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At least 1,045 records · Page 58Linked to original sources
PubMed1979

Experimental homocystinemia, endothelial lesions and thrombosis.

A single intravenous injection of homocystine led to an increase in the number of circulating endothelial cells in the blood of rats. We observed also increased permeability of the lung capillaries, platelet sequestration and activation of the venostatic thrombosis. Endothelial injury is probably the key mechanism of thrombotic and atherosclerotic complications in homocystinuria, an inborn error of the amino acid metabolism.

Animals↗
PubMed1984

Ultrastructure of human placenta: effects of maternal drinking.

Previous investigations employing both animal models and human subjects have already documented that maternal alcohol consumption during pregnancy has definite deleterious effects upon the developing fetus. In these earlier studies, however, only gross morphological assessments were used to determine the toxicity of alcohol upon placenta and fetus. To date, there is nothing in the literature regarding the effects of alcohol upon the ultrastructure of the placenta. In our laboratory, using both scanning and transmission electron microscopy, placental specimens from mothers who drank heavily during the gestational period revealed ultrastructural abnormalities which suggest that maternal alcohol consumption may indirectly affect the fetus by altering the fine structure of the placenta.

Adult↗
PubMed1999

[Evaluation of functional potentials of microcirculation in patients with obliterating diseases of lower limb vessels].

An analysis of the data of laser doppler fluorometry in 136 patients has shown that different obliterating diseases have different typical fluorometric features of changes in microcirculation. Results of the postischemic test are of greater informative value in the noninvasive assessment of the functional state of microcirculation. The significance of the functional tests was particularly increasing in critical ischemia of the lower extremities. The intraoperative determination of the muscle blood flow allowed performing the control of the lower extremity revascularization and determining the optimum level of amputation.

Adult↗