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At least 1,045 records · Page 58Linked to original sources
PubMed1988

Microcirculatory changes in livers of mice infected with murine hepatitis virus. Evidence from microcorrosion casts and measurements of red cell velocity.

Hepatitis has been considered, classically, as a diffuse hepatocellular necrosis, and little attention has been paid to the relationship of lesions to the microvasculature. In livers of mice (Balbc/J) infected with murine hepatitis virus (MHV-3), microcorrosion casts showed spherical cavities where casting compound was unable to fill sinusoids. At 48 hr postinfection such "lesions" had a mean diameter of 83 micron +/- 26 (SD) and their number/mm2 (at the surface of casts) was 0.95 +/- 1.3. Blind-ended sinusoids formed a distinct boundary between perfused and nonperfused areas, and concave impressions at their ends indicated cells blocking the lumen. In vivo microscopy of transilluminated livers in infected mice showed localized rounded areas without flow, corresponding to lesions seen in casts. RBC velocity measurements in sinusoids adjacent to lesions demonstrated that velocities fall from normal values to zero over a narrow border zone. Beginning with the most proximal sinusoid with visible flow and moving outward from the lesion to the second and third sinusoids, mean RBC velocities (micron/sec, +/- SD) were 17.4 +/- 6.7, 33.9 +/- 8.7, 66.6 +/- 27.3, respectively; this last value was not significantly different from velocities in normal liver (69.2 +/- 30.6). Transmission electron microscopy of livers of infected mice confirmed the presence of sinusoidal lumens blocked by protruding lining cells, RBCs, platelets, swollen hepatocytes, and cellular debris. This study demonstrates that the lesions are focal in origin, microvascular blockage leading to gradually increasing necrosis in all directions.

Animals↗
PubMed1994

Moricizine and quality of life in the Cardiac Arrhythmia Suppression Trial II (CAST II).

The Cardiac Arrhythmia Suppression Trial II (CAST II) was a double-masked placebo-controlled randomized trial that compared the survival effects of moricizine to placebo in postmyocardial infarction arrhythmia patients. The quality-of-life outcome measures were designed prospectively for CAST and were previously shown to have high reliability and clinical discriminative validity. The CAST quality-of-life instrument detected significant differences between moricizine and placebo. In particular, moricizine was most strongly associated with inferior social activity and satisfaction scores (p = .014) and lower scores for overall contentment with life (p = .007). Moreover, the quality-of-life measures improved significantly for both the moricizine and placebo treatment groups after entry into the clinical trial. These results indicate that the CAST quality-of-life instrument is sensitive for assessing pharmacological therapies in the treatment of heart disease.

Aged↗
PubMed1995

Relationship between appearance of urinary red blood cell/white blood cell casts and the onset of renal relapse in systemic lupus erythematosus.

The purpose of the study was to determine the extent to which urinary sediment findings (changes in red blood cells [RBCs], white blood cells [WBCs], and the appearance of RBC and WBC casts) predict the onset of renal relapse (defined as a specific increase in proteinuria and/or serum creatinine level) in patients with systemic lupus erythematosus (SLE). Seventeen SLE patients with biopsy-proven diffuse proliferative glomerulonephritis at initial presentation were followed prospectively for 1,129 patient-months under a study protocol. Semiquantitative urinalyses were performed at 2-month intervals during periods with little or no SLE activity and, more frequently, during periods with increased SLE activity. Each urinalysis was accompanied by a clinical evaluation and a panel of screening tests relevant to the evaluation of SLE activity. During this study, 877 semiquantitative urinalyses were performed and 43 renal relapses were observed in 14 patients. No relapse occurred in three patients. Of the renal relapses, 30 were defined as proteinuria relapses (mean baseline proteinuria increased from 0.8 +/- 0.1 g/24 hr to 2.7 +/- 0.3 g/24 hr; P < 0.001) and 13 were defined as serum creatinine relapses (mean baseline serum creatinine increased from 2.7 +/- 0.4 mg/dL to 3.8 +/- 0.5 mg/dL; P < 0.001). Red blood cell and/or WBC casts (cellular casts) were observed before or at the onset of 35 of the 43 renal relapses (sensitivity, 81%). The mean and median intervals between the appearance of cellular casts and the onset of renal relapse was 10 +/- 2 weeks and 8 weeks, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Creatinine↗
PubMed1992

Evaluation of the interactions between amalgam, cement and gold castings.

