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PubMed2003

Screening for diabetic retinopathy in remote Australia: a program description and evaluation of a devolved model.

OBJECTIVES: To describe the diabetic retinopathy screening program operating in the Kimberley and evaluate recruitment into and the quality and timeliness of, the screening procedure. METHOD: Review of the documents relating to the Kimberley diabetic retinopathy screening program and analysis of Kimberley diabetic retinopathy screening database. RESULTS: The Kimberley Public Health Unit developed and maintains a program of training, credentialing and ongoing professional development for retinal camera practitioners and a Kimberley-wide database of retinal photographs taken for diabetic retinopathy screening. As a result of this program, diabetic retinopathy screening is available in or close to most diabetics' home towns/communities and 58% had undergone retinopathy screening in the preceding 2 years. Over 90% of sets of photographs were of excellent or adequate quality. There was a positive relationship between credentialing and photograph quality and timeliness of photographs being sent away for reporting. CONCLUSIONS: Quality diabetic retinopathy screening, at prevalences comparable to, or higher than, other urban and rural populations, can be achieved in a remote area.

Adolescent↗
PubMed2004

Sensitivity and specificity of the 76-suprathreshold visual field test to detect eyes with visual field defect by Humphrey threshold testing in a population-based setting: the Thessaloniki eye study.

PURPOSE: To evaluate the screening performance of the 76-Suprathreshold (76-STHR) visual field test to detect eyes with visual field defect (VFD) as measured by Humphrey threshold testing in a population-based setting. DESIGN: Cross-sectional study. METHODS: All 88 subjects who agreed to participate in the pilot phase of the Thessaloniki Eye Study were included. Participants underwent a 76-STHR visual field test followed by a 30-full threshold (30-2 FTHR) test (Humphrey field analyzer). One eye/subject was randomly selected and included in the analysis. Sensitivity and specificity rates of the 76-STHR to detect eyes with VFD by the 30 to 2 FTHR test were calculated. RESULTS: When eyes with borderline results in the 30 to 2 FTHR test were classified as having a VFD, sensitivity rates of the 76-STHR to detect eyes with VFD by the 30 to 2 FTHR were 85.2%, 77.8%, and 74.1%, whereas specificity rates were 70%, 78%, and 86%, depending on the cutoff used for the 76-STHR. CONCLUSIONS: The 76-STHR test showed high sensitivity and low false-negative results at the "at least one point missed" cutoff level criterion to detect eyes with visual field defect by Humphrey threshold testing in a population-based setting. This criterion should be used when screening in a population-based study setting. By contrast, the 76-STHR would not be the appropriate screening test in a primary care setting with limited resources.

Aged↗
PubMed1995

Assessment of an inner city visual screening programme for preschool children.

AIMS: The efficiency of preschool visual screening programmes to detect amblyopia is questionable. In this study such a programme in an inner city was assessed to determine its effectiveness. METHODS: The results of screening and hospital treatment of 712 patients who were considered to require referral were entered into a database for analysis. Default rates were assessed and the efficacy of treatment determined. RESULTS: The only effective screening test for the detection of amblyopia was visual acuity. A large proportion of referred patients had refractive problems only. High default rates, particularly in geographical areas of lower socioeconomic grading, severely handicapped any attempt to reduce the incidence of amblyopia. CONCLUSION: A fresh approach to the detection and care of amblyopia in the inner city community is required, perhaps by performing screening of children in their first year of attendance at school to reduce default rates. Cycloplegic refraction of children who are found to have reduced visual acuity before their referral to hospital is also recommended.

Amblyopia↗
PubMed2006

Role of frequency doubling technology perimetry in screening of diabetic retinopathy.

PURPOSE: To study the ability of frequency-doubling technology perimetry (FDT) to detect sight-threatening diabetic retinopathy. METHOD: Fifty-eight eyes of fifty-eight patients with established diagnosis of diabetes mellitus with diabetic retinopathy, fifty-five eyes of fifty-five diabetic patients without retinopathy and forty-one eyes of forty-one normals underwent FDT and dilated stereo-biomicroscopic fundus examination. The sensitivity and specificity of FDT in identification of "sight-threatening retinopathy" (severe and very severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy) and clinically significant macular edema (CSME) were determined. RESULTS: For the detection of sight-threatening retinopathy, two abnormal adjacent points depressed to any level on the 20-1 screening program had a sensitivity of 90.5% and specificity of 97.6%. At (assuming a) 10% prevalence of sight-threatening retinopathy in a diabetic clinic, two abnormal adjacent points anywhere in the field depressed to any level has a positive predictive value (PPV) of 48% with a negative predictive value of 98.8%. Sensitivity and specificity for the detection of CSME was poor. CONCLUSIONS: The 20-1 screening program of the FDT is useful in the detection of sight-threatening diabetic retinopathy (PPV 48%). A normal 20-1 test rules out sight-threatening retinopathy. FDT was not useful in the detection of CSME.

