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Differential baroreflex control of heart rate in sedentary and aerobically fit individuals.

PURPOSE: We compared arterial, aortic, and carotid-cardiac baroreflex sensitivity in eight average fit (maximal oxygen uptake, VO2max = 42.2+/-1.9 mL x kg(-1) x min(-1)) and eight high fit (VO2max = 61.9+/-2.2 mL x kg(-1) x min(-1)) healthy young adults. METHODS: Arterial and aortic (ABR) baroreflex functions were assessed utilizing hypo- and hyper-tensive challenges induced by graded bolus injections of sodium nitroprusside (SN) and phenylephrine (PE), respectively. Carotid baroreflex (CBR) sensitivity was determined using ramped 5-s pulses of both pressure and suction delivered to the carotid sinus via a neck chamber collar, independent of drug administration. RESULTS: During vasoactive drug injection, mean arterial pressure (MAP) was similarly altered in average fit (AF) and high fit (HF) groups. However, the heart rate (HR) response range of the arterial baroreflex was significantly attenuated (P < 0.05) in HF (31+/-4 beats x min(-1)) compared with AF individuals (46+/-4 beats x min(-1)). When sustained neck suction and pressure were applied to counteract altered carotid sinus pressure during SN and PE administration, isolating the ABR response, the response range remained diminished (P < 0.05) in the HF population (24+/-3 beats x min(-1)) compared with the AF group (41+/-4 beats x min(-1)). During CBR perturbation, the HF (14+/-1 beats-min(-1)) and AF (16+/-1 beats-min(-1)) response ranges were similar. The arterial baroreflex response range was significantly less than the simple sum of the CBR and ABR (HF, 38+/-3 beats x min(-1) and AF, 57+/-4 beats x min(-1)) in both fitness groups. CONCLUSIONS: These data confirm that reductions in arterial-cardiac reflex sensitivity are mediated by diminished ABR function. More importantly, these data suggest that the integrative relationship between the ABR and CBR contributing to arterial baroreflex control of HR is inhibitory in nature and not altered by exercise training.

Baroreflex↗

Running mileage, movement mileage, and fitness in male U.S. Navy recruits.

PURPOSE: The purpose of this study was to determine whether there is a relationship between overall fitness improvement and varying amounts of running and movement mileage. METHODS: Subjects were male U.S. Navy recruits (N = 1703, 25 divisions), ages 17-35 yr (mean age = 20.1 +/- 2.9 yr), who attended boot camp from April 1996 through August 1996. During the first week of training, recruits performed a 1.5-mile run to determine baseline fitness levels. The results from the initial run were compared with a final 1.5-mile run conducted 6 wk later. RESULTS: Based on an age-adjusted fitness scale for a 1.5-mile run time, about one third of the recruits began recruit training in "Excellent-Superior" condition (N = 558), one third began in "Good" condition (N = 582), and one third began in "Poor-Fair" condition (N = 563). Running mileage among divisions ranged from 11.5 to 43.5 miles for the entire 7-wk training period (mean = 22.7 +/- 7.2 miles; 8-22 run days, mean = 13 +/- 4 d). In addition to running, the divisions accumulated many movement miles (110-202 miles; mean = 145 +/- 26 miles) while marching in formation. Recruits who began training in Poor-Fair condition improved the most with an average decrease in run time of 1:55 +/- 1:06 min (15.6% improvement). The Good group improved by 47 +/- 37 s (7.3% improvement), and the Excellent-Superior group improved by 17 +/- 32 s (2.9% improvement). CONCLUSION: The magnitude of fitness improvement, as measured by run time improvement, was directly related to baseline fitness level but not related to movement mileage or high-intensity run mileage accrued during training.

Adolescent↗

Physical fitness and intraocular pressure.

