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MRI of the knee following prosthetic anterior cruciate ligament reconstruction.

The MRI appearances of the knee in 30 patients with residual symptoms following active biocomposite (ABC) reconstruction of the anterior cruciate ligament were prospectively correlated with the clinical and arthroscopic findings. The variable MR features of the neo-ligament depend on the integrity of the prosthesis, the degree and extent of tissue ingrowth, and the time delay between surgical placement and MRI. The ABC ligament gives a uniform low signal when freshly placed, which is slowly lost by the incorporation of tissue ingrowth and therefore the loss of MR visualization of the ABC ligament is not synonymous with failure. Analysis of the imaging features suggests that a neo-ligament emerging through the tibial tunnel either at or posterior to the mid point of the AP diameter of the tibia is likely to be intact (P = 0.008) compared with one placed anteriorly. The presence of an effusion (64%) indicates that symptoms are more likely to be due to other internal mechanical derangement rather than failure of the neo-ligament. Meniscal tears were seen in 67% while osteo-chondral defects were noted in 30% of all patients. Excellent correlation with arthroscopic findings was established confirming intact neo-ligaments in 16 replacements. MRI in the post-operative period detects rectifiable problems before the development of irreversible mechanical damage and re-rupture of the neo-ligament, but a thorough MRI technique needs to be utilized in examining the entire knee.

Adult↗

The effect of insufficient quadriceps strength on gait after anterior cruciate ligament reconstruction.

OBJECTIVE: To determine the effect of quadriceps strength and joint stability on gait patterns after anterior cruciate ligament injury and reconstruction. DESIGN: Cross-sectional comparative study in which four groups underwent motion analysis with surface electromyography. BACKGROUND: Individuals following anterior cruciate ligament rupture often demonstrate reduced knee angles and moments during the early stance phase of gait. Alterations in gait can neither be ascribed to instability nor to quadriceps weakness alone when both are present. METHODS: Twenty-eight individuals with complete anterior cruciate ligament rupture (10 patients with acute rupture, 8 patients following reconstruction with quadriceps strength >90% of the uninvolved side [strong-anterior cruciate ligament reconstructed group], and 10 patients after reconstruction with quadriceps strength <80% of the uninvolved side [weak-anterior cruciate ligament reconstructed group]), and 10 uninjured subjects underwent an examination of their lower extremity to collect kinematics, kinetics, and electromyography during walking and jogging. Anterior cruciate ligament reconstruction was arthroscopically assisted and a double loop semitendinosis-gracilis autograft or allograft was used as a graft source. All reconstructed subjects had stable knees, full range of motion, and no effusion or pain at the time of testing (more than three months after surgery). RESULTS: Knee angles and moments of the strong group were indistinguishable from the uninjured group during early stance of both walking and jogging. The weak subjects had reduced knee angles and moments during walking, and jogged similarly to the deficient subjects. Regression analysis revealed a significant effect between early stance phase knee angles and moments and quadriceps strength during both walking and jogging. CONCLUSION: Inadequate quadriceps strength contributes to altered gait patterns following anterior cruciate ligament reconstruction. RELEVANCE: Rapid strengthening following anterior cruciate ligament injury or reconstruction may contribute to a safe return to high-level activities.

Adolescent↗

Gait perturbation response in chronic anterior cruciate ligament deficiency and repair.

OBJECTIVE: To determine how chronic anterior cruciate ligament deficient and surgically repaired subjects react to unexpected forward perturbations during gait as compared to healthy controls. DESIGN: Gait testing of 10 chronic anterior cruciate ligament deficient subjects prior to and three months following reconstructive surgery, and 10 uninjured controls. BACKGROUND: The ability of an anterior cruciate ligament injured individual to react and maintain equilibrium during gait perturbations is critical for the prevention of reinjury. No studies have investigated how these individuals respond to unexpected perturbations during normal gait. METHODS: An unexpected forward perturbation was induced upon heel strike using a force plate capable of translational movement. RESULTS: Prior to surgery, the anterior cruciate ligament subjects exhibited a greater knee extensor moment in response to the perturbation compared to healthy controls. Following surgery, the anterior cruciate ligament injured subjects exhibited a static knee position and a sustained knee extensor moment throughout stance in response to the perturbation as compared to controls. CONCLUSIONS: These data suggest that chronic anterior cruciate ligament deficient subjects rely heavily on knee extensor musculature to prevent collapse in response to an unexpected perturbation. This same reactive response was more pronounced 3 months following surgery. RELEVANCE: The results suggest that, prior to and following surgery, chronic anterior cruciate ligament injured subjects respond differently than healthy controls to an unexpected perturbation during gait. Anterior cruciate ligament injured or repaired subjects do not reduce or avoid vigorous contraction of the quadriceps muscles when responding to gait perturbations.

