Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “THYROIDECTOMY”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,045 records · Page 58Linked to original sources
PubMed1979

Hormonal aspects of suction drainage after thyroidectomy.

Suction drainage, after thyroidectomy, for a variety of conditions, varied between zero and 92.5 milliliters. The levels of thyroxine in this fluid were greater than those in the serum, at the same time being an average of 14.0 micrograms per 100 milliliters. The loss of thyroxine for 24 hours could represent up to 11.6 per cent of the total serum thyroxine pool. The serum thyroxine level, after initial fluctuation in either direction settled down, or up, to an average euthyroid level of 6.09 micrograms per 100 milliliters by the 21st day after operation. Possible factors influencing these changes have been considered and discussed. Such changes did not outweigh the advantages most surgeons found in drainage but could be eliminated if the ideal of no drainage could be attained. There was no evidence of exfoliated acinar cells in the drainage fluid.

Female↗
PubMed1979

Serial TSH determination after T3 withdrawal or thyroidectomy in the therapy of thyroid carcinoma.

Exogenous triiodothyronine (T3) was substituted for levothyroxin or desiccated thyroid in 13 athyrotic patients previously treated for papillary, follicular, or mixed papillary-follicular carcinoma of the thyroid. After 4 weeks T3 therapy was discontinued and serial determinations of plasma thyroid stimulating hormone (TSH) concentrations were made. A roughly exponential rise in TSH values, corresponding to a doubling time of 2 days, was observed until a level of 40 microIU/ml was reached, after which the curve passed through a maximum at 20 days. The mean time required for a level of 50 microIU/ml was 11 days, and this time is suggested for TSH determination before I-131 imaging of patients with thyroid cancer. Plasma TSH values in eight patients following "total" thyroidectomy showed a much slower and more variable rise, with a mean doubling time of 7.6 days. Weekly TSH levels beginning at 15 days will provide a rational basis for I-131 imaging in this group, in whom a longer period of hypothyroidism will be required before imaging and therapy. Adherence to these protocols should minimize the duration of hypothyroidism in patients undergoing I-131 treatment of thyroid carcinoma.

Adenocarcinoma↗
PubMed1979

Effect of thyroidectomy upon the activity of three mitochondrial shuttles in rats.

The activities of mitochondrial alpha-glycerophosphate, malate-asparte, and malate-citrate shuttles which oxidize NADH were determined in liver and kidney cortex mitochondria isolated from Tx and control rats. Weight gain, relative liver and kidney size, oxygen consumption, and serum thyroxine were also determined. Tx animals weighed less, had smaller livers and kidneys, and showed significantly lower oxygen consumption of the resting animal and a marked decrease in serum thyroxine levels. The activity of the three shuttles studies was significantly less in liver mitochondria from Tx animals, particularly when studied in the absence of added ADP. Thyroidectomy had less effect upon shuttle activity of mitochondria from the kidney cortex, with significant decrease in activity found only in the complete alpha-glycerophosphate shuttle and in the endogenous malate-aspartate and malate-citrate shuttles studied in the absence of ADP. Changes in shuttle activity caused by thyroid hormone are discussed in relation to other known metabolic effects of thyroxine, and the possible primary role of adenine nucleotide translocase activity in mediating other thyroxine-dependent metabolic changes is considered.

Adenosine Diphosphate↗
PubMed1978

[Long term follow-up after thyroidectomy].

Surgically treated Graves' patients should be submitted to long-term follow-up in order to detect early hypothyroidism, as well as relapses of hyperthyroidism which are not exceptional. The aim of the prolonged care after thyroidectomy for non toxic goiter is to detect a recurrence of the goiter and to control the prophylactic administration of thyroid hormones which should be prescribed in most cases. The follow-up after surgery for thyroid carcinoma depends on the histology of the tumor and on the type of postsurgical treatment.

Follow-Up Studies↗
PubMedDate not supplied

[Interest and limits of beta blocking drugs for preparing Grave's disease to sub-total thyroidectomy (author's transl)].

