhance corticosteronaemia in the female ones. Corticosterone level was decreased by ovariectomy in both short-day and long-day birds. It was decreased by thyroidectomy and increased by thyroxine treatment in short-day birds, while the same interventions were ineffective in photostimulated ones. The data obtained point to that thyroxine treatment enhances, while the lack of ovarian sexual steroids decreases the plasma corticosterone level of female Japanese quails. Comparison of data obtained from ovariectomized + thyroidectomized birds shows that light may be responsible for elevated corticosteronaemia per se.

Animals↗

[Subtotal thyroidectomy in the treatment of hyperthyroidism].

201 cases of hyperthyrotoxic goitre underwent surgery in the period from 1970 to 1977. The importance of team work is emphasized to make reliable decisions concerning indications for surgical or non-surgical treatment. It is stated, that still a considerable controversy remains between Old and New World, concerning both indications for surgical treatment, and extent of surgery in thyreotoxicoses of the G.-B.-typ. The subtotal thyroidectomy represents e reliable method with rapid onset of euthyroidism, advisable in cases in which non-surgical treatment is, from the endocrinological point of view, not recommended, or considered as hazardous.

Adult↗

[A case of successful neurolysis of both recurrent laryngeal nerves following thyroidectomy (author's transl)].

A case of successful bilateral decompression of both recurrent laryngeal nerves two days following thyroidectomy (with injury to the nerves) is reported. The ideal time for surgical intervention in such cases is discussed. Electrodiagnostic tests for objective documentation of nerve injury are mentioned. The authors believe that the recurrent laryngeal nerves should be explored in comparable patients when tracheostomy is indicated for protection of the airway.

Adult↗

[Value of high dosage propranolol and per-operative hypothermia in thyroidectomy when conventional preparatory treatment is unsuitable (author's transl)].

Five hyperthyroid patients could be prepared for surgery wit propranolol alone in daily doses of 240 to 400 mg. The drug administered for 3 to 5 days before, and 5 to 15 days after the operation. Following premedication with levopromazine, almost total thyroidectomy was performed under neuroleptanalgesia and moderate hypothermia. The immediate results were satisfactory and free from acute thyrotoxic crisis. On follow-up, 2 to 18 months after surgery 4 patients had clinically and biologically normal thyroid function, and one patient showed evidence of hypothyroidism. For the common forms of the disease the authors use the conventional preparatory treatment. However, they favour a short course of propranolol in high doses either when non-thyroid emergency operations require preliminary treatment of the patient's hyperthyroidism, or when the conventional treatment is ineffective or contra-indicated on account of haematological complications.

Adult↗

[A case of respiratory distress after bilateral subtotal thyroidectomy].

A case of bilateral subtotal thyroidectomy with acute respiratory distress is presented. The multiple etiological factors involved in causing this life-threatening emergency are discussed. Bilateral recurrent laryngeal nerve palsy was successfully treated conservatively by nasotracheal intubation. Tracheostomy was not necessary.

Adult↗

Factors affecting thyroid function after thyroidectomy for Graves' disease.

A series of 108 patients with surgically treated Graves' disease were analyzed retrospectively in an attempt to determine factors that could affect postoperative thyroid function. Univariate analysis showed that remnant size, resected thyroid weight, antithyroid microsomal antibody and antithyroglobulin antibody titers were all significantly related to the postoperative outcome. Remnant size outweighed the other factors in prediction of thyroid status following subtotal thyroidectomy. When all the potential prognostic factors were individually adjusted by remnant size, only the degree of lymphocytic infiltration and antithyroid microsomal antibody titer were significantly associated with the postoperative outcome. Within the range of optimal remnant size, the higher the antithyroid microsomal antibody titer and the degree of lymphocytic infiltration, the greater the likelihood of postoperative hypothyroidism and the lower the chance of recurrence. Further stepwise discriminant analysis revealed that remnant size can be planned according to the known preoperative antithyroid microsomal antibody titer to achieve the greatest likelihood of a postoperative euthyroid state. The model suggested that when the antibody titer is < or = 640, the remnant size should be 3 to 5 cm3; if the antibody titer is 1,280 to 2,560, then the remnant size should be 4 to 5 cm3; and if the antibody titer is > or = 5,120, then the remnant size should be around 5 cm3.

Autoantibodies↗

The role of total thyroidectomy in the management of differentiated thyroid cancer.

The extent of surgical resection required in the optimal management of differentiated (papillary and follicular) thyroid carcinoma remains controversial. Arguments in favor of total thyroidectomy include the adequate treatment of tumor multifocality, reduction in local recurrence rates and anaplastic transformation, and creating a suitable environment for radioactive iodine scanning and treatment of metastases. The benefits of this procedure have to be weighed against the potential but minimal morbidity.

