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PubMed1989

Effects of preschool environments on nonverbal social behavior: toddlers' interpersonal distances to teachers and classmates change with environmental density, classroom design, and parent-child interactions.

Toddlers' interpersonal spacing patterns were studied in environments of different density and design. Results showed that an apparently spacious (74 m2) classroom may produce behavioral changes reminiscent of crowding in young children. When more space (864 m2) was available: (1) children increased interpersonal distances overall; (2) children aggregated more with classmates and teachers, fragmenting into subgroups which were separated from the class overall. With visual dividers added to the classroom to facilitate subgrouping, toddlers formed larger subgroups with teachers. Parent/child behavior during separation also affected distances: longer hand-holding and verbalization were found in children who stayed further from others.

Child, Preschool↗
PubMed2002

Single molecular detection of a perylene dye dispersed in a Langmuir-Blodgett fatty acid monolayer using surface-enhanced resonance Raman scattering.

The Langmuir-Blodgett (LB) monolayer technique was used to fabricate single molecule LB monolayer containing bis(phenethylimido)perylene (PhPTCD), a red dye dispersed in arachidic acid (AA) with an average doping of 1 molecule per microm2. The monolayer was transferred onto Ag island films to obtain spatially resolved surface-enhanced resonance Raman scattering (SERRS) spectra. The mixed LB monolayers were fabricated with a concentration, on average, of 1, 6, 19 and 118 PhPTCD molecules per microm2 in AA. The AA provides a two-dimensional host matrix whose background signal does not interfere with the detection of the probe molecule's SERRS signal. The properties of the single molecule detection were investigated using micro-Raman with a 514.5-nm laser line. The Ag island surfaces coated with the LB monolayer were mapped with spatial steps of 3 microm and global chemical imaging of the most intense SERRS band in the spectrum was also recorded. The SERRS and surface-enhanced fluorescence (SEF) of the neat and single molecule LB monolayer were recorded in a temperature range from liquid nitrogen to + 200 degrees C. Neat PhPTCD LB monolayer spectra served as reference for the identification of characteristic signatures of the single molecule behavior. The spatial resolution of Raman-microscopy experiments, the multiplicative effect of resonance Raman and SERRS, and the high sensitivity of the new dispersive Raman instruments, allow SERRS to be part of the family of single molecular spectroscopies.

Fatty Acids↗
PubMed2004

Cannabinoid agonist-induced sensitisation to morphine place preference in mice.

The influence of the endocannabinoid system on the sensitisation to the rewarding effects of morphine in the place conditioning paradigm was evaluated. In mice pretreated with morphine this drug induces place preference with lower doses. Pretreatment with non-rewarding doses of the cannabinoid agonist WIN 55,212-2 (0.5 and 1 mg/kg) induces sensitisation to the rewarding effects of morphine. However, the pretreatment with the cannabinoid antagonist SR 144716A plus morphine or WIN 55,212-2 blocks it. Our results suggest the existence of cross-talk between cannabinoids and opiates on the sensitisation to morphine and the implication of the endocannabinoid system in the process of sensitisation to opiates.

Animals↗
PubMedDate not supplied

Parent-child participation in planning children's activities outside of school in European American and Latino families.

This longitudinal research used a sociocultural perspective to examine planning competence in the everyday experiences of European American and Latino children from 7 to 9 years of age. Data on children's participation in planning their activities outside of school, parental expectations about children's planning competence, and children's planning in the classroom were collected yearly from Grades 2 to 4 from 140 children and their mothers, and the children's teachers. Results indicate that decision-making practices and parental expectations change with development and vary by ethnicity. Decision making at home was related to children's classroom planning; however, the nature of these relations changed over middle childhood. Results are discussed in terms of cultural and parental contributions to the development of planning skills.

Child↗
PubMed2004

Attitude formation through exploration: valence asymmetries.