The use of beta blocking drugs as a preparation to the sub-total thyroidectomy in Graves's disease allows to shorten the pre-operation time. However, besides the observance of classical contraindications, it requires that patient who remain hyperthyroid are closely looked after. Within these limits, it seems to be quite useful for patients who need to quickly come back to euthyroid status.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Effect of thyroidectomy on the beta-cell function of the pancreatic islet apparatus].

The functional activity of the insular apparatus of the pancreas with varying function of beta-cells and body sensitivity to insulin were studied in vivo and in vitro in an experimental hypothyroidal condition produced by total removal of the thyroid from rabbits and rats. Insulin was detected by radioimmunoassay, whereas insulin biosynthesis was assessed from 3H-leucin incorporation into the de novo formed islet proteins with insulin immunoreactivity (proinsulin plus insulin). The insulin test (0.3 Units/kg mass, intravenously) was made to study glycemia and the level of non-esterified fatty acids in the blood serum. Thirty days after thyroidectomy glucose homeostasis was not disturbed, and the body sensitivity to sugar-reducing and antilypolytic insulin actions did not undergo any changes. The deficiency of thyroid hormones produced an increase in basal and glucose-induced insulinemia (intravenous glucose tolerance test) and a rise in the exogenous insulin break down rate. No changes in the biosynthesis of insulin by the islets were detected. The increase in the secretory response of beta-cells to glucose with undisturbed insulin formation presents a compensatory reaction aimed at making normal glycemia possible. The regulating effect of thyroid hormones on the secretory response of beta-cells and the essential role of the latter in glucose homeostasis under deficiency of thyroid hormones are discussed.

Animals↗
PubMed1978

Function of the parathyroid glands after total thyroidectomy.

Parathyroid function, defined as the ability to maintain normocalcemia without substitution, was evaluated in 36 patients following total thyroidectomy for carcinoma. In 16 patients, all visualized parathyroid tissue was sliced and autotransplanted into muscle pockets; one year after the operation, 11 patients had substitution for lack of parathyroid function. In 20 patients, the parathyroid glands were preserved in situ with intact vascular supply; one year postoperatively, three patients had evidence of persistent hypoparathyroidism. The difference in the parathyroid insufficiency rate is significant, p less than 0.005. We conclude that parathyroid autotransplantation has been a failure io preserve the parathyroids in situ whenever this is feasible, autotransplantation being reserved for parathyroids unfortunately removed or devascularized.

Adenocarcinoma↗
PubMed1984

[Effectiveness of high-dosage radioiodine therapy in the elimination of remnant tissue following total thyroidectomy].

The efficacy of high doses of radioiodine for total ablation of functional remnants left behind after total surgical thyroidectomy for thyroid cancer decreases with the number of treatments as well with the course of therapy. Most effective are 500 mCi of 131I administered in 5 fractions within 3 years. Up to 1000 mCi of 131I delivered within 5 years are still powerful but much less so. All further treatments with high doses of radioiodine are only of diagnostic value for detection of functional metastases with low radioiodine uptake. In about 45% of all patients even excessively high doses of radioiodine failed to ablate all functional residual thyroid tissue.

Adenocarcinoma↗
PubMed1984

[Surgical treatment of Basedow's disease. I--Traditions and new methods in preparation for thyroidectomy: use of dexamethasone].

The combination of dexamethasone (2 mg every 6 hours) carbimazole (15 mg every 8 hours) and potassium iodide (XV drops every 8 hours) has been proposed in the preparation of 21 patients with hyperthyroid Graves' disease for surgery. The combination was administered for 6 days and the subtotal thyroidectomy was performed on day 7. All patients had normal serum Triiodothyronine levels after 4 days of such treatment. This combined drug therapy appears to be a rapid, sage and effective preparation for thyroid surgery in patients with Graves' disease and should replace conventional preparation with carbimazole and potassium iodide and beta-blocker preparation in all cases where there are no contra-indications to the use of corticosteroids.

Adult↗
PubMed1984

[Surgical treatment of Basedow's disease. II--Evaluation of 36 subtotal thyroidectomies].

