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PubMed1985

Analysis of nonprescription capsules purported to contain an adrenal androgen.

The content of nonprescription capsules purported to contain dehydroepiandrosterone was analyzed. Five capsules labeled "dehydroepiandrosterone (DHEA) 500 mg and natural precursors" were analyzed; all were from a single lot and container. Ether extracts were used to test for DHEA, cortisol, testosterone, and androstenedione using radioimmunoassay (RIA). The protein, starch, reducing-sugar, sodium, potassium, calcium, and magnesium contents were also measured. The mean (+/- S.D.) DHEA content per capsule was 14.40 + 5.16 micrograms. A mean androstenedione concentration of 1.22 + 0.21 micrograms was measured. Cortisol and testosterone were not detectable by RIA. Concentrations of the other ingredients (mean +/- S.D. for five capsules) were as follows: protein 35.2 +/- 2.3 mg, starch 39.9 +/- 2.7 mg, reducing sugars 3.2 +/- 0.2 mg, sodium less than 1.5 mM, potassium less than 0.15 mM, magnesium 0.60 mg, and calcium 3.45 mg. The total amount of free DHEA contained in the capsules was only a small fraction of the labeled amount of that steroid and was probably inadequate for producing any measurable effects.

Capsules↗
PubMedDate not supplied

Liquid chromatographic determination of flucytosine in capsules: collaborative study.

A liquid chromatographic method for the determination of flucytosine in capsules was collaboratively studied by 7 laboratories. The method uses a C18 reverse phase column, water-methanol-acetic acid mobile phase containing 1-octanesulfonic acid sodium salt, p-aminobenzoic acid as internal standard, and photometric detection at 285 nm. The mean recovery value (+/- SD) of flucytosine from a synthetic formulation representing capsules was 99.2 +/- 1.72% (CV = 1.73%). Composited samples of 250 and 500 mg commercial capsules gave assay values of (mean +/- SD) 103.17 +/- 2.21 and 99.29 +/- 1.29% of declared, respectively. CV values were 2.15 and 1.30%. Reproducibility and repeatability CVs were 2.19 and 1.50%, respectively, for the 250 mg capsules, and 1.34 and 0.63%, respectively, for the 500 mg capsules. The method has been adopted official first action.

Capsules↗
PubMed1988

Rattlesnake capsule-associated Salmonella arizona infections.

Three Hispanic patients at our institution developed extragastrointestinal Salmonella arizona infection associated with the ingestion of rattlesnake capsules. All patients had underlying chronic medical illnesses, including the acquired immunodeficiency syndrome, systemic lupus erythematosus, and congestive heart failure. Rattlesnake capsules were obtained from both local pharmacies and patients. Salmonella arizona, as well as various other enteric organisms, was grown on cultures obtained from all capsules tested. Review of the literature disclosed three additional cases of extragastrointestinal S arizona infection linked to rattlesnake capsule ingestion, all associated with underlying medical illness. We postulate that rattlesnake capsules may be frequently ingested by chronically ill Hispanic individuals and serve as a vehicle for serious S arizona infection.

Adult↗
PubMed1983

Immunogenicity of Ty21a attenuated "Salmonella typhi" given with sodium bicarbonate or in enteric-coated capsules.

Ty21a, a stable attenuated mutant of Salmonella typhi, is a safe, protective oral vaccine when 3 doses of 10(9) cells in saline are taken after neutralization of gastric acidity by 1 g NaHCO3. To identify a more convenient method to administer vaccine and to determine the feasibility of immunizing with a single dose, we studied the immune response of children and adults to different formulations of Ty21a with a newly developed, sensitive, enzyme-linked immunosorbent assay (ELISA). In this ELISA, a rise in S. typhi O antibody was defined as a change in net optical density of greater than or equal to 0.15 (more than 3 SD from the mean difference in optical density in a negative control population). Three hundred and thirty-five Chilean children were given 3 doses of 10(9) Ty21a in 150 ml of milk with 0.8 g NaHCO3 or in enteric-coated capsules. In each group, 5% seroconverted by Widal O but 41% by IgG ELISA O antibody titers; mean antibody levels by group were identical. Studies were also carried out in healthy college students in a non-endemic area (U.S.A.) who had no history of prior typhoid immunization. In total, 141 U.S. adults received vaccine formulated in either one of two ways: 1) in gelatin capsules administered with two additional gelatin capsules containing a total of 0.8 gm NaHCO3 or 2) in enteric-coated capsules. Thirty-six persons received one dose, 30 got two doses and 16 ingested three doses of enteric-coated vaccines, while 44 persons receiving one dose and 15 got two doses of vaccine in the gelatin capsule formulation. Rates of seroconversion of ELISA O antibody were similar in all the groups. Ty21a vaccine was not recovered from multiple stool, jejunal fluid or blood cultures of the U.S. vaccine recipients. Based on these observations a large-scale field trial of efficacy has been initiated in 90.000 schoolchildren 6-20 years of age in Santiago, Chile, of whom one-third received one dose of enteric-coated vaccine, one-third got two doses and the remainder received placebo.