Adult↗

Kinematics of the lateral ligamentous constraints of the elbow joint.

Thirty osteoligamentous elbow joint specimens were included in a study of the lateral collateral ligament complex (LCLC). The morphologic characteristics of the LCLC were examined, and then three-dimensional kinematic measurements were undertaken after selective ligament dissections were performed. Isolated sectioning of the annular ligament (AL) or the lateral ulnar collateral ligament (LUCL) induced only minor laxity to the elbow joint with a maximum of 2.2 degrees and 4.4 degrees during forced varus and external rotation (supination), respectively. Transsection of the lateral collateral ligament (LCL) caused a maximal laxity of 15.4 degrees and 22.8 degrees during forced varus and external rotation (supination), respectively. Combined ligament dissections showed that total transection of the LCLC at the ulnar or the humeral insertion was important for joint laxity. Total transection of the LCLC at the humeral or the ulnar insertion induced a maximal laxity of 24.5 degrees and 37 degrees during forced varus and external rotation (supination), respectively. This study suggests the AL and the LUCL are of minor importance as constraints when cut separately, whereas the LCL is a significant preventer of elbow joint laxity. The LCLC was observed to be a complex structure of ligamentous fibers rather than discreet bands. The LCLC forms a ligamentous constraint between the lateral humeral epicondyle and the ulna, stabilizing the elbow joint and forming a base for radial head stability and rotation.

Aged↗

Release of the coracoacromial ligament can lead to glenohumeral laxity: a biomechanical study.

The purpose of this study was to determine change in glenohumeral joint translation after release of the coracoacromial ligament. Six fresh, frozen unpaired glenohumeral joints were tested in a neutral position and at 30 degrees internal and 30 degrees external rotation of the humerus at 0 degrees, 30 degrees, and 60 degrees of abduction on a custom glenohumeral joint translation testing apparatus. A joint compression load of 20 N was simulated; then a 15-N load was applied to the humerus in anterior, posterior, superior, and inferior directions, and translations on the glenoid were measured with an electromagnetic tracking device. The tests were then repeated after a 1.5-cm section of the coracoacromial ligament was released from the acromion. A multivariate analysis of variance was used for statistical analyses with a P value of.05 as the level of significance. At 0 degrees and 30 degrees of abduction, release of the coracoacromial ligament resulted in a significant increase in glenohumeral joint translations, in both the anterior and inferior directions. In addition, the differences in translation between before and after the release of the coracoacromial ligament decreased in all directions as glenohumeral abduction increased, and they were not significant at 60 degrees of abduction in any of the rotations. The results of this study suggest that the coracoacromial ligament has a role in static restraint of the glenohumeral joint. It provides a suspension function and may restrain anterior and inferior translations through an interaction with the coracohumeral ligament. Although this is a biomechanical study without simulation of the shoulder muscles, it indicates that the coracoacromial ligament contributes to glenohumeral stability. Caution should be exercised in the release of the coracoacromial ligament in those with rotator cuff pain associated with glenohumeral instability.

Aged↗

Treatment of anterior cruciate ligament injuries, part 2.

Anterior cruciate ligament tears, common among athletes, are functionally disabling; they predispose the knee to subsequent injuries and the early onset of osteoarthritis. A total of 3810 studies published between January 1994 and the present were identified and reviewed to determine the current state of knowledge regarding the treatment of anterior cruciate ligament injuries. Part 1 of this article focused on studies pertaining to the biomechanical behavior of the anterior cruciate ligament, the prevalence of and risk factors for injuries related to it, the natural history of the ligament-deficient knee, injuries associated with anterior cruciate ligament disruption, indications for the treatment of anterior cruciate ligament injuries, as well as nonoperative and operative treatments. Part 2 includes technical aspects of anterior cruciate ligament surgery, bone tunnel widening, graft healing, rehabilitation after anterior cruciate ligament reconstruction, and the effects of sex, age, and activity level on the outcome of such reconstructive surgery.

