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Humans↗
PubMed1985

Human peripheral blood monocytes release a 30,000 dalton factor (30 KD MF) that stimulates immunoglobulin production by activated B cells.

Supernatants (SN) of well-washed adherent human monocytes, obtained from T cell-depleted peripheral blood mononuclear cells, contain a 30,000 dalton protein (30 KD MF) that increases immunoglobulin (Ig) synthesis by EBV-activated B cells two- to fourfold. This factor is released spontaneously during the first 20 hr after monocytes are placed in culture. SN containing 30 KD MF are inactive in the thymocyte co-stimulator assay, under conditions that will detect as little as 0.5 U of purified IL 1. The addition of autologous T cells to isolated adherent monocytes, previously depleted of T cells, suppresses the release or activity of this B cell stimulator in a dose-dependent manner. In addition, 30 KD MF stimulates a two- to fourfold increase in IgA production by cells of an EBV-transformed B cell line (JB/FF line) without increasing incorporation of [3H]thymidine. In contrast, stimulation of this B cell line with up to 10 U of purified IL 1 increases IgA synthesis by less than 50%, and addition of up to 100 U of recombinant IL 2 causes no change whatsoever in IgA production. However, co-stimulation with 30 KD MF and recombinant IL 2 or recombinant gamma-interferon induces more Ig production than is caused by the monocyte factor alone. These observations suggest that the monocyte, in addition to acting as an antigen-presenting cell and source of IL 1, facilitates B cell differentiation by producing a factor which acts both independently and in synergy with cytokines produced by T cells to stimulate Ig production by B lymphocytes.

Adult↗
PubMed1985

Processes underlying formal thought disorder in psychiatric inpatients.

Three theories about the cognitive processes underlying symptoms of formal thought disorder in psychiatric inpatients were tested. Chapman and Chapman's "excessive yielding to normal bias" theory and a response competition theory were tested by using two ambiguity tasks. Chapman and Chapman's bias theory predicts a smaller ambiguity effect for thought-disordered patients; a response competition hypothesis predicts a larger ambiguity effect. Results showed no difference between thought-disordered and non-thought-disordered patients. To test a distractibility theory of thought disorder, subjects performed a Stroop-type task in which they counted the number of digits (e.g., 3333) or symbols (####) in a set. Thought-disordered patients did show an increased effect of the presence of the digits, and this finding was replicated in a second inpatient sample. Thus, results were consistent with the distractibility theory and with a reformulation of the bias theory, in which the bias shown by thought-disordered patients is not a tendency toward a particular response, but rather toward a particular rule, or set, for responding.

Adult↗