Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Hydroxides”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,063 records · Page 59Linked to original sources
PubMed1977

Studies on the antigenicity of an inactivated, aluminum hydroxide adjuvant equine influenza vaccine.

An inactivated, aluminum hydroxide adjuvant equine influenza vaccine was tested in horses and guinea pigs to determine the levels of antigen that would elicit maximum serological responses. Vaccine containing serial twofold increments of A/Equi-1/Prague and A/Equi-2/Miami strains of equine influenza virus was administered to random groupings of both types of test animals. The hemagglutination inhibition antibody response for each group was then measured. Results in horses and guinea pigs were compared to determine if the equine serological values could be related to a potency test in laboratory animals. The highest mean hemagglutination inhibition antibody response in horses occurred in groups vaccinated, respectively, with 128 or 256 hemagglutination units of A/Equi-1 and 512 or 1024 hemagglutination units of A/Equi-2 antigen. Groups vaccinated with further two- or fourfold increases in these antigens had mean hemagglutination inhibition titers that were somewhat lower than the maximum levels. When graded doses of vaccine were given to guinea pigs, their hemagglutination inhibition antibody titers reached a plateau of maximum values, similar to the serological response in vaccinated horses. Test horses remained clinically free from signs of equine influenza during the year following vaccination and no untoward post-vaccination reactions were observed.

Adjuvants, Immunologic↗
PubMed1990

[Penetration of calcium hydroxide based cements by dental enamel conditioning acids].

It was verified the penetration of phosphoric acid into 3 commercial calcium hydroxide-based cements (Life, Renew and Prisma VLC Dycal). The colorimetric method employed permitted the identidication of phosphorus amount in representative samples of 6 successive layers 0.1 mm thick of each material. The acid etching used were the commercial products Scotchbond Etching Gel--3M at 36.114% by weight and Solução Condicionadora--Johnson & Johnson at 36.054% by weight. The contact time was 60 seconds. The result showed that layers 0.1 mm tick for Life and Prisma VLC Dycal and 0.2 mm thick for Renew were able to block the penetration of phosphoric acid solution whereas layers 0.1 mm thick for the 3 cements were able to block the penetration of phosphoric acid gel.

Acid Etching, Dental↗
PubMed1990

[Effect of adhesive composite resin on pulp and capping of pulp with calcium hydroxide base (Dycal) in deciduous teeth of young dogs].

This study was designed to investigate the effect of adhesive composite resin (Clearfil SC Bond) on dental pulp and the effect of calcium hydroxide base (Dycal) on the protection of the pulp, using 66 deciduous teeth of young dogs. After forming a cavity (class 5) on the labial aspect in each tooth, the teeth were divided by the modes of plugging into 4 groups; stopping alone (Group S), stopping and capping with Dycal (Group D+S), capping with Dycal and resin (Group D+R) and capping with resin alone (Group R). After decalcification, the specimen was embedded in celloidin, sliced into thin sections and stained with hematoxylin and eosin for histopathological examination. Histological changes were examined at 3 days, 1 week, 2 weeks and 4 weeks. The following are the results obtained. 1. In Group S, slight histological changes were observed at 3 days and 1 week. However, the changes began to diminish after the 2nd week and disappeared in the 4th week. 2. In Group R, the severest histological changes persisted throughout the course of observation. The changes were not diminished even in the 4th week. Thus, the resin seemed to exert a strong and long-lasting stimulative effect against the pulp. 3. In Group D+S and D+R, the histological changes were more serve at 3 days and 1 week compared to those found in Group S, but these were diminished after the 2nd week. This seemed to suggest that the pulp was stimulated to a certain degree by Dycal but also, Dycal protected the pulp from stimulation of the resin. 4. Capping of the pulp seemed necessary in vital teeth with resin restoration.

Animals↗
PubMedDate not supplied

[Study of some physical and biological properties of an endodontic sealer composed of calcium hydroxide].

