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At least 1,045 records · Page 58Linked to original sources
PubMed1978

Psychosomatic gastro-intestinal disease.

Psychosomatic disease is the commonest disorder in clinical gastro-enterology. It may be of primary importance in the patient's presentation, or act in a secondary role to modify organic disease and its management. Careful history-taking is essential in differentiating whether symptoms arise as a result of psychological stimuli or organic disease, as the effects may be indistinguishable to the patient. Organic disease should always be excluded by appropriate screening investigations.

Colonic Diseases, Functional↗
PubMed1994

[Methotrexate as possible treatment in refractory chronic inflammatory intestinal disease].

OBJECTIVE: To determine the value of low dose methotrexate therapy in chronic inflammatory bowel disease. SETTING: Catharina Hospital and Diaconessenhuis, Eindhoven, and St. Joseph Hospital, Veldhoven. DESIGN: Descriptive. METHOD: From 1988 until 1993 we treated 15 patients 16 times (one patient was treated twice) with methotrexate 25 mg i.m. once a week during 12 weeks, followed by a tapering oral dose. Our population consisted of 4 men and 11 women with a mean age of 31 year. The diagnosis was Crohn ileitis (1 patient), Crohn colitis (8), ileocolitis (4) and ulcerative colitis (2). The indication for methotrexate was resistance to therapy (9) and steroid dependency (7). Retrospectively the disease activity was determined after 1, 2 and 3 months of therapy. RESULTS: The mean defaecation frequency went down from 7 to 2 times daily after 12 weeks, the ESR from 47 to 17 mm/1st hour, the thrombocytes from 436 x 10(9)/l to 325 x 10(9)/l and the prednisone dose could be lowered from 22 mg to 15 mg after 3 months. In 13/16 treatment cases there was a subjective positive response to methotrexate. Initial response was seen within 4 weeks. No serious side effects were seen. After 10 of the 13 response episodes the disease recurred. CONCLUSION: Methotrexate 25 mg once a week i.m. was associated with a subjective and objective improvement in 12/15 patients, but the risk of recurrence after tapering appears to be large.

Adolescent↗
PubMed1995

[Current therapeutic possibilities in chronic inflammatory intestinal diseases].

Treatment of chronic inflammatory bowel disease can be divided into therapy of active disease, strategies in chronic, active disease and prevention of relapse. In Crohn's disease as well as in ulcerative colitis steroids are of major importance in the treatment of active disease. For ulcerative colitis 5-aminosalicylic acid is used in addition, in particular with mild or moderate disease. It is used for prevention of relapse in chronic inflammatory bowel disease. Immunosuppressive drugs are indicated in chronic, active Crohn's disease, while surgery is important in ulcerative colitis. New developments are predominantly related to nonsystemic steroids, which are studied in different modalities of galenic preparations.

Aminosalicylic Acids↗
PubMed1994

[Surveillance of patients with chronic inflammatory intestinal diseases: problems relevant to clinical practice].

For control of activity of inflammatory bowel diseases, clinical signs and acute-phase proteins are of higher value compared to endoscopy; however this method is necessary for supervision of patients with ulcerative colitis for detection of malignancies. In patients with longstanding and extensive ulcerative colitis, a consequent supervision permits to prevent cancer development markedly. New aminosalicylates are effective in preventing relapse in ulcerative colitis and perhaps in Crohn's disease. Deficiency in vitamins and minerals has to be recognized and balanced. Patients suffering from Crohn's disease should quit smoking because nicotine is worsening the course of the disease.

Colitis, Ulcerative↗
PubMed1996

[Consensus inflammatory intestinal diseases in children: ulcerative colitis and Crohn disease. Work Group Academic Medical Center, Amsterdam].

Members of different societies, including Paediatrics, Gastroenterology, Clinical Chemistry, Radiology and Pathology, involved in the treatment of children with inflammatory bowel disease (IBD) reached consensus during 12 meetings about definition, clinical and diagnostic work-up as well as initial treatment options in paediatric IBD. On the basis of history and physical examination a distinction is made between colitis-like or Crohn-like appearance. Further laboratory investigations are required in the presence of malnutrition, extraintestinal manifestations or growth retardation. Pathology plays an important part in the final diagnosis. Special attention is given to pubertal staging and height measurements as routine aspects of the treatment of children with IBD.

Algorithms↗
PubMedDate not supplied

[Possibilities of the use of parameters of membrane assembly of immunoglobulin receptors of B-lymphocytes in the differential diagnosis of intestinal diseases in children].

Children with different forms of enteric malabsorption were examined using an original method for assessing the parameters of the process of membrane assembling for immunoglobulin receptors of B-lymphocytes, which helps single out several additional criteria for the differential diagnosis of variants of the malabsorption syndrome. The authors consider the phase coefficients characterizing each stage and the general coefficient reflecting the regularities of the kinetics of membrane assembly of receptors in general to be the most essential. Use of this method in pediatrics offers new potentialities in the differential diagnosis, prediction of disease course, and monitoring of the treatment efficacy.

Adolescent↗