The ability of moderate to intense aerobic exercise to reduce intraocular pressure (IOP) has been reported. Previous studies have focused on a single postexercise recovery period not considering the long-term effect of improved physical fitness on IOP. A total of 32 adult subjects, all having IOP's of greater than 18 mmm Hg in each eye as determined by an American Optical Corporation Non-Contact Tonometer, were selected for the study. After a complete medical and visual evaluation, participants were randomly assigned to either an intervention group (N = 18) receiving a 6-month supervised exercise program to improve physical fitness or into a control group (N = 14). After 6 months, each group was reevaluated to observe changes in physical fitness and IOP. Pre- and poststudy measurements of maximum oxygen uptake (ml/kg/min) made with a Beckman O2 analyzer showed significant improvement in physical fitness in the intervention group (p less than 0.05). There was a significant decrease (p less than 0.05) in IOP, 2.0 mmm Hg in the right eye and 1.3 mm Hg in the left eye, in the intervention group; however, decreases in IOP were comparable and significant (p less than 0.05) in the control group. Results from multiple regression analysis for each individual group and for combined groups indicated that changes in IOP were not dependent upon changes in physical fitness.

Adult↗

Effect of prescribed prism on monocular interpupillary distances and fitting heights for progressive add lenses.

Success in fitting progressive addition lenses is dependent upon the accurate placement of the progressive zone. Both eyes must track simultaneously within the boundary of the progressive corridor. Vertical prism will displace the wearer's lines of sight and consequently eye position. Because fitting heights are measured using an empty frame, subjects with vertical phorias usually will fuse, and not show the vertical differences in pupil heights during the measuring process. Therefore, when prescriptions contain vertical prism one must consider the changes in measured fitting heights that will occur once the lenses are placed in the frame. Fitting heights must be altered approximately 0.3 mm for each vertical prism diopter prescribed. The fitting height adjustment is opposite from the base direction of the prescribed prism. An explanation of the effect of prescribed horizontal prism on monocular interpupillary distance (PD) measurements is also included.

Eye↗

Fitting characteristics of 1-day and 14-day Acuvue disposable contact lenses.

The fitting characteristics of 1-day Acuvue disposable soft contact lenses (SCLs) [base curve (BC) 9.0 mm, diameter 14.2 mm] and 14-day Acuvue disposable SCLa (BC 8.8 mm, diameter 14.0 mm) were evaluated and compared with respect to lens centration and post-blink movement in primary gaze and in upgaze. In this double-blind study 25 successful daily wearers of either the 1-day lens or the 14-day lens with the same parameters were randomly fit with three 1-day lenses and three 14-day lenses for a total of 6 lenses per eye. The lene fit was evaluated 5 min after insertion. Lens centration was assessed by measuring temporal, nasal, superior and inferior limbal coverage, and then comparing the net horizontal centration (temporal minus nasal coverage) and the net vertical centration (superior minus inferior coverage) of the 1-day and 14-day lenses. There was no significant difference between the two lenses in terms of temporal, superior, and inferior limbal coverage (p > 0.05). However, the 1-day lens showed statistically more nasal coverage (p < 0.05). No statistically significant difference in movement or in horizontal and vertical differences in centration were found (p > 0.05). Although our findings indicate a subtle statistical difference in fitting characteristics, clinically the two lenses should provide similar fits.

Adult↗

Are fitness, activity, and fatness associated with health-related quality of life and mood in older persons?

PURPOSE: This study sought to determine whether levels of fitness, habitual physical activity, and fatness are associated health-related quality of life and mood in older persons. METHODS: The subjects were men (n = 38) and women (n = 44), ages 55 to 75 years, who had milder forms of hypertension, but who were otherwise healthy and not engaged in a regular exercise or diet program. Aerobic fitness was assessed by maximal oxygen uptake during treadmill testing, muscle strength by a one-repetition maximum, habitual activity by questionnaire, fatness by dual-energy x-ray absorptiometry, and body mass index. Health-related quality of life was assessed by the Medical Outcomes Study SF-36, and mood by the Profile of Mood States (POMS). Correlations were determined by bivariate and multivariate regression. RESULTS: Higher aerobic fitness was associated with more desirable outcomes, as indicated by the POMS anger and total mood disturbance scores and by the SF-36 bodily pain, physical functioning, vitality, and physical component scores. Increased fatness was associated with less desirable outcomes, as indicated by the POMS anger, depression, and total mood disturbance scores and by the SF-36 bodily pain, physical functioning, role-emotional, role-physical, social functioning, vitality, and physical component scores. Higher physical activity was associated with an increased POMS score for vigor and a decreased SF-36 score for bodily pain. Strength was not related to health-related quality of life or mood. Aerobic fitness was the strongest predictor of the SF-36 score for vitality and the POMS score for total mood disturbance, whereas fatness was the strongest predictor of the POMS anger score and the SF-36 bodily pain, physical functioning, and physical component scores. CONCLUSIONS: Even in the absence of regular exercise and a weight-loss diet, relatively small amounts of routine physical activity within a normal lifestyle, slight increases in fitness, and less body fatness are associated with a better health-related quality of life and mood.

