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[Retrorectal cystic hamartomas. Report of one case].

Retrorectal cystic hamartomas (RCH) are rare congenital lesions of the presacral space, of which 68 cases are reported under different terms. Clinicopathologic features are usually constant and similar to the present case. A 23-year-old woman complained of abdominal and perineal pains for several months. Physical examination revealed a nodular mass in the posterior part of the rectum. A pelvic MRI showed a 5.5 cm cystic retrorectal mass compressing the rectum. The patient underwent surgical resection. Pathologic examination found an ill-defined nodular mass, composed by numerous cysts surrounded by fibroadipose tissue. Cysts were lined by different epithelia: keratinized and non keratinized squamous, transitional, ciliated and mucus-producing columnar epithelia. Few mucinous glands were noted, connected to some cysts. These epithelial structures were surrounded by connective tissue in which well-differentiated bundles of smooth muscle fibers were present without well-formed muscularis. The RCH differential diagnosis includes principally congenital cysts: epidermal cysts, cystic teratomas, dermoid cysts, anal gland cysts and rectal duplications. An embryologic origin of RCH from remnants of the postanal gut is currently accepted. Loco-regional inflammatory process frequently complicates this lesion and can cause perirectal fistulae. RCH also possesses a malignancy potential, with development of adenocarcinomas. To avoid these complications, complete excision is recommended.

Abdominal Pain↗

Primary lymphedema precox of the penis and its surgical treatment: a case report.

Primary penile lymphedema occurs infrequently and is seen in conjunction with a similar process in the scrotum. The accepted form of treatment is surgery since conservative medical treatment is of little value. Different surgical techniques have been described, but no single procedure has emerged as the ideal treatment. Radical excision of all lymphedematous tissues and reconstruction using local penile flaps yield excellent functional and cosmetic results. We treated a 13-year-old boy with primary penile lymphedema precox using radical excision and reconstruction with local penile flaps. At follow-up two years later, functional and cosmetic results were satisfactory.

Adolescent↗

The 24-hour society between myth and reality.

The 24-hour society appears to be an ineluctable process towards a social organisation where time constraints are no more "restricting" the human life. But, what kind of 24-hour society do we need? At what costs? Are they acceptable/sustainable? Shift work, night work, irregular and flexible working hours, together with new technologies, are the milestone of this epochal passage, of which shift workers are builders and victims at the same time. The borders between working and social times are no more fixed and rigidly determined: not only the link between work place and working hours is broken, but also the value of working time changes according to the different economic/productive/social effects it can make. What are the advantages and disadvantages for the individual, the companies, and the society? What is the cost/benefit ratio in terms of physical health; psychological well-being, family and social life? The research on irregular working hours and health shows us what can be the negative consequences of non-human-centered working times organisations. Coping properly with this process means avoiding a passive acceptance of it with consequent maladjustments at both individual and social level, but adopting effective preventive and compensative strategies aimed at building a more sustainable society, at acceptable costs and with the highest possible benefits.

Adaptation, Psychological↗

A community coalition board creates a set of values for community-based research.

BACKGROUND: Researchers generally agree that communities should participate in the community-based research process, but neither a universally accepted approach to community participation nor a set of guiding principles exists. CONTEXT: The Morehouse School of Medicine Prevention Research Center was established in 1999 with the support of a grant from the Centers for Disease Control and Prevention. Its partners include a low-income, predominantly African American community, six public agencies, and two other academic institutions. A Community Coalition Board was established to represent the partners. The majority of the board is community members; it serves in a governance rather than an advisory capacity, with the community acting as the senior partner in interactions with the medical school, the agencies, and other academic institutions. METHODS: The Community Coalition Board developed a set of research priorities and a set of 10 community values, or principles, to guide research. A board committee reviews each protocol to ensure they uphold the values. CONSEQUENCES: The Community Coalition Board has been using the values since 1999, and in this article we describe its experience. After an initial period that included some disagreements between researchers and community members on the board, relationships have been good, and protocols have been approved with only minor changes. INTERPRETATION: Although the established community values reflect universally acknowledged principles of research ethics, they also address local concerns. An equal partnership between community members and researchers is most beneficial if the partners can agree on a set of values to govern research.

Black or African American↗

Flexibility of working hours in the 24-hour society.

The 24-hour Society undergoes an ineluctable process towards a social organisation where time constraints are no more restricting human life. The borders between working and social times are no more fixed and rigidly determined, and the value of working time changes according to the different economic and social effects you may consider. Shift and night work, irregular and flexible working hours, together with new technologies, are the milestone of this epochal passage. What are the advantages and disadvantages for the individual, the companies, and the society? What is the cost/benefit ratio in terms of health and social well-being? Coping properly with this process means avoiding a passive acceptance of it with consequent maladjustments at both individual and social level, but adopting effective preventive and compensative strategies aimed at building up a more sustainable society. Flexible working times now appear to be one of the best ways to cope with the demands of the modern life, but there are different points of view about labour and temporal 'flexibility" between employers and employees. For the former it means a prompt adaptation to market demands and technological innovations; for the latter it is a way to improve working and social life, by decreasing work constraints and increasing control and autonomy. Although it can be easily speculated that individual-based 'flexibility" should improve health and well-being, and especially satisfaction, whereas company-based flexibility" might interfere negatively, the effective consequences on health and well-being have still to be analysed properly.

