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Assessing empirical research in bioethics.

Empirical research can aid ethical reflection in bioethics by identifying issues, by seeing how they are currently resolved, and by assessing the consequences of these current resolutions. This potential can be misused when the ethical issues in question are fundamentally non-consequentialist or when they are consequentialist but the empirical research fails to address the important consequences. An example of the former problem is some recent studies about bad consequences resulting from commercialized living kidney donor programs. These consequences could be avoided, but the crucial non-consequentialist ethical issues about exploitation and commercialization would still remain. Examples of the latter problem are provided by recent studies of the allocation of ICU beds and of physician deception, where important consequences were not adequately studied.

Empirical Research↗

The effects of EMG biofeedback on strength acquisition.

This study investigated the effectiveness of electromyographic (EMG) biofeedback in maximizing strength gains and integrated electromyographic (IEMG) levels of the quadriceps muscle group resulting from an isokinetic exercise program. Twenty-one male volunteers recruited from physical education classes at a large southwestern university were randomly assigned to one of the following three treatment groups: (1) a biofeedback (BF) trained group, (2) a deception (DEC) trained group, and (3) a nonfeedback (NF) trained group. Subjects were trained and tested for strength by extension on a Cybex Isokinetic Exercise Machine at a speed of 30 degrees per second. Training sessions were performed three times per week for five weeks; pretest and posttest data were based on the best score of three trials of a 1-RM maximum effort. A pretraining to posttraining comparison indicated significant increases in strength (p less than .001) and IEMG levels (p less than .001) for all treatment groups when a paired t test was applied to the data. A multivariate analysis of covariance (MANCOVA) revealed that the BF trained group showed significantly greater peak torque values than DEC and NF trained groups (p less than .01) and produced significantly greater IEMG levels than the NF trained group (p less than .05). Overall, these results were taken as supporting the hypothesis that a training program of combined isokinetics and EMG biofeedback produces significant gains in maximal force and IEMG activity of leg-extensor muscles.

Adolescent↗

Non-clostridial gas gangrene in the diabetic lower limb.

Three cases of non-clostridial gas gangrene in diabetic lower limbs are reported. This rare condition occurs only in diabetes with peripheral neuropathy and is invariably fatal unless treated surgically. The clinical picture is deceptive with a slow, but insidiously progressive course, and the late appearance of skin necrosis. Antibacterial therapy is ineffective in preventing death. A serious delay may be fostered by inconclusive bacteriological investigations. Urgent radical amputation is required to save the patient's life.

Adult↗

A review of over-the-counter drug therapy.

The authors review the extent of the use of nonprescription drugs as well as possible variables influencing such consumption. Various studies indicate that age, sex, personality characteristics, perceptions of health status, socioeconomic factors, parental example, and pharmacists all play parts in determining over-the-counter (OTC) drug utilization. Several sources express concern about the inaccessibility of accurate OTC drug information to the consumer. Indeed, even the FDA has occasional difficulty obtaining reliable facts on both the numbers and formulae of such products. Several studies indicate that consumers acquire information about their home remedies through advertising, friends and relatives, physicians, pharmacists, and product labels. By far the most influential of these is advertising, and much concern has been voiced over consumers' unquestioning faith in drug ads. Examples are cited of deceptive, inaccurate, and unfair advertising practices used by some OTC drug manufacturers. The pros and cons of the "drug-oriented society" theory are discussed, including an analysis of its underlying origins. Testing of the safety and efficacy of nonrescription remedies has proved to be controversial, especially when considering the ramifications of the placebo effect. Different surveys report widespread misuse of OTC's by consumers through overuse, taking several drugs concurrently, and using home remedies to treat potentially serious diseases.

Adult↗

Unusual intracranial foreign bodies. Report of five cases.

Five patients surgically treated for unusual intracranial foreign bodies are presented. They include representative cases of the three most commonly encountered types of these injuries: industrial accidents, suicidal attempts and the result of criminal assault. Immediate radiological examination is mandatory because the deceptively small entrance wound is usually in no way commensurate with the large size of the foreign body the presence of which is frequently not suspected. The surgical removal of these foreign bodies requires careful pre-operative assessment to avoid hemorrhages and undue injury to the surrounding normal brain tissue.

Accidents, Occupational↗

Families of seven male-to-female transexuals after 5-7 years: Sociological sexology.