Adenocarcinoma, Follicular↗

Tracheal collapse after thyroidectomy: case report.

One case of tracheal collapse in a series of 116 thyroidectomy is reported. The patient presented with multinodular goiter. The tracheal collapse developed after removal of the endotracheal tube. A tracheostomy was performed and retained for 16 days. Follow-up at 1, 3 and 6 months revealed a satisfactory outcome.

Female↗

[Post-thyroidectomy hypocalcemia and ligation of the inferior thyroid artery trunk].

The effect of bilateral truncal ligation of the inferior thyroid artery on parathyroid function is prospectively analyzed in two homogeneous groups of 10 patients treated by total thyroidectomy, with (G1) and without (G2) truncal ligation, comparing immediately postoperative and late serum calcium levels. A significant decrease in mean calcemic levels (minimal ones 2.1, with n.v. 2.1-2.6 mmol/l) was observed in both groups no longer than in the first postoperative days. There was no significant difference in global (clinical + laboratory) hypocalcemia rate (G1 = 0-30% vs G2 = 10-40% respectively); nevertheless hypocalcemia was noted paradoxically to occur more frequently in G-2 patients, out of which one developed a permanent hypoparathyroidism.

Adult↗

[What does the radicality of thyroidectomy depend on?].

Reflections on the radicality of thyroidectomy are based on the persisting lack of uniformity as regards terminology, indications and techniques of thyroid surgery. The authors emphasize four basic factors involved in the solution of thyroid diseases: A. respecting the preoperative examination and recommendations of the endocrinologist, B. philosophy of the surgeon and his workplace, C. experience and skill of the surgeon, D. postoperative follow-up and treatment of patients. The necessity of multidisciplinary collaboration emphasized under A is followed under B by a detailed analysis of principles of the workplace as regards indications and technical and tactical aspects. In part C necessary theoretical and personal problems of the thyroid surgeon are summarized. Without careful postoperative check-up examinations and evaluation of the results of operations mentioned under D we cannot speak of radicality of thyroid surgery.

Humans↗

[Total thyroidectomy in a young girl presenting C cell hyperplasia at the time of a family screening for medullary carcinoma of the thyroid gland].

The authors report on the case of a 5,8 year-old girl whose father died of medullary thyroid carcinoma. When she was 4,5 year-old, her physical examination was normal but plasma calcitonin and katacalcin (PDN-21) levels were abnormally high in response to pentagastrin infusion. Total thyroidectomy was performed and immunohistochemical staining showed confluent C-cell hyperplasia. No recurrence occurred in this patient over four years on follow-up.

Carcinoma, Medullary↗

[Preventive total thyroidectomy in children with MEN IIa syndrome].

Three children of MEN IIa-families underwent a prophylactic total thyroidectomy (at the age of 4, 7 and 8 years). Pathologic examination showed a bilateral C-cell-hyperplasia in each case. The annual follow-up of the physically and mentally well-developing children so far showed normal calcitonin provocative testing. Members of risk families should undergo a screening program as early as possible.

Carcinoma, Medullary↗

Significance of values of thyrotropin binding inhibitor immunoglobulins and appearance of intrathyroidal lymphocytes at subtotal thyroidectomy for Graves' disease.

This study was undertaken to investigate whether thyrotropin binding inhibitor immunoglobulins (TBII) values at and after subtotal thyroidectomy correlated with the outcome or the histologic grade applied to the appearance of intrathyroidal lymphocytes at the time of surgical treatment. In addition, the main reason for the study was to determine whether or not it was possible to predict the outcome after the operation by the data obtained. There was no relation between the TBII results and the grade of the appearance of intrathyroidal lymphocytes at the time of operation or the TBII postoperative results (whether positive or negative) and the final outcome. However, it was of interest that patients with a recurrence of hyperthyroidism had the TBII values of more than 50 percent at the time of surgical treatment, and also manifested continuously positive TBII values after the operation. They also had moderate grades of lymphocytic infiltration and lymph follicle formation in the surgical specimen. It seemed impossible to predict the outcome of each instance in accordance with TBII values and the grade of the appearance of intrathyroidal lymphocytes at the time of the operation. However, it might be possible to predict at least the recurrence of hyperthyroidism by the consideration of changes of TBII values postoperatively.

Adolescent↗

The use of a small feeding tube for suction drainage after thyroidectomy.

The placement of a drain after thyroidectomy is sometimes necessary. A large-sized drain tube is more effective, but often creates a larger scar. We have used a small feeding tube connected to a vacuum ball in 110 cases from July 1991 to December 1991. The function of this drainage system is good with the average amount of 58 ml during the retained period. There is no patient developed any wound complication such as hematoma, hemorrhage or wound infection. This method is proved to be both effective and cosmetic. Whenever necessary, we suggest to use this drain system.

Adult↗