The purpose of this study was to determine the interactive effects between a dental amalgam, cements and a gold alloy and therefore evaluate cements as barriers to corrosion. There were 48 castings cemented to either simulated amalgam cores or teeth using zinc phosphate (ZnPO4) or glass polyalkenoate (ionomer) cement. An additional 12 castings were placed in direct contact with the amalgam restoration. Half of the specimens were thermocycled between 5 degrees and 50 degrees C for 12 weeks. The other half were stored at 37 degrees C for the same period of time. The specimens were then encased in epoxy resin and sectioned. The sectioned specimens were examined for cement loss, as well as evidence and extent of corrosion. Significantly more cement loss occurred with the ZnPO4 compared with the glass polyalkenoate (ionomer) cement when the castings were cemented to amalgam cores. Evidence of corrosion was apparent in all specimens; thermocycling produced significantly more corrosion than the 37 degrees C environment. The direct-contact group produced significantly more corrosion compared with the specimens where castings were cemented with ZnPO4.

Corrosion↗
PubMed1992

Effect of impression tray design upon the accuracy of stone casts produced from a single-phase medium-bodied polyvinyl siloxane impression material.

The study examined the accuracy of stone casts produced from impressions taken in stock polycarbonate trays, some of which had been strengthened with autopolymerizing polymethyl methacrylate resin and four designs of custom-made trays. Impressions of an acrylic master model of the mandibular arch on which two extracoronal crown preparations and one intracoronal inlay preparation had been carried out were taken using a medium-bodied polyvinyl siloxane material. Each preparation had been intended with a reference point for later measurement. Five impressions were taken for each type of tray and these were cast in die-stone after 24 h. The distances between the points were measured with a reflex microscope and the means determined for each design of tray. The mean difference between casts produced from the various tray designs and the acrylic master model were determined for each of the distances between the three measuring points. Statistical analysis showed that, with the stock trays, there were no significant differences between any of the modifications, or between them and the acrylic model, for any of the three distances (P greater than 0.1). When the results from the custom-made trays were analysed there were statistical differences between the acrylic model and the casts from the unperforated tray with no stops (P = 0.02), and between the unperforated tray with no stops and the perforated with stops for the distance A-B (P less than 0.01). There were no other significant differences.(ABSTRACT TRUNCATED AT 250 WORDS)

Dental Impression Materials↗
PubMed1996

An in vitro investigation of cast post and partial core design.

OBJECTIVES: Following endodontic therapy, the provision of a cast post and core restoration may be indicated. Many authors advocate retaining sound coronal dentine where possible, improving the resistance to fracture of the endodontically treated tooth. However, there is little conclusive experimental evidence to support this recommendation. This laboratory study was designed to investigate the effect of retained sound coronal dentine on the strength of a tooth restored with a cemented post and partial core restoration under direct loading. METHODS: Specimens with retained coronal dentine buccally, lingually, or buccally and lingually were restored with cast post and partial cores and tested to failure using an Instron Universal Testing Machine, Model 1195. Control post and full core restorations were also tested. The mode of failure for all specimens was recorded photographically. RESULTS: Teeth with retained buccal coronal dentine and post and partial cores were significantly less resistant to failure than controls with post and full cores (P < 0.01), failure occurring through crack initiation and propagation at the junction of the cast partial core and dentine core. There was no statistically significant difference in the strength of teeth with retained lingual coronal dentine or buccal and lingual dentine when compared to the control. CONCLUSIONS: In conclusion, this in vitro model demonstrates that retained coronal dentine will not strengthen a tooth restored with a cast post and partial core. The clinical benefit of retaining buccal coronal dentine is brought into question when set against the increased technical effort and difficulty of producing the restoration in the dental technical laboratory and the possible overriding benefit of ferruling the crown margin onto a sound root structure.

