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At least 1,063 records · Page 59Linked to original sources
PubMedDate not supplied

Needle revision of failed filtering blebs augmented with subconjunctival injection of mitomycin C.

OBJECTIVE: To evaluate the short-term efficacy and safety of needle revision of failed filtering blebs augmented with subconjunctival injection of mitomycin C. PATIENTS AND METHODS: Needle revision of failed filtering blebs followed by subconjunctival injection of 10 to 20 microg of mitomycin C was performed in 41 eyes. Short-term results were analyzed 6 months postoperatively. RESULTS: The mean (+/- standard deviation [SD]) intraocular pressure decreased from 26.4 +/- 6.2 to 16.4 +/- 6.5 mm Hg (P < .001), and the mean (+/- SD) number of medications decreased from 2.8 +/- 1.4 to 0.7 +/- 1.1 (P < .001). The overall success rate (defined as intraocular pressure between 5 and 21 mm Hg and no serious complications) was 76%. Initial intraocular pressure, number of previous surgical procedures, type of glaucoma, and lens status did not influence the success rate. The resulting bleb was significantly larger in the successful cases (2 +/- 0.8 vs 0.33 +/- 0.5; P < .001). Complications included one case of late suprachoroidal hemorrhage. The mean (+/- SD) visual acuity remained stable (delta visual acuity in Snellen lines = 0.023 +/- 1.1). CONCLUSION: Needle revision followed by subconjunctival injection of mitomycin C is an alternative to more complicated surgical procedures in cases of failed filtering blebs. Bleb formation was essential for successful reduction of intraocular pressure, which suggests subconjunctival injection of mitomycin C by itself may not lower intraocular pressure.

Adolescent↗
PubMed2003

[Hypotony maculopathy diagnosed by optical coherence tomography].

CASE REPORT: A 40 year-old man with advanced pigmentary glaucoma in the left eye underwent trabeculectomy. In the immediate postoperative period, visual acuity decreased with no alterations noted on examination of the fundus or on angiofluoresceingraphy. Through optical coherence tomography, we were able to make a diagnosis of hypotonic maculopathy and treatment was immediately started. DISCUSSION: Hypotony maculopathy is one of the most feared complications of filtering eye surgery. In some cases, optical coherence tomography can be useful to confirm its diagnosis non invasively.

Adult↗
PubMed1997

[Comparison between two therapeutic approaches in patients with cataract and glaucoma].

The paper presents a comparison between two therapeutic approaches in patients with cataract and glaucoma: combined filtering-cataract surgery and two-step surgery (initially glaucoma surgery, then cataract surgery). There are shown the criteria which sustain one or other condition, the kind of control of intraocular pressure, the evolution of visual acuity, and postoperative complications.

Cataract↗
PubMedDate not supplied

Intracameral 2.3% sodium hyaluronate to treat postoperative hypotony in patients with glaucoma.

BACKGROUND AND OBJECTIVE: To evaluate the intracameral use of Healon5 (2.3% sodium hyaluronate) (Advanced Medical Optics, Santa Ana, CA) in patients with hypotony. PATIENTS AND METHODS: Fifteen consecutive patients with glaucoma who had hypotony for at least 7 days were prospectively recruited. Indications for the intracameral injection of Healon5 were an intraocular pressure (IOP) of less than 6 mm Hg with negative results on Seidel test. RESULTS: The mean IOP readings at baseline, 1 to 2 weeks post-injection, and 4 to 6 weeks post-injection were 3.8 +/- 1.58, 6.58 +/- 2.62, and 6.50 +/- 2.24 mm Hg, respectively. The increase in IOP at both follow-up points was significant (P < .01). The visual acuity improvement was small but significant at the 4 to 6 week point (P = .05). In the early-onset cases, IOP increased significantly from baseline at both follow-up points (P< .05), but visual acuity did not. No significant change from baseline IOP or visual acuity occurred among the late-onset cases. The existing hypotony-related conditions consistently improved by the 4 to 6 week point. CONCLUSIONS: Intracameral injection of Healon5 raised IOP more in early-onset hypotony cases than in late-onset cases. Although the improvements in IOP and visual acuity were statistically significant, the overall clinical picture did not change because the endpoint IOP was still hypotonus. Twenty percent of the patients had IOP spikes that required medical treatment.

Adjuvants, Immunologic↗
PubMedDate not supplied

Current concepts in the pathogenesis and management of exfoliation syndrome and exfoliative glaucoma.

Exfoliative glaucoma is a common, sight-threatening disease that develops as a consequence of exfoliation syndrome. There are important differences in the clinical appearance, course, and prognosis of exfoliative glaucoma versus primary open-angle glaucoma. At the clinical, biochemical, and cellular levels, exfoliative glaucoma is a distinct entity, with an intriguing mechanism of development and numerous systemic manifestations that require further elucidation. The subtlety of clinical signs results in the diagnosis of exfoliative glaucoma often being overlooked and resulting in less-than-ideal management. We provide an overview of recent studies investigating the medical, laser, and surgical therapy of exfoliative glaucoma, with a focus on innovative approaches that may slow the progression of, or even prevent, the development of exfoliation syndrome and exfoliative glaucoma.

Antihypertensive Agents↗