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At least 1,027 records · Page 57Linked to original sources
PubMed2001

Modeling hydrocarbon biodegradation in tidal aquifers with water-saturation and heat inhibition effects.

A model is developed for hydrocarbon biodegradation, which includes saturated and unsaturated flow, multi-species transport, heat transport, and bacterial growth processes. Numerical accuracy of the model was tested against analytical solutions. The model was also verified against laboratory results for a saturated-flow problem and reasonable match was obtained. Expressions are proposed for inhibition due to water content and temperature fluctuations. Bioactivities under cyclic water content variation were studied under no-flow conditions. A quantitative approach was used to reconcile some of the apparent contradictory conclusions regarding the efficiency of biodegradation of soils under wetting and drying conditions. The efficiency depends on the nature of the oxygenation process. For cases involving the presence of dissolved oxygen and the absence of O2 vapor, subjecting the soil to constant water content close to its optimal value for degradation is most efficient. However, wetting and drying can enhance degradation if O2 is only provided through aeration or direct contact between air and the medium. Also presented are the results of a typical field application of the model and a discussion of the effects of tides, saturation inhibition, and heat inhibition. Other inhibition factors, such as pH or salinity, can be easily incorporated in the formulation. The quantitative approach developed here can be used in assessing bioremediation not only in tidal aquifers but also in areas where water-table or temperature effects are of significance. The approach can be useful in the design of remediation strategies under water-flow or no-flow conditions involving water content and temperature fluctuations.

Biodegradation, Environmental↗
PubMed1996

A history of rhinology in North America.

The history of rhinology is the story of the efforts of men and women who have tried to help patients who have nasal and sinus disorders or other conditions thought to be related to the nose or sinuses. Woven through this story are the subplots of the progress of surgical technology, the understanding of anatomy and physiology, and the hit-or-miss relationship between them. Through the last half of the nineteenth century, great strides were made in understanding nasal and sinus anatomy and physiology. As that century ended and as the twentieth century began, there was a surge of technology that allowed a marked increase in the type and number of surgeries performed. Unfortunately, nasal and sinus surgery holds the awesome potential to promote health or to severely hurt someone. The knowledge of nasal physiology and anatomy had been exceeded, and often those operations were not in the patient's best interest. Through the middle of the twentieth century the basic science knowledge seems to have caught up with the care being provided, but as the end of the century approaches, another tide of surgical activity seems to be upon us. Perhaps in no other area of surgery has this disparity between biologic knowledge and surgical activity been so well demonstrated. Perhaps the next 100 years will witness a better coordination of these activities.

History, 18th Century↗
PubMed1980

The systemic response of the traumatized patient: an overview.

A metabolic conflict occurs between increased production of easily used substrates and inhibition of their metabolism in any injured animal. The terms ebb and flow describe the dwindling and rising tides of such activity. The ebb may last 24 to 72 hours; the flow is usually over within two weeks but may last up to eight weeks or longer in more severe cases. The ebb phase corresponds to the traumatic and initial post-traumatic period when there usually is adequate substrate (oxygen, glucose, fatty acid) to meet the diminished demand of the tissues. The flow phase is the period of convalescence. The object of the organism's initial defense following injury seems to stabilize the situation during the ebb phase (preservation of the internal milieu). The longer the ebb phase can be maintained and the more substrates that can be conserved, the more likely the animal will recover during the flow phase. The ebb phase is set in motion by an injury such as hemorrhage, burns, fractures, soft tissue damage by crushing sepsis, or diarrhea. After the ebb phase, a variable, integrated response of nervous, endocrine, and metabolic systems begins, which compromises normal function to achieve specific survival objectives (that is, protection, stabilization and adaptation). Systemic changes (such as tissue catabolism) devoted to caloric needs and local growth (that is, wound repair) are all directed at the ultimate objective of survival.

Animals↗
PubMed1996

Fate and effects of nutrients and heavy metals in experimental salt marsh ecosystems.

Fate and effects of the macro nutrients nitrogen and phosphorus, and the heavy metals zinc, copper and cadmium, brought into experimental salt marsh ecosystems via sediment supply, were studied over a three-year period. The supply of sediment from the Marsdiep (at a low and high rate) and from the harbour of Delfzijl (at a high rate) led to an increase of the macro nutrients and heavy metals in the top soil. The growth of the salt marsh plants Aster tripolium, Puccinellia maritima and Spartina anglica and the uptake of the macro nutrients and heavy metals by the plants was only slightly affected by the addition of sediment. A high load of sediment led to an increase in growth or in the concentrations of the macro nutrients or heavy metals in the plants at a number of sampling dates, but only minor differences between treatments were found. From a mass balance constructed over a three-year study period it could be concluded that about 50% of the macro nutrients and heavy metals were retained in the salt marsh sediment. This was equal to the retained amount of organic matter, indicating that retention of the elements was closely related to retention of organic matter. The 50% loss of the macro nutrients and heavy metals probably occurred via ebb tides after resuspension of sediment and organic matter.

