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Myoepithelial activity and the appearances of sialograms: a possible role in the formation of sialectasis.

In experimental studies on dogs it has been shown that the sialographic filling of the ductal system may be severely restricted if the myoepithelial cells are contracting and it seems likely that myoepithelial activity in man will also influence sialographic appearances. It has also been found that when secretory forces were accompanied by myoepithelial contraction against a sialographic pressure the ersuing damage to striated ducts produced appearances of sialectasis. IT IS WONDERED WHETHER SIMILAR EVENTS MAY SOMETIMES BE RESPONSIBLE FOR SIALECTATIC APPEARANCES IN MAN.

Animals↗

Radiological studies of experimentally induced sialoadenitis of the mouse parotid gland: quantitative microsialography and histology.

Sialoadenitis was induced experimentally in mouse parotid glands and the changes in gland morphology analysed over a period of 60 days by means of quantitative microsialography and histology. The microsialogram was digitized as an intensity histogram and the glands evaluated for seven histomorphometric parameters involving both the acini and duct systems. Differences in the intensity-histogram between experimental and control glands were shown to represent changes in duct architecture in the presence of inflammation, while differences in the relative frequency of pixels between low- and high-intensity areas were found to be due to a decrease in intralobular duct size, and acinar size and number in the former compared with an increase in the major duct components in the latter.

Animals↗

Analysis of submandibular gland sialograms in Sjögren's syndrome.

We report here the sialographic appearances of the submandibular gland in both primary and secondary Sjögren's syndrome (SS). In order to compare these with those of the parotid gland, we defined new criteria for the staging for SS based on the degree of depiction of the peripheral ducts. In 24 out of 74 cases the submandibular sialogram showed more advanced, destructive disease compared with the parotid. This study suggests that although SS involves the parotid gland first, it progresses in the submandibular gland more rapidly.

Adult↗

Image analysis of microsialograms of the mouse parotid gland: a study of the effect of contrast medium in experimentally induced sialoadenitis.

Quantitative image analysis of mouse parotid gland sialograms was achieved by conversion of the digital image to a histogram. The relationships between histogram pattern, microsialographic appearance and the amount of contrast medium infused were compared in normal glands and in experimentally induced sialoadenitis. Differences in the pattern enabled a distinction to be drawn between poor sialographic technique and genuine pathology.

Animals↗

Image analysis of microsialograms of the mouse parotid gland using digital image processing.

We compared two digital-image feature-extraction methods for the analysis of microsialograms of the mouse parotid gland following either overfilling, experimentally induced acute sialoadenitis or irradiation. Microsialograms were digitized using a drum-scanning microdensitometer. The grey levels were then partitioned into four bands representing soft tissue, peripheral minor, middle-sized and major ducts, and run-length and histogram analysis of the digital images performed. Serial analysis of microsialograms during progressive filling showed that both methods depicted the structural characteristics of the ducts at each grey level. However, in the experimental groups, run-length analysis showed slight changes in the peripheral duct system more clearly. This method was therefore considered more effective than histogram analysis.

Animals↗

Sialectasis and HIV infection.

The sialographic findings of the parotid gland of an HIV-positive patient are presented. Multiple areas of sialectasia were noted and their similarity to Sjögren's syndrome is discussed.

Constriction↗

Symptomatic and asymptomatic salivary duct abnormalities in Darier's disease: a sialographic study.

Symptoms of obstructive sialadentis have been occasionally reported as a feature of Darier's disease. Parotid sialograms of three patients with confirmed Darier's disease and histories suggestive of salivary obstruction revealed dilatation with periodic strictures and indentations affecting the main ducts. Similar parotid sialograms in three Darier's disease patients with no symptoms attributable to their salivary glands revealed seepage of contrast media associated with the secondary and tertiary ducts. These findings suggest that salivary glands may be more commonly involved in Darier's disease than previous reports indicate.

Adolescent↗

Studies on the quantitative computed tomography of normal parotid and submandibular salivary glands.

A better understanding of computed tomographic (CT) numbers of normal salivary glands might help make CT diagnosis more accurate. The CT numbers of the parotid and submandibular salivary glands were measured using both non-enhanced and enhanced CT images by setting a circular region of interest (ROI). The normal range of CT numbers, the difference between the CT numbers of right and left glands, and the correlation with age were all investigated. There was a close correlation between the CT numbers of right and left glands. No significant difference was seen between the average of right and left CT numbers in both glands, on either non-enhanced or enhanced CT images. The difference between right and left numbers on enhanced CT were larger than those on non-enhanced CT. A significant difference was seen between the CT numbers of the parotid and submandibular glands. A sex difference was seen on both non-enhanced and enhanced CT images in the parotid gland, while it was only seen on enhanced CT in the submandibular gland. The range as well as the mean of CT numbers in all cases of enhanced CT were larger than those of non-enhanced CT. CT numbers of the parotid glands tended to decrease proportionally with age, up to the age of 40 years; over the age of 40, no relationship could be detected. In the submandibular gland, the difference in the correlation coefficient was not significant between the two age groups. Further investigation into the factors affecting the CT numbers of normal glands is required before they can be used for diagnostic purposes.

Adolescent↗