Affect↗

The significance of passive framework fit in implant prosthodontics: current status.

The clinical and laboratory procedures employed for framework fabrication are inadequate to provide an absolute passive fit for implant-supported fixed superstructures. Although some prosthetic complications are attributed to the lack of passive fit, its effect on implant success is questionable. Nevertheless, the clinical results of increasing applications of advanced technology to improve framework fit seem promising. This article reviews the clinical significance of passive fit and the factors that affect the final fit of implant-supported frameworks.

Dental Prosthesis Design↗

Comparison of axial and tangential topographic algorithms for contact lens fitting after LASIK.

PURPOSE: Computerized videokeratography (CVK) has become the standard method for measuring the corneal curvature after refractive surgery. However, few resources exist on the use of CVK data for postoperative contact lens fitting, and no recommendations exist on the selection of the best topographic algorithm relevant to gas-permeable (GP) lens fitting. This study assessed the optimal use of topographic data to fit spherical GP contact lenses on patients who have undergone laser in situ keratomileusis. METHODS: A retrospective analysis of CVK maps from eight post-LASIK eyes fitted with spherical GP lenses was performed in the Contact Lens Service of the Department of Ophthalmology at Case Western Reserve University and University Hospitals of Cleveland. Axial and tangential maps from the Dicon CT 200 (version 3.50) or Humphrey Atlas (version A8) topographer were analyzed. Averaged dioptric curvatures from different locations (inferior, superior, and temporal) at various distances (2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, and 4.0 mm) from the vertex normal of each eye were compared with the base curves of the prescribed GP contact lenses. RESULTS: One-way analysis of variance, Pearson correlation analysis, and paired t tests showed that the best topographic predictors of a successful GP base curve were the average curvatures at the 4.0 mm distance on the axial maps (r=0.8078, P=0.05) and at the 2.0 mm distance on the tangential maps (r=0.9738, P=0.0002). The mean dioptric powers of the GP base curve, axial map 4.0 mm curvature, and tangential map 2.0 mm curvature were 41.50 diopters (D), 42.65 D, and 42.67 D, respectively. CONCLUSION: To simplify and guide GP fitting after LASIK, the average dioptric curvature 4.0 mm from the vertex normal on axial maps or 2.0 mm from the vertex normal on tangential maps are the best predictors of accurate GP base curve selection.

Algorithms↗

The association of health status, worksite fitness center participation, and two measures of productivity.

OBJECTIVES: We sought to examine the associations between participation in a worksite fitness center and worker productivity. METHODS: A modified Work Limitations Questionnaire (WLQ) and employees' short-term disability claims were used as productivity measures with multivariate logistic regression models to control for health risk, age, gender, and work location. RESULTS: Nonparticipants in a worksite fitness center were more likely to report health-related work productivity limitations for time management (odds ratio [OR] = 1.62, 95% confidence interval [CI] = 1.09-2.41), physical work (OR = 1.58, CI = 1.03-2.43), output limitations (OR = 2.24, CI = 1.01-2.12), and overall work impairment (OR = 1.41, CI = 1.00-1.96) than fitness center participants. Fitness center participation also was associated with 1.3 days fewer short-term disability days per year per employee (P = 0.02) and 0.39 fewer health risks (P = 0.01). CONCLUSIONS: These results support the association of worksite fitness center participants with improved worker productivity and fewer short-term disability workdays lost.