Adolescent↗
PubMed1978

[Effect of auxiliary substances on the bioavailability of tetracycline hydrochloride capsules (an in vitro study)].

The rate of tetracycline hydrochloride transfer into solution from capsules containing different auxiliary substances was studied. It was shown that the dispersity level of tetracycline hydrochloride powder had no significant effect on the capsule disintegration and the rate of the antibiotic transfer into solution. The effect of the auxiliary substance composition on the capsule disintegration and the rate of the antibiotic dissolution was shown. The rate of tetracycline liberation from the capsules containing tetracycline hydrochloride without additives or the antibiotic in combination with 23 per cent of lactose was 4 to 6 times higher than that from the capsules with magnesium carbonate or calcium phosphate as the auxiliary substances.

Biological Availability↗
PubMed1982

Structure and biosynthesis of rabbit lens capsule collagen.

The present study was designed to compare collagen synthesized by rabbit lens epithelial cells in culture with rabbit lens capsule collagen. Confluent monolayers of rabbit lens epithelial cells were established. Incorporation of [3H]-proline into glycoproteins secreted into the medium and cell surface components were analyzed in the presence of protease inhibitors. Gel filtration chromatography on sodium dodecyl sulfate--agarose (Bio-gel A-5m) of [3H]-labeled newly synthesized proteins by lens epithelial cells in culture resolved into a single precursor of approximate molecular weight of 160,000 daltons. Neither the medium nor the cell layer showed any evidence of low-molecular weight hydroxyproline-containing material. Limited pepsin digestion of this material cleaved the higher molecular weight chains into smaller components ranging from 25,000 to 110,000 daltons. Pepsin digestion and direct extraction of the collagenous components of the rabbit lens capsule revealed materials of high--molecular weight proteins similar to that synthesized in culture. Low--molecular weight (55,000 daltons) protein was only detected in lens capsules after prolonged pepsin digestion. S-Carboxylation of the lens capsules collagens did not affect their mobilities, but repepsinization gave rise to 110,000 dalton protein, although no significant changes in the amino acid composition were noticed. The absence of synthesis of low--molecular weight protein by cell culture and the presence of low--molecular weight components only after prolonged pepsin digestion of lens capsule could be the result of unusual susceptibility of the basement membrane collagens to pepsin attack.

Amino Acids↗
PubMedDate not supplied

Scheimpflug photography and postcataract surgery posterior capsule opacification.

We describe a method to objectively document postcataract surgery posterior capsule opacification using Zeiss Scheimpflug photography and computerized image analysis. We examined 42 eyes with clear capsules (group A) and 27 with posterior capsule opacities (group B). The group A eyes had significantly better visual acuity (P < .05), lower mean capsular densitometry readings (0.03 +/- 0.03 optical density units versus 0.15 +/- 0.11 optical density units; P < .0001), and thinner capsules (0.03 +/- 0.4 mm versus 0.10 +/- 0.05 mm) than the group B eyes. This new objective method of documenting postoperative capsular haze may be useful for clinical studies such as clinical trials of drugs or surgical techniques being developed to prevent or minimize capsule opacification.

Adult↗
PubMed1995

[Pacinian corpuscles in the articular capsule of the mouse knee joint, with special reference to postnatal development].

