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Thrombus formation in the arterial and venous circulation in hypofibrinogenemic dogs.
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Coagulation studies for severe liver disease detection in a gastroenterologic department.
15 patients with clinical, histological and laboratory findings of cirrhosis were investigated. When the results of routine hemostasis tests--thrombin time, reptilase time and fibrinogen quantitation by clotting methods--were prolonged, further immunological determinations were done. Normal results in the immunological determinations together with prolonged ones obtained by clotting methods are suggestive of dysfibrinogenemic states. A possible survey of the treatment with the help of these determinations is proposed.
[Haemorrhagic diathesis associated with fibrinogenopenia and fibrinolysis; a report of two cases].
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Severe congenital dysfibrinogenemia (fibrinogen-Riyadh): a family study.
Congenital severe dysfibrinogenemia was discovered in a small Saudi family. Their single child exhibited abnormal severe bleeding tendency since birth and his coagulation profile revealed evidence of severe dysfibrinogenemia. The parents who were first-degree cousins and completely asymptomatic showed evidence of dysfibrinogenemia but to lesser degree than in their son. The child presented with large cephalohematoma and evidence of intracranial hemorrhage and left hemiparesis. He was treated with cryoprecipitate and his hematoma resolved, but his neurological deficit remained.
Acute hemorrhagic syndrome with hypofibrinogenemia in metastatic cancer.
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Fibrinolysis as mechanism of hemorrhagic tendency.
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Multiple pulmonary emboli in a patient with afibrinogenaemia.
The case history of a patient with afibrinogenaemia, who developed multiple pulmonary emboli as a consequence of treatment, is described.
Congenital afibrinogenaemia in a Saudi family: a case report and family study.
Afibrinogenaemia in a female Saudi child is reported. Two siblings died of bleeding. The parents, who are first cousins, a brother and two sisters are asymptomatic heterozygotes with fibrinogen levels of less than 1.5 g/l. The presentation was described and compared to other cases reported.
Simultaneous occurrence of hypocholesterolemia, hypocalcemia and hypofibrinogenemia in a case of multiple myeloma.
Hypocholesterolemia, hypocalcemia and hypofibrinogenemia were simultaneously found in a patients with multiple myeloma. An objective remission of the myeloma during Melphalan treatment was accompanied by a normalization of these three parameters.
Increased capillary permeability in haemophilia and afibrinogenaemia.
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Hypofibrinogenemia after Echis colorata bite in man.
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Congenital deficiency of fibrinogen in two sisters. A clinical and haematological study.
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Fatal pulmonary embolus in congenital fibrinopenia. Report of two cases.
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Some effects of a microcrystalline collagen preparation on blood.
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Letter: Hemostatic defects in experimental leukemia.
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Interference on the haemostasis in dogs with induced coagulopathies by drugs affecting the platelet function.
Acetylsalicylic acid and phenylbutazone increased the bleeding significantly from standardized wounds in dogs defibrinogenated with Defibrase. Administration of dipyridamole and Xylocain had no effect. The results were the same in dogs treated with warfarin sodium. The results demonstrate the value of using laboratory animals with an induced coagulopathy when establishing the effect on the haemostasis exerted by drugs known in vitro to interfere with platelet functions. Acetylsalicylic acid and dipyridamole did not alter the activity of the K-vitamin-dependent coagulation factors, factors V, VIII, platelet count or fibrinogen concentration.
Adhesion of human blood platelets to glass polymer surfaces. II. Demonstration of the presence of a natural platelet adhesion inhibitor in plasma and serum.
Adhesiveness of washed platelets resuspended in citrated plasma, serum, or several different media has been investigated. A method specific for quanititation of adhesion was used. Platelets suspended in saline of Tyrode's solution were found to be highly adhesive to glass, polyethylene, polyvinyl chloride, or Cuprophane. This adhesiveness of platelets to test surfaces decreased by nearly 50% when plasma was the suspension medium. When the suspension medium was serum, the decrease in adhesion was nearly 75%. Cohn fraction V also decreased the adhesiveness of platelets significantly, but highly purfied albumin had only a small effect. Several pharmacologic agents decreased platelet adhesiveness when added to platelets suspended in plasma or serum, but had negligible effect on the adhesiveness of platelets suspended in artificial media devoid of proteins. Normal washed platelets, when suspended in citrated plasma obtained from an afibrinogenemic donor or in normal serum, showed a significant decrease in adhesion compared to the same platelets suspended in normal citrated plasma. Addition of fibrinogen to afibrinogenemic plasma or normal serum restored the adhesiveness of platelets to normal levels. Normal platelets resuspended in plasma obtained from a thrombasthenic donor exhibited normal adhesiveness. These observations suggested that while fibrinogen promotes platelet adhesion, plasma or serum possess also an adhesion-inhibiting activity.