Synthesis of new fragrances from 2-methylfuran. Part III.
The synthesis of new 2-methylfuran-based alcohols is described. The odor and physicochemical characteristics of all new compounds are also presented.
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The synthesis of new 2-methylfuran-based alcohols is described. The odor and physicochemical characteristics of all new compounds are also presented.
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The aims of the Research Institute for Fragrance Materials, Inc. (RIFM), an international nonprofit science-based organization established in 1966 by the fragrance industry, include the prevention of adverse cutaneous effects, systemic toxicity, and environmental consequences from fragrance ingredients. This paper gives an overview of the RIFM testing and research program, how priorities are established, and how RIFM's safety evaluation process works.
The essential oils of the leaves, stems, rhizomes and roots of the medicinal plant Alpinia galanga from southern India were investigated by GC-FID, GC-MS and olfactometry. In all four samples, mono- and sesquiterpenes as well as (E)-methyl cinnamate could be identified. They are responsible for the characteristic odor as well as for the reported use in (folk) medicine and in food products of A. galanga. The essential oil of A. galanga leaves is rich in 1,8-cineole (28.3%), camphor (15.6%), beta-pinene (5.0%), (E)-methyl cinnamate (4.6%), bornyl acetate (4.3%) and guaiol (3.5%). The stem essential oil contains 1,8-cineole (31.1%), camphor (11.0%), (E)-methyl cinnamate (7.4%), guaiol (4.9%), bornyl acetate (3.6%), beta-pinene (3.3%) and alpha-terpineol (3.3%). 1,8-cineole (28.4%), alpha-fenchyl acetate (18.4%), camphor (7.7%), (E)-methyl cinnamate (4.2%) and guaiol (3.3%) are the main constituents of the rhizome essential oil. The root essential oil contains alpha-fenchyl acetate (40.9%), 1,8-cineole (9.4%), borneol (6.3%), bornyl acetate (5.4%) and elemol (3.1%). In addition, biological and aroma effects of the main and minor compounds of the four essential oils of Alpinia galanga are discussed in terms of their possible use in medicine, cosmetics and foods.
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The relationship between the fragrance industry and the dermatological community in the past has not always been perceived as one of partnership. IFRA, the International Fragrance Association, has started a series of initiatives to underline the industry's commitment to market safe products that limit any unavoidable risk to the minimum while at the same time enabling the consumer to choose from a variety of fragranced products. This article describes current projects and future initiatives.
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Closed loop stripping analysis (CLSA), a suitable tool for the determination of volatile and semivolatile compounds at low trace levels (ng/l), has been used to determine and quantify seven selected musks and two fragrances (Acetyl cedrene and Amberonne). The obtained extracts are analyzed by high resolution gas chromatography coupled to mass spectrometry (GC/MS) operating in the SIM mode. Quality parameters such as limit of detection; matrix effects; precision expressed as repeatability and reproducibility relative standard deviations of the method and an estimation of the uncertainty have been evaluated. The method has been applied to the analysis of wastewater effluents, surface water and tap water from different places in Europe. All samples contained differents musks at ng/l levels with the polycyclic musks Galaxolide and Tonalide and both fragrances, Amberonne and Acetyl cedrene, being the most abundant. These results suggest the importance of studying and controlling the presence of these ubiquitous environmental compounds in water systems.
The author presents experimental data and suggests a method for extraction of aromatic substances from the blood, urine, lavage water, stomach and its contents, liver and kidneys. The extract is dissolved in 96% ethanol and the aromatic substances are detected in reactions with hydrochloric acid, Marki's reagent, 2,4-dinitrophenylhydrazine, diazotized o-dianisidine, phthivazide, chromotropic acid by UV spectrophotometry, thin-layer and gas-liquid chromatography. The sensitivity of the method is 0.1-0.5 mg %.