The morphology, intracapsular distribution and postnatal development of the Pacinian corpuscle which is one of the sensory nerve endings of the mouse knee joint, was examined by immunohistochemistry for S-100 protein, and by light and electron microscopy. Pacinian corpuscles existed only in the mouse knee joint on the flexor side, and were observed near the insertion of the capsule at the meniscus, at the insertion of the cruciate ligaments, and in the adipose tissue of the joint capsule. An average of 6-7 Pacinian corpuscles were found in one knee joint. The Pacinian corpuscle consisted of a central axon which was surrounded by approximately 20 thin lamellae of inner core cells and 10 layers of perineural capsular cells, and was enveloped by connective tissue capsule. This basic structure was not notably different from that in other experimental animals (cat, rat, etc.). In observation of the postnatal development from 0 to 7 days of age, only sporadic presence of the fasiculus of unmyelinated nerve fibers was observed in the joint capsule. At 9 days of age, a structure, which is considered to be the original form of the Pacinian corpuscle, was observed. This consisted of a central axon surrounded by irregular cytoplasmic processes of Schwann cells which had basal lamina. At 2 weeks of age, the inner core layers around the axon were formed, making up the basic structure of the Pacinian corpuscle. At 3 weeks of age, the numbers of inner core and perineural capsular layers had increased, and structure was closed to the adult morphology of the Pacinian corpuscle. By the 5 weeks of age, the caveolae and coated vesicles, which are characteristically present in the cytoplasm of the lamellar cells of the Pacinian corpuscle, had increased, and the basal lamina was completed. The Pacinian corpuscle, at this point, had become completed in structure and size. The S-100 protein first became positive in the inner core at 3 weeks of age, but negative in the perineural capsule during the entire period. Thus the inner core originated from the Schwann cells and the perineural capsular cells from the connective tissue. The findings suspected that the Pacinian corpuscles of the mouse knee joint start functioning around 3 weeks of age.

Animals↗
PubMed1994

Effects of immobilization on the capsule of the canine glenohumeral joint. A structural functional study.

The effects of immobilization on the function of the glenohumeral joint and its capsule were investigated in eight beagle dogs. One foreleg of each animal was immobilized in a spica cast, and the dogs were euthanized after 4, 8, 12, and 16 weeks of immobilization in groups of two. The contralateral limb and the forelegs of two normal beagles were used as controls. At the time of euthanasia, the range of motion, intraarticular filling volume during passive movements of the joint, and intraarticular filling volume to rupture the capsule were measured. The synovium, including the capsule and the subscapular bursa, were examined histologically. In the immobilized limb, there was progressive restriction in the range of motion with increases in intraarticular pressure, and the filling volume that was required to cause a rupture of the capsule diminished. Morphologically, the capsule and the subscapular bursa showed focal adhesions. Thus, it appeared that immobilization of these canine forelimbs produced changes in the glenohumeral joint that resembled those of frozen shoulder in humans.

Animals↗
PubMed1994

Innervation of the human temporomandibular joint capsule and disc as revealed by immunohistochemistry for neurospecific markers.

An immunohistochemical investigation for the neurospecific markers S-100 protein and protein gene product 9.5 was carried out on 12 healthy temporomandibular joint discs and capsules that were taken at autopsy from human adults. Large nerve trunks in the joint capsule and posterior disc ligament, as well as small nerve bundles and single nerves in almost all parts of the capsule, were heavily stained by anti-S-100 antiserum. The S-100 immunoreactive chondrocytes were also detected in the disc. Antiprotein gene product 9.5 similarly evidenced nerve fibers in the capsule and posterior disc ligament, and it also labeled a few small nerve bundles and a number of single fibers in the peripheral portions of the disc. No corpuscular or specialized endings were encountered in the specimens. These results give new support to the existence of a rich innervation of the human temporomandibular joint capsule and disc that should be further characterized with regard to type, function, and neuropeptide content.

Adolescent↗
PubMed1994

Immunohistochemical approach for the investigation of nerve distribution in the shoulder joint capsule.

Twenty six shoulder joint capsules obtained from 13 autopsy cases were studied to evaluate the nerve distribution using immunohistochemical techniques. Immunohistochemical staining of polyclonal S-100 protein or protein gene product 9.5 was more sensitive, specific, and reproducible compared with conventional gold chloride methods. A small number of clustered nerve fibers were found in the superficial layer, and many nerve fibers with large diameters were found in anteroinferior portions of the deep layer. Nerve fibers of various sizes were more numerous in posterosuperior and anterosuperior portions of the boundary zone between labrum and capsule. A Pacinian corpuscle was clearly recognized in a capsule. In the central portion of the long head of some biceps brachii tendons, relatively large nerve fibers continued from capsules. The results suggest that the capsule and long head of the biceps brachii tendon may play a partial role in the stability of the shoulder joint through afferent feedback.

Aged↗
PubMed1993

Ultrasonographic detection of thickened joint capsules and tendons as marker of dialysis-related amyloidosis: a cross-sectional and longitudinal study.

