Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Forensic Pathology”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,063 records · Page 59Linked to original sources

[Fibrous osteodysplasia in forensic medicine traumatology].

Histo- and ultrastructure of pathologically changed bone tissue in fibrous dysplasia was under study (9 cases were analyzed). Histologically a fibrous dysplasia focus is represented by cellular fibrous osteogenic tissue with scanty primitive coarse-fibrous bone structures. Ultrastructural changes evidence that these structures are formed at the edge of previous bone beams. Inadequate intraperiod fine structure of collagen fibrils does not provide a strong connection between hydroxyapatite crystals. These shifts result in functional inadequacy of bone tissue in fibrous dysplasia, that should be taken into consideration when assessing the severity of injury to osseous organs.

Adolescent↗

Characteristics of gunshot wounds in the skull.

The analysis of trauma to the skeleton is an important aspect of forensic case work, but most pathology references devote limited attention to this topic. This paper describes various aspects of gunshot wounds, including entrance and exit patterns, angle and path, range of fire and velocity, and caliber of the bullet, based on observations of a series of known cases. Skeletal remains of 21 victims of gunshot wounds were studied. In most cases, there was documentation of the investigation, autopsy, and victim's identity. Each case was analyzed in terms of wound location, shape, size and exit/entry surface area ratio, beveling, and direction of shooting Skull entry wounds were most often round or oval. Unusual shapes were observed in bones like the mandible and mastoid process, but were also found to be triangular, nearly rectangular or irregular. Tunneling was observed in the mastoid process. The expected internal beveling was obvious in all but one skull. External beveling of an entry wound was only observed in one case (parietal bone). Exit wounds were roughly round, oval, square, and rectangular and were always more irregular than entry wounds. External beveling of exit wounds was observed in most vault bones, but there was none in the orbit, maxilla, greater wing of the sphenoid, temporal, or left occipital bone. Tangential gunshot wounds were seen in a mastoid process, zygomatic process, mandibular ramus and condyle, and occipital condyle. Most of the exit to entry surface area ratios (cm2) varied from 1.4 to 2.0. In four cases the ratio indicated that entrances were larger than exists. In conclusion, understanding of gunshot wound characteristics is an important matter to interpret distance, velocity, direction and sometimes caliber size. Assessment of this nature of gunshot wounds helps reconstruct events surrounding the death.

Adolescent↗

Bibliography of scanning electron microscopy application in Forensic Medicine.

The following bibliography of SEM - Application is largely oriented to medicolegal studies. Avoiding overlappings with criminalistic research papers were not always possible because the objects of inquiry as well as the forensic questions often are identical, such as investigations on hair or gunshot analyses. One important aspect could not be considered by us: the contact of principal medicolegal problems with those pathological, for example in structural changes of vessels after traumatization (Forensic Medicine: vital reaction - Pathology: thrombosis, hemostasis, wound healing). Publications have not been selected with regard to their relevance. Finally we have listed the problems and methods researched.

Bibliographies as Topic↗

[On the development of the skin of the digital pulp in the early fetal period (author's transl)].

The skin of the digital pulp is of pathologic as well as of forensic interest. Investigations were made with the scanning electron microscope on the fingers of 27 fetuses to get a new insight into the development of this part of the skin. The formation of the peridermal cells is already striking in this region in the early fetal period. A certain grouping together of these peridermal cells appears to resemble the later developed epidermal ridge. The dermatoglyphics are fully developed by the end of the second trimenon. A more exact time sequence cannot be established due to fluxional transitions and, particularly, to marked individual veriations.

Fingers↗

Traumatic rupture of the aorta.

The aim of this study was to determine the incidence and mortality from traumatic ruptures of thoracic aortas (TAR) in a well defined population over a 7 year period. The study provides a retrospective analysis of case files of all deaths from road traffic accidents and falls from heights, the usual causes of TAR, filed in the Forensic Medicine Unit of the Pathology Department of the University of Edinburgh, for Lothian and Borders Region. Of the 276 fatal road traffic collisions and falls from heights identified in archival material, 66 traumatic aortic ruptures were found in the period between 1988 and 1994. Only 11% of these patients were alive on arrival to a hospital or an emergency department. To decrease the high mortality rate the following are required: an earlier, more sustained and vigorous, on site resuscitation; efficient screening methods for the diagnosis of TAR in multi-traumatised patients; identification of the specific characteristics of those traumatic episodes which are likely to be associated with a high risk of rupture, and an increase in the number of surgical interventions for ruptured aortas.

