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Results for “CLOMIPHENE”

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At least 1,063 records · Page 59Linked to original sources
PubMed1991

Changes in hypothalamic monoamine oxidase activity in relation to 17 beta-estradiol and clomiphene citrate treatments in the teleost Channa punctatus during three seasons.

Hypothalamic monoamine oxidase (MAO) activity displayed biphasic responses to administration of estradiol-17 beta (E2) depending on season. Lower doses of 0.05 and 0.10 microgram/g BW of E2 had enhanced enzyme activity and higher doses (0.5 and 1.0 microgram/g BW) depressed it significantly in preparatory season. In prespawning phase, the lowest dose of 0.05 microgram/g BW of E2 was stimulatory and the higher doses were inhibitory to MAO activity. In postspawning season, lower doses (0.05 and 0.10 microgram/g BW) of E2 failed to elicit any significant change in enzyme activity whereas the higher doses (0.5 and 1.0 microgram/g BW) elevated it significantly. Administration of clomid (5, 10, and 20 micrograms/g BW) inhibited MAO activity in a dose-dependent manner during all the three seasons. The results show that E2 may participate in feedback control of gonadotropin secretion by modifying monoaminergic activity at the level of oxidative deamination by MAO.

Animals↗
PubMed1988

Prediction and self-prediction of ovulation in clomiphene citrate-treated patients.

We studied 15 infertile patients for a total of 25 cycles in order to compare the predictive value of the following parameters in timing ovulation: basal body temperature (BBT), cervical mucus, serum E2 and LH, follicular growth as shown by ultrasonography, and urinary LH. The patients themselves tested urinary LH at home using Clearplan kits. BBT had low value as a predictive test for the time of ovulation, whereas ultrasonography had a predictive value of 9%, serum E2 50%, cervical mucus 59%, serum LH 63.6% and Clearplan kits 63.6%. The best predictive reliability in timing ovulation was obtained by considering both serum LH and E2 measurements. The Clearplan kits were as reliable as serum LH measurements and have greater practical advantages.

Adult↗