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At least 1,045 records · Page 58Linked to original sources
PubMed1995

[A case of pulmonary blastoma composed of histological features of both pulmonary blastoma and pulmonary endodermal tumor resembling fetal lung].

A case of pulmonary blastoma in a 71-year-old male was reported. Chest X-ray and CT scan showed a well demarcated mass lesion in the apical segment of the right lung. A polypoid tumor was detected in the apical branch of the right bronchus by bronchoscopy. The biopsy confirmed the diagnosis of pulmonary blastoma. The patient underwent a right upper lobectomy with lymph nodes dissection on Jan. 26, 1990. The resected tumor was really composed of two parts: a main tumor in the lung parenchyma and polypoid one protruding into the bronchus from the main tumor. The polypoid tumor exhibited typical features of pulmonary blastoma with both carcinomatous and sarcomatous components. The histology of the main tumor was identical to pulmonary endodermal tumor resembling fetal lung (PET). The metastases in the excised lymph nodes consisted entirely of carcinomatous elements. The patient died of brain stem metastasis a year after his operation. The present case, with typical pulmonary blastoma and PET present in the same tumor, supports the idea that pulmonary blastoma and PET belong to the same group neoplasma.

Aged↗
PubMedDate not supplied

Fine needle aspiration biopsy findings in endodermal sinus tumors. A report of four cases with cytologic, immunocytochemical and ultrastructural findings.

We present four cases of endodermal sinus tumor affecting children (median age, 20 months). Three tumors were located in the sacrococcygeal region and one in the right testicle. All cases were diagnosed by fine needle aspiration biopsy. The most characteristic features were cells arranged in a papillary-like configuration, vacuolated cytoplasm and intracellular and extracellular deposits of pink, homogeneous material. Immunocytochemical study showed alpha-fetoprotein-positive cells. Ultrastructural study showed intracytoplasmic inclusions of electron-dense material and basement membrane-like material in the intercellular spaces.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1993

Endodermal sinus tumour of the vulva: an interesting clinico-pathological problem.

Endodermal sinus tumours (EST) of the lower female genital tract are uncommon malignancies. The majority of these involve the vagina and cervix, though there are a few case reports of tumours involving the vulva. These are usually either locally advanced or have metastatic disease present at initial diagnosis, and generally do badly on treatment. This case report discusses primary vulval involvement by EST. It shows that the absence of tumour markers can be misleading, and discusses the role of radiation and chemotherapy in the treatment of this rare disease.

Adult↗
PubMedDate not supplied

Pulmonary endodermal tumor resembling fetal lung: report of a case in a 14-year-old girl.

This report describes the clinical and histologic features of a pulmonary tumor in a 14-year-old girl that is most consistent with a rare entity described in the literature as "pulmonary endodermal tumor resembling fetal lung" (PET). This tumor is composed of glycogen-rich columnar cells forming complex glands with focal festooning and mitotic activity, admixed with solid "morules" of cells with eosinophilic cytoplasm and focal nuclear clearing. Patchy tumor necrosis and a bland stroma were also present. Immunoreactivity for carcinoembryonic antigen (CEA), alpha 1-antichymotrypsin, and 12E7 was present in glandular cells and for human chorionic gondatropin (HCG), alpha 1-antichymotrypsin, and 12E7 in morular cells. Ultrastructural features are those of an epithelial tumor. Related entities have been called "pulmonary blastoma lacking sarcomatous elements" and "adenocarcinoma of fetal lung type." Most cases of PET have occurred in adults, and the histologic features thought to have prognostic significance in small published series are applied to our case, in which the patient remains well and without evidence of tumor recurrence or metastasis for 28 months following local resection as the sole treatment.

Adolescent↗