The authors present a study of the physical and biological properties of a new endodontic cement known as Sealapex. In its composition the presence of calcium hydroxide is introduced in order to induce calcification of the periapical tissue. Our results using glass round cover slips implanted on the subcutaneous tissue of mice indicated a persistent foreign body reaction (60 days). The physical properties studied compared to N-Rickert ciment indicated, a decreased leakage. Adhesivity tests didn't give us significant values. Laboratorial studies and clinical trials are necessary to a complete acceptance of this new ciment in endodontic treatment.

Animals↗
PubMed1990

Evaluation of the maternal and developmental toxicity of aluminum from high doses of aluminum hydroxide in rats.

The potential of aluminum hydroxide [Al (OH)3] to induce developmental toxicity in rats was evaluated in the present study. Al (OH)3 was given by gavage at dose levels of 192, 384, and 768 mg/kg/day to groups of pregnant rats from day 6 through day 15 of gestation. Control animals received distilled water. Pregnant rats were evaluated for body weight, weight gain, food consumption, appearance, behavior and reproduction data. Cesarean sections were performed on gestation day 20, and the fetuses were removed for teratological evaluation. No significant maternal or developmental toxicity was observed at any Al (OH)3 dose level. Consequently, the no-observed-effect level (NOEL) for Al(OH)3 maternal or developmental toxicity would be greater than or equal to 768 mg/kg/day, which was the highest dose tested. This dose would be equivalent to a 60 kg person ingesting 16 g Al/day.

Aluminum Hydroxide↗
PubMed1990

[Root canal obturation based on Sealapex calcium hydroxide. A clinical and radiological follow-up after 1 year].

To assess the efficiency of a calcium hydroxide containing root canal sealer (Sealapex), 227 obturated canals were examined clinically and radiologically after one year. When compared to a previously published study (Verdon & Holz 1988), the results show a decline of radiopacity within the canals and an almost complete resorption of the cement overfillings. It was also noted a slight improvement in the radiologic appearance of the periapical lesions.

Calcium Hydroxide↗
PubMedDate not supplied

[Use of calcium hydroxide in the treatment of pulpitis by extirpation under analgesia].

The study included 48 cases of pulpitis grade II of one-root teeth in 42 patients of either sex aged 21-35 years treated by pulp extirpation under analgesia with immediate filling of canals. In 28 teeth Biopulp was used as an intercalated substance between the periapical tissues and the material filling the canal. The control group comprised 20 teeth filled only with Endomethasone paste. The observations made immediately after filling and clinical-radiological control examination after from 6 months to 3 years showed a high usefulness of calcium hydroxide. Good results were achieved in 100% of cases while in the control group in 70% of cases.

Administration, Topical↗
PubMed1989

Pulpal tissue changes following pulpotomies with formocresol, glutaraldehyde-calcium hydroxide, glutaraldehyde-zinc oxide eugenol pastes in primary teeth.

Pulpal tissue changes following pulpotomies with formocresol, glutaraldehyde-calcium hydroxide and glutaraldehyde-zinc oxide eugenol pastes in primary teeth were investigated for a period of 12 months. Compared with the other groups, clinical, radiographic and histologic examinations revealed glutaraldehyde-zinc oxide eugenol combination had a higher success rate.

Aldehydes↗
PubMed1978

Preparation and laboratory testing of plain and aluminum hydroxide-adsorbed cholera vaccines used in a field trial in Indonesia.

TWO TYPES OF CHOLERA VACCINE WERE PREPARED: a plain vaccine and an aluminium hydroxide-adsorbed vaccine, by using the Inaba NIH 35A3 and Ogawa NIH 41 serotypes of Vibrio cholerae. For cultivation, a solid medium was used and the cultures were inactivated with 0.02% thiomersal and by heating for 1 hour at 56 degrees C. The final vibrio concentration of the vaccines was adjusted to 16 x 10(9) vibrios/ml (equal proportions of the two serotypes). The antigenicity of the vaccines was assessed by the active mouse protection test and by the antibody production test, i.e. by determinating the vibriocidal antibodies in the sera of immunized mice. The results of the active mouse protection test showed that the antigenicity of the Inaba and Ogawa components of both vaccines met the WHO Requirements. The antigenicity of the Inaba component of both vaccines was about the same. The antigenicity of the Ogawa component of the plain vaccine appeared to be somewhat higher than that of the adsorbed vaccine. In the antibody production test, the adsorbed vaccine elicited a higher and longer-lasting immune response than the plain vaccine.