Journal Article↗

Paraphilias: phenomenology and classification.

DSM-III incorrectly designates the majority of paraphilias as atypical. Only eight are named, and those because of their forensic history, rather than their pathology and therapeutic need. In this paper, thirty-odd paraphilias are subdivided into six categories on the basis of their phenomenological dynamics. The new concept of the developmental lovemap is introduced for the first time. A new treatment originated by the author in 1966 combines an androgen agonist with counseling therapy.

Combined Modality Therapy↗

[Method for estimating index of coronary arteries patency].

The authors present an original method for evaluating the index of coronary artery patency by perfusion technology. The method is simple, requires no expensive equipment, and effectively diagnoses stenotic processes in coronary arteries. It was tried in cases of sudden cardiac death. The method is intended for forensic medical expert evaluations and for pathology studies.

Algorithms↗

[Autopsy technique and basic legal aspects of autopsy].

Dissection techniques and questions regarding the laws governing autopsy. Autopsy techniques vary. Hamperl's methods, in my opinion, best fulfil the demands of pathology as well as of forensic medicine. In order to obtain more conclusive findings, the dissection of internal organs in several so-called packages, e.g. throat and chest organs and kidneys in the urogenital system, is preferable. Severance of the heart as a means of achieving bloodlessness (Blutleere) should be tolerated only in isolated cases. Some comments on hygienic working methods are in order, not least because of frequent violations in this area. The dignity of the deceased demands hygienic conditions and that the external appearance of the body be reestablished. The removed organs should be returned to the body for burial. Burial should not be used as a means of waste disposal for the institute. The most common and well-known autopsy cases are also dealt with: legal and administrative autopsy. Only forensic autopsy is governed by Para. 87 StPO, albeit incompletely. The definition of the medical examiner is difficult. According to the law on the standardization in Public Health dated 3. 7. 1934 (RGBl. I., p. 531), these tasks should come under the jurisdiction of the health authorities. Since these are not in a position, either from a personnel or material standpoint, to assume these tasks, it is customary, as is the case in the Frankfurt area, for a service contract to be concluded with the director of the institute for forensic medicine. This solution harbours two dangers.(ABSTRACT TRUNCATED AT 250 WORDS)

Autopsy↗

THE BATTERED CHILD SYNDROME. RESPONSIBILITIES OF THE PATHOLOGIST.

A pathologist working in a medical examiner's or coroner's office dealing with the syndrome of the battered child is responsible for performing a complete external examination of the body with careful detailed description of all injuries, supplemented by roentgenograms of the entire skeleton, taken before the autopsy, to determine the existence of old or recent bone injury. The complete autopsy with microscopic studies must include the dissection and microscopic study of the osseous lesions.All findings possibly related to trauma are recorded in diagrams and photographs in color. The pathologist's findings and police reports dealing with the circumstances of the injuries and death must be evaluated with utmost care to determine whether inconsistencies exist in their statements as to the time and the nature of the events associated with the injuries. When confronted with the findings, suspects frequently confess.

Autopsy↗

Cocaine and the heart.

There is increasing evidence that cocaine can have serious adverse effects on the heart. Angina, myocardial infarction, coronary artery spasm, arrhythmia, and sudden death have been reported in association with its use. There have been only two reports of actual myocardial pathology. In an attempt to clarify the pathophysiology of cocaine-associated cardiotoxicity and to search for pathologic changes that might be useful forensically, we reviewed random microscopic sections of hearts from 30 cases of cocaine-associated death seen by the San Francisco Medical Examiner. The age of the patients at death ranged from 25 to 74 years (mean 33.9 years). Pathologic findings included the presence of mild atherosclerotic coronary artery disease without evidence of thrombosis in three cases, associated with mild interstitial fibrosis in one case as well as mild focal myocardial fibrosis without coronary disease in four other cases. The most notable abnormality was the presence of myocardial contraction bands in 28 (93 per cent) cases. In comparison to 20 control cases of death secondary to sedative-hypnotic overdose, the hearts from the cases of cocaine-associated contained significantly more myocardial contraction bands (P less than .001; two-sided). The diffuseness of the contraction bands correlated directly with the level of cocaine found in the urine and blood at autopsy during routine screening. The presence and number of contraction bands in these cases was independent of other drugs found in the urine and blood, the number of sections of myocardium examined, and a history of attempted resuscitation. Contraction bands may act to supply the anatomic substrate for the arrhythmias associated with cocaine use. They may also provide a morphologic marker that can be sought in suspected cases of lethal cocaine overdose. Their presence may also suggest a cause of death in cases of sudden and unexpected death in which autopsy reveals no other pathology, and a drug screen is positive for cocaine.

