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Blood Cell Count↗

Bart's syndrome: a mechanobullous disease of the newborn. Report of five cases and review.

Bart's syndrome is one among the lesser known presentations of epidermolysis bullosa. It is characterized by congenital localized bullae of skin and mucous membranes sometimes associated with nail deformities, all of which disappear during the neonatal period. Early recognition allows for avoidance of inappropriate systemic or local therapy.

Diagnosis, Differential↗

A clinical appraisal of flucloxacillin in the management of skin and soft tissue infections in Nigeria.

The resolution of skin and soft tissue infections following a single course of treatment with flucloxacillin was assessed in 235 patients recruited by nineteen physicians. In all, 88.5% of patients were completely cured or showed a highly satisfactory improvement after 3 to 12 days' treatment. Only three patients failed to show any improvement at all. Side-effects were limited to twelve patients (5.1%) all of whom were able to complete their course of treatment.

Abscess↗

Azithromycin, erythromycin and cloxacillin in the treatment of infections of skin and associated soft tissues. European Azithromycin Study Group.

Azithromycin (total dose 1.5 g) given orally in five or six doses over 5 days was compared with erythromycin and cloxacillin both given orally as 500 mg four times daily for 7 days in two multicentre studies of patients with skin and associated soft-tissue infections. Azithromycin eradicated baseline pathogen(s), mainly Staphylococcus aureus, in 89% compared with in 78%, of erythromycin-treated patients (P = 0.501) and in 78% compared with in 59% of cloxacillin-treated patients (P = 0.421). No statistically significant difference in clinical cure was reported between azithromycin (74%) and erythromycin (75%, P = 1.00) and between azithromycin (60%) and cloxacillin (47%, P = 0.301) treatment groups. The side-effects reported for azithromycin were mainly mild or moderate gastro-intestinal complaints and there were no major abnormalities in laboratory parameters. It is concluded that azithromycin was as effective as, but better tolerated than, either erythromycin or cloxacillin and short-course therapy may improve patient compliance.

Abscess↗

Flucloxacillin in the treatment of infectious conditions in children.

A multi-centre study was carried out in 107 children with skin and soft-tissue infections (46) or upper respiratory tract infections (61) to assess the effectivness of flucloxacillin (125 mg. q.d.s. for 5 days). Swabs were taken from the lesion sites before and after treatment for bacteriological assessment and sensitivity of the isolated organisms. The clinical success rate achieved was 93% in skin and soft-tissue infections and 94% in upper respiratory tract infections and these results correlate closely with the bacteriological findings. The main causative organism in the skin and soft-tissue infections was Staph. aureus which was resistant to benzyl penicillin and to ampicillin in all but 2 cases. All strains proved sensitive to flucloxacillin. Minimal side-effects were reported and the syrup presentation was well accepted.

Administration, Oral↗

Extracellular products of Staphylococcus aureus reversibly inhibit the terminal differentiation of cultured mouse epidermal cells.

The effect of extracellular products from Staphylococcus aureus on the differentiation of mouse epidermal cells was studied using an in vitro cell culture system. The extracellular products from a clinical strain of S. aureus isolated from human skin lesions reversibly inhibited the Ca++-induced terminal differentiation of epidermal cells, as determined by their morphology and the extent of cornified envelope formation. This suggests that a similar modification of cell differentiation is involved in the pathogenesis of S. aureus-induced skin disease.

Animals↗