Four black and three whilte families have a male-to-female transexual member surgically reassigned more than 5 years ag. The black families were more open than the white in declaring the reassignment within the family and community. Thereby they relieved themselves and the transexual member of a need for deception, defiance, or defensiveness, and they were less scheming and manipulative. Without the anxiety of concealment, they could feel more positive about sex reassignment as a form of rehabilitation. A formal public declaration of sex reassignment, analogous to a declared change of citizenship, would be advantageous in transexual rehabilitation.

Adult↗

[Factitious disease. Observations on 44 cases at a medical clinic and recommendation for a subclassification].

From 1971 to 1985, 44 cases of self-induced factitious disorders were observed in the Medical Department of a University Hospital. The diseases were often severe, one patient even died. The various symptoms and diseases presented by the patients, the methods of producing them, and the diagnostic and therapeutic aspects of these cases are described. Patients were analysed with regard to age, sex, profession, psychosocial adaptation, number and duration of hospitalisations, presentation of complaints, behaviour on the ward, relation to the doctor, self-destructive tendencies, readiness to suffer and possible motivations. According to the criteria of the DSM-III, seven patients were malingerers (DSM-III: V 65.20) and 37 had a "chronic factitious disorder with physical symptoms" (DSM-III: 301.51). However, the findings in the patients of the latter group strongly suggest that they form an extremely heterogeneous population. Therefore we propose a subclassification of the DSM-III category 301.51 as follows: Type A. Muenchausen syndrome in the proper sense; dramatic deception of mainly acute illness; pseudologia fantastica; social maladaptation, chaotic life situations; many, mostly short hospitalisations; many interventions; at first well adapted, later hostile; mostly men. Type B. Self-induced, mainly chronic illness; behaviour adequate, highly compliant; often little emotion, contrasting with the sometimes severe illness; socially adapted; history remarkably blank with regard to psychosocial stress; several often longlasting hospitalisations and many interventions; almost exclusively younger women from (para-)-medical professions. Type C. Willfull interference with the healing of wounds, cutaneous ulcers, abscesses or dermatological artefacts; history with marked personal losses or severe chronic medical problems; at first well adapted, later hostile, passive/aggressive; women prevail. A conversion syndrome (DSM-III: 300.11) was not observed. In contrast to malingering, the basis of the disorder in types A, B and C is unconscious in origin, thus similar to the conversion syndrome. Contrary to the latter, however, the production of physical symptoms is under voluntary control. The proposed subclassification represents a hypothesis for testing which might facilitate the analysis of the basic personality disorder, so far lacking. The investigation of the psychopathology of these patients and their treatment is difficult if not impossible because most refuse psychiatric exploration and therapy. Consequently follow-up studies and data on the prognosis are rare.

Adolescent↗

Signal processing in 2 dimensional Doppler echocardiography.

Blood flow recordings made by 2 dimensional Doppler echocardiography can sometimes be understood more easily than conventional Doppler recordings, because of the anatomical 2 dimensional presentation. In contrast, signal processing has become more complicated and requires more explanation. In 2 dimensional Doppler echocardiography the analog ultrasonic signal received by the transducer is converted into an audible signal, which next is digitized and analyzed for its mean frequency and variance. Data collection and processing require application of multigating and high speed frequency analysis, generally based upon autocorrelation. Some artifacts may be perceived, such as color reversal due to aliasing, deceptively colored tissue surfaces due to beam motion, and wall motion ghost signals due to multiple reflections. Color flow imaging is appropriate for a rapid scan of the heart cavities to detect and roughly evaluate flow abnormalities. Quantification is still accomplished by switching to conventional Doppler mode.

Echocardiography↗

Influence of caffeine on information processing stages in well rested and fatigued subjects.

The effects of caffeine on different information processing stages were examined by using choice reaction time tasks. Independent variables were stimulus degradation, stimulus-response compatibility, time-uncertainty, state of the subject, and caffeine treatment. The task variables were assumed to affect the following processing stages; encoding, response selection and motor preparation, respectively. A 200 mg dose at the beginning of the experiment and a maintenance dose of 50 mg caffeine or lactose half-way through the session were administered to well rested and fatigued subjects, double-blind and deceptively. Behavioural measurements, event-related potentials (ERPs) and mood questionnaires were used to assess caffeine effects. The data showed that caffeine shortened reaction time. This effect showed an interaction with stimulus degradation and time uncertainty. In addition, ERP results supported the view that caffeine increases cortical arousal and perceptual sensitivity. Stimulating effects of caffeine were mainly located at input and output stages of the information processing system. Central processes were unaffected by caffeine. Fatigued subjects showed larger improvements in performance after caffeine than well-rested subjects. The results also indicated that caffeine effects were not stimulating in all subjects: 6 out of 30 subjects did not show arousing effects of caffeine.

