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Cartilage of the baboon contains estrogen receptors.

Castrated-adrenalectomized aged female baboons were injected with 3H-estradiol-17 B (E2) and killed one hour later. Specimens from all regions of the larynx and oral cavity were taken and processed for autoradiography. A consistent and heavy uptake of 3H-E2 by the perichondrium and cartilage was found in all laryngeal sections with cartilage present and in the articular cartilage of the condyle of the mandible. These data provide evidence that cartilage contains receptors for estrogen. These data along with data already present in the literature suggest that circulating estrogen may act directly on cartilage to modulate collagen synthesis and further that the loss in circulating estrogen associated with menopause might in part explain the large sexual dimorphism associated with the incidence of osteoarthritis.

Aging↗

[The sonography of laryngeal cysts].

To evaluate the sonographic appearance of laryngeal cysts, ultrasound examinations of 7 patients were evaluated retrospectively. The ultrasound studies were correlated with endoscopic findings. In two cases, the diagnosis was confirmed histologically, and in 4 patients, a CT examination was additionally performed. The endolaryngeal space could be well seen if the thyroid cartilage was not calcified (n = 6), whereas in one patient, the endolaryngeal part of the cyst could not be seen because of complete calcification of the thyroid cartilage. The laryngeal cysts presented as unechoic (n = 4) or hypoechoic (n = 3) masses, which demonstrated smooth margins in all cases and ranged in size from 6 to 38 mm. In three cases, the cyst was located in the endolaryngeal space, and in 4 cases, it extended cranial of the thyroid cartilage into the pre-epiglottic space. All cysts were closely related to the inner surface of the thyroid cartilage, from which they were delineated by a thin hyperechoic band in all cases.

Adult↗

Supracricoid hemilaryngopharyngectomy. Analysis of 240 cases.

The supracricoid hemilaryngopharyngectomy consists of resection of the supracricoid hemilarynx and ipsilateral pyriform sinus. Two hundred forty patients underwent this procedure from 1964 through 1983. Two hundred twenty-two patients had no airway impairment, and 204 recovered normal deglutition. The local recurrence rate was 5.2%. Indications for the procedure are carcinoma of the supracricoid upper part of the pyriform sinus and carcinoma of the lateral laryngeal margin with normal vocal cord mobility.

Adult↗

A genetic factor controlling morphogenesis of the laryngotracheo-esophageal complex the mouse.

A new autosomal, recessive lethal mutation in the mouse cause failure of division of the embryonic foregut into totally separate digestive and respiratory ducts. The newborn homozygote has a cleft that extends between the laryngotracheal and esophageal tubes, allowing excessive air to pass into the stomach and subsequently into the peritoneal cavity. This mutation has been designated lec (laryngotracheo-esophageal cleft). The common region shared by the respiratory and digestive tubes has features characteristic of both structures. Development of cartilage around the laryngotracheo-esophageal complex is also affected in the mutant.

Animals↗

Thyroid cartilage at the suprasternal notch with low situated thyroid gland.

The thyroid cartilage and thyroid gland forming a lump at the suprasternal notch is a surprising congenital anomaly which I believe has not been previously reported. A case with co-existent low hyoid bone, pharyngo-oesophageal junction and intrathoracic cricoid cartilage with no cervical trachea is presented. Its pathogenesis is suggested and its surgical importance is discussed.

Abnormalities, Multiple↗

Anterior cricoid split: a "simple" surgical procedure and a potentially complicated care problem.

The anterior cricoid split (ACS) has been described as an alternative to tracheotomy in management of the premature infant who develops upper airway compromise after extubation. Sixteen patients at the Children's Hospital National Medical Center (CHNMC) and ten patients at four other hospitals had the ACS operation. For the patients at the CHNMC, average gestational age was 29 weeks, birth weight was 1,264 g, and length of time intubated was 6.2 weeks. Overall success in achieving extubation after the ACS was 69% at the CHNMC and 40% for the group of other hospitals. However, a success rate in achieving extubation after ACS was 75% for both the CHNMC and the group of other hospitals in patients who had become stable enough to have been previously discharged from a neonatal intensive care unit. Problems encountered following the ACS include malposition of tip of the endotracheal tube, increased need for assisted ventilation, myocardial infarction, subcutaneous emphysema, and unexplained inability to ventilate. Analysis of results suggests that the ACS is a valuable operative procedure that can avoid need for tracheotomy in infants with adequate pulmonary function who have narrowing within the airway at the subglottic level. Postoperative care may be problematic and the infant having had the ACS is best managed by an experienced team of experts who are familiar with care of the infant with respiratory insufficiency.

Cricoid Cartilage↗

[Effects of pull upon the growth of the trachea (author's transl)].

The effect of pull following segmental resection with subsequent anastomosing was studied in animal experiments in regards to the growth of the trachea. A corresponding decrease in body-weight is demonstrated following resection of 4-7 tracheal segments. Even a small pull leads to a decrease of cartilage thickness of the entire trachea. The correlation between the number of the resected cartilage segments and the resulting stenosis in the region of the anastomosis is significant. The decreased area of the canal in the anastomosed region amounts to a maximum of 66% after resection of 7 tracheal segments without the appearance of disorders of ventilation in form of an in- and expiratory stridor. After resection of up to 3 tracheal segments telescopic cartilage overlappings are observed. The mucosa shows a metaplastic regeneration at the anastomosis.

Animals↗

Thyroplasty type I (lateral compression) for dysphonia due to vocal cord paralysis or atrophy.