Results of subtotal thyroidectomy in 36 patients with Graves' disease emphasize the need for strict medical preparation, with the administration of corticoids more particularly, and the technical imperatives required during operation. Analysis of endocrine factors showed that euthyroidism was obtained in 76% of cases with a fairly stable state after 6 months. Hyperthyroidism was rare and developed before the end of the first year. Hypothyroidism, mainly biologic, was frequent during the immediate postoperative period but compensatory hypertrophy of remaining tissue was the usual outcome. It was persistent in 14% of cases, however, but easily compensated by substitutive therapy and a less severe complication than prolonged hyperthyroidism. Biologic hypocalcemia was also frequent but normal levels were reinstituted rapidly. Surgical treatment of Graves' disease is usually effective and rapidly performed, and is particularly indicated when socio-ethnic conditions make medical treatment difficult or impossible.

Adolescent↗
PubMed1983

Midtrimester thyroidectomy in the ovine fetus.

Six lamb fetuses at 63-101 days gestation had thyroidectomy (Thx) and were investigated at term for weights, radiologic study, serum thyroxine (T4), and thyroid-stimulating hormone concentrations (TSH), electron-microscopic lung examination, acid base, blood flow, EEG, and brain metabolism. Compared to age-matched controls, body weight was significantly reduced (P less than .025). Brain and lung weights were reduced but not significantly. Brain weight as a percent of body weight was significantly increased in Thx fetuses (Thx = 1.85% +/- 0.18; control = 1.41% +/- 0.08; P less than .025). Hemoglobin was reduced (P less than .025), as was O2 content (P less than .005) and cerebral blood flow (P less than .05). Fetal T4 was low (Thx = 4.1 +/- 1.7 microgram %, control = 9.4 +/- 1.3 microgram %); (P less than .05). Fetal Thx cortisol, calcium, phosphate, glucose, lactate, pH, pO2, pCO2, O2 saturation, heart rate, and blood pressure remained unchanged. Thx-fetal brain O2 consumption and glucose consumption, as well as lactate production, were unchanged. EEG showed no consistent pattern of change regarding maturity, but did show immaturity with the two lowest T4 levels. Bone microradiographs showed growth and maturity retardation, specifically delayed epiphyseal closure, endochrondral ossification, and lack of secondary ossification centers in Thx fetuses. Electron-microscopic examination of lung showed Thx fetuses had fewer lamellar bodies in type II cells, fewer type II cells, and more glycogen granules. Thx causes fetal reduction of T4 and anemia, delays lung maturation and bone growth and maturation.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1983

[Effect of thyroidectomy on the histochemical and electrophysiological properties of the soleus muscle in rats].

In the musculus soleus of mature male rats, 6 weeks after thyroidectomy, muscle fibers with a low adenosin triphosphatase activity of myosin decrease in number, as well as the cross section area of the muscle fibers with a moderate and high activity of the enzyme. Optic density of the muscle fibers staining also decreases when succinatedehydrogenase activity is determined histochemically. There is no change in the rest membrane potential and in the character of the muscle fiber membrane sensitivity to acetylcholine. The change in the muscle fiber histochemical properties is combined with chromatolysis in the motor neurons of the spinal cord ventral horns.

Acetylcholine↗
PubMed1978

[Morphogenesis of the "myxedematous heart" after experimental thyroidectomy in rabbits].

Electrocardiographic, biochemical, morphohistochemical and ultrastructural changes in the rabbit's heart were studied after thyroidectomy. The data obtained suggested that the changes in the heart of the test animals were characteristic of the "myxedematous heart". Certain regularities in the dynamics of the tissue and structure changes in the myocardium depending on the postoperative period were revealed.

Animals↗
PubMed1978

[Change in the adrenal cortex of rats in stress after hypophysectomy, thyroidectomy and castration].