Adolescent↗

Less is more: the case for "basic" psychiatry and the Colorado Medical Student Log.

Because of the rapid growth of our field, psychiatric educators are faced with two related questions. Are we teaching our students about too many things thereby making it difficult for them to discern our essential message(s)? And, two, have we really decided on what our essential message(s) actually is? The answer is "yes" to the former and "no" to the latter. The problem is deceptively simple: as distinct from what we teach, as a profession we have not yet parsed out the minimum we expect our students to really know-and really know how to do-by the time they graduate from our schools. We, therefore, developed the menu and method of the Colorado Medical Student Log which articulates the minimal educational goals for our students: ten core clinical experiences and ten core psychiatric screens. The log also provides an easy method by which we can be satisfied that our minimal goals are being met.

Colorado↗

[Psychosomatic problems of childless couples].

We discuss the late "wish for pregnancy" (involving women over 45 years of age). Late hopes for in vitro fertilization occur, encouraged by "solutions" that are deceptive and to our experience distract from inner conflicts. We consider the problems of idiopathic infertility, a diagnosis that is frequently accepted as final without exploration of the psychological background. Finally, we discuss secondary sexual dysfunctions, caused by a very technical approach to infertility treatment. We conclude with a demand for critical discussion of neuralgic problems in modern reproductive medicine (e.g., manipulation of embryonic structures and breaking up of family structures).

Female↗

Bifurcating spatially heterogeneous solutions in a chemotaxis model for biological pattern generation.

We consider a simple cell-chemotaxis model for spatial pattern formation on two-dimensional domains proposed by Oster and Murray (1989, J. exp. Zool. 251, 186-202). We determine finite-amplitude, steady-state, spatially heterogeneous solutions and study the effect of domain growth on the resulting patterns. We also investigate in-depth bifurcating solutions as the chemotactic parameter varies. This numerical study shows that this deceptively simple-chemotaxis model can produce a surprisingly rich spectrum of complex spatial patterns.

Animals↗

Evaluating polygraphy from a psychophysiological perspective: a specific-effects analysis.

It is suggested that purportedly scientific positions and technologies are actually spiritualistic or superstitious to the extent that specific effects are not identified and evaluated. This claim is then examined with respect to polygraphy, which appears to have particularly strong spiritualistic tendencies. This technology's putative basis is the science of psychophysiology, which is the study of psychological processes by means of unobtrusive physiological measures that reflect functions over which there is relatively little voluntary control. The underlying rationale of polygraphy is that information about these functions provided to the examiner has a specific, beneficial effect of improving the detection of deception. Before considering the validity of the polygraph in these specific-effect terms, the paper notes some serious societal problems involved in the use of the polygraph, problems that suggest that polygraphy is appropriately characterized as a serious "social disease". As to its scientific status, the technique suffers from at least three significant and possibly insurmountable problems: 1) the records are not read "blind"; 2) the method of scoring is subjective, compared to the standards of scientific psychophysiology; and 3) the so-called "control" question method does not involve control in the standard, accepted, scientific sense of that term. However, much of the rest of psychology is also criticised as teleological and spiritualistic, and it is suggested that the polygraph is merely a dramatic illustration of the spiritualist approach that permeates the thought of most researchers in, and practitioners of, the science of psychology.

Electrophysiology↗

[Paraphilia, sexual preference disorders. Diagnosis, etiology, epidemiology, treatment and prevention].

Hostility towards relationships is one prominent characteristic symptom for disorders of sexual preference (ICD-10) and paraphilias (DSM-IV). Paraphilic symptoms sometimes progress to obsessive or addictive- like forms leading to a loss of self-control but can occur also as single incidents or as episodic events. Besides constitutional aspects, problems in the development of close relationships to primary caregivers (attachment) play an important role in the development of these disorders. Actual relationship- and self-confidence problems often trigger the severity of disturbance, especially in the episodic forms of paraphilia. For patients who are in conflict with the law, cognitive-behavioral therapeutic approaches with the aim to minimize self-deception regarding the effects of the paraphilic behavior have become more and more relevant. Regarding the medical treatment, anti-hormonal therapy plays an important role, but also treatment with serotonergic agents and naltrexone are used. Only little can be advised in terms of prevention; general psycho-hygiene (regarding the parent-child relationship) is recommended. Beside these general measures, institutions which offer special treatment for people in danger to become delinquents may be able to prevent serious harm for possible victims of abuse.

