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At least 1,063 records · Page 59Linked to original sources
PubMed1994

Regulation of plasma osmolality: thirst and vasopressin.

Sudden changes in plasma osmolality may have lethal consequences, because of abrupt changes in the volume of cells in the central nervous system. Acute osmotic disequilibrium can result in brain shrinkage or brain swelling. This article explores how the integrated responses of vasopressin and thirst maintain osmotic equilibrium through regulation of body water balance. These two mechanisms provide almost insurmountable barriers to excessive dilution or concentration of body fluids.

Humans↗
PubMedDate not supplied

Role of leptin in the regulation of body fluid volume and pressures.

Leptin is a circulating polypeptide hormone produced by an adipocyte-specific gene. It regulates energy balance by binding to receptors in the hypothalamus, leading to alterations in food intake, temperature, and energy expenditure. More recent pharmacologic information suggests that this circulating hormone may play an important role in the regulation of body fluid volume and pressures through direct and indirect actions. Although the relevance of the endogenous leptin on cardiovascular and renal function is yet to be clearly determined, it seems to be a potential salt-regulating factor and may function pathophysiologically as a common link to obesity and hypertension.

Animals↗
PubMed1995

Hormonal regulation during a 60-day confinement (ESA-EXEMSI'92) in humans.

EXEMSI'92 was a 60-day isolation and confinement experiment with an international crew. During this second experiment of the European Space Agency (the first one was a 28-day confinement with 6 men: ISEMSI'90), blood volume regulating hormones and water balance were studied. During ISEMSI'90, stress level was elevated as shown by specific markers and we observed some interesting results which have been already observed before, during bed-rest experiments. Thus, our conclusion was that some of the physiological effects observed during bed rest could be the consequence of the "confinement effect" and/or stress imposed to the subjects during such experiments. The aim of the present physiological study was: 1/to define the origin of the blood pressure increase seen during ISEMSI'90; 2/ to study the blood volume regulating hormones (ANP, renin, aldosterone) variations; 3/ to determine the dehydration level by measuring the total body water with the doubly labeled water (DLW) method and fluid balance in general.

Aldosterone↗
PubMed2003

Aminopeptidases in visceral organs during alterations in body fluid volume and osmolality.

Enzymatic cleavage of some peptides in the local environment could be included among the mechanisms related to the regulation of hydrosaline balance. In order to examine this hypothesis, we measured representative aminopeptidase activities in visceral organs of rats after applying certain hydrosaline challenges. Decreased levels (about 30%) of particulate puromycin-insensitive-neutral aminopeptidase in the renal medulla and of soluble acid aminopeptidase in the lung were observed under hyperosmolality and hypovolemia. Decreased levels (more than 45%) of particulate type-I-pyroglutamyl aminopeptidase in the heart were observed under altered volemia. These results indicate that aminopeptidases at these anatomical locations might be involved in the regulation of body fluid volume and osmolality.

Aminopeptidases↗
PubMed1998

Variations in plasma sodium concentration in post-operative patients depend on an electrolyte-free water balance, part of a tonicity balance.

BACKGROUND: There is an inverse relationship between changes in the concentration of sodium in plasma (PNa) and intracellular fluid (ICF) volume. Intakes and losses of sodium (Na), potassium (K) and water can be divided into two volumes: isotonic and electrolyte-free water (EFW). Calculations of these volumes assess a tonicity balance, a tonicity imbalance results in a change of PNa: when EFW is added to body fluids, PNa decreases. Moreover, the concept of EFW permits a good understanding of the renal contribution to the defence of body tonicity. PURPOSE: To illustrate that the measurement of a tonicity balance provides the best estimate of changes in PNa in an ICU setting. METHODS: Twenty-two patients were admitted to the Post-Operative Intensive Care Unit. We investigated how well changes in EFW balance correlated with PNa variations and what is the best formula to calculate EFW in this setting. RESULTS: PNa changes depend on EFW balance; there is no significant relationship with other classical factors such as urinary osmolality or Na-free water. CONCLUSION: The utility of a tonicity balance is demonstrated. A formula is derived facilitating at the bedside the prediction of changes in PNa following fluid therapy: PNa2 = [(PNa1.TBW) + balance (Na + K)]/[TBW + balance H2O]. PNa changes can be understood and/or modified exclusively by a careful measurement of intakes and losses of Na, K and water.

Female↗
PubMed1993

Bioelectric and anthropometric assessments and reference data in the elderly.

Most studies using bioelectric impedance have estimated the volume of total body water, fat-free mass and on occasion extracellular fluid volume using whole-body resistance and reactance. However, the validity of bioelectric impedance has not been established for the elderly except in small samples of limited age ranges. The estimation of whole-body composition from impedance of body segments may be an alternative method that can be applied to many chair- and bedfast elderly patients. Also, measures of bioelectric impedance at lower and higher frequencies than 50 kHz are reported to differentiate the proportions of intra- and extracellular fluid volumes, and this could also provide important information about fluid quantities and balances in the elderly. Distribution statistics for body measurements for persons 65-85 y of age are available from the national health surveys and large clinical studies but reference data for persons > or = 80 y are sparse. Some reference data may be from groups that are not representative of the elderly because the samples were from cohorts older than elderly persons living today and significant group and racial differences existed among these as children and adults. These differences may have increased interindividual variances among the elderly. Suitable reference data for the present generations of elderly in the United States will be available with the culmination of NHANES III after 1994, but limited reference data for elderly persons up to 90 y of age have been published.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMedDate not supplied

Fluid balance documentation: a case study of daily weight and intake/output omissions.

Daily intake and output (I&O) and weight documentation is frequently incomplete or omitted completely, even when a physician's order is in place. This brief case study illustrates the importance of maintaining these records to avoid fluid balance disorders and negative patient outcomes, as well as support patient well-being.

Body Fluids↗
PubMedDate not supplied

Fluid and electrolyte balance in the pediatric patient.

Maintaining adequate fluid and electrolyte balance is an important aspect of all patient care. The intravenous nurse's skill and expertise in starting and maintaining i.v. access is extremely vital to providing adequate fluids and electrolytes. Children and infants present unique problems in the management of fluid and electrolyte balance. Differences in rate of metabolism and body surface area are just two examples of special circumstances that affect diagnosis and management. An awareness of predisposing factors, early recognition of signs and symptoms that may be indicative of a developing problem, and knowledge of medical and nursing interventions help provide safe patient care. This article presents unique aspects of caring for infants and children, reviews important electrolytes, and discusses dehydration.

Child↗
PubMed1998

Monitoring relative fluid balance alterations in haemodialysis of diabetic patients by electrical impedance.

Measurements of total-body electrical impedance in the frequency range between 200 Hz and 300 kHz were performed on 37 diabetic patients undergoing chronic haemodialysis. Special attention was paid to the instrument design, where a self-balancing differential current source was used, reducing considerably the common-mode voltage at the amplifier input. The patient-instrument interface includes screened leads, separately driven by unity-gain buffers. The measurement error was < 1% for the impedance within the range of 20 to 1000 omega and < 0.3 degree (mean) for the phase angle. Impedance/phase and ultrafiltration measurements were carried out throughout the entire procedure. Total and extracellular water were computed and compared with extracted fluid volumes. The trends of change of the extracellular and intracellular fluid volumes during and immediately after dialysis corresponded to the respective clinical condition of the patients and enabled us to divide them into four groups. This approach is a step toward continuous monitoring and adaptive treatment, tailored to the individual patient needs.

Adult↗