Journal Article↗
PubMed2000

Evolving concepts in the pathogenesis of chronic obstructive pulmonary disease.

It is arguable that more biologic insight has been gained from the study of COPD than from any other pulmonary disorder. A vast knowledge of the biology of extracellular matrix proteins, proteinases, and proteinase inhibitors has largely stemmed from the elastase:anti-elastase hypothesis for the pathogenesis of emphysema. An equally compelling case could be made that interest in, and funding for, COPD research has been woeful, and investigators have made no significant medical breakthroughs in the treatment of this disorder, which, unfortunately, is becoming epidemic worldwide. Indeed, it cannot be argued that physicians have very little treatment to offer to the many patients with COPD. Humankind is rapidly approaching a time when all human genes will be sequenced, and genetic engineering will allow determination of the function of these proteins in vivo. Expression profiling and bioinformatics will allow clinicians to assess the spectrum of genes and proteins regulated in biologic processes, no longer limiting study to naïve candidate genes. These advances will allow investigators to decipher precise pathways of complex diseases, identify genetic and environmental interactions, and ultimately lead to specific (pre)diagnoses and rational treatment. Answers to the question as to why only a subset of smokers develop COPD will enhance the understanding of the disease process. Fortunately, there has been a resurgence of interest in COPD, led largely by the pharmaceutical industry, which has discovered the potential of this unmet need. Consequently, these state-of-the-art scientific techniques are being directly applied to COPD, lending hope for the future. Of even greater importance, the tide seems to be turning on the cigarette industry. Although difficult to imagine, perhaps cigarettes will disappear in this lifetime or at least the next generation won't be fooled by this deadly habit! Well ... the rational therapy thing could work.

Airway Obstruction↗
PubMed1997

The socio-spatial stigmatization of homelessness and HIV/AIDS: toward an explanation of the NIMBY syndrome.

A central element of community response to controversial human service facilities is the socio-spatial construction of stigma. This paper develops a conceptual framework for understanding the constitution and role of stigma in community rejection of human services, particularly those associated with homelessness and HIV/AIDS. Three facets of stigma concerning homelessness and HIV/ AIDS (non-productivity, dangerousness, and personal culpability) are offered as a way of understanding the rising tide of community rejection toward human service facilities.

Acquired Immunodeficiency Syndrome↗
PubMed2001

[Determination of the state of emaciation of eel (Anguilla Anguilla) in migration in coastal and estuary zones].

The objective of this work is to characterise the variations of the quality of the glass eels recruitment during a season of migration, from November till March and before and after the transition from marine to continental environment. The emaciation state measured from the ratio DNA/Dry weight and percentage of body water is analysed from a sampling of glass-eels collected at sea and in estuary, in the South of the Bay of Biscay during the migration period 1999/2000. The length and the mass are taken into account, they decrease during the season while the individuals are more and more pigmented. However, our work shows that groups of glass eels arriving on the coasts of the Bay of Biscay are homogeneous from the point of view of their energetic and hydride reserves with a high individual variability within these groups. Also no significant difference in losses of water and energetic reserve were observed among the individuals migrating at the beginning and during tide stream. Fluctuations of the biochemical indication and the percentage of water between the glass eels caught in sea and in estuary show that the transition between maritime and continental environment is not a mobilising event of a lot of energy for glass eels. Differences were only observed in December.

Anguilla↗
PubMed1999

Metabolic impact of obesity in childhood.

Childhood and adolescent obesity have become the most prevalent nutritional diseases in the United States. The results of a number of studies demonstrate that the metabolic alterations caused by excess body fat are expressed early in the natural history of obesity. Such alterations seem clinically important even in children, as evidenced by the recent increase in type 2 diabetes in obese adolescents. These observations underscore the need for research efforts directed at the development of effective interventions to stem the tide of the childhood obesity epidemic.

Adolescent↗
PubMed1996

Methods for voluntary weight loss and control: update 1996.