Adult↗
PubMed1989

Behavioral control of visual field screening using a microcomputer.

A computer algorithm is described which automatically controls the presentation of visual field targets and analyzes the subject's responses. Data relating to the procedure's reliability and validity are reported along with experience using it with normal subjects on an IBM PC compatible. Suggestions are made for the further development of the microcomputer approach to visual field investigations.

Algorithms↗
PubMed2003

The reliability of frequency-doubling technology (FDT) perimetry in a pediatric population.

PURPOSE: Frequency-doubling Technology IFDT) Perimetry was introduced as a rapid, easy method for detection of visual-field defects in adults. Its reliability, howev, has never been tested among pediatric patients. The purpose of this study was to determine if children could complete a screening program of FDT Perimetry reliably and to define the age range over which it might be most applicable. METHODS: Two hundred fifty-nine normal children (mean age, 10.7 years; range, 4 to 17 years) were asked to complete the FDT C-20-1 screening test as part of their general eye examination. The visual-field results were analyzed for reliability using the number of false-positive errors, fixation losses, and visual-field defects. For the purposes of this analysis, field results were considered unreliable with false-positives > or = 1 or fixation errors > or = 1. The visual-field test was also considered unreliable if > 2 sectors were flagged. RESULTS: Data from 254 children were included in the analysis. Five children were excluded because of suspected malingering or ocular health diagnosis that may have produced a visual-field defect. False-positives were less than one for all but the youngest age group 14 years old). Fixation errors decreed with increasing age and fell below one (became reliable) at approximately 9 years of age, and remained less than one through 17 year. Visual-field loss for purposes of this study when present in more than two sectors was considered unreliable in this normal population. CONCLUSIONS: Children ages 10 years of age and older can reliably complete the FDT C-20-1 screening field test using the strictest criteria, combining false-positives, fixation losses, and visual-field losses. These data are derived from normal subjects, who on complete eye examination, had no ocular disease or reason to suspect visual-field defects.

Adolescent↗
PubMed2006

Ocular morbidity among children studying in private schools of Kathmandu valley: A prospective cross sectional study.

A prospective cross sectional study of students of two private schools was done and students were screened in detail. A total of 1816 students aged 5 to 16 years were evaluated, out of which 52.8% were males and 47.2 % were females. Among the total, 65.8% had no ocular abnormalities and 34.2% had some form of ocular disorders. Refractive error was the commonest problem seen accounting for 21.9% out of total, followed by infective disorders, which accounted for 7.2%, 3.5% of them were noted to have Orthoptic problem including various types of strabismus, 2.2% were color blind, 2.6% were found to have various other disorders. The prevalence of refractive error among private school children seems to be higher. Color blindness also seems to be prevalent among these children. This kind of school screening would help in detecting the eye problems timely and thus would reduce the ocular morbidity as well as prevent children from going blind unnecessarily.

Adolescent↗
PubMed2002

Current status of screening for diabetic retinopathy in the UK.

This article reviews the current status of retinopathy screening schemes in the UK. There is evidence that high-quality diabetic retinopathy screening schemes are in existence but provision is patchy. Many health authorities have ad hoc screening programmes reaching only about 60% of patients, with unacceptable or undocumented efficacy and minimal quality control. Several models of screening are currently in use with the current preferred option being camera-based screening. Digital imaging systems offer the best prospects for image acquisition, although at present evidence of adequate effectiveness only exists for 35 mm film-based systems. The final report of the National Diabetic Retinopathy Screening Programme commissioned by the UK National Screening Committee for inclusion into the national service framework for diabetes, is thus eagerly awaited and should set standards for screening programmes, in order to improve the care of all those with diabetes. Quality assurance will be the main driver in the immediate future of improvements in screening programmes. Research data will provide the evidence to refine techniques and set targets in the longer term, with the emphasis on cost-effectiveness and quality of life.