Based on the experimental results of thyroplasty, thyroplasty type I which aims at medical shifting the vocal cord was performed on 8 patients with dysphonia, 6 with vocal cord paralysis and 2 with vocal cord atrophy. The surgery was conducted on either in- or out-patient basis and local anesthesia was used. Usually, a rectangular incision was made on the thyroid cartilage at the level of the vocal cord, and the fragmemt was depressed inward. A cartilage piece taken from the opposite side was used as a wedge, if necessary, to enhance the effect of lateral compression of the vocal cord. The voice after surgery was generally satisfactory, except in one case of traumatic vocal cord paralysis. Complications such as stridor or dyspnea were nil. As surgical intervention inside the thyroid cartilage is minimal, fine and reliable adjustment of depression is possible during the surgery.

Adolescent↗

CT diagnosis of laryngeal cricoid chondrosarcoma.

Computerized tomography is the imaging method of choice for evaluation of neoplastic involvement of the larynx. There are unusual primary neoplasms of the larynx which include chondroma and chondrosarcoma. These lesions may cause vocal cord paralysis and respiratory symptoms secondary to compression of the recurrent laryngeal nerve. We present a single patient with computerized tomographic imaging of laryngeal chondrosarcoma resulting in unilateral vocal cord paralysis and hoarseness.

Aged↗

The relevance of using tragal cartilage in tympanoplasty.

Chronic endotympanic depression is a pathological situation which leads to tympanic atelectasis, retraction pockets and cholesteatoma. It is also at the origin of tympanoplasty failure. Tragal composite perichondrium-cartilage graft is a procedure which gives good results in these difficult surgical cases.

Humans↗

[Etiopathogenesis and biodynamics of closed laryngo-tracheal injuries].

The blunt laryngotracheal trauma, once quite a rare phenomenon, has become quite relevant today, particularly because of the great increase in automotive traffic. It was, therefore, felt knowledge of the etiopathogenesis and biodynamics of this form of trauma is important for proper diagnosis and treatment. After having noted that the literature in this regard is generally incomplete and fragmentary, the authors felt it worth compiling the various etiopathogenesis and biodynamic factors involved; characteristics of blunt laryngotracheal trauma. Three basic elements of this form of trauma were studied. These are: trauma subject, trauma forces and impact plane. The biodynamic mechanisms responsible for the damage caused to the laryngotracheal skeleton and its soft parts have been analyzed. Finally, a case study was made including 99 cases drawn from international literature and 23 cases which had come under observation by the authors. The purpose of this analysis was to determine the frequency of various etiologies in relation to trauma type and site. The difficulties involved in drawing these simple data from the literature is underlined. This stems from the fact that often the various authors report overall data failing to give the etiology and site of individual cases. Traffic accidents have proved to be the cause of 80% of all such traumas and 90% of those with fracture, dislocation or separation of the laryngotracheal skeleton. The most serious lesions are to be seen in cases of frontal trauma. In the elastic cartilage of young people, the elastic snapback is of particular significance in the genesis of damage to the soft tissues. The most frequently encountered lesion is fracture of the thyroid cartilage alone while fracture of the cricoid alone is quite unusual. Fractures or detachment within the cricoid-tracheal area is quite common. In 85% of the cases cricoid cartilage involvement is associated with that of the tracheal cartilage. The authors assert that, due to a question of resistance, cricoid fracture traumas almost always involve the trachea while thyroid cartilage fractures act as a relief, letting off and absorbing the forces, thus preventing cricoid involvement. On the basis of these considerations the authors feel it fitting to classify the blunt laryngotracheal traumas into three groups according to topography: supraglottic laryngeal trauma with or without involvement of the glottis; subglottic laryngeal trauma, generally associated with the trachea and only rarely involving the glottic region; isolated trauma of the cervical trachea.

Accidents, Traffic↗

Experimental animal model of subglottic stenosis.

An animal model of subglottic stenosis has been developed. The results of this pilot study show evidence to suggest that injury to the cricoid cartilage leading to perichondritis is the important factor in the development of subglottic stenosis.

Animals↗

A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1).

Relapsing polychondritis (RP) differs from rheumatoid arthritis (RA) in that primarily cartilage outside diarthrodial joints is affected. The disease usually involves trachea, nose, and outer ears. To investigate whether the tissue distribution of RP may be explained by a specific immune response, we immunized rats with cartilage matrix protein (matrilin-1), a protein predominantly expressed in tracheal cartilage. After 2-3 weeks, some rats developed a severe inspiratory stridor. They had swollen noses and/or epistaxis, but showed neither joint nor outer ear affection. The inflammatory lesions involved chronic active erosions of cartilage. Female rats were more susceptible than males. The disease susceptibility was controlled by both MHC genes (f, l, d, and a haplotypes are high responders, and u, n, and c are resistant) and non-MHC genes (the LEW strain is susceptible; the DA strain is resistant). However, all strains mounted a pronounced IgG response to cartilage matrix protein. The initiation and effector phase of the laryngotracheal involvement causing the clinical symptoms were shown to depend on alphabeta T cells. Taken together, these results represent a novel model for RP: matrilin-1-induced RP. Our findings also suggest that different cartilage proteins are involved in pathogenic models of RP and RA.

Animals↗

What causes lower neck uptake in bone scans?

Lower neck uptake, frequently seen on anterior views of bone scans done with 99mTc-phosphate compounds, was studied in 122 patients to determine its incidence and etiology. Increased uptake was identified in the lower neck anteriorly in 46 patients (38%). In 14 of these, moderately severe to severe arthritis appeared to cause the uptake; metastatic disease was the cause in 8 cases; and in 1 case there was prominent uptake in the thyroid cartilage. Positioning artifact accounted for the uptake in the other 23 cases. Thyroid uptake was never observed.

Adult↗