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A practice-based assessment of the handling of a fast-setting polyvinyl siloxane impression material used with the dual-arch tray technique.

OBJECTIVE: The purpose of this study was to assess a new impression material used in conjunction with the dual-arch technique. METHOD AND MATERIALS: Ten members were selected at random from the Product Research and Evaluation by Practitioners (PREP) panel, a United Kingdom-based group of dental practitioners who are prepared to undertake research projects in their practices. Explanatory letters, a questionnaire, packs of the impression material, and dual-arch trays were distributed to the evaluators, together with instructions on the use of the materials. The practitioners were asked to use the materials and return the questionnaire after using the materials for a minimum of 10 impressions. RESULTS: Three evaluators had not previously used the dual-arch technique, six had used it in the past or occasionally, and one used the technique routinely. A total of 115 impressions were recorded with Quick Step. The overall rating for ease of removal of impressions from the mouth was 4.7 on a linear scale in which 5 represented easy to remove and 1 represented difficult to remove. Four of the evaluators rated the working time as excellent and the remaining six as good. Eight of the evaluators stated that the quality of fit of the single-unit restoration constructed with the combined-arch tray was the same as that obtained when a conventional tray technique was used. CONCLUSIONS: The impression material under test scored highly for application in circumstances where the fields above and below the preparation margin were dry or had limited moisture problems. Eighty percent of the evaluators considered the impression and dual-arch tray technique to be of benefit to their practice.

Dental Impression Materials↗
PubMed2002

XRCC1 and CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers.

Mutant p53 protein and anti-p53 antibody in circulating blood can be detectedamong individuals with mutations of the p53 tumor suppressor gene. Plasma mutant p53 protein and anti-p53 antibody have also been associated with vinyl chloride monomer (VCM) exposure, although the mechanism of VCM-related carcinogenesis remains unclear. Polymorphisms of metabolic and DNA repair genes have been implicated in chemical exposure-related carcinogenesis. The aim of this study is to explore the association between polymorphisms of metabolic and DNA repair genes with mutant p53 protein and anti-p53 antibody expression induced by VCM. Study subjects comprised 333 male workers occupationally exposed to VCM. Plasma mutant p53 protein and anti-p53 antibody detected with ELISA were grouped together as p53 overexpression. Genotypes of cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2), glutathione S-transferase T1 (GSTT1), and X-ray repair cross-complementing group 1 (XRCC1, exon 10) genes were identified by the PCR. High VCM exposure group had significantly higher p53 overexpression as compared with low exposure group [odds ratio (OR), 2.1; 95% confidence interval (CI), 1.1-3.8]. Individuals having experienced a high VCM exposure and displaying a XRCC1 Gln-Gln genotype had a highest risk of p53 overexpression among those having different combinations of VCM exposure and XRCC1 genotypes (OR, 6.5; 95% CI, 1.7-24.2). Interestingly, those subjects reflecting a CYP2E1 c2c2 genotype among the low VCM-exposure group demonstrated a greater risk of p53 overexpression (OR, 9.8; 95% CI, 1.2-81.6) as compared with those experiencing a low VCM exposure and CYP2E1 c1c1/c1c2 genotypes. Additional analysis revealed that individuals possessing more susceptible XRCC1 Gln-Gln, CYP2E1 c2c2, ALDH2 1-2/2-2, and non-null GSTT1 genotypes were more likely to reveal p53 overexpression. Our results suggest that susceptible XRCC1 and CYP2E1 genotypes may modulate the mutation of the p53 gene among VCM-exposed workers.

Age Factors↗