The formation of attitudes toward novel objects was examined as a function of exploratory behavior. An initial experiment, in which participants played a computer game that required them to learn which stimuli, when sampled, produced favorable or unfavorable outcomes, demonstrated learning, attitude formation, and generalization to novel objects. The findings also revealed 2 interesting valence asymmetries: a learning asymmetry involving better learning for negatively valenced than positively valenced objects and a generalization asymmetry involving stronger generalization as a function of negative than of positive attitudes. Findings from 4 experiments led to an explanation of the learning asymmetry in terms of information gain being contingent on approach behavior and related the generalization asymmetry to a negativity bias that weighs resemblance to a known negative more heavily than resemblance to a positive.

Adult↗
PubMed2004

cAMP response element-binding protein is required for stress but not cocaine-induced reinstatement.

Reinstatement of previously extinguished conditioned place preference (CPP) is precipitated by stress or drug exposure. Here, we show that acute exposure to forced swim stress (FS), in a context distinct from conditioning, induces reinstatement of cocaine CPP in wild-type mice. This behavior is accompanied by a pattern of phosphorylated cAMP response element-binding protein (pCREB) activation in discrete brain regions that is distinct from the pattern observed after cocaine-induced reinstatement. For example, previous cocaine conditioning increases pCREB levels in the amygdala, and acute exposure to FS, but not to cocaine, further augments these changes. In contrast, previous cocaine conditioning does not alter levels of pCREB in the nucleus accumbens, but acute exposure to FS increases pCREB levels in this region on reinstatement day. Furthermore, to determine whether these alterations of CREB are necessary in FS or cocaine-induced reinstatement, we examined the effect of these stimuli on reinstatement behavior in mice deficient in alpha and Delta isoforms of CREB. The CREB(alphaDelta) mutant mice show deficits in FS-induced reinstatement of conditioned place preference. In contrast, they show robust cocaine-induced reinstatement. This deficit in stress but not drug-induced reinstatement indicates a specific requirement for CREB in stress-induced behavioral responses to drugs of abuse.

Amygdala↗
PubMed1982

The development of proxemic spacing behavior: children's distances to surrounding playmates and adults change between 6 months and 5 years of age.

The patterns of distances maintained between 30 children and 15 adult caretakers were measured to determine developmental trends in children's patterns of interpersonal spacing toward adults and playmates. Children's positions during free play were photographed at 60-sec intervals and analyzed with a computer to determine the mean distances children maintained toward their 1st through 5th nearest adult caretakers and toward their 1st through 5th nearest playmates. Children's distances from adults increased with age, while distances from playmates and spatial variability decreased with age. Only infants (6-18 months) stayed significantly close to any of their adult caretakers; toddlers (19-27 months) and preschoolers (30-60 months) avoided proximity to their 3rd through 5th nearest adult caretakers more than could be expected by chance. All age groups significantly avoided proximity to their 4th and 5th nearest playmates; avoidance of playmates' space decreased with age.

Adult↗
PubMed2004

Rewarding effects elicited by cocaine microinjections into the ventral tegmental area of C57BL/6 mice: involvement of dopamine D1 and serotonin1B receptors.

RATIONALE: The role of ventral tegmental area (VTA) in mediating the rewarding effects of cocaine has not been extensively studied. OBJECTIVES: We used the intracranial self-administration (ICSA) procedure to assess the involvement of the VTA in the rewarding effects of cocaine, and the effect of dopamine (DA) D(1)- and serotonin (5-HT)(1B)-receptor antagonists on ICSA of cocaine. METHODS: Adult male C57BL/6 mice were stereotaxically implanted, unilaterally, with a guide cannula either 1.5 or 2.3 mm above the VTA. After 1 week, mice were trained to discriminate between the two arms of a Y-maze over seven daily sessions, one arm being reinforced by intracranial cocaine microinjections. Starting from session 8, the D(1) and 5-HT(1B)-receptor antagonists were injected IP pre-test each day over five consecutive sessions. RESULTS: Mice injected into the VTA rapidly exhibited a preference for the cocaine-reinforced arm, whatever the dose of cocaine available (30 pmol or 150 pmol per injection), reaching optimum ICSA performance within 5 days. In contrast, mice injected 0.8 mm above the VTA did not discriminate between the arms of the maze and performed at random, except for one subject. Once the ICSA response was acquired, systemic pre-injections of either the D(1) (SCH23390; 25 microg/kg IP) or 5-HT(1B) (GR127935; 0.5 mg/kg IP) antagonist disrupted this behavior. Replacement of each antagonist by vehicle led to the reinstatement of intra-VTA cocaine self-administration. CONCLUSIONS: The results of the present study suggest that VTA neurons play a critical role in mediating the rewarding effects of acute cocaine and that both D(1) and 5-HT(1B) receptors modulate these effects.

