Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “HEMOSTASIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,063 records · Page 59Linked to original sources
PubMed1990

[Effect of therapeutic plasmapheresis on the system of hemostasis in patients with chronic glomerulonephritis].

Coagulative and thrombocytic hemostasis as well as the fibrinolytic system were studied in 20 patients with chronic glomerulonephritis on plasmapheresis (PA). It is shown that PA promotes activation of platelet aggregation which can be related to their contact activation. Coagulation enhances, antithrombic potential reduces, fibrinogen is mechanically removed as well as fibrin-monomer soluble complexes, fibrin degradation products. In view of the importance of the fibrinolytic system in chronic glomerulonephritis, measures should be taken to correct the disturbances detected.

Adolescent↗
PubMedDate not supplied

[State of the hemostasis system in patients with malignant III-stage neoplasms of the maxilla and larynx].

Hemostasis of patients with III stage malignant neoplasms of the maxilla and larynx was investigated. We examined 40 patients, 8 of which had maxillary tumor and 32 had laryngeal tumor. The age of the patients varied from 44 to 68 years. It was found that the patients with malignant neoplasms of the maxilla and larynx had hemostatic disorders which formed the thrombohemorrhagic syndrome. During the surgical intervention they displayed the hypocoagulation phase of the syndrome, which indicated the most dangerous prethrombotic state of the blood system.

Adult↗
PubMed1990

[Microtests for evaluating hemostasis and their clinical value].

A system of microtests, adapted for pediatric practice, has been developed, tested, and proposed for practical use. The system includes 13 microtests, 4 of them meet the requirements of a rapid diagnostic test, the others are used as differentiating and specifying. For the first time three levels of the coagulation status have been distinguished in the newborn: physiologic, border and pathologic; this enables orientation in hemorrhagic and thrombohemorrhagic diseases in the newborn. On the basis of the unified microtests the authors have determined the tactics in early diagnosis and follow-up of newborns suffering from hemorrhage treated outpatiently. The diagnosis was verified under dispensary conditions in 158 (66.6%) children with hemorrhagic diathesis. The results of the investigations described are promising for further improvement of the diagnosis and treatment of hemostasis disorders in newborns with the use of the microtests of new generation.

Blood Coagulation↗
PubMed1990

[Changes in hemostasis as one of the paraneoplastic manifestations].

Derangements of hemostasis and hemocoagulation in patients with malignancies are known as paraneoplastic syndrome. Their origin, however, has not been unequivocally established and explained, and data on their occurrence are controversial. Examination of 157 patients with different malignant tumor diseases yielded pathological laboratory findings in 94.2%. The most frequent finding was the state of hypercoagulation in 41.0%; hypercompensated syndrome of disseminated intravascular blood clotting (DIC) was found in 10.9%, compensated DIC syndrome in 18.0%, consumptive coagulopathy in 3.8%, and in 19.2% hypocoagulation state caused by other abnormalities. The laboratory finding was normal only in 5.8% of the patients. In the light of the high occurrence rate of hemostatic and hemocoagulation changes in malignant diseases, established by laboratory analysis, the use of anticoagulants and antiaggregation substances appears to be justified in the majority of cases, both to prevent the development of these changes which may complicate the course of the malignant condition, and in preoperative care to reduce the rate of postoperative thromboses in patients with tumors.

Blood Coagulation↗
PubMed1990

[Endoscopic hemostasis in hemorrhagic peptic ulcer. A review and pilot study of local thrombin injection combined with systemic fibrinolysis inhibition (with tranexamic acid)].

Today, most upper GI-haemorrhages can be handled without surgery. We discuss the available endoscopic haemostatic methods. Injection therapy seems to be as effective as laser-, heater probe- and bipolar electrocoagulation, and is often preferred because the equipment is inexpensive. In a pilot study of 37 patients with haemorrhage from peptic ulcer (13 with active bleeding and 24 with stigmata of recent hemorrhage) we injected thrombin in the ulcer base and treated the patients systemically with an antifibrinolytic drug (tranexamic acid) for five days. Endoscopic follow-up revealed stigmata of recent haemorrhage in 23 patients on day 1 and in eight patients on day 5. "Blood in stomach" was seen in eight patients on day 1 and in two patients on day 5. Four patients had clinical signs of rebleeding, but only one of them needed operation (definite hemostasis 97%). There were no obvious side effects of the treatment. Contrary to other endoscopic methods, local injection of thrombin does not damage the normal mucosa. However, the method has not been sufficiently explored as yet, and cannot be recommended without strict control and follow-up measures. Early control endoscopy seems to be a sensitive way of monitoring haemostasis.

Cyclohexanecarboxylic Acids↗
PubMed1985

[The effect of selected drugs on the interpretation of hemostasis- related study results].

