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At least 1,063 records · Page 59Linked to original sources
PubMed1999

Results of EUS in detecting perirectal lymph node metastases of rectal cancer: the pathologist makes the difference.

BACKGROUND: Accurate preoperative staging of primary rectal cancer is mandatory because the result may affect therapeutic decisions. Endoscopic ultrasonography (EUS) is considered the most accurate method for locoregional staging, but the issue of possible variations in the assessment of its accuracy related to technical aspects of pathologic staging has never been raised. The aim of this study was to assess EUS results as determined by two different methods of dissection of surgical specimens. METHODS: Among all cases with primary rectal cancer staged with EUS from April 1991 to April 1997, 131 patients underwent surgery without preoperative radiotherapy; EUS results for nodal staging were compared with those obtained by pathology. Resected specimens were examined using two different techniques (conventional vs. special dissection). RESULTS: There was a significant decrease in diagnostic accuracy of EUS according to pathologic technique. Overall accuracy, sensitivity, specificity, positive and negative predictive values for conventional versus special dissection were as follows: 74.6% vs. 43. 3% (p = 0.0001), 67.8% vs. 21.8% (p = 0.0002), 79.1% vs. 67.8% (p = 0.14), 67.8% vs. 43.7% ( p = 0.02), and 79.1% vs. 43.2% (p = 0.0003), respectively. EUS sensitivity according to size of metastatic lymph nodes was significantly lower for nodes smaller than 5 mm in diameter (p = 0.025) when special dissection was performed because of a larger number of lymph nodes harvested. CONCLUSIONS: Our findings raise concern about the results of EUS staging of lymph node metastases in rectal cancer. Further prospective studies on a node-by-node basis could clarify the real diagnostic yield of EUS.

Adenocarcinoma↗
PubMed1977

Falsely positive urinary cytology: pathologist's error or preclinical cancer?

The reluctance to accept urinary cytology as a diagnostic procedure in urologic cancer has been partially owing to a relatively high incidence of falsely positive results. The recent recognition of bladder cancer as a field change and the identification of urothelial dysplasia support the contention that these cytologic findings represent early neoplasia rather than laboratory errors. Of 64 patients with positive or suspicious urinary cytology short-term histologic confirmation could not be obtained in 10. Of these 10 patients review of the clinical and pathologic material was possible in 9 and significant urologic abnormalities were found in 7. Among patients with bladder cancer there were no falsely negative reports. Urinary cytology is a reliable procedure in the diagnosis of urologic malignancies. Unconfirmed positive results require careful examination and followup.

Adult↗
PubMed1989

The pathologist's perspective of genetic disease. Malformations and dysmorphology.

The pathologic approach to the study of malformations and congenital abnormalities emphasizes the importance of careful dissection and pathologic studies. Concepts and terms of morphogenesis as defined by the International Working Group are presented. The developmental field is the central concept of a malformation. Malformation syndromes, disruptions, sequences, deformations, dysplasias, and associations are presented. The significance of fetal hydrops and short umbilical cord is discussed. Pathologic studies in chromosome defects suggest pathologic markers for some chromosome abnormalities.

Chromosome Aberrations↗
PubMed2000

Small peripheral glandular lesions detected by screening CT for lung cancer. A diagnostic dilemma for the pathologist.

The early detection of lung cancer by helical CT provides an important opportunity for radiologic-pathologic and clinical correlation of borderline glandular lesions. Little is known about the clinical course of atypical adenomatous hyperplasia, solitary noninvasive, nonmucinous BAC, and early-phase invasive adenocarcinomas, therefore, a single protocol for specimen handling and a central tissue registry are essential. The most important separation among the various types of adenocarcinoma is the diagnosis of BAC, a potentially curable malignancy, from invasive adenocarcinoma. Therefore, for small lesions of 2 cm or less, the entire tumor should be processed. For larger lesions, one section per centimeter should be sampled, and if the initial sections show a purely lepidic growth pattern, additional sections should be taken to exclude an invasive component. If foci of invasion are identified, the tumor should be classified as an adenocarcinoma with bronchioloalveolar features. At the International Conference on Screening for Lung Cancer held in October 1997, it was recommended that an international panel be used to reach consensus on difficult lesions of the lung detected by CT screening, and that a tissue bank of these lesions be established to ensure further clinical, radiographic, light microscopic, immunohistochemical, and molecular studies of putative precursor lesions and small carcinomas. Through the collection of these lesions, we can further our understanding of the biologic behavior of lung cancer, particularly because little is known about the progression from a purely lepidic growth pattern to invasive adenocarcinoma.

Adenocarcinoma↗