To elucidate factors producing destructive changes in the adrenal cortex under severe stress, the following experiments were performed: 1) severe combined stress (KC) including unilateral adrenalectomy and fixation in supin position for 24 h (control group); 2)hypophysectomy KC; 3) thyroidectomy KC; 4) bilateral orchiectomy KC; 5) injection of vitamine "E" for 14 days + KC. The adrenals were studied by a complex of morphometrical and histochemical methods. Hypophysectomy prevented estructive changes in the adrenal cortex under KC. This effect was not connected with hypofunction of the thyroid gland and the testes, as their excision (in rats without hypophysectomy) did not prevent the development of necrobiotic changes in the adrenal cortex. A suggestion is made on a "corticolytic" effect of ACTH which reveals itself under severe stress. Destruction of adrenocorticocytes is supposed to result from activation of peroxide oxidation of lipids. This is indirectly supported by a large number of lipofuscin containing cells, by decrease in the activity of alkaline phosphatase and ATPh-ase, by activation of acid phosphatase and also by decreasing alterative phenomena at the injection of vitamine "E".

Adrenal Cortex↗
PubMed1983

Thyroid carcinoma: criteria in selection of patients for total and subtotal thyroidectomy.

Surgical management of patients with thyroid carcinoma continues to be a controversial subject among surgeons throughout the nation. The authors have recently treated patients with differentiated thyroid carcinoma using a selective surgical approach based on criteria classifying patients into high- and low-risk subgroups. Categorization is based on patient age, size and invasiveness of the tumor, and the presence or absence of distant metastatic disease. Women older than 50 and men over the age of 40 were classified as "high-risk" patients. Other criteria qualifying patients for high-risk categorization included lesion size greater than 3 cm and/or the presence of distant metastases. For patients with follicular tumors, histologic evidence of significant vascular invasion also constituted a high-risk criterion. Patients with high-risk criteria are associated with a significantly poorer prognosis. The records of 136 patients treated from 1958 to 1978 were reviewed. The findings and research from the literature suggest that these high-risk patients, when treated by total thyroidectomy, have an overall increased rate of survival when compared with those under-going lesser surgical procedures.

Adenocarcinoma↗
PubMed1982

Thyroidectomy: is Lugol's iodine necessary?

In a randomised controlled clinical trial of Lugol's iodine against placebo in 44 patients undergoing thyroidectomy we have failed to show any benefit in terms of reduced bleeding or operative facility after using iodide solution.

Adult↗
PubMed1982

[Influence of thyroidectomy and PTU treatment on cartilage ultrastructure in the embryo and very young dogfish (scyllium canicula, chondrichthyes) (author's transl)].

In embryos and very young dogfish made hypothyroidian by various treatments (radiothyroidectomy, surgical thyroidectomy and PTU treatment), ultrastructural abnormalities have been observed in all tested cartilages : Meckel's, branchial and pelvic cartilages. Many chondrocytes show a dark nucleus, enlarged REG vesicles and very electron dense hyaloplasm giving the cell a very peculiar reticulated aspect. Other chondrocytes appear unaffected. Cartilage ultrastructure is almost fully restored after a 21 days' recovery time. Around abnormal chondrocytes, extracellular matrix components are scarce. Moreover, matrix mineralization occurs around some abnormal chondrocytes by hydroxyapatite crystalization, never seen in normal embryos. During recovery, these crystals are preserved. When the antithyroid effects of PTU are compensated for by a simultaneous thyroxine treatment, cartilage abnormalities are minimized. If radiothyroidectomy is performed on young embryos, chondrocyte differentiation is delayed. It is concluded from these various experiments that thyroid hormones are required for the normal differentiation of cartilage and for the maintenance of its integrity in this fish.

Animals↗
PubMedDate not supplied

Arteriovenous fistula following thyroidectomy.

An arteriovenous fistula between the superior thyroid artery and internal jugular vein is described, diagnosed 20 years after thyroidectomy. This unusual fistula produced only local symptoms, but the bruit was initially attributed to atherosclerotic obstruction of the carotid artery. Although a systolic/diastolic bruit may be generated by a tight carotid obstruction, the presence of a continuous cervical bruit should suggest an arteriovenous fistula.

Arteriovenous Fistula↗