Dental Prosthesis Design↗
PubMed2004

Semi-simultaneous application of neutron and X-ray radiography in revealing the defects in an Al casting.

A semi-simultaneous application of neutron and X-ray radiography (NR, XR) respectively, was applied to an Al casting. The experiments were performed at the 10MW VVR-SM research reactor in Budapest (Hungary). The aim was to reveal, identify and parameterize the hidden defects in the Al casting. The joint application of NR and XR revealed hidden defects located in the Al casting. Image analysis of the NR and XR images unveiled a cone-like dimensionality of the defects. The spectral density analysis of the images showed a distinctly different character for the hidden defect region of Al casting in comparison with that of the defect-free one.

Journal Article↗
PubMed2005

Fabrication of tubular tissue constructs by centrifugal casting of cells suspended in an in situ crosslinkable hyaluronan-gelatin hydrogel.

Achieving the optimal cell density and desired cell distribution in scaffolds is a major goal of cell seeding technologies in tissue engineering. In order to reach this goal, a novel centrifugal casting technology was developed using in situ crosslinkable hyaluronan-based (HA) synthetic extracellular matrix (sECM). Living cells were suspended in a viscous solution of thiol-modified HA and thiol-modified gelatin, a polyethyleneglycol diacrylate crosslinker was added, and a hydrogel was formed during rotation. The tubular tissue constructs consisting of a densely packed cell layer were fabricated with the rotation device operating at 2000 rpm for 10 min. The majority of cells suspended in the HA mixture before rotation were located inside the layer after centrifugal casting. Cells survived the effect of the centrifugal forces experienced under the rotational regime employed. The volume cell density (65.6%) approached the maximal possible volume density based on theoretical sphere packing models. Thus, centrifugal casting allows the fabrication of tubular constructs with the desired redistribution, composition and thickness of cell layers that makes the maximum efficient use of available cells. Centrifugal casting in this sECM would enable rapid fabrication of tissue-engineered vascular grafts, as well as other tubular and planar tissue-engineered constructs.

Animals↗
PubMed2004

HLA DRB1* and DQB1* allelic diversity among Nadars: a primitive south Indian Dravidian caste group.

South India is one of the oldest geophysical regions occupied mainly by Dravidian language-speaking people. In the present study, 84 unrelated healthy Nadar individuals from Tamil Nadu State were analyzed for human leukocyte antigen (HLA) DRB1* and DQB1* allele frequencies and their haplotype frequencies were analyzed by high resolution polymerase chain reaction (PCR)-typing of genomic DNA. Results revealed that Nadars possessed >0.1 allele frequencies of HLA DRB1*15011, 03, 04, 1404, 0701, 1001, and DQB1*0201, 03, 0501, and 0503. The highest frequencies of DRB1*0317 (0.048), DRB1*1317 (0.012), and DRB1*1404 (0.107) in the world were found among the Nadar caste. The most frequent two-locus haplotypes identified among the Nadars were DRB1*0701-DQB1*0201 and DRB1*1000-DQB1*0501, and DRB1*1404-DQB1*0503 and DRB1*15011-DQB1*0601. When compared with world populations, HLA DRB1*1322, DRB1*1434, and DQB1*0614 were identified exclusively among Nadars. The heterozygosity and Watterson's homozygosity tests indicated that balancing selection still operates among the South Indian caste groups. The hierarchical cluster analysis for DRB1 data from the Indian caste and population groups showed that the Nadars cluster with Kashmir Brahmins and North Indians. The present study shows that the Nadar caste has several unique alleles and haplotypes at high frequency that are rare or absent in other populations of India and the world.

