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At least 1,063 records · Page 59Linked to original sources
PubMed1991

Effect of middle ear effusion on the vestibular labyrinth.

Although middle ear effusion was once described as the most common cause of vestibular disturbance in children, the association between glue ear and symptoms of dysequilibrium has never been quantified objectively. In this study the effect of middle ear effusion on the vestibular system of the inner ear was studied in a select group of children suffering from long lasting effusion in the middle ear with no evidence of infection at least one year prior to the study. The results were compared with results obtained from otitis free children, as well as from examinations of children after the insertion of ventilating tubes. The results of this study confirm the assumption that middle ear effusion has an adverse effect on the vestibular system, which can be resolved following the insertion of ventilation tubes. This effect may also contribute to the adverse effect that otitis media has on a child's development.

Child↗
PubMed1997

Labyrinth exploration, emotional reactivity, and conditioned fear in young Roman/Verh inbred rats.

An inbreeding program has been carried out with the Swiss sublines of Roman high- and low-avoidance rats since 1993. The present study reports the first experiments conducted with young animals of those inbred strains (RHA-I/Verh and RLA-I/Verh, respectively) from the sixth and seventh inbreeding generations. The results confirmed expected behavioral profiles. Compared to the RHA-I/Verh strain, RLA-I/Verh rats showed decreased entries into the illuminated central arena of an hexagonal tunnel maze, as well as decreased spontaneous locomotor activity and increased defecations, in two independent experiments. Young RLA-I/Verh females explored less than did their RHA-I/Verh counterparts during session 1 of a conditioned-fear experiment preceding shock administration, and in session 2 (conducted 24 h after the application of three footshocks), they showed greater conditioned behavioral inhibition (i.e., reduced amount of rearing), as well as higher defecation scores, than did RHA-I/Verh females.

Analysis of Variance↗
PubMed2006

Viroids: an Ariadne's thread into the RNA labyrinth.

Viroids are structurally, functionally and evolutionarily different from viruses. Despite their small, non-protein-encoding, single-stranded circular RNA genome, viroids can infect higher plants and cause certain diseases. Members of the two viroid families, Pospiviroidae and Avsunviroidae, have evolved to usurp the transcriptional machinery of their host nuclei and chloroplasts, respectively, in which replication proceeds through a rolling-circle mechanism involving RNA polymerization, cleavage and ligation. Remarkably, viroids subvert certain DNA-dependent RNA polymerases to transcribe RNA templates, and, in the family Avsunviroidae, post-transcriptional cleavage is catalysed by hammerhead ribozymes. Viroids are models for studying RNA evolution and for analysing RNA transport in plants, because they can move intracellularly, intercellularly through plasmodesmata and to distal parts of the plant through the vascular system. Viroids elicit RNA-silencing phenomena, which might mediate some of their biological properties, including pathogenesis. As some viroids behave as catalytic RNAs, they are regarded as remnants of the RNA world.

Base Sequence↗
PubMed2000

The labyrinth of health as perceived by two groups of community nurses.

The purpose of this research was to examine a group of 16 health visitors and a group of 16 community mental health nurses perceptions of health and health awareness. The study was mainly qualitative and exploratory in nature with some quantitative data being collected to condense the data. All 32 respondents were interviewed using a semistructured, tape recorded format. The content of the data was scrutinized and emerging patterns, themes, and concepts were noted and coded using a tried and tested theoretical process. The findings were related to the questions asked and comparisons were drawn between the information received from each group. An examination of the data revealed that the group of health visitors defined health terms of 'functional' states, described health in physical terms, and practiced physical exercises as their health valuing behaviours in order to keep themselves healthy. This key theme also emerged with reference to their value of health at family and global levels. Taking their health for granted and being grateful for it when they saw someone in the community less well off than themselves was also highlighted as a major theme. The group of community mental health nurses defined their health in 'being' states and described health in a holistic manner. They perceived the value and concept of 'freedom' to be related to and embraced within the concept, definition and value of health at individual, family and global levels. They practiced aesthetic health valuing behaviours to enhance their appreciation of health and self. Mental health, the ability to make choices, being self actualizing and the capacity to love and be loved were the key themes emerging throughout this group's responses. It would be interesting to develop this research from a community health perspective.

Attitude of Health Personnel↗
PubMed2002

Are we lost in the labyrinth of the sinoatrial node pacemaker mechanism?

Despite extensive electrophysiologic studies performed to date, the ionic mechanisms of sinoatrial node pacemaker activity are unclear. This article highlights three recent topics associated with this issue: (1) sustained inward current (Ist)); (2) the role of Ca2+ release from the sarcoplasmic reticulum; and (3) the role of L-type Ca2+ current (I(Ca,L)). New observations on these topics seem to make the scenario of the pacemaker mechanism increasingly complex. However, such complexity and diversity of ionic events and their orchestration may be important for the sinoatrial node to perform its robust pacemaking activity under a variety of pathophysiologic circumstances.

Animals↗