Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “DOG DISEASES”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,063 records · Page 59Linked to original sources
PubMed2005

Cardiac troponin I: evaluation I of a biomarker for the diagnosis of heart disease in the dog.

OBJECTIVES: To assess the value of measuring blood levels of the myocardial protein cardiac troponin I (cTnl) in the diagnosis of congenital and acquired heart disease in the dog and in the evaluation of the severity of heart failure. METHODS: Serum samples obtained from healthy dogs (n = 26) and from dogs diagnosed with a variety of congenital and acquired heart conditions (n = 35) were assayed for cTnl concentration using an automated immunoassay method. Results were also analysed according to the degree of heart failure as assessed using the International Small Animal Cardiac Health Council's scheme. RESULTS: Healthy dogs had very low or undetectable blood cTnl levels, as did dogs with congenital heart disease. However, cTnl levels were significantly elevated in dogs with acquired mitral valve disease, dilated cardiomyopathy and pericardial effusion. Blood cTnl levels also varied with severity of heart failure. CLINICAL SIGNIFICANCE: Measurement of blood cTnl levels may be a useful aid in the diagnosis of dogs with suspected heart disease and in indicating the severity of heart failure.

Animals↗
PubMed1997

Isolation and transplantation of multipotential populations of epidermal growth factor-responsive, neural progenitor cells from the canine brain.

Glial cell transplantation into myelin-deficient rodent models has resulted in myelination of axons and restoration of conduction velocity. The shaking (sh) pup canine myelin mutant is a useful model in which to test the ability to repair human myelin diseases, but as in humans, the canine donor supply for allografting is limited. A solution may be provided by self-renewing epidermal growth factor (EGF)-responsive multipotential neural progenitor cell populations ("neurospheres"). Nonadherent spherical clusters, similar in appearance to murine neurospheres, have been obtained from the brain of perinatal wildtype (wt) canine brain and expanded in vitro in the presence of EGF for at least 6 months. Most of the cells in these clusters express a nestin-related protein. Within 1-2 weeks after removal of EGF, cells from the clusters generate neurons, astrocytes, and both oligodendroglial progenitors and oligodendrocytes. Transplantation of lacZ-expressing wt neurospheres into the myelin-deficient (md) rat showed that a proportion of the cells differentiated into oligodendrocytes and produced myelin. In addition, cells from the neurosphere populations survived at least 6 weeks after grafting into a 14-day postnatal sh pup recipient and at least 2 weeks after grafting into an adult sh pup recipient. Thus, neurospheres provide a new source of allogeneic donor cells for transplantation studies in this mutant.

Animals↗
PubMed1989

Neutrophil myeloperoxidase deficiency associated with canine hepatozoonosis.

Hepatozoonosis is a very important disease in dogs in Nigeria. Hepatozoonosis was reported in Nigeria in 18 dogs. The clinical signs included fever, anorexia, loss of weight, lameness, oculonasal discharge and conjunctivitis. Hematologic findings included leukocytosis due to neutrophilia and eosinophilia. Parasitemia varied from 1 to 9% of the circulating neutrophils in the peripheral blood smears of the dogs examined. Hepatozoon canis gametocytes were identified in circulating neutrophils of dogs. Peripheral blood smears from dogs confirmed to have natural H. canis infection were cytochemically stained for myeloperoxidase. Parasitized neutrophils were myeloperoxidase deficient while non-parasitized neutrophils were myeloperoxidase positive. This is considered important, because deficiency of the enzyme may be responsible for poor response of H. canis to chemotherapeutic agents.

Animals↗
PubMed1990

New topics on leptospirosis.

In the United States, leptospirosis takes the second place in human diseases transmitted by animals. The clinical features of leptospirosis are very various in man and domestic animals by the nature of the serovar involved and the animal species infected. There are many epidemiological cycles of leptospirosis but environmental conditions are always important.

Acute Disease↗
PubMed1991

Reassessment of two Boyden chamber methods for measuring canine neutrophil migration: the leading front and the lower surface count assays.

Laboratory investigation of neutrophil locomotion has attracted a great deal of attention owing to its potential usefulness to veterinary clinical medicine. Two of the most important principles for measurement of chemotaxis are the leading front and lower surface count techniques. The latter assay has become increasingly popular following the introduction of multi-well chambers utilizing polycarbonate filters. In the present study, this method was compared quantitatively and qualitatively to the leading front assay. Further, the potential usefulness of a simple shape-change assay as a rapid measure of chemotactic activation of neutrophils was assessed and compared with the migration assays. It was concluded that the two migration assays are superior to the shape-change assay, even though both suffer from certain methodological drawbacks. This may be relevant to the elucidation of clinical cases of neutrophil dysfunction.

Animals↗
PubMed1992

Biometrical observations on different strains of Trypanosoma evansi.

Biometrical studies on buffalo, bovine and canine strains of Trypanosoma evansi isolated from species in Madras, India, were carried out. The buffalo, bovine and canine trypanosomes varied significantly in total length and width. The buffalo strain had a greater free flagellum, total length and width compared with the canine strain.

Animals↗
PubMed1980

What are Askanazy cells?

Considerable confusion exists over the names that are used in the study of thyroid pathology. In particular is the use of the name Askanazy cell. This is said to occur in Hashimoto's disease and has been described by a variety of names.

Animals↗
PubMed2004

Medical therapy of otitis externa and otitis media.

Medical regimens for the successful treatment of infectious otitis may vary widely depending on the degree of pathologic changes of the external ear canals, the status of the tympanic membranes, and the specific microorganisms involved. Chronic otitis media is especially problematic, because impaction of the bullae can be difficult to resolve and these cases often involve antibiotic-resistant bacterial organisms. In fact, the continuing emergence of resistant Pseudomonas spp and Staphylococcus spp will ensure that the medical therapy of otitis remains a dynamic art for the foreseeable future. This article considers the specific antimicrobial agents available for otic use, their potential toxicities, and guidelines for their use.

Acute Disease↗
PubMed2005

Assessment and treatment of central nervous system abnormalities in the emergency patient.

Disease of or injury to the central nervous system is a common rea-son for hospital admission on an emergency basis in veterinary medicine. Head injuries, seizures, and diseases that lead to intra-cranial hypertension frequently result in significant alteration of neurologic function. A thorough understanding of the pathophysiologic disturbances that occur during these conditions is para-mount for providing stabilizing emergent care. A detailed approach that focuses on meticulous physical evaluation, provision of timely and optimal stabilizing treatment, and continued monitoring can aid in improving outcomes in animals with signs and symptoms of neurologic disease or injury.

Animals↗
PubMed2004

Tryptic peptides of canine thyroglobulin reactive with sera of patients with canine hypothyroidism caused by autoimmune thyroiditis.

Canine thyroglobulin (cTg) was treated with trypsin at a ratio of trypsin to cTg of 1:100 (w/w). Tryptic peptides of cTg were analysed by Western immunoblotting for their reactivity to serum thyroglobulin autoantibodies (TgAA) from patients with TgAA-positive hypothyroidism and normal individuals. The sera of patients with TgAA-positive hypothyroidism reacted with several peptides: 43, 32.5 and 31 kDa; the sera of normal individuals did not bind these tryptic peptides. Some of the TgAA-positive sera of patients reacted with 25 kDa peptide in addition to three tryptic peptides above. This experiment was the first report about antigenic epitopes of cTg. These small tryptic peptides recognized by TgAA may be related with the induction of TgAA and may be useful as markers for autoimmune thyroid diseases in dog.

Animals↗