Cost-Benefit Analysis↗
PubMed2004

Factors influencing the detection of visual developmental deficits in 3-year-old kindergarten children.

PURPOSE/BACKGROUND: In the 'Tübingen Kindergarten study', an orthoptic screening program for amblyopia in three-year-olds was evaluated. In the retrospective analysis presented here, the association between a child's history--especially participation in the regular preventive care examinations in Germany (U4 to U7)--and the time of detection of target diseases was investigated. METHODS AND SUBJECTS: The parents of three groups of children were interviewed by telephone. Group 1 consisted of 21 children already treated for amblyopia before orthoptic screening; group 2 of 26 children with target conditions newly detected by orthoptic screening; and group 3 of 32 children with newly detected moderate ametropia. The groups were tested for differences in history and utilization/results of the regular preventive care examinations. RESULTS: Participation in regular preventive care ranged from 82% to 92%. There were no significant differences between the groups. Nearly 90% of parents from groups 2 and 3 had not heard of amblyopia before orthoptic screening. Only one child had been referred after regular preventive care examinations. CONCLUSIONS: The regular preventive care examinations contributed little to the detection of amblyopia. The strong position of the pediatrician should be used for the early information of parents.

Amblyopia↗
PubMed2004

Feasibility of tele-ophthalmology for screening for eye disease in remote communities.

We assessed the feasibility of tele-ophthalmology in a remote location, Tungyin, an island 200 km from Taiwan, which has no ophthalmologist. Screening for eye diseases was carried out among residents aged 40 years or more. A total of 113 subjects, approximately 31% of the whole population, were enrolled in the screening programme. Images were transmitted (via ADSL) to a retinal specialist in Taiwan for diagnosis. The average processing time, excluding the time for copying files, was 6.4 s (SD 2.1) per subject. Transmission took 60-90 s for most of the images (83%). The average time required to make a diagnosis for each subject, including data entry, was approximately 34 s (SD 18). In screening for retinopathy, the detection rate with digital imaging (8.8%) was two times higher than with indirect ophthalmoscopy (4.4%). In 12% of cases macular degeneration was identified, and in 6% there were mild or moderate problems with the optic disc. Community-based screening for four categories of eye disease was successfully demonstrated using store-and-forward tele-ophthalmology.

Adult↗
PubMed1997

Off-axis photorefractive eye screening in children.

PURPOSE: To determine the utility of mass photoscreening for detecting visual anomalies in young, school-age children. SETTING: Seventy elementary schools in Alabama, Florida, Georgia, North Carolina, and Virginia, USA. METHODS: An off-axis photorefractive technique was used to screen 14,591 children in kindergarten, first, and fourth grades in 70 schools in 5 southeastern states in the United States. RESULTS: A total of 14,075 (96.5%) of the screenings yielded analyzable photographs. Overall, 647 (4.6%) children had significant ocular findings; significant was defined as hyperopia 2.50 diopters (D) or more, myopia 1.00 D or more, anisometropia 1.00 D or more, astigmatism 2.00 D or more, media opacity 1.0 mm or more in diameter, or 5 degrees or more or 10.00 prism diopters or more of ocular misalignment. Another 950 (6.7%) had possibly significant findings, defined as the sign being present but in an amount less than that considered significant. The most common refractive error was myopia (4.5%), followed by anisometropia (3.1%), hyperopia (2.9%), and astigmatism (1.0%). Alignment problems were found in 1.7% and media opacities in 0.1%. Among the 1.0% with other ocular anomalies were cases of anisocoria greater than 2.0 mm or irregular pupils, ptosis greater than 2.0 mm, and subconjunctival hemorrhages. In all, 202 children had significant anomalies thought to predispose to amblyopia, including 196 with significant anisometropia and 6 with significant lens opacities. At a screening cost of $5 per child for the whole study, the cost of identifying these children with potentially blinding eye disease was $361 each. CONCLUSION: Mass photoscreening may be used to detect amblyogenic conditions in children early enough to prevent blindness with timely and appropriate treatment.

Amblyopia↗
PubMedDate not supplied

Factors associated with missed eye examinations in a cohort with diabetes.