Dialysis-related amyloidosis is characterized by a beta 2-microglobulin (beta 2M) infiltration of joint synovia, tendons and capsules. We report a cross-sectional ultrasonographic evaluation of supraspinatus tendon and femoral neck capsule thickness in 49 patients on long-term haemodialysis. Ultrasonographic evaluation was repeated 21 +/- 4 (SD) months later in 16 patients. Normal values for the supraspinatus tendon and femoral neck capsule were defined in a group of control subjects without history or signs of joint disease. Among the 49 patients, aged 21-86 (median 59) years, dialysed for 1-228 (median 97) months, 33 had at least one abnormal joint. The prevalence of patients with at least one and at least two abnormal joints, the number of abnormal joints per patient, and the thickness of the supraspinatus tendon and femoral neck capsule increased significantly with dialysis duration (P < 0.001 for all parameters considered). By multiple linear regression analysis, mean thickness of the supraspinatus tendon was positively related to both dialysis duration (P < 0.0001) and age (P = 0.036) independently. All (n = 11) patients with radiological and/or histological evidence of dialysis-related amyloidosis at the time of ultrasonography had thickened supraspinatus tendon and/or femoral neck capsule; which were also thickened in an additional 22 patients without radiological evidence of dialysis-related amyloidosis. Three died within 5-10 months of the ultrasonographic investigation: post-mortem examination of the periarticular tissue confirmed that the detected thickening was due in all three to beta 2M amyloid infiltration.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1996

Gingival overgrowth in renal transplant patients administered cyclosporin A in mixture or in capsule form. A longitudinal study.

Cyclosporin A (CsA)-induced gingival overgrowth was longitudinally studied in 45 adult renal transplant patients randomly assigned to be administered CsA orally in mixture or in capsule form. After 1 year of CsA therapy, 37% of the mixture and 43% of the capsule patients exhibited gingival overgrowth. In mixture patients gingival overgrowth was present, already after 1 month of CsA therapy and, after 12 months, mixture patients exhibited an increased number of sites with gingival overgrowth in the regions of the upper front and lower molars compared to capsule patients. In addition, the relative increase in gingival width of the interdental papillae of the maxillary central incisors and the mandibular first molars, measured buccolingually on stone casts, was also higher in mixture patients than in capsule patients. In a stepwise multiple logistic regression analysis, the use of nifedipine and the total CsA dose administered during the first 6 posttransplant months were the predictors associated with gingival overgrowth. The study suggests that concomitant administration of nifedipine in renal transplant patients should be avoided and a change from the mixture form of CsA to the capsule form should be considered in order to minimize the development of CsA-induced gingival overgrowth.

Adult↗
PubMed1995

Primary posterior chamber intraocular lens implantation in traumatic cataract with posterior capsule breaks.

BACKGROUND: In patients with incomplete posterior capsule support, posterior chamber intraocular lenses (PC-IOLs) were implanted with both haptics transscleral fixation. This causes more damage to the eye and may result in more complications. In patients with small posterior breaks, non-fixation or single haptic fixation may be adequate. METHODS: Thirty-two consecutive patients of traumatic cataract with posterior capsule breaks caused by penetrating eye trauma were retrospected. Posterior chamber intraocular lenses were implanted in all these patients with three techniques, ie, without fixation, with single haptic fixation and with both haptics fixation. The selection of the technique was based on the position and size of the posterior capsule. The follow-up period was 21 days to 28 months (mean, 15.2 months). RESULTS: Intra-operative problems included ciliary body bleeding (two patients, 6.25%) and enlargement of posterior capsule breaks (2 patients, 6.25%). Postoperative visual acuity was 0.5 or better (corrected) in 28 case (87.5%) and 0.1-0.4 in four patients (12.5%). Postoperative complications included hyphema (6 eyes, 18.8%), transient intraocular pressure elevation (6 eyes, 18.8%), transient hypotention (7 eyes, 21.8%). Postoperative IOL position were good except one case of IOL tilt. No pupillary capture or endophthalmitis was found. CONCLUSIONS: Not all PC-IOLs have to be fixed by two haptics. In patients with small posterior capsule breaks, PC-IOL may not be fixed or fixed by only one haptics.

Adolescent↗
PubMed1996

[Intraocular implants in the posterior chamber after intraoperative posterior capsule tear].