DNA Fingerprinting↗
PubMed2005

Caste-based differences in gene expression in the polyembryonic wasp Copidosoma floridanum.

The polyembryonic parasitoid Copidosoma floridanum produces two larval castes, soldiers and reproductives, during development within its host. Soldier larvae defend the brood against competitors while reproductive larvae develop into adult wasps. As with other caste-forming insects, the distinct morphological and behavioral features of soldier and reproductive larvae likely involve differential gene expression. In this study we used a bi-directional suppression subtractive hybridization (SSH) approach to isolate differentially expressed genes from C. floridanum soldier and reproductive larvae. We isolated 230 novel expressed sequence tags (ESTs) from the two subtractions (114 soldier/116 reproductive ESTs). Among these ESTs were sequences with significant similarity to genes coding for serine proteinases, proteinase inhibitors, odorant-binding and chemosensory proteins, and cuticular proteins. Also, three novel genes were isolated that resemble one another in conceptual translation and share the cysteine spacing pattern of short scorpion toxins and insect defensins. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of 20 ESTs from the two libraries indicated that 85% were differentially expressed in one caste or the other. We conclude that our SSH strategy was effective in identifying a number of genes differentially expressed in soldier and reproductive larvae and that several of these genes will be useful in characterizing caste-specific gene networks in C. floridanum.

Amino Acid Sequence↗
PubMed2004

Tensile properties and hardness of cast Fe-Pt magnetic alloys.

STATEMENT OF PROBLEM: There is little information about the mechanical properties of castable magnetic attachments made of iron-platinum (Fe-Pt) alloys after heat treatment. MATERIAL AND METHODS: Dumbbell-shaped tensile specimens were cast with 5 alloys: 2 types of Fe-Pt alloys for magnets and keepers, pure Ti, Ti-6Al-7Nb, and Co-Cr alloy. The tensile specimens of the Fe-Pt magnets and keepers underwent different heat treatments to obtain the appropriate properties for a magnet and a keeper. Vickers hardness was measured prior to testing. Tensile testing was conducted in a universal testing machine at a crosshead speed of 2 mm/min until failure. Ultimate tensile strength, yield strength, elongation, and modulus of elasticity were recorded. The data were analyzed using 1-way analysis of variance and the Tukey test (alpha=.05), fractured surfaces were examined using a scanning electron microscope (SEM). RESULTS: The highest tensile and yield strengths were found for Ti-6Al-7Nb, followed by Co-Cr, CP Ti, and the Fe-Pt keeper. There was no significant difference in ultimate tensile strength between the CP Ti and the Fe-Pt keeper. The lowest elongation was found for the Fe-Pt magnet (2.8%), whereas the Fe-Pt keeper had the highest elongation (14.0%). The Fe-Pt magnet and keeper had similar modulus of elasticity values. The hardness of the cast Fe-Pt magnets was the highest among the metals tested. SEM micrographs of the Fe-Pt keepers showed a microstructure with ductile dimple fractures, whereas the Fe-Pt magnets were characterized by brittle fractures at the grain boundaries. CONCLUSIONS: The mechanical properties of the cast Fe-Pt keepers were similar to those of the cast pure Ti. The Fe-Pt magnets were extremely hard and brittle.

Analysis of Variance↗
PubMed1978

Radiological features of vascular compression of the duodenum occurring as a complication of the treatment of scoliosis (the cast syndrome).

The application of a body cast or the surgical correction of scoliosis is occasionally associated with acute obstructive vascular compression of the duodenum. The clinical and radiological manifestations observed in 10 such patients are described. All cases manifested abdominal distension and vomiting, while epigastric pain was present in 50%. Plain radiographs of the abdomen demonstrated duodenal distension with little gas in the remainder of the bowel in three cases. Barium studies in nine patients demonstrated an intact mucosal pattern and a duodenum dilated proximal to the site where the superior mesenteric vessels crossed it. All cases recovered with non-operative treatment which included nasogastric suction, intravenous fluids, change in position, particularly nursing in the prone position, and, occasionally, cast removal. The obstruction may sometimes persist or recur and then duodenojejunal side-to-side anastomosis is the surgical procedure of choice. The term "cast syndrome" is a misnomer as vascular compression of the duodenum may also occur in patients who are undergoing treatment for scoliosis without the use of a body cast.