Age Factors↗

Effect of functional bracing on knee injury in skiers with anterior cruciate ligament reconstruction: a prospective cohort study.

BACKGROUND: The role of knee bracing in anterior cruciate ligament reconstructions is controversial. HYPOTHESIS: Functional bracing will have an effect on subsequent knee injury in skiers with anterior cruciate ligament reconstruction. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: From 1991 to 1997, 11606 skiers at a major destination ski resort underwent preseason knee screening. The anterior cruciate ligament-reconstructed group consisted of 820 skiers who had had an anterior cruciate ligament reconstruction 2 years or more earlier. Of these, 257 skiers selected the use of functional knee brace during skiing. The dependent variable was subsequent knee injury, identified via workers' compensation records. Covariates included age, gender, ski occupation, Lachman grade, pivot-shift grade, KT-1000 arthrometer manual maximum displacement, and use of a functional brace. Univariate and multivariate risk factors for subsequent knee injury were determined. RESULTS: In this study, 257 skier-employees with anterior cruciate ligament reconstruction wore braces and 563 skier-employees with anterior cruciate ligament reconstruction did not. Braced skiers had significantly higher preseason rates of grade II or higher Lachman and pivot-shift tests (braced, 29% and 22%, respectively; nonbraced, 11% and 10%, respectively; P < .05). Sixty-one subsequent knee injuries were identified, 51 (8.9 injuries/100 knees/ski season) in the nonbraced group and 10 (4.0 injuries/100 knees/ski season) in the braced group (P = .009). Nonbraced skiers were 2.74 times more likely to suffer subsequent injury than were braced skiers (odds ratio, 2.74 [confidence interval, 1.2-4.9]). Logistic regression modeling identified nonbracing as a significant independent multivariate risk factor for subsequent knee injury in the high-demand skiers with anterior cruciate ligament reconstruction. CONCLUSION: Because of the increased risk of subsequent knee injury in nonbraced skiers, the authors recommend functional bracing for skiers with anterior cruciate ligament reconstruction. Whether the protective effect of functional bracing can be extrapolated to other high-demand patients is yet to be determined.

Adolescent↗

Quadriceps muscle contraction protects the anterior cruciate ligament during anterior tibial translation.

The proposed skiing injury mechanism that suggests a quadriceps muscle contraction can contribute to anterior cruciate ligament rupture was biomechanically investigated. The effect of quadriceps muscle force on a knee specimen loaded to anterior cruciate ligament failure during anterior tibial translation was studied in a human cadaveric model. In both knees from six donors, average age 41 years (range, 31 to 65), the joint capsule and ligaments, except the anterior cruciate ligament, were cut. The quadriceps tendon, patella, patellar tendon, and menisci were left intact. One knee from each pair was randomly selected to undergo destructive testing of the anterior cruciate ligament by anterior tibial translation at a displacement rate of 30 mm/sec with a simultaneously applied 889 N quadriceps muscle force. The knee flexion during testing was 30 degrees. As a control, the contralateral knee was loaded correspondingly, but only 5 N of quadriceps muscle force was applied. The ultimate load for the knee to anterior cruciate ligament failure when tested with 889 N quadriceps muscle force was 22% +/- 18% higher than that of knees tested with 5 N of force. The linear stiffness increased by 43% +/- 30%. These results did not support the speculation that a quadriceps muscle contraction contributes to anterior cruciate ligament failure. In this model, the quadriceps muscle force protected the anterior cruciate ligament from injury during anterior tibial translation.

Adult↗

The effect of functional knee bracing on the anterior cruciate ligament in the weightbearing and nonweightbearing knee.