Fragrances are a common cause of contact dermatitis and account for a large percentage of reactions to cosmetic products. Novel fragrance compounds that may not be detected by the common fragrance screening agents (including balsam of Peru and fragrance mix) are continually being produced. Lyral is one of those allergens found in many cosmetic and household products. This review will discuss the recent literature and the significance of this allergen to allergic contact dermatitis.
Polycyclic and nitro musks and two fragrances (Acetyl cedrene and Amberonne) have been determined and quantified in influent and effluent waste water, river water and tap water samples from different European countries by closed loop stripping analysis (CLSA) as a method of preconcentration and GC/MS operating in the SIM mode. Limits of detection; precision expressed as repeatability and reproducibility relative standard deviations of the method; matrix effects and the estimation of the uncertainty have been evaluated. All samples contained different musks at ng/l levels being the polycyclic musks Galaxolide and Tonalide and both fragrances, Amberonne and Acetyl cedrene the most abundant. Removal of these main compounds is achieved partially in all waste water treatment plants studied. These results suggest the importance of studying and controlling the presence of these ubiquitous environmental compounds in water systems.
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Contact dermatitis is a common skin disease. Disease was diagnosed by a history of contact substance together with geographic distribution of lesion. Up till now, standard patch test is one of the most reliable test to identify and confirm causative agent of allergic contact dermatitis. To determine the rate of positive standard patch test and to identify the common allergen of contact dermatitis in Thailand, we performed the standard patch test in 129 patients, suspected having allergic contact dermatitis at Department of Dermatology, King Chulalongkorn Memorial Hospital, Thailand from June 1, 2003 to September 1, 2004. The rate of positive standard patch test is 59.7% (n = 77/129). The most 3 common positive allergens were nickel sulfate (18.60%), cobalt chloride (17.05%) and fragrance mix (14.73%), respectively. The chance of positive standard patch test significantly correlated with sex (woman), initial diagnosis as contact dermatitis and history of house-worker (p = 0.017, p = 0.005 and p = 0.023, respectively). Whereas, there were no significant correlation between the chance of positive standard patch test and age of patient, location of lesion, history of recurrence, history of atopy, history of drug and food allergy. In addition, history of metal allergy significantly correlated with the chance of positive nickel sulfate or cobalt chloride in standard patch test (p = 0.017). In conclusion, this study demonstrated the prevalence of causative allergen of contact dermatitis in Thai patients using that standard patch test. Moreover, our data shown that the chance positive standard patch test was greater in patient, who were women or initial diagnosed as contact dermatitis or had history of houseworker or history of metal allergy.
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Allergic contact dermatitis (ACD) is an important disease with high quality of life and economic impact. Patch testing is the procedure by which identification of the cause of ACD can be elicited. Proper performance of the test, from taking an appropriate patient history to placing the correct allergens to evaluating and educating the patient, is of utmost importance. The purpose of this article is to highlight common allergens encountered in our environment, to increase awareness for this important disease, and to underscore the importance of this testing modality. An early index of suspicion can lead to appropriate testing, diagnosis, avoidance, and cure.
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The ability of some aromatic waters at the in-use concentrations to enhance or inhibit the growth of microorganisms was determined by the antimicrobial preservative challenge method. Anise, chloroform, cinnamon, clove, dill, lemon, peppermint and rose waters were challenged with Ps. aeruginosa. Levels of the surviving cells at different times were determined by the pour plate method. The antimicrobial effect of the corresponding undiluted aromatic oils against Ps. aeruginosa was determined by the cup-plate method. Results showed that cinnamon water possesses profound and useful preservative activity against Ps. aeruginosa. The inhibitory effect of anise, chloroform and rose waters on Ps. aeruginosa is not much pronounced. Similarly, clove, dill and peppermint waters exhibited no significant preservative actions. Lemon water was found to enhance the growth of Ps. aeruginosa. The survival pattern of Ps. aeruginosa in the majority of the aromatic waters conforms with the antimicrobial actions of their undiluted oils.