By applying in vitro and additional in vivo investigations of analysing coagulation in human beings with the routine methods TPZW, PTT and TZ it was possible to exclude influences of hemostasis described in literature and often uncritically generalised in papers and articles as well as assumed influences for such medicaments as acetylsalicylic acid, ascorbic acid, chlorpromazine, fluphenazine, gentamycin, haloperidol, lincomycin, methyldopa, sodium fluoride and penicillin G in therapeutic doses or concentrations in vitro respectively which correspond to therapeutic or toxic doses. For such solutions of infusion as infucoll 6% and gelafusal there exist these influences in the sense of an acceleration of coagulation in vitro. They can be regarded as shiftings within the normal range of methods which have no clinical relevance. Infucoll M 40 will to a concentration of 0.25 mmol/l of blood which corresponds to therapeutic conditions, to a shortening of Tz falling below the normal range of the method. These findings correlate with data in literature and could be identified even in lower concentrations by excluding the effect of dilution. According to literature these relations are identical with those in vivo some minutes after infusion.

Adult↗
PubMed1989

[Changes in the platelet-vascular system of hemostasis in patients with ischemic heart disease and hypertension after the treatment].

The status of platelet aggregability, cyclic nucleotides and the thromboxane-prostacyclin system was examined in 40 patients with Functional Class II-III angina pectoris treated with perdipine, a calcium antagonist, and in 40 patients with Stage II hypertensive disease treated with tenolol, a beta-adrenoblocker. The therapy was found to modify the initially abnormal parameters of platelet-vessel hemostasis both in coronary heart disease and hypertension. When the initial parameters of platelet functional activity were normal, the treatment with perdipine and tenolol caused no noticeable changes.

Adrenergic beta-Antagonists↗
PubMed1989

[Pseudopathology of hemostasis in dental practice].

The authors demonstrate, with a 66 patients research, that also when laboratory tests on hemostasis indicate pathology like XII factor penia, disfibrinogenemy, lupus (Lac), pyastrinopenia, we manage pseudopathology. In these cases haemostasis is completely normal, even after surgery, like tooth extraction.

Adolescent↗
PubMed1989

Hemostasis and cold knife cone biopsy: a prospective randomized trial comparing a suture versus non-suture technique.

Two methods of obtaining hemostasis after cold knife cone biopsy were compared in a prospective randomized trial involving 200 patients. One method relied primarily on hemostatic sutures, and the other involved the use of a styptic solution (Monsel's solution) and vaginal pack, thus avoiding the use of sutures altogether. The short- and long-term morbidity in these two groups were compared and 12-month follow-up was completed. The use of sutures did not reduce the incidence of primary hemorrhage. Secondary hemorrhage was twice as frequent in the suture group, although this trend did not quite reach statistical significance. During long-term follow-up, significantly more patients in the suture group developed menstrual symptoms, cervical stenosis, and unsatisfactory colposcopy, requiring further operative intervention as a result.

Adult↗
PubMedDate not supplied

Endoscopic hemostasis.

The paper is a survey of the methods of perendoscopic hemostasis used in the treatment of bleeding esophageal varices and ulcers. The various procedures used are enumerated and their technical indication, risks, limitations and complications are described. The advantage of the new methods as compared with the classical treatments (conservative or surgical) are pointed out.

Esophageal and Gastric Varices↗
PubMed1989

Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.

Tissue factor (TF), the primary cellular initiator of the coagulation protease cascade, is implicated in having important roles in hemostasis, thrombogenesis, inflammation, and the cellular immune response, although the cytologic distribution of TF in tissues has yet to be described. This study used epitope-defined monoclonal antibodies to human tissue factor for immunohistochemical localization of TF in normal human tissues. TF was selectively expressed in tissues and was associated with cells rather than extracellular matrix. It was anatomically sequestered from blood, being undetectable in endothelium and peripheral blood cells. TF was present in vascular adventitia, organ capsules, epidermis, and mucosal epithelium. Most dermal and submucosal fibroblasts were negative. Except for alveolar macrophages and possibly dendritic cells of some lymphoid follicles, tissue macrophages did not express TF; (expression was demonstrable in LPS stimulated monocytes). Cerebral cortex, renal glomeruli, and cardiac myocytes were additional sites of prominent TF expression. Based on the cellular distribution of TF, it is hypothesized that intravascular initiation of coagulation requires induced expression by intravascular cells, and that the normal distribution of TF represents a hemostatic "envelope" ready to activate coagulation when vascular integrity is disrupted.

Blood Cells↗
PubMed1989

[Clinical significance of disorders of hemostasis in children with chronic pneumonia and mucoviscidosis].

The results of the clinical observations over 127 patients with mucoviscidosis and chronic (primary and secondary) pneumonia are presented. The children were aged from 1 to 15 years. Study of the plasma and platelet links of hemostasis permitted one to reveal considerable disorders seen during exacerbation in all the groups. The intensity of the disorders correlated well with the gravity of the patient's condition and with the bronchopulmonary process spreading as well as with the presence of complications on the part of the cardiovascular system (cor pulmonale) and the hepatobiliary system (liver cirrhosis). The chronic form of the disseminated intravascular coagulation (DIC) syndrome was diagnosed in 50 percent of the patients with mucoviscidosis, in 1/3 of the patients with secondary and in 18 percent of the patients with primary chronic pneumonia. The subacute form of the DIC syndrome was diagnosed in 15 percent of the patients with mucoviscidosis and in 4.5 percent of the patients with secondary chronic pneumonia. The multimodality treatment without heparin made it possible to correct the hemostatic disturbances in the majority of the patients under observation. In some children with mucoviscidosis and secondary chronic pneumonia, the use of heparin in the form of intravenous injections or ultrasonic inhalations permitted making such a correction more rapidly and more completely.