Adult↗

Subjective and quantitative assessment of patient fitness for cadaveric kidney transplantation: the "equity penalty".

BACKGROUND: Patient fitness at the time of organ allocation has an impact on graft survival equivalent to the effect of human leukocyte antigen (HLA) matching. The variation between institutions in assessment of fitness is not known, nor is the potential impact on mean graft survival of incorporating patient fitness into local adult cadaveric-kidney transplant-allocation algorithms. METHODS: Data from the Collaborative Transplant Study (CTS, 1985-2000) were reviewed. Quantitative criteria (QC) of patient fitness based on national transplant society guidelines were compared with subjective categorization (SC) of each patient on the current local transplant waiting list (n=109) determined by their supervising nephrologist. RESULTS: Five-year cadaveric graft survival was 70%, 61%, and 53% for good-, moderate-, and poor-risk patients in the CTS data set (n=102, 612), equivalent to half lives of 12.7, 9.8, and 8.7 years, respectively, with similar results from the local program. The distribution of local waiting-list patients into fitness categories A (good), B (moderate), C (poor), and D (unacceptable) was 51%:31%:13%:5% by SC and 25%:40%:27%:8% by QC. At one hospital, 61% (n=51) of patients were classified category A by SC, and falling to 16% by QC (P<.0001). Compared with preferential category A recipient allocation, an unrestricted allocation policy was estimated to sacrifice 1.5 years of overall program-mean graft survival. CONCLUSIONS: Use of QC may reduce the variation in subjective patient assessment seen between institutions. Any proposed changes in organ allocation methods should address the "equity versus efficiency" balance in an open fashion and predict the impact on the overall graft survival for the program by quantifying the "equity penalty."

Adolescent↗

Positive genetic correlation between female preference and offspring fitness.

In many species, females display preferences for extreme male signal traits, but it has not been determined if such preferences evolve as a consequence of females gaining genetic benefits from exercising choice. If females prefer extreme male traits because they indicate male genetic quality that will enhance the fitness of offspring, a genetic correlation will evolve between female preference genes and genes that confer offspring fitness. We show that females of Drosophila serrata prefer extreme male cuticular hydrocarbon (CHC) blends, and that this preference affects offspring fitness. Female preference is positively genetically correlated with offspring fitness, indicating that females have gained genetic benefits from their choice of males. Despite male CHCs experiencing strong sexual selection, the genes underlying attractive CHCs also conferred lower offspring fitness, suggesting a balance between sexual selection and natural selection may have been reached in this population.

Animals↗

Fitness effects on the cognitive function of older adults: a meta-analytic study.

A meta-analytic study was conducted to examine the hypothesis that aerobic fitness training enhances the cognitive vitality of healthy but sedentary older adults. Eighteen intervention studies published between 1966 and 2001 were entered into the analysis. Several theoretically and practically important results were obtained. Most important fitness training was found to have robust but selective benefits for cognition, with the largest fitness-induced benefits occurring for executive-control processes. The magnitude of fitness effects on cognition was also moderated by a number of programmatic and methodological factors, including the length of the fitness-training intervention, the type of the intervention, the duration of training sessions, and the gender of the study participants. The results are discussed in terms of recent neuroscientific and psychological data that indicate cognitive and neural plasticity is maintained throughout the life span.

Aged↗

Improving functional skills and physical fitness in children with Rett syndrome.