Analysis of Variance↗
PubMed2002

Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.

Repeated THC administration produces motivational and somatic adaptive changes leading to dependence in rodents. To investigate the molecular basis for cannabinoid dependence and its possible relationship with the endogenous opioid system, we explored delta9-tetrahydrocannabinol (THC) activity in mice lacking mu-, delta- or kappa-opioid receptor genes. Acute THC-induced hypothermia, antinociception, and hypolocomotion remained unaffected in these mice, whereas THC tolerance and withdrawal were minimally modified in mutant animals. In contrast, profound phenotypic changes are observed in several place conditioning protocols that reveal both THC rewarding and aversive properties. Absence of microreceptors abolishes THC place preference. Deletion of kappa receptors ablates THC place aversion and furthermore unmasks THC place preference. Thus, an opposing activity of mu- and kappa-opioid receptors in modulating reward pathways forms the basis for the dual euphoric-dysphoric activity of THC.

Analysis of Variance↗
PubMedDate not supplied

Bilateral otolith contribution to spatial coding in the vestibular system.

Recent work on the coding of spatial information in central otolith neurons has significantly advanced our knowledge of signal transformation from head-fixed otolith coordinates to space-centered coordinates during motion. In this review, emphasis is placed on the neural mechanisms by which signals generated at the bilateral labyrinths are recognized as gravity-dependent spatial information and in turn as substrate for otolithic reflexes. We first focus on the spatiotemporal neuronal response patterns (i.e. one- and two-dimensional neurons) to pure otolith stimulation, as assessed by single unit recording from the vestibular nucleus in labyrinth-intact animals. These spatiotemporal features are also analyzed in association with other electrophysiological properties to evaluate their role in the central construction of a spatial frame of reference in the otolith system. Data derived from animals with elimination of inputs from one labyrinth then provide evidence that during vestibular stimulation signals arising from a single utricle are operative at the level of both the ipsilateral and contralateral vestibular nuclei. Hemilabyrinthectomy also revealed neural asymmetries in spontaneous activity, response dynamics and spatial coding behavior between neuronal subpopulations on the two sides and as a result suggested a segregation of otolith signals reaching the ipsilateral and contralateral vestibular nuclei. Recent studies have confirmed and extended previous observations that the recovery of resting activity within the vestibular nuclear complex during vestibular compensation is related to changes in both intrinsic membrane properties and capacities to respond to extracellular factors. The bilateral imbalance provides the basis for deranged spatial coding and motor deficits accompanying hemilabyrinthectomy. Taken together, these experimental findings indicate that in the normal state converging inputs from bilateral vestibular labyrinths are essential to spatiotemporal signal transformation at the central otolith neurons during low-frequency head movements.

Animals↗
PubMed1999

The identification of coordination constraints across planes of motion.

Two dominant coordination constraints have been identified during isofrequency conditions in previous work: the egocentric constraint, i.e., simultaneous activation of homologous muscle groups, and the allocentric constraint, i.e., moving the segments in the same direction in extrinsic space. To verify their generalization, bimanual drawing movements were performed in different planes of motion (transverse, frontal, sagittal, frontal-transverse) according to the in-phase and anti-phase mode along the X- and Y-axes. Convergent findings were obtained across the transverse, frontal, and frontal-transverse planes. The in-phase mode along both axes was performed most accurately/consistently, whereas the anti-phase mode resulted in a deterioration of the coordination pattern and this effect was most pronounced when the latter mode was introduced with respect to both dimensions. For sagittal plane motions, the in-phase mode was again superior but the second most optimal configuration was the anti-phase mode along both axes. This finding was hypothesized to result from the familiarity with the pattern since it resembles cycling behavior. It illustrates how cognitive mapping is superimposed onto the dynamics of interlimb coordination. Overall, these results support the presence of both the egocentric and allocentric constraint during bimanual movement production.