PURPOSE: To present the results of cataract surgery with IOLs implantation complicated by posterior capsule tear. MATERIAL AND METHODS: 38 eyes of 38 patients with cataract, operated on between August 1993 and May 1994 were examined. In all cases posterior capsule tear occurred during surgery but the IOLs were supported by the residual capsule or, when the tear was large, by the residue of the anterior capsule with haptics being placed in the ciliary sulcus. RESULTS: Useful visual acuity was achieved in 78% of the eyes. The main complications observed in post-operative period were increase of intraocular pressure in 11 eyes, dislocation of IOL in 4 and dyscoria in 24 eyes. CONCLUSION: The applied surgical technique seems to be very useful in cases of posterior capsule tear but in each case the surgeon must decide what is the best for the eye: anterior or posterior chamber IOL.

Cataract Extraction↗
PubMed1996

[Effects of capsules on attachment of human periodontal ligament fibroblasts to root surface].

Inhibition of attachment of human periodontal ligament fibroblasts to root surface by three capsules were determined with the methods of trypan blue and L*a*b* color difference measurement. The results showed that capsule from porphyromonas gingivalis was the strongest one in inhibiting attachment and followed by the one from provotalla intermedia. Capsule from porphyromonas endodontolis was the weakest one. The values of color difference from that of control root surface were 11, 13, 8.28 and 4.09 respectively. Inhibitory mechanism of capsules may include a direct growth inhibition of fibroblasts and a decrease in attachment due to changes of root surface properties. There were a few fibroblasts attached to root surface with progressive periodontitis, this was a sharp contrast with that of control root surface. We deduce that long term affections of toxins including capsules and other substances led to changes of root surface with periodontitis, which made fibroblasts difficult to attach.

Bacterial Capsules↗
PubMed1976

[Studies on erythromycin stearate capsules (OE-7) (author's transl)].

The blood concentration and urinary excretion of OE-7 (erythromycin stearate capsules) and control drug were investigated in 6 volunteers having gastroptosis. OE-7, newly arranged capsules containing erythromycin stearate, was investigated and obtained the results of high blood concentration by oral administration. To confirm the above, we measured blood concentration and urinary excretion of OE-7 comparing with ordinary erythromycin stearate capsules in 6 volunteers having gastroptosis. The peaks of blood concentration were noted at 3 hours after administration in 6 volunteers uniformly. The mean maximum blood concentration of OE-7 was 1.17 mcg/ml which was significantly higher than ordinary erythromycin stearate capsules. In time course of mean blood concentration, the blood concentration levels of OE-7 were higher than those of control erythromycin stearate capsules at any measurement. Effective blood levels were continuously high in OE-7. Urinary excretion of OE-7 reached to the maximum from 4 to 6 hours after administration which was also higher than control erythromycin stearate. Clinical efficacy of OE-7 was investigated in 28 cases in acute respiratory infection. The results noted were excellent in 5 cases (17.9%), good in 16 cases (57.1%), no change in 6 cases (21.4%), and undetermined in 1 case (3.6%). There were 5 cases of slight gastro-intestinal discomfort as the side effects. As the conclusion, OE-7 revealed good bioavailability and seemed to be useful antibiotic for acute respiratory infections.

Adult↗
PubMed1998

Capsule-bending ring for the prevention of capsular opacification: a preliminary report.

BACKGROUND AND OBJECTIVE: To report the preliminary results of a study on the preventive effect of the capsule-bending ring on anterior and posterior capsule opacification (ACO and PCO, respectively). PATIENTS AND METHODS: The ring is an open, band-shaped, circular polymethylmethacrylate (PMMA) ring measuring 11 mm in diameter with pre-tension (13 mm in diameter when the ring is open), 0.2 mm in thickness, and 0.7 mm in width. To retain sharp edges, the ring is not polished. The sharp edges should create a sharp, discontinuous capsular bend in the fornix, which induces contact inhibition of migrating lens epithelial cells after cataract surgery. This capsule-bending ring is inserted into the capsular fornix following phacoemulsification, prior to the implantation of an intraocular lens (IOL). In a multicenter trial, 100 patients were scheduled to undergo phacoemulsification and IOL implantation in both eyes within 1 month. The procedure was performed with the ring in 1 eye and without the ring in the other eye of each patient. RESULTS: The anterior capsule was prevented from coming into contact with the IOL, and ACO was significantly reduced in the eyes with the ring, rendering the capsular opening larger 3 months after surgery. PCO was obviously reduced on slit-lamp examination in the follow-up period up to 6 months, but needs to be evaluated during a longer period. CONCLUSION: This band-shaped, sharp-edged capsule-bending ring may be useful for cases that need good fundus visualization for photocoagulation or expected vitreoretinal surgery and for the prevention of PCO.

Biocompatible Materials↗