The prevalence of obesity increased nearly eight percent over the last decade. In response to the obesity epidemic in the United States. The National Institutes of Health Technology Assessment Conference Panel published "Methods for voluntary weight loss and control" in 1993. Unfortunately, in 1996, the evidence suggests that the prevalence of obesity is still steadily increasing. Current trends predict that most Americans will struggle with weight problems and obesity in the future. There have been no major advances in the treatment of obesity. Interventions produce short-term losses followed by weight regain, and no current treatments appear capable of producing permanent weight loss. Newer treatment approaches assume that obesity is a chronic disorder that requires a continuous care model of treatment. Social and environmental influences on eating and physical activity, along with perceptions of inability to self-control, continually mitigate against maintenance of prudent weight management behaviors. Since the etiology of obesity is multifactorial and can be viewed as an interaction between biology and environmental factors, environmental changes and biological interventions aimed at correcting genetic and metabolic irregularities will be central to any efforts to stem the tide of obesity.

Behavior Therapy↗
PubMed1995

Acute symptoms and sequelae of Ross River virus infection in South-Western Australia: a follow-up study.

BACKGROUND: Unusually high tides along the south-west coast of Western Australia (WA) during the spring and summer of 1988-89 provided ideal breeding conditions for mosquito vectors of Ross River virus (RRV). This was followed by the biggest outbreak of RRV infection ever documented in WA (330 notified cases). OBJECTIVES: To describe the nature and duration of symptoms of RRV infection in WA, and associated functional disability; to determine the perceived effectiveness of treatments; to determine the usefulness of available information on RRV infection. STUDY DESIGN: A retrospective study of all cases of RRV infection reported from South West WA during the 1988-89 outbreak, using a self-administered patient questionnaire. RESULTS: The most common symptoms were arthralgia, tiredness and lethargy, and joint stiffness and swelling. In patients with joint manifestations, the knees, wrists and ankles were almost always affected. Non-steroidal anti-inflammatory agents, rest, simple analgesics and hydrotherapy were subjectively the most helpful treatments. Only 27% of patients had recovered completely within 6 months of onset of symptoms. Three years after the outbreak, up to 57% still experienced at least intermittent joint symptoms. Less than one-third of people reported that the available information adequately explained the consequences of RRV infection. CONCLUSIONS: Compared with patients elsewhere in Australia, people infected with RRV in the South West of WA experience a slightly different spectrum of clinical symptoms, with a longer period of disability. This may be related to the presence of a different topotype of the virus to that found elsewhere in Australia. Better information for doctors and patients on the likely course of the illness is needed. Future studies should examine the economic cost associated with RRV infection, and evaluate treatments to shorten the period of disability.

Journal Article↗
PubMed2001

Initial fermentation of sea sludge using aerobic and thermophilic microorganisms in a mangrove soil.

As sea sludge has the potential to cause eutrophication and red tide resulting in the death of shellfish and offensive odors, an effective method to treat it is needed. It was found that adding soil taken from a mangrove swamp to sea sludge promoted an initial fermentation of the sludge constituents. The result suggested that certain microorganisms that were thought to inhabit the sub-tropical mangrove soil had the potential to play a significant role in the fermentation and that the use of the microorganisms in the mangrove soil might be useful for composting sea sludge.

Bacteria, Aerobic↗
PubMed2002

Geochemical monitoring of thermal waters in Slovenia: relationships to seismic activity.

Thermally anomalous fluids released in seismic areas in Slovenia were the subjects of geochemical monitoring. Thermal waters were surveyed from the seismically active area of Posocje (Bled and Zatolmin; NW Slovenia) and from Rogaska Slatina in eastern Slovenia. Continuous monitoring of geochemical parameters (radon concentration, electrical conductivity, and water temperature) was performed with discrete gas sampling for their (3)He/(4)He ratio. The observed values were correlated with meteorological parameters (rainfall, barometric pressure and air temperature) and with seismic activity. Only a few earthquakes occurred in the vicinity of the measuring sites during the monitoring period. Nevertheless, changes in radon concentration, water temperature, electrical conductivity and helium isotopic ratio were detected at the three thermal springs in the periods preceding the earthquakes. A close correlation was also observed of both water temperature and electrical conductivity with the Earth tide, making the observations in the selected sites a promising tool for addressing the widely debated question of earthquake prediction.

Journal Article↗
PubMed2001

Effects of solar radiation on the Patagonian macroalga Enteromorpha linza (L.) J. Agardh-Chlorophyceae.

