Enamel dysplasia and caries.
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Clinical and experimental studies on 64 children aged 3-4 years and 80 non-inbred rats showed that the degree of dental enamel mineralization depends on the level of consumption of easily available carbohydrates during the antenatal period and the intensity of dental caries involvement on the degree of teeth mineralization.
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Ground and decalcified sections of human, goat and pig teeth were examined using polarized and ultraviolet fluorescence microscopy, microradiography and electron microscopy. The experimental animals were given doses of tetracycline within the range 3-150 mg/kg. After the low doses there was no evidence of any disturbance of mineralization or of structural organization in either the goat or the pig. After the higher doses, however, the tetracycline lines usually corresponded with a disturbance of structural organization and often with a disturbance of mineralization as well. In the human cases, the tetracycline lines sometimes corresponded with a disturbance of mineralization or of structural organization. However, our evidence suggests that the disturbances in the structure or mineralization of the dentine in the human subjects were not caused by the tetracycline. It was concluded that, provided the dose is kept low (3-31 mg/kg) tetracycline can be used as a reliable non-toxic marker in growth studies and is also used in the study of mineral deposition.
The pattern of tetracycline labelling in dentine was investigated in ground sections of human teeth under visible and ultraviolet light. The tetracycline lines presented different appearances near the enamel-junction region, near the dentine-cementum junction, in the mantle dentine, and in the circumpulpal dentine, depending on whether the mineralization front was linear, globular or linear-globular.
Considerable knowledge has accumulated over the years on the structure and function of the dental pulp and dentin. Some of this knowledge has important clinical implications. This review, which is the first of seven articles, will be limited to those parts of the normal structure and physiology of the pulp and dentin that have been shown to result in, or are likely lead to, tissue reactions associated with the clinical treatment of these tissues. Although certain normal structures will be highlighted in some detail, a basic knowledge of pulpal and dentinal development and structure is a prerequisite for an understanding of this text.
OBJECTIVE: The purpose of this investigation was to study the development of the premolars in a sample of Greek children with cleft lip and palate. METHOD AND MATERIALS: The study material consisted of panoramic radiographs of 34 individuals (22 boys and 12 girls) with cleft lip with or without cleft palate. The boys ranged from 9.0 to 14.0 years of age and the girls ranged from 8.0 to 14.5 years of age. The mean age was 11.3 years. Each panoramic radiograph was matched with a corresponding one of an unaffected individual of the same sex and chronologic age (+/- 3 months). The panoramic radiographs were used to categorize the stages of tooth development according to the 10 stages of mineralization described by Nolla. The assessment was repeated by a second observer. RESULTS: Individuals with clefts exhibited a statistically significant delay of formation and mineralization of the maxillary right and left second premolars and the mandibular right second premolar in comparison to individuals without clefts. In the cleft group, there was no statistically significant difference between boys and girls in premolar development. No asymmetric development of contralateral premolar teeth was observed in individuals with cleft lip and palate. CONCLUSION: Although the exact biologic explanation remains to be found, the formation of premolars is delayed in children with cleft lip and palate.
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