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At least 1,045 records · Page 58Linked to original sources
PubMed1984

Adrenal function in the cat: comparison of the effects of cosyntropin (synthetic ACTH) and corticotropin gel stimulation.

The serum cortisol responses of 10 normal cats to natural adrenocorticotrophic hormone (ACTH) gel and synthetic ACTH (cosyntropin) were evaluated and compared. Following administration of either ACTH gel or cosyntropin, mean serum cortisol concentrations increased significantly (P less than 0.05) within 30 minutes and reached a maximal response (2.5 to 10 times basal values) at 90 minutes. The time to reach peak serum cortisol concentrations was variable, however, and occurred sooner after cosyntropin (30 to 60 minutes) than after ACTH gel administration (90 to 180 minutes). While ACTH gel tended to produce a prolonged cortisol response, the effects of cosyntropin were more transient, with serum cortisol concentrations returning to normal range within three hours after injection. Results of this study indicate that the administration of either ACTH gel or cosyntropin consistently produces an adequate adrenocortical response in the cat. Based on the time response studies, post ACTH cortisol samples should be collected 60 to 90 minutes after cosyntropin or 90 to 120 minutes after ACTH gel injection to ensure detection of peak adrenocortical response with either ACTH preparation.

Adrenal Cortex↗
PubMed1982

Dexamethasone suppression of adrenocortical function.

To investigate the potency of dexamethasone in suppressing adrenocortical function, we gave various evening doses to laboratory staff members. Plasma corticotropin, cortisol, and dehydroepiandrosterone sulfate concentrations were measured the following day, to quantitate the degree of suppression after both short- and long-term treatments. We found that the minimum amount for effective suppression was 1 mg for a single evening dose, 0.5 mg per day for a long-term evening dose. On these regimens plasma corticotropin and cortisol were consistently suppressed, but plasma dehydroepiandrosterone sulfate was suppressed only with long-term treatment.

Adrenal Cortex↗
PubMed1978

[11-hydroxycorticosteriod content in the peripheral blood plasma and in the cerebrospinal fluid in acute disorders of the cerebral circulation].

The author studied the glucocorticoid function of the adrenal cortex in 93 patients (40 males and 53 females) with acute disturbances of brain circulation, in 59 patients with ischemic strokes and 21 patients with cerebral hemorrhages. The functional activity of the adrenal cortex was judged by the content of 11-oxycorticosteroids in the plasma of the peripheral blood and in the liquor in the dynamics during 4 weeks from the beginning of the stroke. The patients with a severe course of the stroke (in spite of its character) demonstrated a statistically significant increase of 11-OCS concentration in the above-mentioned biological fluids during the acute period of the disease (first 14 days).

11-Hydroxycorticosteroids↗
PubMed1984

Increased oestrogen production and adrenal cortical hyperfunction in patients with pulmonary disease and clubbing of the fingers.

Raised serum oestradiol levels were demonstrated in men and postmenopausal women with pulmonary disease and clubbing of the fingers. The site of production is thought to be a hyperfunctioning adrenal cortex; this conclusion is supported by the finding of elevated adrenocortical responses to intramuscular injection of adrenocorticotrophic hormone.

Adrenal Cortex Function Tests↗
PubMed1978

[Functional state of the adrenal cortex in calculous cholecystitis complicated by mechanical jaundice in elederly patients].

The functional status of the adrenal cortex in 26 elderly patients suffering from calculous cholecystitis complicated with mechanical jaundice has been studied. The activation of the glucocorticoid function and the depression of the androgenic one have been found. These changes of hormonal balance were found at all the stages of surgical treatment; they were the most pronounced in case of a severe clinical course of the disease.

Adrenal Cortex↗