The photosynthetic performance of Enteromorpha linza (L.) J. Agardh-Chlorophyceae was determined with a portable PAM instrument in situ and under seminatural radiation conditions in Patagonia, Argentina. Solar radiation was measured in parallel with a three-channel radiometer, ELDONET (Real Time Computer, Möhrendorf, Germany), in three wavelength ranges, UV-B (280-315 nm), UV-A (315-400 nm), and PAR (400-700 nm). The effective photosynthetic quantum yield decreased after 15-min exposure to solar radiation when the thalli were kept in a fixed position but recovered in the subsequent shade conditions within several hours. A 30-min exposure of free floating thalli, however, caused less photoinhibition. The photosynthetic quantum yield of E. linza was also followed over whole days under clear sky, partly cloudy and rainy conditions in a large reservoir of water (free floating thalli) and in situ (thalli growing in rock pools). Most of the observed effect was due to visible radiation; however, the UV wavelength range, and especially UV-B, caused a significant reduction of the photosynthetic quantum yield. Fluence rate response curves indicated that the species is a typical shade plant which showed non-photochemical quenching at intermediate and higher irradiances. This is a surprising result since these algae are found in the upper eulittoral where they are exposed to high irradiances. Obviously they utilize light only during periods of low irradiances (morning, evening, high tide) while they shut down the electron transport chain during intensive exposure. Fast induction and relaxation kinetics have been measured in these algae for the first time and indicated a rapid adaptation of the photosynthetic capacity to the changing light conditions as well as a fast decrease of PS II fluorescence upon exposure to solar radiation. There was a strong bleaching of chlorophyll due to exposure to solar radiation but less drastic bleaching of carotenoids.

Argentina↗
PubMed1996

Exciton coupled circular dichroic studies of self-assembled brevetoxin-porphyrin conjugates in lipid bilayers and polar solvents.

BACKGROUND: Brevetoxins, involved in the 'red tide' as well as shellfish poisoning, are known to bind to cell membranes and membrane proteins. Brevetoxin B (BTX-B) interacts specifically with neuronal sodium channels. We recently found that BTX also induces selective ion movements across lipid bilayers through transmembrane BTX self-assemblies. RESULTS: We examined the self-assembly of several BTX derivatives in the presence and absence of cations and lipid bilayers using the powerful porphyrin chromophores as circular dichroism labels. BTX derivatives self-assemble into tubes, which can bind to metals both when soluble and when inserted into the bilayer to form transmembrane pores. Depending on the tendency of the BTX derivative to self-aggregate (the critical 'micelle' concentration, cmc), it may aggregate in solution before membrane insertion, or may insert itself into the membrane as a monomer before assembling the pore. CONCLUSIONS: The active BTX-B complex in lipid bilayers is a cyclic, transmembrane self-assembly consisting of antiparallel aligned BTX molecules that can mediate selective ion movement through membranes. The differences in pore formation mechanisms between BTX derivatives may be reflected in differences in pore formation by natural BTX variants, perhaps explaining their varying levels of toxicity.

Circular Dichroism↗
PubMed2002

Force and compliance: rethinking morphogenesis in walled cells.

In the turgid cells of plants, protists, fungi, and bacteria, walls resist swelling; they also confer shape on the cell. These two functions are not unrelated: cell physiologists have generally agreed that morphogenesis turns on the deformation of existing wall and the deposition of new wall, while turgor pressure produces the work of expansion. In 1990, I summed up consensus in a phrase: "localized compliance with the global force of turgor pressure." My purpose here is to survey the impact of recent discoveries on the traditional conceptual framework. Topics include the recognition of a cytoskeleton in bacteria; the tide of information and insight about budding in yeast; the role of the Spitzenkörper in hyphal extension; calcium ions and actin dynamics in shaping a tip; and the interplay of protons, expansins and cellulose fibrils in cells of higher plants.

Bacteria↗
PubMed2002

The 70-kDa heat shock protein response in two intertidal sculpins, Oligocottus maculosus and O. snyderi: relationship of hsp70 and thermal tolerance.

The role that hsp70 plays in influencing thermal tolerance of a whole animal is not clearly understood. We explored this question by examining liver hsp70 response in the tidepool sculpin (Oligocottus maculosus) and fluffy sculpin (O. snyderi), which have distinct distribution patterns in the intertidal zone. The tidepool sculpin is in upper and lower tidepools, while the fluffy sculpin is exclusively in lower tidepools during a low tide. We conducted experiments in order to investigate: (1) habitat water temperatures; (2) upper thermal tolerance limits; (3) the cellular hsp70 response to changes in water temperature in nature; (4) induction temperatures for hepatic hsp70 and hsp70 mRNA; and (5) effects of long-term heat stress on liver hsp70 levels, in these sculpins. Accordingly, we found: (1) the tidepool sculpin was exposed to a wider temperature range in nature; (2) the tidepool sculpin had higher lethal and induction temperatures for hsp70; (3) the liver hsp70 level of the tidepool sculpin was less sensitive to changes in water temperatures; and (4) the tidepool sculpin had higher constitutive hsp70 levels in nature, compared with the fluffy sculpin. From these results, we proposed that the less thermally sensitive tidepool sculpin may enhance its thermal tolerance by having a large pool of cellular hsp70, thus allowing it to inhabit the upper intertidal zone with relatively large and unpredictable fluctuations in environmental variables.