BACKGROUND: The diabetes screening program in Moosonee and Moose Factory, Ontario was evaluated to explore which factors may be associated with individuals who had/had not attended screening examinations for diabetic retinopathy. METHODS: Exposure data were collected from patient charts for basic demographic and medical history data. The main outcome of interest was the absence of a retinal examination in the two years preceding data collection. RESULTS: There were 248 subjects identified with diabetes who had complete data for the variables of interest. On univariate analysis, younger age and shorter duration of diabetes were significantly associated with not having an eye examination. On multivariate analysis, younger age, residence in Moosonee, and shorter duration of diabetes remained in the final model. INTERPRETATION: Screening programs for diabetic retinopathy in the James Bay Cree should consider targeting younger individuals with diabetes of less than 5 years duration since this sub-group is not as likely to attend eye examinations.

Adult↗
PubMed2006

Use of optical coherence tomography, fluorescein angiography and indocyanine green angiography in a screening clinic for wet age-related macular degeneration.

AIMS: To assess the utility of optical coherence tomography (OCT) in a nurse-led, fast-track clinic for new age-related macular degeneration (AMD) referrals, and to see how often indocyanine green angiography (ICGA) led to an additional diagnosis to that provided by fundus fluorescein angiography (FFA). METHOD: Retrospective audit of a consecutive series of 134 new patients referred with suspected wet AMD. When visual acuity was >or=6/60 an OCT was performed. If the OCT was consistent with "wet" AMD, the patient underwent simultaneous FFA/ICGA. The sensitivity and specificity of this clinic was calculated. The number of additional diagnoses made using ICGA was recorded. RESULTS: 23/134 (17.16%) patients had OCT only and were not subsequently found to have wet AMD. FFA/ICGA was performed in 111 patients, showing wet AMD in 90 (81%) patients. OCT as used in our clinic had a sensitivity of 1 and a specificity of 0.65 for detecting wet AMD. ICGA provided additional diagnoses in 19 (14.17%) patients. ICGA detected a specific vascular abnormality in 58% of the occult lesions. CONCLUSIONS: OCT proved to be an effective screening tool for wet AMD in this clinic, with excellent sensitivity and reasonable specificity. ICGA provided an additional diagnosis in a significant number of cases, but did not define a vascular abnormality in all occult cases.

Aged↗
PubMedDate not supplied

[Visual screening in children].

The Early Visual Screening (EVS) before verbal communication and, certainly, before one year old, is essential to prevent strabismus and/or amblyopia. We consider the PREFERENTIAL LOOKING (PL) for visual acuity determination and screening of the amblyopia and the PHOTOREFRACTION (VIDEO-REFRACTION: VPR-1) for refractive screening, adequated methods for Early Visual Screening. We suggest that these two technics are used as EVS methods, four times in childhood (newborn, 6-8 weeks, 6-8 months, 18-24 months) performed by an Ophthalmologist at a Pilot Health Center of the National Health Service. The classic methods of visual screening such as: child's reaction to the eye occlusion, pursuit movements, STYCAR balls and miniature toys, Cover test, Hirschberg test, red fundus reflex, anterior segment examination, each of these used according to the child's age, must be performed by an Ophthalmologist. We think they are a positive alternative until we are able to use the PREFERENTIAL LOOKING and VIDEO-REFRACTION in Early Visual Screening. In the kindergarten and primary school the ASTENOPIC complaints due to hipermetropia, minor astigmatism and convergent deficit as well as chronic inflammation of the anterior segment eyelids and anexus, can be related with poor school performance more than with strabismus or myopia.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

Reliability in perimetry.

As perimetric instrumentation becomes more sophisticated, patient reliability emerges as an important limiting factor in testing. Modern instrumentation for threshold and suprathreshold perimetry incorporate up to five separate indicators of patient reliability. For these perimetric methods, patient reliability is enhanced with specific techniques such as refractive correction, control of pupil size, and actively monitoring patient responses. With the manual (Goldmann) perimeter and the tangent screen, special statokinetic techniques help in both assessment and enhancement of patient reliability. In screening perimetry, reliability is assessed by analyzing the relative number, relative location, and repeatability of misses. Reliability in confrontation perimetry is both assessed and enhanced by using finger-counting and color-naming techniques. Review of the ophthalmic literature on perimetry shows how the various methods of patient reliability assessment and enhancement can be applied in the clinic.

Humans↗
PubMedDate not supplied

Protocols for screening and treatment of diabetic retinopathy in Europe.