Cocaine↗

[Forensic and medical aspects of lethality from thromboembolytic complications of trauma, diseases and certain pathological conditions].

A total of 743 lethal outcomes of thromboembolytic complications of trauma, diseases and certain pathological conditions as observed in 1999-2001 and in the three quarters of 2002 were studied. The undertaken analysis confirmed two factors provoking the pathological thrombosis, i.e. 1. Pathological changes observed in the surface vascular wall preconditioned by mechanical damages, atherosclerotic process and aging; and 2. A slower blood flow due to an impaired blood circulation, a forced positioning and to hypodynamics. While deciding on a possibility of a direct cause-effect relation between past traumas, surgeries, poisonings and death of thromboembolism of the pulmonary arteries (TEPA), such relation can be mentioned only on rare occasions. It is more often the case that an indirect, mediated relationship is found, when TERA evolves due to an unfavorable combination of risk factors, i.e. a forced immobility, changing coagulated blood system, impaired blood vessels etc.

Adolescent↗

The pathological features and circumstances of death of lethal crush/traumatic asphyxia in adults--a 25-year study.

A 25-year retrospective study of cases of crush/traumatic asphyxia autopsied at Forensic Science SA, Adelaide, Australia from 1980 to 2004 was undertaken. A total of 79 cases of crush asphyxia was found consisting of 63 males (80%) and 16 females (20%). The age range of the males was 19-86 years (mean=41.8 years) and of the females was 19-75 years (mean=38.6 years). In 18 cases the exact circumstances of death were unclear, leaving 61 cases in which details of the fatal episode were available. Major categories included vehicle crashes (N=37), industrial accidents (N=9), farm accidents (N=6) and entrapment beneath vehicles (N=5). Forty of the 79 victims (51%) had only very minor bruises and abrasions; 28 (35%) had evidence of chest compression with rib and sternal fractures and large areas of soft tissue bruising of the chest; 7 cases (9%) had other significant injuries or findings that had contributed to death. All of these victims had signs of crush asphyxia in the form of intense purple congestion and swelling of the face and neck, and/or petechial hemorrhages of the skin of the face and/or conjunctivae. The pattern of pathological findings of crush asphyxia was not influenced by the presence or absence of concomitant serious or lethal injuries. In 4 cases (5%) where the circumstances of the lethal episode were those of crush asphyxia there were no characteristic pathological findings. This study has shown that a high percentage of crush asphyxias may be caused by vehicle accidents. It has also demonstrated that on occasion fatal crush asphyxia may have to be a diagnosis of exclusion, made only when there are characteristic death scene findings, and no evidence of lethal natural diseases or injuries at autopsy, with negative toxicological screening.

Adult↗

[Traumatic heart rupture or infarct?].

A 70-year-old motorist driving on the wrong side of the road caused a car-to-car head-on collision and died some minutes later. The autopsy revealed a lethal rupture of the right heart ventricle. The insurance company argued that driving on the wrong side was an act of gross negligence so that the damage was not covered by the full comprehensive insurance. Surprisingly, the microscopic examination of the myocardium performed by a clinical pathologist brought to light a severe myofibrillar degeneration (MFD) which was interpreted as diagnostic of acute myocardial infarction. It was supposed that this could have caused an incapacity of the driver to control his car, which in turn would commit the insurance to payment. A critical re-evaluation of the heart tissue material, however, revealed the pattern of trauma-induced hypercontraction banding of the myocardium along the cleft edges but no findings suggestive of myocardial infarction. Thus, the accident was not the result of a cardiac attack. But there was a severe preexisting pathology including cardiac hypertrophy, scarring of the myocardium, siderophages of the lungs, and an infarction of the pons, so that a cerebral dysfunction was the most plausible explanation for the accident. Thus, gross negligence had to be denied, and the insurance company was obliged to pay. This observation points to the existence of two different variants of MFD: Clinical pathologists are familiar with "tyical" MFD occurring in reperfusion after ischemia, in catecholamine toxicity, and around infarct necroses. But hypercontraction banding, regularly found along penetrating heart lesions and well known to forensic pathologists, is uncommon in clinical pathology.

Accidents, Traffic↗