Adjuvants, Immunologic↗
PubMed1987

Induction of intestinal metaplasia in rats by N-ethyl-N'-nitro-N-nitrosoguanidine but not by sodium hydroxide.

Intestinal metaplasia (IM) in the glandular stomach of male Wistar rats induced by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and/or intubation of 0.1N sodium hydroxide (NaOH) was studied as follows. Experiment I, sequential study: Rats in group I were given 100 micrograms/ml ENNG in drinking water for 12 weeks. Rats in group II were given 5 ml of 0.1N NaOH by gastric intubation once a week for 12 weeks. Group III control rats were given tap water. Rats were killed from week 1 until week 69 sequentially. IM was first found at week 26 in group I and at week 58 in groups II and III, its incidence being significantly higher in group I than in the other two groups (P less than 0.01), but without any difference between group II and group III. Experiment II, two-stage carcinogenesis: Rats in groups I and II were treated in the same way as in experiment I, while rats in group III were given 100 micrograms/ml ENNG for 12 weeks, followed by 0.1N NaOH once a week for 12 weeks intragastrically. All rats were killed at week 56. The numbers of metaplastic glands in groups I and III were higher than in group II. Gastric carcinomas were induced in all groups of rats treated with ENNG. The results of these two experiments show that IM is effectively induced by a carcinogen but is not enhanced by regeneration induced by alkaline treatment.

Aging↗
PubMed1977

Controlled trials of aluminum hydroxide gels for peptic ulcer.

Relief of duodenal ulcer pain by aluminum hydroxide gel (AG) was compared with that obtained by a dummy gel (DG) in randomized trials. In 44 individual pain episodes, complete relief was obtained by 15-ml doses of AG in 79% and by DG in 45% (P less than 0.05). In 48 identical blind trials replicated at another hospital the difference was not significant. The gels were also tested against ulcer pain induced by intragastric acid instillation (Palmer test) in 35 patients; pain was relieved by AG in 63% and by DG in 62%. Presumed effectiveness in terminating ulcer episodes was studied in 65 patients admitted for pain; 37 received milk and cream hourly and 28 did not. All were treated with 15 ml of AG or DG during waking hours. Median time for complete disappearance of spontaneous pain was 3 days for AG and 7 days for DG, the same in both groups. In all patients the acid instillation test was repeated every few days. For the milk and cream group it became negative after 4 days with AG and after 6 days with DG. In 18 patients with gastric ulcer treated for 4 weeks AG led to greater reductions in size than did DG. A number of these trials indicate AG to be more effective than DG, but sampling and other methodological problems limit the certainty of any conclusions.

Aluminum Hydroxide↗
PubMed1987

[Treatment of wheat straw with urea, calcium hydroxide or ammonium sulfate].