Adaptation, Physiological↗
PubMed1999

Respiratory consequences of feeding in the snake Python molorus.

Snakes can ingest large meals and exhibit marked increases in metabolic rate during digestion. Because postprandial oxygen consumption in some snakes may surpass that attained during exercise, studies of digestion offers an alternative avenue to understand the cardio-respiratory responses to elevated metabolic rate in reptiles. The effects of feeding on metabolic rate, arterial oxygen levels, and arterial acid-base status in the snake Python molorus are described. Four snakes (180-250 g) were cannulated in the dorsal aorta and blood samples were obtained during 72 h following ingestion of a meal (rat pups) exceeding 20% of body weight. Oxygen consumption increased from a fasting value of 1.71 +/- 0.08 to 5.54 +/- 0.42 ml kg-1 min-1 at 48 h following feeding, and the respiratory gas exchange ratio increased from 0.67 +/- 0.02 to a maximum of 0.92 +/- 0.03 at 32 h. Plasma lactate was always less than 0.5 mM, so the postprandial increase in metabolic rate was met by aerobic respiration. In fasting animals, arterial PO2 was 66 +/- 4 mmHg and haemoglobin-O2 saturation was 92 +/- 3%; similar values were recorded during digestion, but haematocrit decreased from 15.8 +/- 1.0 to 9.8 +/- 0.8 due to repeated blood sampling. Plasma [HCO3-] increased from a fasting level of 19.3 +/- 0.8 to 25.8 +/- 1.0 mmol l-1 at 24 h after feeding. However, because arterial PCO2 increased from 21.1 +/- 0.5 to 27.9 +/- 1.4 mmHg, there was no significant change in arterial pH from the fasting value of 7.52 +/- 0.01. Acid-base status returned to pre-feeding levels at 72 h following feeding. The increased arterial PCO2 is most likely explained by a reduction in ventilation relative to metabolism, but we predict that lung PO2 does not decrease below 115 mmHg. Although ingestion of large meals is associated with large metabolic changes in pythons, the attendant changes in blood gases are relatively small. In particular, the small changes in plasma [HCO3-] and stable pH show that pythons respond very differently to digestion than alligators where very large alkaline tides have been observed. It is unclear why pythons and alligators differ in the magnitude of their responses, but given these interspecific differences it seems worthwhile to describe arterial blood gases during digestion in other species of ectothermic vertebrates.

Acid-Base Imbalance↗
PubMed2003

Toxicogenomic effects of marine brevetoxins in liver and brain of mouse.

Although the polyether brevetoxins (PbTx's) produced by Karenia brevis (the organism responsible for blooms of the Florida red tide) are known to exert their acute toxic effects through ion-channel mediated pathways in neural tissue, prior studies have also demonstrated that at least one form of the toxin (PbTx-6) is bound avidly by the aryl hydrocarbon receptor (AhR). Since AhR binding of a prototypical ligand such as dioxin is the first step in a cascade pathway producing major changes in gene expression, we reasoned that PbTx-6 might produce similar genomic-wide changes in expression. Mice were injected i.p. with sub-lethal doses of PbTx's (either 1.5 or 3 mg/g body weight of PbTx-6; or 0.15 mg/g body weight of PbTx-2, a toxin not avidly bound by the AhR), and liver and brain tissues were sampled at 8, 24 and 72 h and RNA was isolated. Changes in gene-specific RNA levels were assessed using commercially available mouse cDNA arrays (Incyte) containing >9600 array elements, including many elements from AhR-mediated genes. Histopathology of the two organs was also assessed. We observed minor histopathological effects and a total of only 29 significant (>2.0-fold) changes in gene expression, most of which occurred in the liver, and most of which could be attributable to an 'acute phase' inflammatory response. These results argue against the hypothesis that PbTx-6 acts via a classic AhR-mediated mechanism to evoke gene expression changes. However, given the avidity with which PbTx-6 binds to the AhR, these findings have important implications for how PbTx's may act in concert with other toxicants that are sensed by the AhR.

Animals↗