Adolescent↗
PubMed2006

Monitoring metal-fill in a lost foam casting process.

The lost foam casting (LFC) process is emerging as a reliable casting method. The metal-fill profile in LFC plays an important role among several factors that affect casting quality. The metal-fill profile is in turn affected by several factors. Several casting defects may result due to an improper metal-fill process. Hence, it becomes essential to characterize and control, if possible, the metal-fill process in LFC. This research presents instrumentation and a technique to monitor and characterize the metal-fill process. The characterization included the determination of the position of the metal front and the profile in which the metal fills up the foam pattern. The instrumentation included capacitive sensors. Each sensor is comprised of two electrodes whose capacitive coupling changes as the metal fills the foam pattern. Foundry tests were conducted to obtain the sensors' responses to the metal fill. Two such sensors were used in the foundry tests. Data representing the responses of these sensors during the metal-fill process were collected using a data acquisition system. A number of finite element electrostatic simulations were carried out to study the metal-fill process under conditions similar to those experienced in foundry tests. An artificial neural network was trained using the simulation data as inputs and the corresponding metal-fill profiles as outputs. The neural network was then used to infer the profile of the metal-fill during foundry tests. The results were verified by comparing the metal-fill profile inferred from the neural network to the actual metal-fill profile captured by an infrared camera used during the foundry tests. The match up between the inferred profiles and the infrared camera measurements was satisfactory, indicating that the developed technique provides a reliable and cost effective method to monitor the metal-fill profile in LFC.

Journal Article↗
PubMed2002

Reproductive and worker castes in the primitively eusocial wasp Belonogaster petiolata (DeGeer) (Hymenoptera: Vespidae): evidence for pre-imaginal differentiation.

Until recently, morphological differences between castes in independent-founding polistine wasps were considered absent. This paper investigates the extent of morphological and physiological differences between reproductive (foundress and gyne) and worker castes of Belonogaster petiolata, and tests the hypothesis that caste differentiation in this species occurs pre-imaginally.Foundresses were significantly larger than workers, to the extent that foundress/worker ratios were comparable with those between queens and workers in some swarm-founding Polistinae. Early emerging workers were small, but body size increased over the colony cycle such that late-season workers were similar in size to gynes. In proportion to body size, workers possessed broader heads while foundresses and gynes had broader thoraces and gasters. All queens, 98% of subordinate foundresses, and 95% of over-wintering gynes were inseminated. Workers were never inseminated and lacked mature ovaries in colonies with active queens. However, in the absence of the queen (and other foundresses), 11% of workers developed mature ovaries. Ovarian size and fat content of foundresses and gynes was significantly greater than that of workers. The differences in external morphology and reproductive physiology between castes support the hypothesis that differentiation occurs pre-imaginally. However, imaginal factors, in particular social dominance of the queen, maintain the reproductive subordinance of workers.

Journal Article↗
PubMed2000

Discontinuous gas exchange in the fire ant, Solenopsos invicta Buren: Caste differences and temperature effects.