Adult↗

Gynecologic sonography. Report of the ultrasonography task force. Council on Scientific Affairs, American Medical Association.

Sonography, because it is nonionizing, is the preferred imaging modality for the female pelvis. Traditionally, transabdominal, transcystic studies were performed However, development of transvaginal and transrectal transducers has led to enhanced imaging capabilities of the pelvis. These new technologies will likely improve our ability to understand gynecologic pathology. The clinical use of pelvic ultrasonography depends on a thorough understanding of normal anatomy and cyclical changes and on the relative limitations of the imaging modality in specifically characterizing pathologic processes. This article reviews the accepted role of pelvic sonography in gynecologic disease and provides a preview of some of the potential applications of recent advances in sonographic technology.

American Medical Association↗

Densitometric evaluation of seven dental film processing solutions.

In order to determine the effect of 7 dental film processing solutions on the quality of the radiographic image, an aluminium step-wedge phantom was exposed, using Agfa Dentus M2, speed group D, intra-oral x-ray films. The exposures were done under standardized conditions. Processing was carried out, using each of the 7 processing solutions, namely Agfa, Dürr, EBX, Kolchem, MEMS, Premier and Pro-tech strictly in accordance with the manufacturers' recommendations. After the processed films were subjected to densitometric evaluation, a step-wedge curve was drawn for each processing solution. The data pertaining to the radiographic contrast and relative speed values were calculated from the step-wedge curve and, together with the base plus fog values, were tabulated. Kolchem produced the highest radiographic contrast, followed closely by MEMS and Dürr. The relative film speed was almost identical for Kolchem, MEMS and Dürr. Regarding the base plus fog values, all 7 processing solutions were within the acceptable limit of 0.25.

Densitometry↗

Nurse practitioner research: selected literature review and research agenda.

Selected literature is reviewed to illustrate current conceptual and methodological issues in nurse practitioner research. Concepts of style of practice, acceptance, satisfaction, and outcome are discussed. Methodological issues are linking process to outcome, complexity measures, use of existing data, and the effect of nurse practitioner education and experience on interpretation of findings. A research agenda with two objectives is proposed: studies designed to improve rather than evaluate practice and studies designed with a policy framework in mind.

Clinical Competence↗

["Released" employees of the 6th decade--a new retirement generation. Report on central results of a meeting of experts on the topic].

More and more workers and employees leave their working places and renumerated employment for good from the age of 50 onwards - by way of acknowledged incapacity to continue work due to health reasons, unemployment, forced retirement after production plants have closed down and early retirement schemes. How retirement is experienced very much depends on the living conditions encountered and on the process of transition to retirement. Acceptancy of premature retirement is of central importance - as are the opportunities of influencing by one's own decisions the age of retirement, the predictability of this event and the chances of transition through a phase of gradual re-orientation. Differentiation between those with good and very good income levels and those with only minimal financial means is imperative. Negative outcomes of the latter situation may be a feeling of total hopelessness, frictions within the family, reduction of social contacts and of out-of-door activities--a tendency to hide away in shame. To be labelled as old in too early a phase in life is not acceptable. The social status attained tends to be unclearly defined with accompanying negative effects on the self-concept as well as on the image held by others.

Aged↗

[Hearing rehabilitation, possibilities and limitations].

The increase of hearing loss in the aged looks like a natural process. The handicap problems caused by this process have not to be accepted as such. A hard of hearing aged may be helped by a hearing aid if he is willing to learn again how to communicate. Just in the learning period professional support has to be given, in the field of handling the hearing aid, training lipreading and learning a number of hearing tactics.

Aged↗

[Effect of conditions of agitation and aeration on the biosynthesis of oleandomycin].

The data on the effect of the aeration and agitation conditions on biosynthesis of oleandomycin in 0.75, 3 and 50 m3 apparatus are presented. The relationship between the biosynthetic parameters, oxygen dissolution rate and specific power consumption for agitation was studied. It was shown that the values of the specific power consumption for agitation were not acceptable for scaling up the process of oleandomycin biosynthesis.

Bacteriological Techniques↗

A computerized neuromuscular blockade monitor with visual-display unit: a preliminary report.

A programmable microprocessor has been developed to control a nerve stimulator, to accept electromyographic potentials and to process them to produce derivatives related to neuromuscular function which can then be stored and displayed. Examples are given of its use to assess the physiological state of the neuromuscular junction and to quantify the degree of blockade in clinical situations.

Action Potentials↗

Foods for patients with celiac disease.

As a general rule patients with celiac disease must avoid five cereals--wheat rye, triticale, barley and oats. Very sensitive individuals must also avoid two products of these cereals--malt and hydrolyzed vegetable protein. Some less sensitive individuals may be able to tolerate barley and oats in small quantities. All other foods are acceptable, including the cereals corn, rice, buckwheat, millet and sorghum, as well as malt-flavored breakfast cereals. Wine, spirits, beer and ale are also acceptable unless otherwise contraindicated. Monosodium glutamate, other food additives and pharmaceutical preparations are also acceptable. The ingredients of prepackaged processed foods are listed on the labels. Patients with celiac disease must examine labels to ensure that they avoid the harmful cereals. With appropriate precautions they need not be concerned about eating away from home.