BACKGROUND: To investigate the feasibility of a physical exercise programme with treadmill for persons with Rett syndrome (RS) in order to promote fitness and health. METHODS: A daily training programme on a treadmill was designed for four females with RS over a period of 2 months with tests performed in three intervals, at time 1, 2 and 3, 2 months apart with intervention taking place between tests 2 and 3. Participants were four girls with RS aged 8.5-11 years (mean: 10 years) attending the educational facility Beit Issie Shapiro, Raanana, Israel, all with independent mobility and with typical characteristics of RS stage III. The training took place at the educational facility, on a 1400 model treadmill (Trimline, capable of very low speeds < 0.5 k/h), with very long side rails. Special low side rails were adapted to the treadmill in order to fit the height of the children and velcro straps were added to assist in safely placing the hands. Pulse was monitored constantly during exercise by an A3 polar pulse belt. Pulse measurements at rest during training were considered as evaluators of aerobic physical condition. Functional measurement was based on a scale specially established for the present study. The scale was a 31-item motor-functioning tool that measures the ability of participants to knee walk and knee stand, to get up to a standing position, duration of walking different paths, and to go up and down stairs and slopes. RESULTS: The study showed that physical fitness of the children at the end of the training programme had improved considerably (P < 0.05). Tests showed that general functional abilities had improved considerably (P < 0.0001). Although all items of the functional ability measure showed impressive positive change, some of the 31 items on it showed statistically significant improvement (knee walking, going up and down stairs and speed of walking for 25 m. Pearson correlation showed high linkage (r = -0.76) between functional improvement and change in physical fitness. CONCLUSIONS: Physical fitness programme executed on a daily basis is capable of improving functional ability of children with RS. Nonprofessional personnel can execute such a programme under supervision of a qualified physical therapist.

Activities of Daily Living↗

Relationships between physical fitness and risk factors for coronary heart disease in men and women.

The aim of the study was to examine the cross-sectional relationships between physical fitness and risk factors for coronary heart disease (CHD). Measurements were made of fitness (defined as predicted maximal oxygen uptake), blood pressure, total cholesterol, triglycerides, and glucose in 1500 healthy men and women aged 20 to 65 years. After controlling for the effects of age, physique, smoking, alcohol use and stress, by multiple regression analyses, it was found that fitter men had lower blood pressure, cholesterol, and triglycerides than less fit men, and fitter women had lower blood pressure than less fit women. However, these fitness/risk factor relationships were seen as weak trends, probably of minor clinical importance. It is emphasised that such cross-sectional data should not be interpreted as support for the popular claim that people who increase their fitness can expect to improve their CHD risk factor status.

Adult↗

Walking and motoring: fitness and the social organisation of movement.

This essay applies the approach of the relational model to the quotidian modes of contemporary movement, walking and motoring, in order to analyse fitness. The social model of disability provides a tool for de-individualising fitness discourse, as well as for embedding fitness within sociomaterial and cultural contexts. Fitness, or 'being able to', is seen as an outcome of the interpenetrations and interactions of mind-bodies moving within their environments. The analysis indicates that the social model has general relevance for the sociology of health and illness. Here, it is extended beyond the study of disability to encompass fitness. In future, the social model may prove fruitful in the analysis of other socially situated conditions as well.

Automobile Driving↗

Differential fitness returns in relation to spatial position in groups.