Adolescent↗
PubMed1989

[Changes in thrombocyte-vascular hemostasis and cyclic nucleotide levels after anti-arrhythmia therapy in patients with ischemic heart disease].

Platelet-vascular hemostasis and cyclic nucleotide levels as well as the effects of mexitil, ritmilen and prolecofen on those were examined in 58 coronary patients with various heart rhythm disorders. The patients showed considerably increased platelet activity, low prostacyclin level and high thromboxane and cyclic nucleotides levels, particularly in patients with high-grade ventricular extrasystoles. Mexitil did not essentially affect the parameters in question. Ritmilen produced a significant increase in 6-keto-PGF1 alpha and a decrease of platelet activity. In prolecofen-treated patients, platelet activity decreased significantly, cAMP and cGMP dropped while the cAMP/cGMP ratio went up; prostacyclin and thromboxane changes were not significant. This may be a mechanism of prolecofen's antiarrhythmic action.

Adult↗
PubMed1989

[Rheologic properties of the blood and the system of hemostasis in patients with circulatory encephalopathy treated by hemosorption].

In patients with atherosclerotic encephalopathy (AE) the major indices of blood rheology, hemostasis and its cells' functional state were under investigation. Different patterns of blood rheology changes were detected with increased counts of pathological red blood cells and hypercoagulability. These disorders correlated with the rate of major neurological signs and syndromes, and with the disease stage as well. A multilevel positive effect of hemosorption was shown in different pathogenic links of AE related to disorders in lipid metabolism, blood rheology, shape and functional activity of erythrocytes, shifts in the homeostatic systems. This suggested the use of hemosorption as a tool in prevention of ischemic stroke.

Adult↗
PubMed1989

[Hemostasis and homeostasis].

It has been established as a result of experimental and clinical studies that the phase of hypercoagulation of the DIC syndrome is marked by an appreciable increase of noradrenaline content in blood and tissues whereas the phase of hypocoagulation by a considerable diminution of the substance in blood and tissues. During hypercoagulation of the DIC syndrome, the function of mast cells in the animals' tissues rises. On the contrary, administration of heparin reduces the noradrenaline content in tissues to a considerable degree. All the four prostaglandin groups (A2, B2, F2 and E2) alter the function of the tissue component within the system of regulation of the aggregate state of the blood. At the same time their effect is determined by the specificity of the respective prostaglandin, by exposure, and by the character of the metabolism of the respective tissues. The data obtained provide new evidence in favour of the author's conception that hemostasis is a private case of homeostasis both as regards the biological significance of the process and its common character with respect to the neuroendocrine forms of regulation.

Adrenal Glands↗
PubMedDate not supplied

[Role of carbon dioxide in the correction of coagulation hemostasis during hypoxia].

In acute animal experiments coagulation hemostasis reactions and blood acid-base state were investigated when dogs were breathing hypoxic (10% O2) or hypoxic-hypercapnic (10% O2, 5% CO2) gas mixtures. When given the hypoxic mixture, activation of blood coagulation was accompanied by depression of anti-coagulatory and fibrinolytic properties. These changes developed together with distinct hypoxemia, respiratory alkalosis and secondary metabolic acidosis. When given the hypoxic-hypercapnic mixture, no hypercoagulation occurred which can be explained by higher (than on the hypoxic mixture) paO2, lack of disorders in acid-base equilibrium and in oxygen supply. It is believed that the ability of carbon dioxide to maintain relative normocoagulation when added to the hypoxic mixture is one of the factors that increase tolerance to hypoxia.

Animals↗
PubMed1979

Uncontrollable postpartum bleeding: a new approach to hemostasis through angiographic arterial embolization.

A case of severe postpartum hemorrhage is reported. Three separate surgical procedures failed to reveal the source of bleeding, and standard surgical techniques, including bilateral ligation of the hypogastric arteries, were unsuccessful in producing hemostasis. However, angiography successfully identified the specific bleeding vessel, and transcatheter embolization with Gelfoam fragments quickly and effectively stopped the hemorrhage. The authors consider angiographic embolization to be an effective alternative approach to the control of pelvic hemorrhage and recommend that the technique be considered prior to surgical intervention.

Adult↗
PubMed1986

[Prostacyclin control of thrombocyte-vascular hemostasis in irradiation].

Disorders in prostacyclin control of the functional state of thrombocyte-vascular wall system are associated rather with decreased PGI2 stability in the blood flow, its accelerated decomposition and as a result with its shorter and weaker effect on thrombocyte-vascular hemostasis, than with the decline in PGI2 synthesis. It is suggested that rapid PGI2 decomposition in irradiation may significantly limit its therapeutic effect, requiring adequate correction of PGI2 dosage and mode of administration.

Animals↗