We investigated the effect of functional bracing on anterior cruciate ligament strain in humans by arthroscopic implantation of a differential variable reluctance transducer on the ligament and measurement of its strain behavior. Strains were measured while "injury mechanism" loads were applied to the weightbearing and nonweightbearing knees for both braced and unbraced conditions. For the unbraced knee, there was a significant increase in ligament strain values when subjects went from a seated position (minimal shear and compressive loads across the knee) to a standing posture (substantial shear and compressive loads across the knee). Similar strain values were found between these same seated and standing postures when a 140-N anterior-directed load was applied to the tibia. This indicates that the ligament is strained during weightbearing and demonstrates that the compressive load across the knee produced during weightbearing does not significantly reduce ligament strain values in comparison with the unweighted joint with relaxed muscles for the 140-N load limit of our anterior shear test. Bracing produced a protective effect on the ligament by significantly reducing the strain values for anterior-directed loading of the tibia up to 140 N with the knee in both weightbearing and nonweightbearing conditions. Likewise, bracing produced a protective effect on the ligament by significantly reducing strain values in response to internal-external torque of the tibia up to 6 N-m with the knee nonweightbearing. The brace strap that contacts the tibia just distal to the insertion of the patellar tendon was instrumented with a load sensor, allowing us to measure the posterior-directed loads applied by the brace to the tibia. Adjustment of strap tension between low and high settings did not modulate the protective effect of the brace on the ligament.

Adult↗

A biomechanical study of replacement of the posterior cruciate ligament with a graft. Part 1: Isometry, pre-tension of the graft, and anterior-posterior laxity.

UNLABELLED: Twelve fresh-frozen knee specimens from cadavera were subjected to anterior-posterior laxity testing with 200 newtons of force applied to the tibia; testing was performed before and after a femoral load-cell was connected to a mechanically isolated cylindrical cap of subchondral femoral bone containing the femoral origin of the posterior cruciate ligament. The posterior cruciate ligament then was removed, the proximal end of a thin trial isometer wire was attached to one of four points designated on the femur, and displacement of the distal end of the wire relative to the tibia was measured over a 120-degree range of motion. The potted end of a ten-millimeter-wide bone-patellar ligament-bone graft was centered over the femoral origin of the ligament and attached to the femoral load-cell. Isometry measurements were repeated with the wire attached to the bone block of the free end of the graft in the tibial tunnel. Force was recorded at the load-cell (representing force in the intra-articular portion of the graft) as pre-tension was applied, with use of a calibrated spring-scale, to the tibial end of the graft. A laxity-matched pre-tension of the graft was determined such that the anterior-posterior laxity of the reconstructed knee at 90 degrees of flexion was within one millimeter of the laxity that was measured after installation of the load-cell. Anterior-posterior testing was repeated after insertion of the graft at the laxity-matched pre-tension. The least amount of change in the relative displacement of the trial wire over the 120-degree range of flexion occurred when the wire was attached to the proximal point on the femur (a point on the proximal margin of the femoral origin of the posterior cruciate ligament, midway between the anterior and posterior borders of the ligament). The greatest change in the relative displacement was associated with the anterior point (a point on the anterior margin of the femoral origin of the ligament, midway between the proximal and distal borders). The mean relative displacements of the trial wire when it was attached to a point at the center of the femoral origin of the ligament were not significantly different from the corresponding mean displacements of the distal end of the graft when the proximal end of the graft was centered at this point. At 90 degrees of flexion, the force recorded by the load-cell averaged 64 to 74 per cent of the force applied to the tibial end of the graft. The laxity-matched pre-tension of the graft at 90 degrees of flexion (as recorded by the load-cell) ranged from six to 100 newtons (mean and standard deviation, 43.0 +/- 33.4 newtons). With the numbers available, the mean laxities after insertion of the graft were not significantly different, at any angle of flexion, from the corresponding mean values after installation of the load-cell. CLINICAL RELEVANCE: Isometer readings from a trial wire attached to a point on the femur provided an accurate indication of the change in the length of a graft subsequently centered at that point. Anteriorly placed femoral tunnels should be avoided, as the isometer readings indicated increased tension, with flexion of the knee, in a graft placed in this region. The force in the intra-articular portion of the graft was always less than the force applied to the bone block in the tibial tunnel. Therefore, the femoral end of the graft should be tensioned to avoid frictional losses from the severe bend in the graft as it passes over the posterior tibial plateau. With correct pre-tensioning of a graft, normal anterior-posterior laxity at 0 to 90 degrees of flexion can be restored. However, because of the considerable range in the laxity-matched pre-tensions, we recommend that the pre-tension be greater than forty-three newtons for all patients to ensure that normal laxity is restored.