1. A general overview of position-related fitness differences in group-living animals is given for the first time. 2. Differential fitness returns in groups are often related to competition for resources among group members due to resource limitation. If resources are very scarce, then competition may finally lead to the disbandment of groups. The encounter-dilution effect predicts that grouping confers a benefit if the conspicuousness of large groups does not outweigh the dilution effect and each predator or parasite attacks only one (or a few) prey per encounter (Uetz & Hieber, 1993). While the encounter-dilution effect limits the number of predators and parasites a group is faced with at a given time, marginal predation and communal defence are probably the most important factors for position-related differences in predation risk. 3. Limitation of resources increases competition between groups members and should widen the gap between fitness returns of dominant and subordinate group members. In some group-living animals such as schooling fish, however, predator pressure has apparently selected for uniformity in morphology and behaviour which presumably restricts the potential for resource competition (Magurran & Seghers, 1991). 4. A general problem of assessing individual fitness returns in that different short-term strategies may achieve the same long term goals (Magurran, 1993). The use of feeding rates and predation risks as currencies for fitness returns over short time periods is therefore questionable and can only be a first step. So far, hardly any information is available on long-term effects of differences in positioning behaviour. 5. Food availability and food intake rates tend to be higher in edge positions, whereas energy expenditure does not differ significantly with group position in non-roosting mobile groups. This suggests that edge positions achieve a higher net-energy pay-off and should therefore be preferred by individuals with low energy reserves. 6. Differential predation risks are well documented for stationary and colony-breeding species, but there is a lack of data for mobile, non-breeding species. The reason for the latter is that predation is rarely observed (in the field) and often difficult to relate to group position in fast-moving species such as flocks of birds. Further studies, especially in the field, are needed. 7. Vigilance rates and attack rates do not necessarily give a true reflection of mortality risk. Vigilance is not exclusively related to predation and can be confounded by competition effects and hunger. Attack rates are difficult to translate into per capita risks if hardly any mortality is observed and therefore little information is available about the ratio of successful attacks/total attacks. 8. Most of the literature up to date consists of descriptive studies. There is a need for experimental work that investigate (a) the influence of predator attack mode on differential predation risks; (b) the influence of internal states (such as hunger) on the tradeoff between predation risk and foraging behaviour and its consequences for the positioning behaviour in groups; (c) the 'egalitarian' nature of groups with respect to group position. Do all individuals continuously rotate positions? Or do dominant individuals monopolize certain positions?, and (d) that separate the effects of nutritional state, vigilance and food availability on feeding rates in different group positions. 9. Reproductive success is often related to group position in breeding colonies and lekking animal species. Females probably prefer the safer territories in the group centre, but more empirical data are required to test this hypothesis. 10. Position-related differences in parasitism rate between group members are well documented with per capita rate of parasitism being lower in the centre of groups than at the periphery.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

A community-based fitness and mobility exercise program for older adults with chronic stroke: a randomized, controlled trial.

OBJECTIVES: To examine the effects of a community-based group exercise program for older individuals with chronic stroke. DESIGN: Prospective, single-blind, randomized, controlled intervention trial. SETTING: Intervention was community-based. Data collection was performed in a research laboratory located in a rehabilitation hospital. PARTICIPANTS: Sixty-three older individuals (aged > or = 50) with chronic stroke (poststroke duration > or = 1 year) who were living in the community. INTERVENTION: Participants were randomized into intervention group (n=32) or control group (n=31). The intervention group underwent a fitness and mobility exercise (FAME) program designed to improve cardiorespiratory fitness, mobility, leg muscle strength, balance, and hip bone mineral density (BMD) (1-hour sessions, three sessions/week, for 19 weeks). The control group underwent a seated upper extremity program. MEASUREMENTS: Cardiorespiratory fitness (maximal oxygen consumption), mobility (6-minute walk test), leg muscle strength (isometric knee extension), balance (Berg Balance Scale), activity and participation (Physical Activity Scale for Individuals with Physical Disabilities), and femoral neck BMD (using dual-energy x-ray absorptiometry). RESULTS: The intervention group had significantly more gains in cardiorespiratory fitness, mobility, and paretic leg muscle strength than controls. Femoral neck BMD of the paretic leg was maintained in the intervention group, whereas a significant decline of the same occurred in controls. There was no significant time-by-group interaction for balance, activity and participation, nonparetic leg muscle strength, or nonparetic femoral neck BMD. CONCLUSION: The FAME program is feasible and beneficial for improving some of the secondary complications resulting from physical inactivity in older adults living with stroke. It may serve as a good model of a community-based fitness program for preventing secondary diseases in older adults living with chronic conditions.

Activities of Daily Living↗

Passive fit of implant-retained prosthetic superstructures improved by electric discharge machining.

PURPOSE: An absolutely passive fit at the interface with the superstructure and the abutment cylinders is needed for implant longevity. In this study, a method of cast framework correction using electric discharge machining (EDM) was evaluated. MATERIALS AND METHODS: An original research model incorporating strain gages was devised to measure the fit of implant superstructures in three dimensions as cast and to compare this relationship with the fit following framework machining with EDM. RESULTS: Visually, the fit of the frameworks was excellent, and the results of ANOVA demonstrated that the mean fit of the frameworks significantly improved (P > .04) after machining with EDM. CONCLUSIONS: The EDM process offers a rapid, accurate, and simple technique to correct for casting inaccuracies in the fabrication of hybrid implant prostheses.

Analysis of Variance↗