An experiment was conducted to evaluate the effectiveness of urea, ammonia sulphate or calcium hydroxide, in improving the nutritive value of wheat straw for ruminant feeding. Wheat straw was treated with each of three solutions (w/w) containing: 5% urea - 50% H2O (5U); 2% urea - 2% CaOH - 50% H2O (2U), or 5% ammonia sulphate - 2% CaOH - 50% H2O (5S). The treated straw was then ensiled in triplicate in sealed polyethylene bags for 30 days at ambient temperature (15-22 degrees C), except for the untreated straw, which was used as control (T). All treatments were then subjected to the following determinations: pH, moisture, crude protein, ammonia N, ashes, cellular walls, hemicellulose, cellulose, lignin, silica, gross energy, and dry matter in vitro digestibility. The pH value of the 5U treatment was higher (p less than 0.01) than that of 2U and 5S, and the moisture percentage increased in all treated straws, as compared to the control. Both crude protein and ammonia N contents were higher in the 5U treated straws (14.66; 0.6%), 2U (6.41; 75%), 5S (9.54; 94%) in comparison with T (2.63; 50%). The ash percentage increased significantly in 2U and 5S (p less than 0.01) in relation to T and 5U, and the cellular wall content decreased in the 5U, 2U and 5S treated straws, as did cellulose. Gross energy values were higher in the treated straws, and the dry matter per cent digestibility was also higher, although not in a significant degree (p less then 0.01) in the 5% urea-treated straw (45.03) than in 2U (42.43), 5S (34.82), and T (42.36).(ABSTRACT TRUNCATED AT 250 WORDS)

Ammonium Sulfate↗
PubMedDate not supplied

Immunity induced with an aluminum hydroxide-adsorbed Mycoplasma gallisepticum bacterin in chickens.

The protective effect of an inactivated Mycoplasma gallisepticum (MG) bacterin was evaluated in chickens subsequently challenged intratracheally (IT) with the homologous strain. Antibody responses in sera and tracheal washings (TWs) from these chickens were determined by an enzyme-linked immunosorbent assay. A group of chickens was vaccinated intramuscularly (IM) with two doses of the bacterin containing aluminum hydroxide gel (IM + IM). Another group was vaccinated IM with the same bacterin followed by IT with bacterin lacking the adjuvant (IM + IT). Chickens of both vaccinated groups had similar levels of antibody in TWs at the time of challenge. MG was eliminated from the trachea at higher rates and inflammatory lesions in the trachea were less severe in vaccinated chickens than in unvaccinated controls. The protective effect in chickens vaccinated IM + IT was greater than that in chickens vaccinated IM + IM. Perhaps vaccinal immunity is mediated by local rather than systemic antibody responses, or perhaps resistance provided by vaccination IM + IT is conferred partly by another immune mechanism such as cell-mediated immunity.

Adsorption↗
PubMed1978

A controlled field trial of plain and aluminium hydroxide-adsorbed cholera vaccines in Surabaya, Indonesia, during 1973--75.

A controlled field trial comparing the effectiveness of a plain cholera vaccine with that of a vaccine adsorbed to aluminium hydroxide was carried out in a cholera-endemic area of Indonesia during 1973-75. Tetanus toxoid adsorbed to aluminium phosphate was used as the control. In vaccinees aged 1-4 years, the adsorbed cholera vaccine provided about 88% protection for 6 months following vaccination and still provided about 50% protection between 11 and 14 months after vaccination. In the same age group, the plain vaccine provided only 53% protection during the first 6 months and no appreciable protection beyond that period. In those aged 5 years and over, both vaccines provided 50-60% protection throughout the period of observation (14 months). Neither vaccine caused any serious side effects.

Adjuvants, Immunologic↗
PubMed1985

Augmentin bioavailability following cimetidine, aluminum hydroxide and milk.

Previous studies [Jackson et al. 1980] have shown that the bioavailability of Augmentin is not affected by food. The present work has shown that aluminum hydroxide, milk and cimetidine do have some influence on the bioavailability of a single dose of oral Augmentin, but the small differences observed are unlikely to be of therapeutic importance. It is concluded that Augmentin may be administered in clinical practice with any of these substances.

Administration, Oral↗
PubMed1979

[Cutaneous foreign body granulomas caused by aluminium-hydroxid after desensitization with h Mischpollen-Depotallergen (author's transl)].

Report on a 16 years old female patient suffering from pollinosis and asthma. After desensitization with Mischpollen-Depotallergen foreign body granulomas developed in the injection areas. By fluorescence histochemical examination aluminiumhydroxid was found as cause. The increasing possibility of this side effect by more frequent employment of aluminium-hydroxid, for example in the production of vaccine, is directed on.

Adolescent↗