Humans↗
PubMed1983

Multidimensional influences of cerebral asymmetries on visual half-field asymmetries and cognitive skills.

Evoked potentials to laterally presented stimuli were collected from left and right tempero-parietal sites during performance of two visual half-field tasks, lexical decision, and line orientation discrimination. Reaction time and accuracy data were simultaneously collected. The behavioral data indicated the development of a right field advantage for the lexical decision task as a function of practice. A principal components analysis revealed three independent evoked potential components which displayed task-dependent hemispheric asymmetries. Multiple regression analyses revealed that visual half-field asymmetries in response accuracy were closely related to hemispheric asymmetries on several independent evoked response components. Subject's scores on independent tests of verbal reasoning and spatial relations were also found to be closely related to hemispheric asymmetry on several independent evoked response components. These data support a multidimensional concept of cerebral specialization. They also suggest that visual field asymmetries reflect the confluence of several underlying processes which have independent lateralization distributions across the population. In general, the results underscore the need for further research on the nature of the relationship between cerebral and perceptual asymmetries.

Adolescent↗
PubMed2002

Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area.

The present study was designed to investigate the rewarding effect, G-protein activation and dopamine (DA) release following partial sciatic nerve ligation in the rat. Here we show for the first time that morphine failed to produce a place preference in rats with nerve injury. Various studies provide arguments to support that the mesolimbic dopaminergic system, which projects from the ventral tegmental area (VTA) to the nucleus accumbens (N.Acc), is critical of the motivational effects of opioids. In the present study, there were no significant differences between sham-operated and sciatic nerve-ligated rats in the increases in guanosine-5'-o-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding to membranes of the N.Acc stimulated by either DA, the D1 receptor agonist SKF81297, the D2 receptor agonist N-propylnoraporphine or the D3 receptor agonist 7-hydroxy-2-dipropylaminotetralin (7-OH DPAT). In contrast, the increases in [35S]GTPgammaS binding to membranes of the VTA induced by either morphine or a selective micro -opioid receptor agonist [d-Ala2, NMePhe4, Gly(ol)5]enkephalin were significantly attenuated in nerve-ligated rats as compared with sham- operated rats. Furthermore, the enhancement of DA release in the N.Acc stimulated by morphine was significantly suppressed by sciatic nerve ligation. These findings suggest that attenuation of the morphine-induced place preference under neuropathic pain may result from a decrease in the morphine-induced DA release in the N.Acc with reduction in the mu-opioid receptor-mediated G-protein activation in the VTA.

Animals↗
PubMed2001

Visuospatial stimulus-bound automatic writing behavior: a right hemispheric stroke syndrome.

Three cases of visuospatial stimulus-bound automatic writing behavior were identified among 80 patients (4%) with acute right cerebral hemispheric stroke. All cases had similar clinical characteristics and writing behavior, and visuospatial stimulus-bound automatic writing was related to visually perceived letters. This syndrome might be specific for right hemispheric stroke and might be included among other hypergraphic syndromes attributable to right hemispheric damage.

Aged↗
PubMed2006

The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology.

Disturbance to early brain development is implicated in several neuropsychiatric disorders including autism, schizophrenia, and mental retardation. Epidemiological studies have indicated that the risk of developing these disorders is enhanced by prenatal maternal infection, presumably as a result of neurodevelopmental defects triggered by cytokine-related inflammatory events. Here, we demonstrate that the effects of maternal immune challenge between middle and late gestation periods in mice are dissociable in terms of fetal brain cytokine responses to maternal inflammation and the pathological consequences in brain and behavior. Specifically, the relative expression of pro- and anti-inflammatory cytokines in the fetal brains in response to maternal immune challenge may be an important determinant among other developmental factors for the precise pathological profile emerging in later life. Thus, the middle and late gestation periods correspond to two windows with differing vulnerability to adult behavioral dysfunction, brain neuropathology in early adolescence, and of the acute cytokine responses in the fetal brain.

