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PubMed1977

Argemone oil poisoning.

A family of three suffering from Argemone oil poisoning was investigated. The effects of the oil and its toxic alkaloid sanguinarine have been discussed. A test for detecting sanguinarine has been described.

Adult↗
PubMed1984

[Inhibition of the reactions of DNA hydrolysis and RNA synthesis by the alkaloid sanguinarine].

The increase of the contour length of the low molecular linear duplex DNA in the complex with an alkaloid sanguinarine has been evidenced by the viscometric method. The enzymatic hydrolysis of modified DNA by pancreatic deoxyribonuclease I and RNA synthesis of DNA by rat liver nuclear RNA polymerase were studied. Sanguinarine has been shown to inhibit the first stages of DNA hydrolysis. This alkaloid is a weaker inhibitor than ethidium bromide, a more potent inhibitor than actinomycin D and exerts an inhibiting effect similar to that of distamycin A. Sanguinarine also decreases the rate of the labelled precursor incorporation into the acid-insoluble fractions by nuclear RNA polymerase from rat liver. A 50% inhibition by sanguinarine was observed at the same alkaloid concentration as that of ethidium bromide.

Alkaloids↗
PubMed1983

[Electron microscope study of the effect of sanguiritrin on bacteria in vitro].

Electron microscopic studies aimed at the determination of the mode of action of sanguiritrin have shown that the drug induced significant morphological changes in grampositive and gramnegative bacteria. Sanguiritrin at a concentration equal to 1 MIC induced local elimination of the inner electron dense layer of the cell wall and deformation of the division septa in Staph. aureus. This resulted in the impairment of the cell division. Impairment of the cell integrity and formation of the protoplast-like structures were observed. The cytoplasm of the cells exposed to sanguiritrin had diffuse electron dense formations and homogenous zones of medium electron density as a result of destructive processes in it. At a concentration of 2 MIC sanguiritrin induced significant thinning of the cell walls, elimination of the inner electron dense layer and increasing of the bacterial cell size. A small granular component of varying electron density was observed at the site of the nucleoid.

Alkaloids↗