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[Outcome of 470 pregnancies after artificial insemination with frozen sperm].

UNLABELLED: This article describes the outcome of the pregnancies conceived after AID with frozen semen in the Tours CECOS Centre between January 1st 1988 and December 31st 1986. There were 487 (including multiple pregnancies). These have been compared with a control group and with the national study conducted by INSERM in 1981. The study of the literature allows comparisons. The rate of pregnancies not resulting in a living child is not significantly different from the control series (abortions 11.4%, ectopic pregnancies 1% and in utero fetal deaths 0.4%). Pregnancies that continued: the rate of multiple pregnancies was higher (2.7%). There were more cases of bleeding (6.8% compared with 2.4%), more hypertensions (13.3% compared with 11.6%) and the same rate of premature labour (9.4%) as in the control group. The Caesarean section rate (22% as against 6%) was higher. The rate of forcepts delivery was lower (9.2% as against 12.8%). Concerning the children we found more premature babies (15.8% versus 5.6%) but no difference in the sex ratio, their height-weight as against their term, their Apgar score, morbidity or number or type of malformations (3.4%). IN CONCLUSION: the quality of the children is about the same with the proviso that the group is too small to conclude about the incidence of chromosomal abnormalities.

Abortion, Spontaneous↗

[AIDS: is it an indication for artificial insemination with anonymous donor sperm?].

Such demands raise difficulties, as the physician has to consider (and has to be the defender of) the coming child. A thorough psychological investigation must be conducted, as the couple's motives and those of each partner considered separately are not necessarily in agreement. Most important for the couple are the persistence of common projects and the strengthening of the bonds. The husband wants to survive through a child, to give an ultimate present and to increase the chance of keeping his partner. The wife shows her faithfulness and diminishes her partner's guilt feelings. She is, anyway, in a difficult situation if trying not to become pregnant, especially if she had already expressed a wish for maternity in normal circumstances. Unconscious mechanisms can intervene, such as fantasmatic adultery (through IAD) which reequilibrates the couple: the husband who brought the HIV has to be forgiven, or punished. Also, and most importantly, one has to analyze the prospects for the child, who is at risk of loosing his father, and also his mother: a later transmission of the virus to her cannot be excluded. The child will be confronted by illness and death of his father, and by heavy family secrets. The attitude of the medical team remains problematic: no clearcut attitude prevails.

Acquired Immunodeficiency Syndrome↗

[A psychological study, using interviews and projective tests, of patients seeking anonymous donor artificial insemination].

A Thematic Aperception Test was used with 13 male and 16 female patients who were requesting A.I.D. The following main psychological reactions were found in women: anxiety and depression (fear of rejection by their family and friends; lowering the image of the husband--the donor being considered as a rival), aggression (the narcissistic woman "demands" A.I.D.; the donor is esteemed highly); mother is protective ("true" paternity comes through love of the child and the need to forget the donor). They found, in men: an inability to abandon fertility as lost (with denial of sterility); ambivalence, castration anxiety and a feeling of being excluded from the mother-child symbiosis with later acceptance of loss of fertility and (sometimes excessively) identification with the "mother". Most subjects studied were not intending telling the child about his true origin; because disclosure would be tantamount to transgressing twice over the laws of paternity and the rules against Oedipus behaviour. There is often a great difference between the ways the partners view the matter and inter-relate. We strongly recommend that psychological advice should be taken before treatment with A.I.D. is started.

Aggression↗

[Results of conjugal artificial insemination using Percoll].

Selection of spermatozoa on Percoll's medium has enabled to obtain 33 pregnancies in 217 couples. This simple and inexpensive technique, which is most successful during the first nine months, deserves to be attempted, in case of deficient sperm, before contemplating more complex techniques.

Adult↗

[Control of fertility outcome in artificially inseminated gilts and old sows. 2: Addition of oxytocin to boar semen. Its effect on length of insemination, pregnancy rate and litter size].

Toleration-oriented insemination was applied to 1,373 oestrous sows that had undergone bio-engineering treatment, with two insemination portions having been used for each oestrous. Five International Units of oxytocin were added immediately before insemination proper to the semen applied to 315 gilts and 377 old sows. The control group included 296 gilts and 385 old sows inseminated in parallel. Semen intake, on average, was complete between four and eight minutes with the majority of gilts and between four and seven minutes with most of the old sows, but no evidence was obtained as to any action of the oxytoxin upon intake intensity. The treated gilts were superior to the controls by 6.3 per cent in pregnancy rate and by 56 born piglets to each 100 first inseminations. Superiority, consequently, was significant. In both gilts and old sows added oxytocin prolonged insemination by more than five minutes and gave clearly better fertility results.

Age Factors↗