Cognitive Behavioral Therapy↗

A butterfly's chemical key to various ant forts: intersection-odour or aggregate-odour multi-host mimicry?

Deception is a crucial yet incompletely understood strategy of social parasites. In central Europe, the Mountain Alcon Blue, Maculinea rebeli, a highly endangered butterfly, parasitises several Myrmica ant species. Caterpillars gain access to host nests probably by faking the ants' odour. We analysed gas chromatography-mass spectrometry data of body surface hydrocarbons of pre-adoption and hibernated larvae of Maculinea rebeli and of their host species Myrmica sabuleti and M. schencki. Data were ordinated by different methods, based on similarities in the relative quantities of compounds between chromatograms. The two Myrmica species exhibit species-specific profiles. The Maculinea rebeli pre-adoption larva has a complex profile that simultaneously contains species-specific substances of the two investigated host species. This evidence leads to the interpretation that, in central Europe, Maculinea rebeli is predisposed for multi-host use by the chemical signature of its pre-adoption larva. The Maculinea rebeli larva clearly does not rely on an "intersection-odour" of compounds common to all host ant species, but synthesises an "aggregate-odour" containing specific compounds of each of the investigated hosts. We term this previously unknown chemical strategy "aggregate-odour multi-host mimicry".

Animal Feed↗

["How this conflict tortures me!" The man Emil Kraepelin as viewed in his poems].

In 1928, Emil Kraepelin's poems were published posthumously. They provide thus far unknown insight into his intellectual and emotional world. Here we meet the man Kraepelin rather than the psychiatrist. We feel the rather pensive mood he expresses using the same allegories from the world of nature again and again. Kraepelin suffers from the fate of his mother country and his profession as a doctor, which puts him in "slave chains," thus preventing him from following his own course and fulfilling his longings. Those can be seen in his wish to dedicate himself fully to his nosological, psychopathological, or experimental psychological research. One wonders why he did not push his aims through more forcefully in these areas. Procrastination became Kraepelin's self-deception, since he could enter those worlds periodically only. In this way, they resemble his journeys to the south, which became a metaphor for freedom.

Germany↗

Evolution of +1 programmed frameshifting signals and frameshift-regulating tRNAs in the order Saccharomycetales.

Programmed translational frameshifting is a ubiquitous but rare mechanism of gene expression in which mRNA sequences cause the translational machinery to shift reading frames with extreme efficiency, up to at least 50%. The mRNA sequences responsible are deceptively simple; the sequence CUU-AGG-C causes about 40% frameshifting when inserted into an mRNA in the yeast Saccharomyces cerevisiae. The high efficiency of this site depends on a set of S. cerevisiae tRNA isoacceptors that perturb the mechanism of translation to cause the programmed translational error. The simplicity of the system might suggest that it could evolve frequently and perhaps be lost as easily. We have investigated the history of programmed +1 frameshifting in fungi. We find that frameshifting has persisted in two structural genes in budding yeasts, ABP140 and EST3 for about 150 million years. Further, the tRNAs that stimulate the event are equally old. Species that diverged from the lineage earlier both do not employ frameshifting and have a different complement of tRNAs predicted to be inimical to frameshifting. The stability of the coevolution of protein coding genes and tRNAs suggests that frameshifting has been selected for during the divergence of these species.

Amino Acid Sequence↗

Osteomyelitis of the ischiopubic synchondrosis: imaging findings.

Osteomyelitis of the ischiopubic synchondrosis in children is not rare and presents a diagnostic problem because of the diversity of presentation and the deceptive nature of symptoms. Radiological assessment is extremely difficult because of the variation in normal ossification on radiography and normal physiological uptake on radioisotope bone scan. We present two cases of osteomyelitis of the ischiopubic synchondrosis and describe findings on radiographs, isotope bone scan, computed tomography (CT) and magnetic resonance imaging (MRI). MRI changes have not been described in any of the case reports in the English literature. Aspiration and biopsy remain the gold standard for diagnosis. However, MRI appearances can significantly increase diagnostic confidence prior to intervention.

Acute Disease↗