Aged↗

Knee stability following anterior cruciate ligament rupture and surgery. The contribution of irreducible tibial subluxation.

BACKGROUND: Knee stability after anterior cruciate ligament reconstruction is generally determined by measuring total anteroposterior tibial motion. In spite of a decrease in excessive anteroposterior tibial motion after anterior cruciate ligament reconstruction, problems can still develop. In the present study, we sought to define the tibiofemoral relationship more accurately with use of stress radiographs of human knees after anterior cruciate ligament rupture and after anterior cruciate ligament reconstruction. METHODS: A previously described radiographic technique was used to evaluate the position of the tibia relative to the femur with the application of an anteriorly directed tibial force and subsequently with the application of a posteriorly directed tibial force. Tibial position and total tibial translation were calculated from these radiographs. In addition, KT-1000 measurements were obtained. Three groups of patients were studied: Group 1 included twenty-eight patients with an untreated anterior cruciate ligament rupture, Group 2 included nineteen patients who had undergone a clinically successful anterior cruciate ligament reconstruction, and Group 3 included twenty-five control subjects with normal knees. RESULTS: KT-1000 testing showed that the average side-to-side differences in Group 1 (5.8 mm) and Group 2 (2.7 mm) were significantly different from that in Group 3 (0.8 mm) (p < 0.01 and p < 0.05, respectively). Stress radiographs showed that the average total tibial translation in Group 1 (9.8 mm) was significantly different from those in Group 2 (5.6 mm) and Group 3 (4.3 mm) (p < 0.05 and p < 0.001, respectively). Within Group 1, knees with radiographic signs of osteoarthritis were more stable, with an average total tibial excursion of 6.8 mm. The improved stability of the reconstructed knees in Group 2 and the osteoarthritic knees in Group 1 was not entirely the result of decreased anterior tibial translation; it was, in part, due to an irreducible anterior subluxation of the tibia. A posteriorly directed stress in these knees did not reduce the tibia to the anatomic position relative to the femur; the osteoarthritic knees in Group 1 were 9.9 mm short of full reduction and the knees in Group 2 were 3.1 mm short of full reduction (p < 0.01) CONCLUSIONS: Irreducible tibial subluxation can be present in the knee following surgical reconstruction of the anterior cruciate ligament. Osteoarthritic changes following an untreated anterior cruciate ligament rupture are also associated with uncorrectable tibial subluxation along with a decrease in instability. The irreducible tibial subluxation could explain why osteoarthritic changes still may develop in stable, reconstructed knees in spite of the improved stability. Currently used arthrometric measurements, such as KT-1000 scores, do not measure this phenomenon.

Adult↗

A sixteen-year follow-up of three operative techniques for the treatment of acute ruptures of the anterior cruciate ligament.

BACKGROUND: This study compares three surgical procedures that we used in the past to treat ruptures of the anterior cruciate ligament: acute primary repair, acute repair augmented with a synthetic ligament-augmentation device, and acute repair augmented with autologous bone-patellar tendon-bone graft. METHODS: This is the third report on a group of patients who were randomized to the three different procedures between 1986 and 1988. There were fifty patients in each group. The patients were evaluated prospectively at one, two, five, and sixteen years with use of the Tegner activity score and the Lysholm functional score. Stability of the knee was assessed with clinical examination and with use of the KT-1000 arthrometer. RESULTS: One hundred and twenty-nine (88%) of the 147 patients who were available for follow-up completed the study. Eleven patients (24%) who had a primary repair, four patients (10%) who had repair with a ligament augmentation device, and one patient (2%) who had augmentation with autologous bone-patellar tendon-bone graft underwent anterior cruciate ligament revisions between the primary operation and the sixteen-year follow-up examination. The rate of revision was ten times higher in the group that had primary repair than in the group that had repair with bone-patellar tendon-bone graft (p = 0.003). In the remaining patients, those who had repair with a bone-patellar tendon-bone graft had significantly more stable knees than those who had repair with a ligament augmentation device, as measured by the Lachman test (p = 0.026). Nine (11%) of the eighty-five patients for whom data were available had osteoarthritis in the primarily reconstructed knee, and three patients (3.5%) had osteoarthritis in the contralateral knee at sixteen years (p = 0.001); no difference was noted among the three groups. The mean Lysholm score at sixteen years was 88 points for the knees that had primary repair, 85 points for those that had repair with the ligament augmentation device, and 90 points for those managed with a bone-patellar tendon-bone graft (p = 0.286). CONCLUSIONS: At long-term (sixteen-year) follow-up, the rate of revision anterior cruciate ligament surgery is much higher following primary repair than after primary repair augmented by a bone-patellar tendon-bone graft. It can be expected that approximately 10% of patients undergoing anterior cruciate ligament reconstruction acutely will have osteoarthritis develop in the reconstructed knee. We no longer perform any of these surgical techniques as open procedures.