The discontinuous gas exchange cycle (DGC), the cyclic release of CO(2) and uptake of O(2), were investigated in workers and female and male alates of the red imported fire ant, Solenopsis invicta Buren, using real-time CO(2) emission measurement by flow-through respirometry. All S. invicta castes displayed discontinuous emission of CO(2) in the temperature range of 15-25 degrees C, but only male alates and workers exhibited a DGC at 30 degrees C. The closed (C) and flutter (F) periods of the DGC were distinguishable in alates of both sexes at the lowest temperature, but not clearly differentiated in females at temperatures above 15 degrees C, in males above 20 degrees C, or workers at any temperature. DGC frequency increased for all castes as temperature increased, ranging from a low of 0.9+/-0.05 mHz (male alates at 15 degrees C) to 18+/-0.79 mHz (workers at 30 degrees C). O period (or burst) volumes of all castes decreased as temperature increased, and increased with body mass - this mass effect was most pronounced at lower temperatures. Q(10) values for DGC frequency (4.27, 5.81, and 5.62 for workers, female and male alates, respectively) were high compared with Q(10)'s for standard Vdot;(CO(2)). Differences in the salient characteristics of the DGC between castes are presented and discussed, and S. invicta DGC patterns are compared to known values for some other ant species.

Journal Article↗
PubMed1995

In vivo marginal adaptation of cast crowns luted with different cements.

Large marginal crown discrepancies are deleterious. Although previous studies have examined casting seating in vitro, few have evaluated the effects of different luting cements on in vivo seating. Hence this in vivo study compared marginal discrepancies created by different cements on cast crowns. Tooth preparations were completed according to acceptable procedures on previously intact human molars that were severely periodontally compromised and scheduled for extraction. Castings were made by conventional techniques. The castings were randomly assigned to the following luting agents: zinc phosphate cement, resin-modified glass-ionomer cement, and the same resin-modified glass-ionomer cement with a dentinal bonding agent. After 6 months the teeth were carefully extracted, embedded, and sectioned, and vertical and horizontal discrepancies were measured. Analysis of variance revealed that all cements resulted in similar discrepancies. Vertical discrepancies were considerably greater than horizontal discrepancies, and the distributions of marginal discrepancies were skewed towards upper ranges.

Analysis of Variance↗
PubMed1998

An accurate method for occlusal registration and altered-cast impression for removable partial dentures during the same visit as the framework try-in.

Preparation of mandibular distal-extension removable partial dentures usually requires a secondary impression (the altered-cast impression) to improve the stability of the prosthesis. A potential problem with conventional altered-cast impression procedures is incorrect or incomplete seating of the framework in the mouth or on the cast. This article describes a procedure for obtaining the interjaw relationship and an accurate altered-cast impression in a single appointment (that of the framework try-in).

Acrylic Resins↗
PubMed1998

Mechanical properties of laser-welded cast titanium joints under different conditions.

STATEMENT OF THE PROBLEM: Data on optimal conditions for laser welding commercial pure cast titanium used in dental restorations are sparse and not well established. PURPOSE: The mechanical properties of laser-welded cast commercially pure titanium under different laser welding conditions were evaluated to find the optimal parameters in terms of duration and voltage (energy level). MATERIAL AND METHODS: Fifty-seven cast pure titanium specimens according to ISO specification 6871 were divided into nine experimental groups and one control group. The sectioned titanium bars were laser-welded under different duration (8, 10, and 12 ms) and energy (290, 300, and 310 V) levels and evaluated for ranges of ultimate tensile strength (374 to 562 MPa), 0.2% yield strength (206 to 338 MPa), and percentage elongation (2.49% to 10.58%). RESULTS: Under a suitable laser-welding setting parameter the ultimate tensile strength and 0.2% yield strength of experimental groups were weaker than the unsectioned control specimens (control group ultimate tensile strength 540 +/- 11 MPa, 0.2% yield strength 258 +/- 49 MPa) or too brittle (control group percentage elongation 12.41% +/- 1.83%). Two-way ANOVA, nonparametric tests showed that voltage was the only significant factor for all parameters studied (p < 0.01). Optimal conditions were determined with three-dimensional response curves (305 V, 12 ms ultimate tensile strength; 310 V, 10 ms 0.2% yield strength; 300 V, 12 ms percentage elongation). CONCLUSION: Optimal duration and voltage (energy level) used in laser welding for cast CP grade I titanium bar was superior to or comparable with and produced properties that were superior to or comparable with the unsectioned control specimens.

Analysis of Variance↗