[Sneddon syndrome (its association with anti-cardiolipin antibodies)].
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We describe a patient with cerebral systemic lupus erythematosus (SLE) who had 2 episodes of prolonged apnea in addition to other manifestations of brainstem dysfunction. Oligoclonal bands, uncommonly found in SLE, were detected in the cerebrospinal fluid. Also present in our patient were anticardiolipin antibodies which have often been reported to be associated with neurological events in patients with SLE. With mechanical ventilation and high dose corticosteroid therapy, she recovered with only minimal neurological deficit. Our case stresses the potential reversibility of life threatening cerebral SLE.
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ELISA is a sensitive method extensively used to detect anticardiolipin antibodies, but up to now there is no standardization of the assay to make a reliable comparison in the results obtained from various laboratories. For that it appears more useful to use a commercial kit for detecting these antibodies. The authors have carried out a comparison between this commercial kit and an ELISA prepared in laboratory in order to evaluate its usefulness. There is a significant correlation between the two tests, but the ELISA prepared in laboratory reveals more positive cases than the commercial kit. Many factors may explain these different results.
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