Adolescent↗

Microstructural morphology in the transition region between scar and intact residual segments of a healing rat medial collateral ligament.

This study used a rat model to investigate the microstructural organization of collagen through the transition from scar to intact residual segments of a healing medial collateral ligament (MCL). Twenty-two male retired breeder Sprague-Dawley rats were randomly separated into two groups. Eleven underwent surgical transections of both MCLs and were allowed unrestricted cage activity until euthanized two weeks post surgery. The remaining eleven rats were used as normal controls. All 44 MCLs were harvested including intact femoral and tibial insertions and prepared for scanning electron microscopy (SEM) imaging. At harvest the scar region in the healing ligaments was more translucent than the normal tissue. Ligaments were viewed from femoral to tibial insertions at magnifications of 100X through 20,000X. Tissue away from the scar region in the transected MCLs was indistinguishable from normal tissue in uninjured ligaments. Collagen fibers and fibrils in these tissues were more aligned along the longitudinal axis of the ligament than in the scar tissue. Continuity of collagen fibers and fibrils were consistently observed from the residual portions of the transected ligament through the scar region. Bifurcations/fusions, but no anastomoses, in fibers and fibrils were observed in both normal and scar tissues of ligaments. Qualitatively, bifurcations were encountered more frequently in scar tissue. In the transition region, larger diameter fibers from the residual tissue bifurcated into smaller diameter fibrils in the scar. This connection between larger diameter and smaller diameter fibers and fibrils indicates that bifurcations/fusions are likely to be the dominant way in which force is transmitted from a region with larger fibrils (residual ligament) into and through a region with smaller fibrils (scar).

Animals↗

Passive muscle tension augments the anterior cruciate ligament. An in vivo study in the rat.

The contribution by passive muscle tension to the structural load-bearing capacity of the anterior (cruciate) ligament in the anesthetized rat was investigated. Using a stereomicroscope, the joint capsule and ligaments of the right knee, except the anterior ligament, were cut and the menisci removed leaving the anterior ligament and the tendons of the denervated muscle to constrain the knee. The ligament was tested in tension until failure, using a loading rate of 2.5 mm s-1 (approximately 0.6 s-1). As a control, the femur-anterior ligament-tibia complex of the left knee was tested. The mean ultimate tensile load on the anterior ligament augmented by muscle tendons was 48 percent higher. The energy absorption at failure was 84 percent higher; and the stiffness 26 percent higher. The deformation remained unchanged. This investigation suggests that, when the strain rate is high, muscle may be passively stretched and thus absorb energy and increase the force needed to rupture the anterior ligament.

Animals↗

Lateral ankle ligaments and tibiofibular syndesmosis. 13-MHz high-frequency sonography and MRI compared in 20 patients.

To test the ability of ultra-high frequency ultrasound (13 MHz scanner) to distinguish between intact and ruptured ligaments on the lateral side of the ankle, we examined 20 patients with an acute inversion injury with MRI and ultrasound. When judged by the MRI diagnosis, an injured anterior talofibular ligament was correctly diagnosed by ultrasound in 13 of 14 and an intact anterior talofibular ligament in 5 of 6 patients. In the case of the calcaneofibular ligament, 4 ruptured and 16 intact ligaments were diagnosed equally well with both methods. The injured anterior tibiofibular ligament was correctly diagnosed by ultrasound in 6 of 9 patients, while the intact ligament was correctly recognized in 10 of 11 patients. Our findings indicate that it is possible to distinguish injured from intact ligaments sonographically.

Fibula↗

Anterior cruciate ligament injuries. Evaluation, arthroscopic reconstruction, and rehabilitation.