Analysis of Variance↗
PubMed2003

Decreased anxiety, altered place learning, and increased CA1 basal excitatory synaptic transmission in mice with conditional ablation of the neural cell adhesion molecule L1.

L1, a neural cell adhesion molecule of the immunoglobulin superfamily, is involved in neuronal migration and differentiation and axon outgrowth and guidance. Mutations in the human and mouse L1 gene result in similarly severe neurological abnormalities. To dissociate the functional roles of L1 in the adult brain from developmental abnormalities, we have generated a mutant in which the L1 gene is inactivated by cre-recombinase under the control of the calcium/calmodulin-dependent kinase II promoter. This mutant (L1fy+) did not show the overt morphological and behavioral abnormalities observed previously in constitutive L1-deficient (L1-/-) mice; however, there was an increase in basal excitatory synaptic transmission that was not apparent in L1-/- mice. Similar to L1-/- mice, no defects in short- and long-term potentiation in the CA1 region of the hippocampus were observed. Interestingly, L1fy+ mice showed decreased anxiety in the open field and elevated plus-maze, contrary to L1-/- mice, and altered place learning in the water maze, similar to L1-/- mice. Thus, mice conditionally deficient in L1 expression in the adult brain share some abnormalities, but also display different ones, as compared with L1-/- mice, highlighting the role of L1 in the regulation of synaptic transmission and behavior in adulthood.

Animals↗
PubMed1975

An experimental study of crowding: effects of room size, intrusion, and goal blocking on nonverbal behavior, self-disclosure, and self-reported stress.

This study hypothesized that stress in high room density, or crowding, depends on interpersonal disturbances such as intrusion and goal blocking. High room density was expected to intensify individual reactions to these disturbances. In a 2 X 2 X 2 design, groups of six male college students containing three subjects and three confederates were placed in a large or small room. Subjects and confederates interacted in pairs; confederates introduced intrusion by leaning forward, touching subjects, and attempting 80% eye contact as confederates talked. Goal blocking involved inattention and interruptions as subjects talked. Interactions were videotaped through two-way mirrors to record nonverbal behaviors associated with affiliation and stress. Subjects also completed self-report measures of stress and self-disclosure. Intrusion led to initial discomfort that decreased with time, and lower levels of facial regard. Goal blocking produced self-reported irritation that increased with time, and lower levels of facial regard, gesturing, and positive head nodding. Contrary to predictions, stress responses to intrusion and goal blocking were not intensified by high room density. Lower levels of affiliative behavior were viewed as coping responses to interpersonal disturbances--subjects apparently coped successfully with intrusion, but not with goal blocking. Results are interpreted in terms of a sequential, interpersonal model of crowding.

Adolescent↗
PubMed2003

A virtual environment for investigating schizophrenic patients' characteristics: assessment of cognitive and navigation ability.

Patients with schizophrenia have thinking disorders such as delusions or hallucinations because they have a deficit in the ability to systematize and integrate information. Therefore, they cannot integrate or systematize visual, auditory, and tactile stimuli. The multimodal integration model of the brain can provide a theoretical background from which one can approach multimodal stimulus integration. In this study, we suggest a virtual reality system for the multi-modal assessment of cognitive ability of schizophrenia patients. The virtual reality system can provide multimodal stimuli, such as visual and auditory stimuli, to the patient and can evaluate the patient's multimodal integration and working memory integration abilities by making the patient interpret and react to multimodal stimuli, which must be remembered for a given period of time. The clinical study showed that the virtual reality program developed is comparable to those of the Wisconsin Card Sorting Test (WCST) and the Standard Progressive Matrices (SPM), and it provides some information related to the schizophrenic patients' behavior in 3D virtual environment.

Adult↗