Adult↗

Localization of the start and the end point of a moving stimulus path during eye tracking.

The subjects track visually a smoothly moving light target which increases its brightness at a definite point in the visual field and after traversing a path with a definite length, again decreases its brightness to the initial level. The subjects' task is to localize the start and the end point of this path. Systematic misperceptions are observed in the performance of the task, influenced by the position of the stimulus in the visual field and by the length of the path. The mislocation of the end point of the stimulus path is algebraically smaller than the mislocation of the start point. The data are not in agreement with the hypothesis that the visual system first determines the path length and then determines the path position as a whole. The most probable assumption is accepted to be that the processes of localization of the start and the end point of the path are not independent.

Adult↗

[Lack of in vitro effect of antithyroid drugs upon peroxidase antigen expression in autoimmune thyroid disease].

The aim of this study is to determine whether antithyroid drugs (ATD) act via inhibiting thyroid hormone synthesis or by interfering with the immune process which leads to autoimmune disease. Previously we had demonstrated that ATD do not affect HLA-DR and TPO antigen expressions induced by appropriate stimulus in normal thyrocytes, so we decided to study what happens when the same experiments are performed using autoimmune thyrocytes. Cultured thyroid tissue from patients operated on for Graves' Disease or Hashimoto's Thyroiditis were stimulated with TSH or TBII alone or associated with ATD; TPO antigen expression was evaluated by the Cytotoxicity Assay using human monoclonal antiTPO. When autoimmune thyrocytes were cultured and no stimulus was used or with the addition of MMI or PTU alone, very low values of TPO expression were noted (8.6 +/- 6.7, 5.0 +/- 7.1 and 4.2% +/- 2.3% respectively); if they were stimulated with TSH or TBII, a sharp rise of TPO antigen expression was detected (54.4 +/- 23.3 and 62.6 +/- 16.5%), these figures being significantly different from unstimulated cells (p < 0.001). If both stimulus were used associated with ATD, the high TPO antigen expression was unaffected. It is concluded that, at least in vitro, ATD have no effect upon induced-antigen expression in autoimmune thyrocytes. Since they do not alter antigen presentation, a primary step in the immune process, it is difficult to accept that their mechanism of action is through interference with the immune response.

Antithyroid Agents↗

Nurse anesthesia admission qualifications.

This study describes criteria used by graduate nurse anesthesia educational programs (GNAEPs) in selecting students for admission. The investigators prepared and distributed a 15-item questionnaire to 71 GNAEPs as listed by the Council on Accreditation of Nurse Anesthesia Eduational Programs for December 1992. Thirty-eight of 71 (54%) of GNAEPs participated in this study. Upon examination of standardized test scores, mean Graduate Record Exam scores were: analytical 533, quantitative 512, verbal 510, and cumulative 1,552. The mean Millers Analogy Test score was 47. The mean overall grade point average (GPA) was 3.32 and the mean science GPA was 3.20. Experience in critical care nursing averaged 5 years, with 54% of students coming from surgical intensive care units and 81% Advanced Cardiac Life Support certified. The most commonly identified prerequisite course was organic/biochemistry. All programs required references, 97% required interviews, and 68% required essays. Program directors ranked overall GPA, interview, and science GPA among the factors considered most in the selection process. The sample revealed an acceptance rate of 22% for those applying to GNAEPs.

Education, Nursing, Graduate↗

Minireview: regulation by second messengers of permeability in the cerebral microvessels.

The view that the cerebral endothelial cells represent the cellular analogue of the blood-brain barrier has been generally accepted. The regulation of transport processes operating in the cerebral endothelial cells is of great current interest. Different elements of the intracellular signaling messenger systems have been detected in the course of our studies in the cerebral endothelial cells. Our knowledge of these regulatory mechanisms is briefly reviewed here with special emphasis on the importance of second messenger molecules and phosphorylation of certain proteins of microvascular origin.

Animals↗

[Relationship between normal aging and Alzheimer's dementias. Practical applications].

During the process of normal ageing significant loss of neural brain cells is known to take place. To a greater or lesser degree, all ageing persons undergo the process which does not deviate in a qualitative sense from the morphological changes observed in the dementias. It is therefore reasonable to assume that the following 3 relationships can occur between normal ageing and the dementias. Firstly, dementia may results directly from the ageing process of the C.N.S. alone. Secondly, a number of diverse factors either augments normal ageing deficits or accelerates the very process. Finally, normal ageing and dementias are assumed to be coincidental. There exists considerable evidence that most dementias are generated by an accelerating rate of ageing of the C.N.S. or by augmentation of the process by diverse factors. The acceptance of the above hypothesis may be beneficial not only from the theoretical point of view but could also produce new treatment techniques and, particularly, assist in preventing Alzheimer's and other dementias.

Aged↗