The advantages of arthroscopic reconstruction of the anterior cruciate ligament tear over arthrotomy are quite obvious: reduced pain and morbidity. Some arthroscopists are performing these procedures on an outpatient basis. The physician can choose from several graft substitutes for anterior cruciate ligament replacement. Autografts consisting of the iliotibial band, semitendinosus, gracilis, and meniscus have been used as grafts. The most common autograft is the bone-patellar tendon-bone, which has been used since 1930 and has been shown to have a tensile strength near that of the anterior cruciate ligament. The state of the art in surgical alternatives for anterior cruciate ligament tears is arthroscopic reconstruction using the midthird of the patellar tendon. Treatment of anterior cruciate ligament injuries requires prompt and adequate evaluation of the laxity of the ligament as well as other structures in the knee, appropriate treatment options offered to the patient with complete descriptions of knee function after each treatment option, and comprehensive rehabilitation program. Patient compliance is an integral part of the success of this procedure. The nurse must include a description of the injury, preoperative testing, surgical intervention, and rehabilitation program when educating the patient. The successful postoperative anterior cruciate ligament rehabilitation program is multifaceted. In general, there must be specific guidelines applied by a physical therapist who has knowledge of the surgical procedure, understands principles of ligament healing, and has the ability to individualize the program as needed. For any level of athlete or active person, there must be achievement of all goals per phase to a high performance level. In addition, there must always be objective measurements to document progress to the physical therapist and physician but, perhaps most importantly, to reassure the patient that normalcy is being restored.

Anterior Cruciate Ligament↗

Meningovertebral ligaments and their putative significance in low back pain.

OBJECTIVE: To determine the presence and morphology of the meningovertebral ligaments (ligaments of Hofmann) as well as postulate their possible contribution to low back pain. DESIGN: Sagittal dissections were performed on 12 embalmed cadaver specimens including the L5/S1 intervertebral level cephalad to T1. Meningovertebral ligaments were labeled and documented in both the lumbar and thoracic regions. RESULTS: Meningovertebral ligaments were found in both the lumbar and thoracic regions of all cadaveric specimens. These ligaments were much more prevalent in the lumbar vertebral column but were also present throughout the thoracic vertebral column. The meningovertebral ligaments in the lumbar region were more robust as well as more frequently encountered than those found in the thoracic region. CONCLUSION: Dural sac attachments to the posterior aspect of the vertebral bodies and the posterior longitudinal ligament could act to traction the dural sac in the event of nuclear bulge or herniation. The prevalence of these ligaments in the lumbar spine, coupled with the high incidence of herniated nucleus pulposus and disc bulges in this region, may compound the effects of disc pathology and result in increased low back pain.

Aged↗

Decrease in fibronectin occurs coincident with the increased expression of its integrin receptor alpha5beta1 in stress-deprived ligaments.

Stress deprivation secondary to immobilization leads to atrophic changes in periarticular soft tissues. The changes in ligaments include a disorganization of collagen and cellular ultrastructure with varied biochemical alterations resulting in a functionally weaker tissue. This study tests the hypothesis that alterations in fibronectin (Fn) and the expression of its integrin receptor alpha5beta1 in ligament fibroblasts accompany the extracellular matrix remodeling which occurs in stress-deprived knee ligaments. The left knees of eighteen New Zealand white rabbits were surgically immobilized in acute flexion. Fibroblasts within three nine week and three twelve week stress-deprived anterior cruciate ligaments (ACLs) and medial collateral ligaments (MCLs) demonstrated markedly increased immunostaining for the beta1 and alpha5 integrin subunits, as compared to fibroblasts in the contralateral unoperated control ligaments. The effects of stress deprivation on the concentration of Fn was measured by competitive ELISA on the remaining twelve rabbits. Decreases in Fn of 54.0 percent and 63.7 percent occurred in the ACL after nine and twelve weeks of stress deprivation when compared to contralateral controls. The MCL had less of a decrease, losing 37.7 percent and 41.7 percent at nine and twelve weeks, respectively. These results suggest an important role for the Fn-specific integrin receptor alpha5beta1 in remodeling stress-deprived periarticular ligamentous tissue, and the importance of maintaining normal stresses on periarticular ligaments to prevent the degradation of extracellular matrix components such as Fn.

Animals↗