Diabetes eye complications, and particularly diabetic retinopathy, are the major cause of blindness in the working age groups of industrialised countries. Laser photocoagulation has been proven to reduce blindness due to retinopathy by at least 60% but even more patients would benefit if treatment were delivered at an early enough stage. High risk retinopathy, though, does not cause visual symptoms and when the latter occur it is often too late to reverse them. Hence, a screening programme for diabetic retinopathy should aim at detecting patients at risk when they can still be effectively treated. This can be obtained by regularly checking the patients' eyes. Its target, as defined by the joint World Health Organisation/International Diabetes Federation Saint Vincent Declaration Working Group, is to reduce diabetes-related blindness by one third or more in the next 5 years. The number of persons to be screened is high, 30,000/million total population/year, but available data indicate that this is feasible and that the initial investments in professional and material resources are more than justified by the reduction of preventable blindness and of the financial burdens that go with it. Indeed, prevention of the major cause of blindness in the working age should rate the same priority as other widely deployed programmes, such as those to screen for cancer, neonatal hypothyroidism and phenylketonuria. The concerted action of government health departments, patients' and professional associations will be vital for the successful implementation of this programme. The texts of this document (a protocol for the screening of diabetic retinopathy and cataract), Appendix 1 (data collection card) and Appendix 2 (informative leaflet for the patients) were approved by 57 specialists, representing 30 diabetic and ophthalmic societies from 21 European countries, and endorsed for translation into all European languages and distribution at the appropriate levels.

Cataract Extraction↗
PubMed1998

Screening for diabetic retinopathy using a non-mydriatic retinal camera in rural Victoria.

PURPOSE: To develop a screening programme for the early detection of diabetic retinopathy using non-mydriatic retinal photography. METHODS: A community based screening service was offered to all people with known diabetes mellitus in selected townships in the LaTrobe and Goulburn Valleys in Victoria. At the local examination centre, basic sociodemographic information was collected as well as details of previous use of eye care services for the early detection of diabetic retinopathy. The examination included visual acuity (VA), glycosylated haemoglobin level and Polaroid photographs of each fundus using a Canon CR5-45NM non-mydriatic retinal camera (Canon, Tochigiken, Japan). Dilating drops were not used. Photographs were subsequently reviewed and letters were sent to all participants (with copies to their general practitioners) with recommendations for appropriate follow up. RESULTS: A total of 1177 people with diabetes attended the screening service, which is estimated to be 40% of the total population with known diabetes in the study area. The mean age was 65 years (range 20-94 years); 559 (48%) people reported not having a dilated fundus examination within the past 2 years; 345 (29%) people had never had a dilated fundus examination. Of the 2354 eyes, 2126 (90%) of the photographs were gradable. A total of 704 people (60%) had normal VA and no evidence of diabetic retinopathy, 209 people (18%) had diabetic retinopathy, 101 people (9%) had evidence of other fundus pathology, 42 people (3%) had reduced acuity (< 6/18) in one or both eyes (with no fundus pathology evident) and 121 people (10%) had ungradable photographs in one or both eyes. CONCLUSIONS: The present study demonstrates the usefulness of a screening programme with non-mydriatic retinal photography as an adjunct to current eye care services for the early detection of diabetic retinopathy.

Adult↗
PubMed1990

Screening and surgical intervention results from cataract-free-zone projects in Campinas, Brazil and Chimbote, Peru.

Two cataract-free-zone projects, one in Brazil and the other in Peru, were designed to provide surgery to all those who need and want it within a defined geographic area. In-home visual acuity screening was accepted by three-fourths of the enumerated population aged 50 years or more. Those with reduced bilateral visual acuity were referred to a community health post for ophthalmic examination. Among those diagnosed as bilaterally blind (less than or equal to 20/200), comprising 5% of the screened population, two-thirds were thought to be blind from cataract. Because of other ocular pathology and general health conditions, surgery was not indicated for 30-50%. Two-thirds of those recommended for out-patient surgery accepted. Motivational efforts to convince the refusers were uniformly unsuccessful. The average age of those accepting and those refusing surgery was in the mid-seventies. Those already aphakic were 7-8 years younger. Post-operative acuity was greater than or equal to 20/50 for only one-half of those operated. A significant number of cases had previously undetected macular degeneration and other causes of decreased vision. These projects have given increased attention to cataract blindness and the need for further operational research to develop effective methods for its control using outpatient surgery.

Aged↗