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At least 1,045 records · Page 58Linked to original sources
PubMed1994

Laparoscopic urology: fantasy or foundation.

Laparoscopy is the latest addition to the urologist's endoscopic skills. The increasing interest in the application of laparoscopy to urologic procedures has been reflected in the prevalence of reports in the urologic literature in recent years. However, there remains considerable debate as to the ultimate clinical applicability and appropriateness of these procedures in the management of patients. Laparoscopic urology is still in its infancy of development. The impact of technological advances and innovative practitioners may culminate in laparoscopic surgery being the catalyst to the development of a surgical cure devoid of incisional morbidity.

Journal Article↗
PubMed2003

New perspectives in the management of osteoarthritis. structure modification: facts or fantasy?

Several entities have been carefully investigated for the symptomatic and structural management of osteoarthritis (OA). The most compelling evidence of a potential for inhibiting the structural progression of OA has been obtained with glucosamine sulfate, while some preliminary results also suggest that other compounds could be used in the same indication. At any rate, several medications have clearly demonstrated a symptomatic action, mainly in OA of the lower limbs, including pain relief and improvement of functional disability. An important issue is that all conclusive studies with such chemical entities resulted from the use of prescription medicines and not over-the-counter or nutriceutical supplements.

Anthraquinones↗
PubMed1992

[Be wise--refer! Fact or fantasy?].

On the occasion of his retirement as an active specialist in Surgery dr. P.H.A. Poll describes the history of the development of the specialties in Veterinary Medicine in The Netherlands and carefully looks forward. As a tribute, his specialist colleagues, all related to the Companion Animal Hospital "De Wagenrenk", publish one or more case reports from there respective disciplines (ophthalmology, surgery, radiology, dermatology).

Animals↗
PubMed1992

Total versus subtotal gastrectomy in cancer of the distal stomach: facts and fantasy.

The purpose of this review is to analyse critically the pros and cons of 'en principle' total gastrectomy for cancers of the distal stomach. The theoretical advantages of total gastrectomy would be the guarantee of no infiltration of the margin of proximal transection owing to multicentric cancers or to a microscopical intramural spreading of tumoral cells beyond the macroscopically detectable boundaries of the lesion. However, these expectations are not substantiated since multicentric tumours are rare, a safe margin of resection can be achieved maintaining a proximal clearance of 6 cm from the cranial edge of the tumour. Moreover, recurrences confined to the gastric stump, after subtotal gastrectomy (and originally preventable with a total gastrectomy) are extremely rare according to literature. Furthermore, current experience suggests that the extent of lymph node dissection is not affected by the extent of the resection of the stomach. Analysis of the published series of patients undergoing an en principle total gastrectomy fails to demonstrate any advantage for long-term survival compared with patients treated by subtotal gastrectomy. A recent randomized trial comparing these two procedures is in keeping with the above-mentioned conclusions. It is true, however, that the gap in surgical mortality for total and subtotal gastrectomy tends to disappear when total gastrectomy is electively performed in patients with tumours of the distal stomach. So, whereas the long-term oncological results of the two surgical procedures seem to be similar, the main disadvantage of total gastrectomy is the onset of malnutrition, which is common, but incapacitating only in a few patients. This condition is likely to be of relevance should the patients be selected for aggressive postoperative adjuvant treatments which require good general status and nutritional integrity. The main disadvantage of subtotal gastrectomy is that the patients are exposed to the risk of a gastric stump cancer. However, this risk, owing to the advanced median age of the resected patients and the actual reconstructive procedures which minimize the biliary reflux, cannot be quantified. We think that when two surgical procedures are compared, if the oncological results are the same, the operation which is associated with least discomfort and impairment of the quality of life, should be chosen.

Gastrectomy↗
PubMedDate not supplied

Seasonal fantasies in scaffolds.

When tissue-engineering (TE) products started to emerge a few years ago, it seemed that the natural choice for the degradable scaffolds would be the same synthetic aliphatic polyesters that are used for absorbable medical devices. However, it is now becoming clearer that different solutions are required for the construction of these important constituents of TE products.

Absorbable Implants↗
PubMed2003

[Immunologic control of HIV-1 infection. Fantasy or soon reality?].

The human immunodeficiency virus-1 (HIV-1) preferentially infects CD4+ cells, leading to their destruction. In contrast to other viral infections, the immune system is unable to keep the HIV infection under permanent control in most cases. This failure ultimatively results in immunodeficiency with occurrence of AIDS-defining diseases. In recent years, highly active antiretroviral therapy (HAART) has become available, and the number of AIDS cases and deaths have decreased dramatically. However, limitations of HAART become more apparent, demanding greater emphasis on search for alternative approaches. Stimulation and modulation of the immune response to HIV are new and promising strategies. A prerequisite, however, is the knowledge about immunologic defense mechanisms against HIV. In this article, the major factors of innate and acquired immune responses to HIV are described.

AIDS Vaccines↗
PubMed2004

Mitochondrial uncoupling proteins--facts and fantasies.

Instead of a comprehensive review, we describe the basic undisputed facts and a modest contribution of our group to the fascinating area of the research on mitochondrial uncoupling proteins. After defining the terms uncoupling, leak, protein-mediated uncoupling, we discuss the assumption that due to their low abundance the novel mitochondrial uncoupling proteins (UCP2 to UCP5) can provide only a mild uncoupling, i.e. can decrease the proton motive force by several mV only. Contrary to this, the highly thermogenic role of UCP1 in brown adipose tissue is not given only by its high content (approximately 5 % of mitochondrial proteins) but also by the low ATP synthase content and high capacity respiratory chain. Fatty acid cycling mechanism as a plausible explanation for the protonophoretic function of all UCPs and some other mitochondrial carriers is described together with the experiments supporting it. The phylogenesis of all UCPs, estimated UCP2 content in several tissues, and details of UCP2 activation are described on the basis of our experiments. Functional activation of UCP2 is proposed to decrease reactive oxygen species (ROS) production. Moreover, reaction products of lipoperoxidation such as cleaved hydroperoxy-fatty acids and hydroxy-fatty acid can activate UCP2 and promote feedback down-regulation of mitochondrial ROS production.

Animals↗
PubMed2004

Fact and fantasy.

Explore the source record for details and available documents.

Evidence-Based Medicine↗
PubMed2004

Fact and fantasy.

Explore the source record for details and available documents.

Anti-Bacterial Agents↗
PubMed2005

Cardiac restoration: frontier or fantasy?

Heart failure is reaching epidemic proportions in Canada. The current medical and surgical therapies are inadequate to restore cardiac function. Increasingly, cell therapy has been investigated as a novel approach to regenerate the heart and to restore function. Animal studies have been promising and clinical trials are proceeding. Early results suggest that cell therapy may be efficacious in humans as well, but adverse events have been noted. Although the optimal cell type, mode of delivery and ideal patient population have not been identified, the bulk of the evidence suggests that both cardiologists and cardiac surgeons will use cellular therapy to treat heart failure in the future.

Animals↗