[HYPERPIGMENTATIONS OF THE CHLOASMA TYPE FOLLOWING TREATMENT WITH HYDANTOIN PREPARATIONS].
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Pigmented actinic keratosis and melanoma may exhibit overlapping clinical features, thus representing a diagnostic challenge for dermatologists. Although the differentiation between these two entities is traditionally done by histopathology, dermoscopy has been utilized as a useful additional aid for improving the clinical diagnostic accuracy of such pigmented skin lesions. We report the clinical and dermoscopic features of two pigmented actinic keratoses to discuss the difficulties in their preoperative differential diagnosis.
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Phenothiazines have been responsible for pigmentary changes in the skin (phototoxic reaction) and for pigment deposits in the cornea, lens and retina, which can result in blindness. Reversible agranulocytosis has also been reported with these agents. Psychotic exacerbation, including a form responsive to antiparkinsonian agents, may occur with high-potency antipsychotic drugs. Neuroleptic malignant syndrome, usually following high-dose therapy in young men, is a disorder of thermoregulatory mechanisms.
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We reported a case of photoleukomelanodermatitis (Kobori) type drug eruption due to afloqualone (Arofuto). The patient was given afloqualone and imipramine hydrochloride (Chrytemin) for cervical spondylosis from November of 1990. Edematous erythema with slight itching appeared on the sun-exposed areas in December of 1990. As drug eruption was suspected, drugs were ceased, and the cutaneous lesions almost disappeared but pigmentations and depigmentations developed in spots in sun-exposed areas in March of 1991. Photopatch and oral challenge tests were positive.
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